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Polyvinylpyrrolidone VA 64 is a versatile copolymer that helps improve film strength, adhesion, and formulation stability.
Polyvinylpyrrolidone VA 64 is commonly preferred in hair styling, pharmaceutical, coating, and adhesive products because it forms clear and flexible films.
Polyvinylpyrrolidone VA 64's balanced vinylpyrrolidone and vinyl acetate structure provides good solubility, binding performance, and compatibility with many formulation systems.
CAS Number: 25086-89-9
Synonyms: Polyvinylpyrrolidone VA 64, PVP/VA 64, VP/VA Copolymer, Vinylpyrrolidone-vinyl acetate copolymer, Polyvinylpyrrolidone-vinyl acetate copolymer, Povidone-vinyl acetate copolymer, Copovidone, PVP-VA Copolymer, Poly(1-vinyl-2-pyrrolidone-co-vinyl acetate), Vinyl acetate-vinylpyrrolidone copolymer, PVP/VA resin, Film-forming copolymer, Binder polymer, Cosmetic film former, Pharmaceutical binder
Polyvinylpyrrolidone VA 64 liquid acts as a film former and pigments dispersant.
Polyvinylpyrrolidone VA 64 is used in cosmetic applications like aerosol hair sprays, pump sprays, setting lotions, setting mousses, gels and hair waxes.
Polyvinylpyrrolidone VA 64 is a vinylpyrrolidone-vinyl acetate copolymer, commonly used as a film-forming agent, binder, stabilizer, and dispersing polymer.
Polyvinylpyrrolidone VA 64 provides good adhesion, flexibility, solubility, and film strength in cosmetic, pharmaceutical, coating, adhesive, and industrial formulations.
Polyvinylpyrrolidone VA 64 is especially valued for forming clear, flexible films and improving the stability and performance of formulations.
Polyvinylpyrrolidone VA 64 is a copolymer of vinylpyrrolidone with vinyl acetate in an an easy-to-use aqueous solution.
Polyvinylpyrrolidone VA 64 is preserved with 0.05% max.
Polyvinylpyrrolidone VA 64 is an excellent film-former and hair styling agent.
Polyvinylpyrrolidone VA 64 is a copolymer composed of 60% vinylpyrrolidone and 40% vinyl acetate.
Polyvinylpyrrolidone VA 64 is an excipient used in the pharmaceutical grade, conforming to the monographs of the European Pharmacopoeia (Ph. Eur.) and the American Pharmacopoeia (USP).
Polyvinylpyrrolidone VA 64 is a 6:4 linear random copolymer of N-vinylpyrrolidone and vinyl acetate.
The vinyl acetate component of Polyvinylpyrrolidone VA 64 reduces the hydrophilicity and glass transition temperature (Tg) compared to povidone homopolymers of similar molecular weight.
As a result, Polyvinylpyrrolidone VA 64 is the ultimate tablet binder that extends its excellent adhesive property in wet granulation, as well as in dry granulation and direct compression.
Due to its spherical, hollow particle morphology and high plasticity, Polyvinylpyrrolidone VA 64 performs exceptionally well as a binder for direct compression.
In addition, a lower Tg makes Polyvinylpyrrolidone VA 64 an ideal polymer matrix for solid dispersions/solutions via hot melt extrusion, which enhances the dissolution of poorly soluble drug actives.
Applications of Polyvinylpyrrolidone VA 64:
Polyvinylpyrrolidone VA 64 is used in hair sprays, hair styling gels, cosmetics, pharmaceutical tablets, coatings, adhesives, inks, paints, and industrial formulations.
Polyvinylpyrrolidone VA 64 acts as a binder, film former, dispersant, stabilizer, and thickening aid depending on the application.
In personal care products, Polyvinylpyrrolidone VA 64 improves hold, film durability, flexibility, and product texture.
Pharmaceutical Industry:
Carrier polymer in solid dispersions (especially to increase the solubility of low-solubility active ingredients)
Film former in film coatings:
Additive in granulation and direct compression formulations
Nutritional Supplements:
To improve tablet stability and solubility
Cosmetics:
Film former and binder in hair sprays, lotions and creams
Advantages of Polyvinylpyrrolidone VA 64:
Polyvinylpyrrolidone VA 64 increases the solubility and bioavailability of poorly soluble drugs (e.g., in amorphous solid dispersions).
Polyvinylpyrrolidone VA 64 has good tablet binding properties.
Polyvinylpyrrolidone VA 64 is compatible with both hydrophilic and lipophilic substances.
Polyvinylpyrrolidone VA 64 is a pharmaceutically safe and non-toxic polymer.
Polyvinylpyrrolidone VA 64 is a very important excipient used in drug formulations, especially as a solid dispersion carrier.
Polyvinylpyrrolidone VA 64 is preferred for increasing the bioavailability of low-solubility active ingredients.
