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Polyvinylpyrrolidone-vinyl acetate copolymer is a white to yellowish-white amorphous powder.
Polyvinylpyrrolidone-vinyl acetate copolymer is typically spray-dried with a relatively fine particle size.
Polyvinylpyrrolidone-vinyl acetate copolymer has a slight odor and a faint taste.
CAS Number: 25086-89-9
Molecular Formula: C10H15NO3
Molecular Weight: 197.23
EINECS Number: 200-001-8
Synonyms: Ganex E 535, ethenyl acetate;1-ethenylpyrrolidin-2-one, Copovidone (Technical Grade), Polectron 845, Luviskol VA 28I, Luviskol VA 37E, Luviskol VA 64, Kolima 10, Kolima 35, Gantron S 860, GAF-S 630, I 535, I 735, MFCD00134018, NSC114024, Luviskol VA 281, Luviskol VA 28 I, Luviskol VA 37 E, I 635, S 630, 25086-89-9 (Solution), Copovidone CRS, kolima10, Kolima 1, Luviskol VA-64, Gantron S860, vinyl acetate; 1-vinylpyrrolidin-2-one, SCHEMBL29127, vinylpyrrolidone/vinyl acetate, Vinyl Pyrrolidone/Vinyl Acetate, N-vinylpyrrolidone/vinyl acetate, 1-vinylpyrrolidone vinyl acetate, NSC114023, NSC114025, NSC114026, AKOS015898247, vinyl acetate;1-vinylpyrrolidin-2-one, 733045-73-3, DA-56957, I635, 1-ethenylpyrrolidin-2-one; ethenyl acetate, Poly(1-vinylpyrrolidone-co-vinyl acetate) solution, Acetic acid ethenyl ester, polymer with 1-ethenyl-2-pyrrolidinone, Poly(1-vinylpyrrolidone-co-vinyl acetate) (Copolymer, 7:3) (50% in Ethanol), Poly(1-vinylpyrrolidone-co-vinyl acetate), 50% in Ethanol (Copolymer, 3:7), Poly(1-vinylpyrrolidone-co-vinyl acetate), 50% in Ethanol (Copolymer, 7:3), Poly(1-vinylpyrrolidone-co-vinyl acetate), average Mw ~50,000 (GPC vs. poly(ethylene oxide)), powder, VA64, VA55, VA37, VA73., kolima10;kolima35;kolima75;luviskolva28i;luviskolva37e;luviskolva37i;luviskolva55e;luviskolva55i
Polyvinylpyrrolidone-vinyl acetate copolymer is a synthetic, water-soluble to water-dispersible copolymer made from two monomers: vinylpyrrolidone (VP) and vinyl acetate (VA).
Polyvinylpyrrolidone-vinyl acetate copolymer combines the strong film-forming and hydrophilic properties of PVP with the flexibility and hydrophobic character of vinyl acetate, making it widely useful in pharmaceuticals, cosmetics, adhesives, and coatings.
It is designed to balance solubility, adhesion, and film strength in formulations.
Polyvinylpyrrolidone-vinyl acetate copolymer improves material versatility and performance control.
Chemically, it is a random copolymer where vinylpyrrolidone units and vinyl acetate units are distributed along the same polymer chain.
The ratio between the two monomers determines its solubility, hardness, and flexibility.
Polyvinylpyrrolidone-vinyl acetate copolymer improves tunability of physical properties.
Physically, it is typically a white to off-white powder or granule that can dissolve or swell in water and organic solvents depending on composition.
It forms clear, flexible films upon drying.
Polyvinylpyrrolidone-vinyl acetate copolymer improves formulation handling and film quality.
Functionally, it acts as a film-former, binder, stabilizer, adhesion promoter, and solubilizer in many industrial and pharmaceutical systems.
Its amphiphilic nature allows it to interact with both polar and non-polar ingredients.
This improves compatibility in complex formulations.
Polyvinylpyrrolidone-vinyl acetate copolymer is best described as a versatile synthetic copolymer used to improve film formation, adhesion, stability, and solubility in pharmaceutical, cosmetic, and industrial applications.
Polyvinylpyrrolidone-vinyl acetate copolymer is a versatile, synthetic polymer valued for its excellent film-forming, binding, and adhesive properties.
Polyvinylpyrrolidone-vinyl acetate copolymer is widely used across the pharmaceutical, cosmetics, and agricultural industries as a tablet binder, hair styling agent, and protective coating.
Polyvinylpyrrolidone-vinyl acetate copolymer, also commonly called povidone, is a water-soluble polymer compound made from the monomer N-vinylpyrrolidone.
