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Potassium Salicylate is the monopotassium salt of Salicylic Acid and a water-soluble aromatic hydroxycarboxylate.
Potassium Salicylate provides salicylate functionality in aqueous pharmaceutical, cosmetic, analytical, biochemical, and chemical-processing systems.
Potassium Salicylate is used as a preservative where authorized, a research reagent, a synthesis intermediate, and a soluble source of salicylate ions.
CAS Number: 578-36-9
EC Number: 209-421-6
Molecular Formula: C₇H₅KO₃
Molecular Weight: 176.21 g/mol
SYNONYMS
Potassium Salicylate, Salicylic Acid Potassium Salt, Salicylic Acid Monopotassium Salt, Potassium 2-Hydroxybenzoate, Potassium o-Hydroxybenzoate, Potassium Ortho-Hydroxybenzoate, Benzoic Acid, 2-Hydroxy-, Monopotassium Salt, Benzoic Acid, 2-Hydroxy-, Potassium Salt, 2-Hydroxybenzoic Acid Potassium Salt, 2-Hydroxybenzoic Acid Monopotassium Salt, Monopotassium Salicylate, Salicylate Potassium Salt, Potassium Salt of Salicylic Acid, Potassium Salt of 2-Hydroxybenzoic Acid, Potassium 2-Hydroxybenzenecarboxylate, Potassium o-Salicylate, Potassium Orthosalicylate, Potassium Salicylate Powder, Potassium Salicylate Crystals, Potassium Salicylate Reagent, Potassium Salicylate Solution, Aqueous Potassium Salicylate, Pharmaceutical Potassium Salicylate, Cosmetic Potassium Salicylate, Analytical Potassium Salicylate, Laboratory Potassium Salicylate, High-Purity Potassium Salicylate, Technical-Grade Potassium Salicylate, Salicylate Ion Potassium Salt, Potassium Hydroxybenzoate, Potassium Hydroxybenzoic Acid Salt, Potassium Phenolic Carboxylate, Aromatic Hydroxycarboxylate Potassium Salt, Potassium Salicylate Preservative, Water-Soluble Salicylate, Soluble Salicylic Acid Salt, Salicylic Acid Potassium Derivative, Potassium Salicylate Intermediate, Potassium Salicylate Standard, Potassium Salicylate Reference Material, Potassium Salicylate Research Reagent, Potassium Salicylate Biochemical Reagent, Potassium Salicylate Plant Research Reagent, Potassium Salicylate Cosmetic Preservative, Potassium Salicylate Pharmaceutical Salt, CAS 578-36-9, EC 209-421-6, EINECS 209-421-6, PubChem CID 23664627, UNII K91YT16P5M, C₇H₅KO₃
APPLICATIONS
Potassium Salicylate serves as a readily water-soluble source of salicylate ions in aqueous formulation and laboratory systems.
Potassium Salicylate allows salicylate concentration to be adjusted without relying on the limited water solubility of free Salicylic Acid.
Potassium Salicylate supports pharmaceutical formulation research involving aqueous salicylate solutions, suspensions, gels, and semisolid dosage forms.
Potassium Salicylate pharmaceutical use requires suitable purity, validated dosage, regulatory authorization, and complete safety assessment.
Potassium Salicylate functions in research formulations investigating the analgesic, antipyretic, or anti-inflammatory behavior of salicylate salts.
Potassium Salicylate should not be represented as an approved medicinal treatment unless the exact product and jurisdiction support that claim.
Potassium Salicylate contributes to topical pharmaceutical research requiring a dissolved salicylate source.
Potassium Salicylate performance depends on formulation pH, concentration, vehicle composition, skin exposure, and conversion to Salicylic Acid.
Potassium Salicylate can be evaluated in oral-liquid and soluble-powder research where a potassium salicylate salt is specifically required.
Potassium Salicylate oral applications require careful control because excessive systemic salicylate exposure can produce serious toxicity.
Potassium Salicylate functions as a cosmetic preservative in product categories and markets where such use is legally authorized.
Potassium Salicylate preservative concentration must comply with current destination-market limits calculated according to the applicable regulatory definition.
Potassium Salicylate supports shampoo formulations requiring preservation or salicylate functionality under permitted conditions.