Stability and Reactivity of Polyvinylpyrrolidone VA 64:
Chemical stability:
Polyvinylpyrrolidone VA 64 is stable under recommended storage and handling conditions.
Reactivity:
No dangerous reaction is expected under normal conditions of use.
Polyvinylpyrrolidone VA 64 is generally considered a stable synthetic copolymer.
Conditions to avoid:
Avoid excessive heat, open flames, sparks, direct sunlight, moisture, dust formation, and contamination.
Incompatible materials:
Strong oxidizing agents, strong acids, strong bases, and reactive chemicals.
Hazardous decomposition products:
Thermal decomposition or combustion may produce carbon monoxide, carbon dioxide, nitrogen oxides, smoke, and irritating organic fumes.
Handling and Storage of Polyvinylpyrrolidone VA 64:
Handling:
Handle in accordance with good industrial hygiene and safety practices.
Avoid contact with eyes, skin, and clothing.
Avoid breathing dust.
Prevent dust accumulation and avoid creating airborne dust clouds.
Storage:
Store in a cool, dry, and well-ventilated area.
Keep container tightly closed when not in use.
Storage conditions:
Protect from heat, direct sunlight, moisture, ignition sources, and contamination.
Store away from incompatible materials.
Packaging materials:
Keep in original sealed bags, drums, fiber drums, boxes, or suitable industrial packaging.
Shelf life:
Stable under recommended dry and sealed storage conditions.
First Aid Measures of Polyvinylpyrrolidone VA 64:
Inhalation:
Move person to fresh air.
If dust causes coughing, irritation, or breathing difficulty, seek medical attention.
Skin contact:
Wash affected area with soap and plenty of water.
Remove contaminated clothing if necessary.
Seek medical attention if irritation persists.
Eye contact:
Rinse cautiously with clean water for several minutes.
Remove contact lenses if present and easy to do.
Continue rinsing and seek medical attention if irritation persists.
Ingestion:
Rinse mouth with water.
Do not induce vomiting unless instructed by medical personnel.
Seek medical attention if discomfort occurs.
Most important symptoms:
Dust may cause mild mechanical irritation to eyes, skin, and respiratory tract.
Firefighting Measures of Polyvinylpyrrolidone VA 64:
Suitable extinguishing media:
Use water spray, foam, dry chemical powder, or carbon dioxide.
Unsuitable extinguishing media:
Do not use a direct high-pressure water jet, as Polyvinylpyrrolidone VA 64 may spread burning powder or dust.
Specific hazards:
Product may burn under fire conditions.
Dust may form combustible dust clouds in air.
Combustion or thermal decomposition may produce carbon monoxide, carbon dioxide, nitrogen oxides, dense smoke, and irritating organic fumes.
Protective equipment for firefighters:
Firefighters should wear self-contained breathing apparatus and full protective clothing.
Firefighting instructions:
Cool exposed containers with water spray.
Avoid inhalation of smoke and decomposition gases.
Prevent contaminated firefighting water from entering drains or waterways.
Accidental Release Measures of Polyvinylpyrrolidone VA 64:
Personal precautions:
Avoid contact with eyes, skin, and clothing.
Avoid breathing dust.
Spilled powder may create a slipping hazard.
Use appropriate personal protective equipment.
Environmental precautions:
Prevent material from entering drains, soil, surface water, or waterways.
Methods for containment:
Stop spill if safe to do so.
Avoid dust generation and prevent material from spreading.
Methods for cleaning up:
Sweep, shovel, or vacuum using dust-control methods.
Place into suitable labeled containers for reuse or disposal.
Clean the area thoroughly after collection.
Disposal:
Dispose of collected material according to local, regional, and national regulations.
Exposure Controls / Personal Protective
Engineering controls:
Use adequate ventilation.
Provide local exhaust ventilation where dust may be generated during weighing, mixing, transfer, or processing.
Respiratory protection:
Normally not required under standard handling conditions.
Use suitable dust mask or respirator if dust levels are high or ventilation is insufficient.
Hand protection:
Wear protective gloves suitable for chemical handling.
Eye protection:
Wear safety glasses or chemical splash goggles.
Skin and body protection:
Wear suitable protective clothing to prevent prolonged or repeated contact.
Hygiene measures:
Wash hands after handling and before eating, drinking, or smoking.
Remove contaminated clothing and wash before reuse.
Keep away from food, beverages, and animal feed.
Identifiers of Polyvinylpyrrolidone VA 64:
Common name: Polyvinylpyrrolidone VA 64
CAS No.: 25086-89-9
EC No.: Not usually assigned as a single EC number for polymeric grades
INCI name: VP/VA Copolymer
Properties of Polyvinylpyrrolidone VA 64:
Appearance: White to off-white powder or granules
Odor: Mild characteristic odor
Solubility: Soluble in water, alcohols, and selected organic solvents depending on grade