Polyvinylpyrrolidone-vinyl acetate copolymer is available in a range of molecular weights and related viscosities, and can be selected according to the desired application properties.
Polyvinylpyrrolidone-vinyl acetate copolymer is especially important in formulation science because it behaves as a tunable amphiphilic polymer, meaning its balance between water-loving and water-repelling behavior can be adjusted by changing the VP/VA ratio.
This allows engineers to design materials with specific dissolution, adhesion, and film properties.
Polyvinylpyrrolidone-vinyl acetate copolymer improves formulation precision and product customization.
In solid dispersion technology, it is widely used to stabilize drugs in an amorphous (non-crystalline) state, which generally improves solubility and dissolution rate compared to crystalline forms.
It works by preventing molecular rearrangement and recrystallization during storage.
Polyvinylpyrrolidone-vinyl acetate copolymer improves long-term drug performance and stability.
In spray drying and hot-melt processes, it acts as a carrier matrix that encapsulates active ingredients and forms uniform microparticles.
Its film-forming nature helps protect sensitive compounds during processing.
Polyvinylpyrrolidone-vinyl acetate copolymer improves manufacturing yield and product consistency.
In moisture protection systems, PVP–VA copolymer forms flexible films that reduce water uptake and protect sensitive ingredients from humidity.
This is especially useful for moisture-sensitive pharmaceuticals and coatings.
Polyvinylpyrrolidone-vinyl acetate copolymer improves shelf stability and product protection.
In adhesion science, it is used because it can adhere to a wide range of surfaces including metals, plastics, glass, and biological materials.
Polyvinylpyrrolidone-vinyl acetate copolymer broad adhesion profile comes from its mixed polarity structure.
Polyvinylpyrrolidone-vinyl acetate copolymer improves bonding versatility.
In cosmetic film technology, it is used to form lightweight, flexible films in hair styling products that provide hold without excessive stiffness or flaking.
Polyvinylpyrrolidone-vinyl acetate copolymer also helps maintain style durability under humidity.
Polyvinylpyrrolidone-vinyl acetate copolymer improves cosmetic performance and user experience.
In sunscreen and topical formulations, it can help stabilize dispersed UV filters and improve even film formation on the skin.
Polyvinylpyrrolidone-vinyl acetate copolymer ensures more uniform coverage and consistent protection.
Polyvinylpyrrolidone-vinyl acetate copolymer improves formulation stability and effectiveness.
In controlled-release systems, it can influence how water penetrates a formulation and how quickly active compounds are released.
Its swelling and dissolution behavior can be tuned by composition.
Polyvinylpyrrolidone-vinyl acetate copolymer improves release control and dosing precision.
In microencapsulation technologies, it is used to coat sensitive ingredients such as flavors, vitamins, or drugs, protecting them from oxidation, heat, or light.
This helps extend shelf life and improve stability.
Polyvinylpyrrolidone-vinyl acetate copolymer improves protection and functional durability.
In polymer blending systems, it is often combined with other polymers (like cellulose derivatives or PEG-based materials) to optimize mechanical strength and solubility.
Polyvinylpyrrolidone-vinyl acetate copolymer improves material performance and flexibility in formulation design.
Density: 1.27 g/mL at 25 °C (lit.)
Tg: 108
refractive index: 1.4300–1.4380
Flash point: 72 °F
solubility: Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane.
form: powder
color: white
Viscosity: 800.0 to 3000.0 mPa·s
Stability: Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.
Major Application: pharmaceutical (small molecule)
Cosmetics Ingredients Functions: BINDING; FILM FORMING; HAIR FIXING
InChI: 1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
InChIKey: FYUWIEKAVLOHSE-UHFFFAOYSA-N
SMILES: C(N1CCCC1=O)=C.O(C=C)C(=O)C
LogP: 0.370 (est)
Polyvinylpyrrolidone-vinyl acetate copolymer added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.
Polyvinylpyrrolidone-vinyl acetate copolymer complex is used in various products such as solutions, ointment, pessaries, liquid soaps, and surgical scrubs.
It is sold under the trade names Pyodine and Betadine, among others.
The performance of Polyvinylpyrrolidone-vinyl acetate copolymer depends strongly on the VP/VA ratio, which can be adjusted during manufacturing.
Higher vinylpyrrolidone content increases water solubility and hydrophilicity, while higher vinyl acetate content increases hydrophobicity and film strength.
Polyvinylpyrrolidone-vinyl acetate copolymer improves formulation customization.