Potassium Salicylate must be tested for surfactant compatibility, finished-product pH, preservation efficacy, scalp tolerance, and packaging stability.
Potassium Salicylate contributes to rinse-off hair-care products where a water-soluble salicylate ingredient is permitted.
Potassium Salicylate cannot independently establish antidandruff or therapeutic claims without the required regulatory authorization and efficacy evidence.
Potassium Salicylate can be evaluated in skin-cleansing formulations requiring a soluble aromatic hydroxycarboxylate.
Potassium Salicylate concentration and pH must be selected to prevent unacceptable irritation, sensitization, or excessive systemic exposure.
Potassium Salicylate supports creams, lotions, gels, and aqueous serums when preservative or conditioning use is authorized.
Potassium Salicylate compatibility must be confirmed with emulsifiers, polymers, electrolytes, fragrances, preservatives, and active ingredients.
Potassium Salicylate functions in cosmetic formulation studies comparing Salicylic Acid with sodium, potassium, calcium, and organic-amine salicylates.
Potassium Salicylate allows researchers to examine differences in solubility, ionic strength, pH response, crystallization, and skin availability.
Potassium Salicylate contributes to aqueous pH-control systems involving the Salicylic Acid and salicylate equilibrium.
Potassium Salicylate can be combined experimentally with Salicylic Acid to prepare salicylate-buffered solutions within an appropriate pH region.
Potassium Salicylate serves as a chemical intermediate for recovering Salicylic Acid through controlled acidification.
Potassium Salicylate releases free Salicylic Acid when a sufficiently strong compatible acid protonates the salicylate carboxylate group.
Potassium Salicylate supports preparation of other salicylate salts through ion-exchange, precipitation, or metathesis procedures.
Potassium Salicylate reaction conditions must account for counterion solubility, pH, temperature, water content, and product-purification requirements.
Potassium Salicylate functions as an analytical reference substance in chemical and pharmaceutical quality-control laboratories.
Potassium Salicylate can support identification, assay calibration, retention-time confirmation, and salicylate recovery studies.
Potassium Salicylate contributes to high-performance liquid chromatography methods developed for salicylate determination.
Potassium Salicylate can be used to prepare aqueous standards after concentration, purity, moisture, and volumetric conditions are accurately controlled.
Potassium Salicylate supports ion-chromatography and capillary-electrophoresis research involving aromatic carboxylate ions.
Potassium Salicylate migration and retention depend on electrolyte composition, pH, ionic strength, column chemistry, and detector selection.
Potassium Salicylate functions in ultraviolet and visible spectrophotometric methods used to quantify salicylate.
Potassium Salicylate solutions can provide calibration points when absorbance conditions, pH, wavelength, and matrix effects are validated.
Potassium Salicylate contributes to colorimetric laboratory tests based on complex formation between salicylate and suitable metal ions.
Potassium Salicylate can produce colored iron-salicylate complexes under controlled acidic or aqueous analytical conditions.
Potassium Salicylate supports development and calibration of salicylate-sensitive electrodes, membranes, and chemical sensors.
Potassium Salicylate provides a defined salicylate ion source for evaluating sensitivity, selectivity, interference, response time, and detection range.
Potassium Salicylate serves as a salicylate source in plant-physiology and plant-defense research.
Potassium Salicylate can be evaluated for effects on signaling, stress response, antioxidant systems, growth, and pathogen-related plant processes.
Potassium Salicylate supports seed-germination and seedling-development experiments requiring controlled salicylate exposure.
Potassium Salicylate plant response depends strongly on species, concentration, growth stage, application method, and environmental conditions.
Potassium Salicylate contributes to postharvest research involving physiological stress, senescence, quality retention, and plant signaling.
Potassium Salicylate should be used only within validated experimental designs and should not be assumed suitable for commercial crop treatment.
Potassium Salicylate functions in microbiological and biochemical research requiring soluble salicylate ions.
Potassium Salicylate can be evaluated for effects on microbial growth, enzyme activity, gene expression, metabolism, and membrane behavior.
Potassium Salicylate supports synthesis of coordination compounds and functional metal-salicylate complexes.
Potassium Salicylate provides both carboxylate oxygen atoms and a neighboring phenolic group capable of influencing metal-ion coordination.