In pharmaceutical applications, it is widely used to improve the dissolution of poorly soluble drugs by forming solid dispersions and stabilizing amorphous drug states.
Polyvinylpyrrolidone-vinyl acetate copolymer helps prevent recrystallization during storage.
Polyvinylpyrrolidone-vinyl acetate copolymer improves drug bioavailability and stability.
In tablet manufacturing, it acts as a binder that improves compressibility and mechanical strength of tablets.
Polyvinylpyrrolidone-vinyl acetate copolymer helps maintain structural integrity during handling and transport.
This improves dosage form reliability.
In film coating systems, it forms smooth, flexible, and transparent coatings that protect active ingredients from moisture and light.
These coatings also improve appearance and swallowing comfort.
Polyvinylpyrrolidone-vinyl acetate copolymer improves protection and patient usability.
In cosmetic formulations, it is used as a film-forming agent in hair sprays, gels, and styling products where it provides hold and flexibility without excessive stiffness.
Polyvinylpyrrolidone-vinyl acetate copolymer also helps stabilize emulsions.
Polyvinylpyrrolidone-vinyl acetate copolymer improves cosmetic performance and texture.
In adhesives and industrial coatings, it is used to enhance adhesion to various surfaces, including plastics, metals, and paper.
Its balanced polarity allows strong bonding across different materials.
Polyvinylpyrrolidone-vinyl acetate copolymer improves adhesive strength and durability.
In spray-drying and granulation processes, it acts as a binder and stabilizer for active ingredients during particle formation.
Polyvinylpyrrolidone-vinyl acetate copolymer helps produce uniform powders with controlled properties.
This improves manufacturing efficiency.
In food packaging coatings (indirect use depending on regulation), similar copolymers can be used to improve barrier properties and film integrity.
Polyvinylpyrrolidone-vinyl acetate copolymer helps extend shelf life and maintain product quality.
This improves packaging performance.
In research and material science, it is studied as a model amphiphilic copolymer for understanding how polymer composition affects solubility, adhesion, and film mechanics.
Polyvinylpyrrolidone-vinyl acetate copolymer improves polymer design knowledge.
Polyvinylpyrrolidone-vinyl acetate copolymer is widely used because it offers a rare combination of adhesion, flexibility, and controlled solubility, making it a “bridge polymer” between fully water-soluble and more hydrophobic systems.
Polyvinylpyrrolidone-vinyl acetate copolymer allows it to work in formulations where ingredients would otherwise separate or crystallize.
This improves formulation stability and compatibility.
In amorphous stabilization systems, it plays a key role in preventing active pharmaceutical ingredients from returning to their crystalline form over time.
Polyvinylpyrrolidone-vinyl acetate copolymer does this by molecular-level interaction with drug compounds, reducing mobility and rearrangement.
This improves long-term drug stability and performance.
In humidity-sensitive formulations, PVP–VA helps reduce the effect of moisture uptake by forming a protective polymer matrix.
Polyvinylpyrrolidone-vinyl acetate copolymer is especially important for drugs and cosmetics stored in variable climates.
This improves shelf-life reliability.
In surface energy modification, it can adjust how surfaces interact with liquids by changing wetting behavior and adhesion.
Polyvinylpyrrolidone-vinyl acetate copolymer makes it useful in coatings and film applications where controlled spreading is important.
This improves coating uniformity and performance.
In multi-layer film systems, it is often used as an intermediate layer that improves adhesion between different coating materials.
Polyvinylpyrrolidone-vinyl acetate copolymer acts as a compatibility enhancer between otherwise incompatible polymers.
This improves multilayer structural integrity.
In aerosol and spray formulations, it contributes to uniform film formation after spraying by quickly forming a continuous layer as the solvent evaporates.
Polyvinylpyrrolidone-vinyl acetate copolymer helps ensure even distribution of active ingredients.
This improves application consistency and coverage.
In taste-masking technologies (pharmaceuticals), it is used to coat unpleasant-tasting active ingredients, preventing immediate dissolution in the mouth.
Polyvinylpyrrolidone-vinyl acetate copolymer improves patient compliance and product acceptability.
In microencapsulation of volatile compounds, such as flavors or fragrances, it helps trap and protect sensitive molecules from evaporation or oxidation.
This extends functional lifetime and storage stability.
Polyvinylpyrrolidone-vinyl acetate copolymer improves product durability and performance.
Uses:
Polyvinylpyrrolidone-vinyl acetate copolymer is a water-soluble polymer used to improve the uptake and drug loading of various pharmaceutical agents, including contraceptive patches.
Polyvinylpyrrolidone-vinyl acetate copolymer is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations.
In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent.
Polyvinylpyrrolidone-vinyl acetate copolymer provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.
Polyvinylpyrrolidone-vinyl acetate copolymer is a frequently used binder in pharmaceutical tablet formulations.
Polyvinylpyrrolidone-vinyl acetate copolymer studies in humans and various laboratory animal models indicate no to very little systemic absorption of PVP following oral administration.
Polyvinylpyrrolidone-vinyl acetate copolymer is used in pleurodesis (fusion of the pleura because of incessant pleural effusions).
For this purpose, povidone-iodine is as effective and safe as talc, and may be preferred because of its easy availability and low cost.
Polyvinylpyrrolidone-vinyl acetate copolymer is used in some contact lenses and their packaging solutions.
Polyvinylpyrrolidone-vinyl acetate copolymer reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Examples of this use include Bausch & Lomb's Ultra contact lenses with MoistureSeal Technology, Air Optix contact lens packaging solution (as an ingredient called "copolymer 845"), and Johnson & Johnson's Acuvue contact lenses.
Polyvinylpyrrolidone-vinyl acetate copolymer is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes.
Polyvinylpyrrolidone-vinyl acetate copolymer has also been used in contact lens solutions and in steel-quenching solutions.
Polyvinylpyrrolidone-vinyl acetate copolymer is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.
Polyvinylpyrrolidone-vinyl acetate copolymer can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer.
It is also exceptionally good at absorbing polyphenols during DNA purification.
Polyvinylpyrrolidone-vinyl acetate copolymer are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.
Polyvinylpyrrolidone-vinyl acetate copolymer is mainly used as a film-former, binder, adhesion promoter, stabilizer, and solubilizer because it combines hydrophilic and hydrophobic properties in a single material.
In pharmaceutical formulations, it is used to improve drug solubility and stability.
Polyvinylpyrrolidone-vinyl acetate copolymer improves bioavailability and formulation performance.
In tablet and capsule production, it is used as a binder and structural agent.
Polyvinylpyrrolidone-vinyl acetate copolymer improves mechanical strength and dosage reliability.
In film coating systems, it is used to form protective and flexible coatings.
Polyvinylpyrrolidone-vinyl acetate copolymer improves stability, appearance, and patient acceptability.
In cosmetic products (hair sprays, gels, styling products), it is used as a film-forming agent.
Polyvinylpyrrolidone-vinyl acetate copolymer improves hold, flexibility, and texture.
In adhesives and industrial coatings, it is used to improve bonding and surface adhesion.
Polyvinylpyrrolidone-vinyl acetate copolymer improves durability and material performance.
In spray-dried and granulated formulations, it is used as a stabilizer and processing aid.
Polyvinylpyrrolidone-vinyl acetate copolymer improves manufacturing efficiency and product uniformity.
Polyvinylpyrrolidone–vinyl acetate copolymer is mainly used as a film-former, binder, solubilizer, stabilizer, adhesion promoter, and carrier polymer because it combines hydrophilic and hydrophobic properties in a single adaptable structure.
In pharmaceutical solid dispersions, it is used to improve solubility and stability of poorly soluble drugs.
Polyvinylpyrrolidone-vinyl acetate copolymer improves bioavailability and therapeutic effectiveness.
In tablet and capsule formulations, it is used as a binder and matrix-forming agent.
Polyvinylpyrrolidone-vinyl acetate copolymer improves mechanical strength and dosage consistency.
In film coating applications, it is used to form flexible, protective coatings.
Polyvinylpyrrolidone-vinyl acetate copolymer improves stability, appearance, and moisture resistance.
In cosmetic products (hair sprays, gels, styling products), it is used as a film-forming agent.
Polyvinylpyrrolidone-vinyl acetate copolymer improves hold, flexibility, and humidity resistance.
In adhesives and industrial coatings, it is used to improve adhesion across different materials.
This improves durability and bonding performance.
In spray-dried powders and granules, it is used as a carrier and stabilizer.
This improves particle quality and manufacturing efficiency.
Polyvinylpyrrolidone–vinyl acetate copolymer is mainly used as a film-former, binder, solubilizer, stabilizer, adhesion promoter, and carrier polymer because it provides balanced hydrophilic–hydrophobic performance.
In pharmaceutical solid dispersions, it is used to improve drug solubility and prevent crystallization.
Polyvinylpyrrolidone-vinyl acetate copolymer improves bioavailability and stability.
In tablet and capsule formulations, it is used as a binder and structural matrix.
This improves mechanical strength and dosage uniformity.
In film coating systems, it is used to form flexible protective coatings.
Polyvinylpyrrolidone-vinyl acetate copolymer improves stability, appearance, and moisture resistance.
In cosmetic products (hair sprays, gels, styling formulations), it is used as a film-forming agent.
Polyvinylpyrrolidone-vinyl acetate copolymer improves hold, flexibility, and humidity resistance.
In adhesives and coatings, it is used to improve bonding across different materials.
Polyvinylpyrrolidone-vinyl acetate copolymer improves adhesion and durability.
In spray-dried and granulated formulations, it is used as a stabilizing carrier polymer.
This improves particle quality and manufacturing efficiency.
Polyvinylpyrrolidone–vinyl acetate copolymer is mainly used as a film-former, binder, solubilizer, stabilizer, adhesion promoter, and carrier polymer because it combines hydrophilic (PVP) and hydrophobic (vinyl acetate) properties in a single adaptable material.
In pharmaceutical solid dispersions, it is used to improve the solubility and dissolution rate of poorly water-soluble active ingredients.
Polyvinylpyrrolidone-vinyl acetate copolymer improves bioavailability and therapeutic effectiveness.
In tablet and capsule formulations, it is used as a binder and matrix-forming agent that improves mechanical strength and integrity.
Polyvinylpyrrolidone-vinyl acetate copolymer improves dosage consistency and product stability.
In film coating systems, it is used to form smooth, flexible, and protective coatings on tablets and granules.
Polyvinylpyrrolidone-vinyl acetate copolymer improves moisture protection, stability, and appearance.
In spray-dried and granulated formulations, it is used as a carrier polymer to stabilize active ingredients during particle formation.
Polyvinylpyrrolidone-vinyl acetate copolymer improves powder quality and manufacturing efficiency.
In cosmetic products (hair sprays, gels, styling products), it is used as a film-forming agent that provides hold and flexibility.
Polyvinylpyrrolidone-vinyl acetate copolymer improves styling performance and humidity resistance.
In adhesives and industrial coatings, it is used to improve adhesion to different surfaces such as plastics, metals, and paper.
Polyvinylpyrrolidone-vinyl acetate copolymer improves bonding strength and durability.
In microencapsulation systems, it is used to coat sensitive ingredients like flavors, vitamins, or drugs to protect them from oxidation and moisture.
Polyvinylpyrrolidone-vinyl acetate copolymer improves shelf life and stability.
In controlled-release formulations, it is used as a matrix material that helps regulate how quickly active ingredients are released.
Polyvinylpyrrolidone-vinyl acetate copolymer improves dosing control and consistency.
In suspension and dispersion systems, it is used as a stabilizer to keep particles evenly distributed.
Safety Profile:
Polyvinylpyrrolidone-vinyl acetate copolymer is used widely in pharmaceutical formulations and is generally regarded as nontoxic.
However, it is moderately toxic by ingestion, producing gastric disturbances.
Polyvinylpyrrolidone-vinyl acetate copolymer has no irritating or sensitizing effects on the skin.
A study was conducted to look at the carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs.
The results of these studies demonstrated the absence of any significant toxicological findings of high dietary levels of copodivone in rats and dogs, resulting in noobserved- adverse-effect levels of 2800 mg/kg body-weight/day in rats and 2500 mg/kg body-weight/day in dogs, the highest doses tested.
Polyvinylpyrrolidone–vinyl acetate copolymer is generally considered a low-toxicity, low-reactivity polymer, widely used in pharmaceutical and cosmetic products under regulated conditions.
The main hazard is dust-related irritation, which may occur during handling of the dry powder.
It can cause temporary irritation to the eyes, nose, throat, or respiratory tract.
Polyvinylpyrrolidone-vinyl acetate copolymer improves workplace safety awareness.
Inhalation of airborne particles may cause mild respiratory discomfort, especially in poorly ventilated industrial environments.
Proper ventilation and dust control are recommended.
Polyvinylpyrrolidone-vinyl acetate copolymer improves occupational exposure management.
Eye contact with powder may cause mechanical irritation, but it is not corrosive or chemically damaging.
Rinsing with water is sufficient for first aid.
Polyvinylpyrrolidone-vinyl acetate copolymer improves handling safety.
Skin contact is generally considered low risk, and the polymer is widely used in topical and oral pharmaceutical formulations with good tolerability.
Polyvinylpyrrolidone-vinyl acetate copolymer improves consumer safety confidence.
From a toxicological perspective, both monomers and the final polymer are considered to have low acute toxicity in regulated applications, and it is widely accepted in pharmaceutical manufacturing.