DESCRIPTION
Potassium Salicylate is the potassium salt formed by neutralization of the carboxylic acid group of Salicylic Acid.
Potassium Salicylate is systematically identified as potassium 2-hydroxybenzoate.
Potassium Salicylate has the molecular formula C₇H₅KO₃ and a molecular weight of approximately 176.21 g/mol.
Potassium Salicylate is identified by CAS Number 578-36-9 and EC Number 209-421-6.
Potassium Salicylate consists of one potassium cation and one 2-hydroxybenzoate anion.
Potassium Salicylate retains the phenolic hydroxyl group of Salicylic Acid while the carboxyl group exists predominantly as a carboxylate.
Potassium Salicylate normally appears as a white to off-white crystalline powder or crystalline solid.
Potassium Salicylate exact appearance can vary with hydration, purity, particle size, storage history, and manufacturing specification.
Potassium Salicylate is substantially more compatible with water than free Salicylic Acid.
Potassium Salicylate dissociates in aqueous solution to produce potassium ions and salicylate ions.
Potassium Salicylate aqueous solutions generally display a higher pH than equivalent solutions of free Salicylic Acid.
Potassium Salicylate solution behavior depends on concentration, temperature, water quality, dissolved carbon dioxide, and added acids or bases.
Potassium Salicylate can be manufactured by neutralizing Salicylic Acid with potassium hydroxide, potassium carbonate, or another suitable potassium base.
Potassium Salicylate production normally includes dissolution or reaction, pH adjustment, concentration, crystallization, separation, and drying.
Potassium Salicylate can be converted back to free Salicylic Acid by acidification below the effective dissociation region of the carboxyl group.
Potassium Salicylate acidification can reduce water solubility and cause Salicylic Acid to crystallize or precipitate.
Potassium Salicylate interacts with selected metal ions through its carboxylate group and neighboring phenolic functionality.
Potassium Salicylate can form colored or sparingly soluble complexes depending on metal identity, pH, concentration, and competing ligands.
Potassium Salicylate is nonvolatile under ordinary storage and handling conditions.
Potassium Salicylate dust can nevertheless become airborne during weighing, charging, grinding, transfer, and cleanup.
Potassium Salicylate quality is commonly controlled through identity, assay, water content, appearance, solution clarity, pH, and related-substance testing.
Potassium Salicylate pharmaceutical, cosmetic, analytical, biochemical, and technical grades are not automatically interchangeable.
Potassium Salicylate is listed in European substance records as a permitted cosmetic preservative subject to applicable restrictions.
Potassium Salicylate cosmetic use must follow the current concentration limits, age restrictions, product-category conditions, and finished-product safety assessment.
Potassium Salicylate is commonly notified as harmful if swallowed and capable of causing serious eye damage.
Potassium Salicylate exact hazard classification must be confirmed from the current jurisdiction-specific and grade-specific Safety Data Sheet.
PROPERTIES
Chemical Name: Potassium 2-Hydroxybenzoate
Chemical Class: Aromatic Hydroxycarboxylate Salt
CAS Number: 578-36-9
EC Number: 209-421-6
Molecular Formula: C₇H₅KO₃
Molecular Weight: 176.21 g/mol
Physical Form: Crystalline Powder or Solid
Appearance: White to Off-White
Water Solubility: Readily Soluble
Ionic Character: Potassium and Salicylate Ions in Water
Primary Functions: Salicylate Source, Preservative Where Authorized, Research Reagent, and Chemical Intermediate
Main Uses: Cosmetics, Pharmaceutical Research, Analytical Chemistry, Plant Research, and Chemical Synthesis
Common Hazard Concerns: Harmful if Swallowed and Serious Eye Damage
Storage: Cool, Dry, Tightly Closed, and Protected from Moisture and Contamination
FIRST AID
Inhalation
Potassium Salicylate dust exposure should be followed by movement to fresh air and rest in a position comfortable for breathing.
Potassium Salicylate inhalation requires medical attention if coughing, throat irritation, wheezing, dizziness, or breathing difficulty persists.
Skin Contact
Potassium Salicylate contamination should be removed from the skin using soap and plenty of water.
Potassium Salicylate skin exposure requires medical attention if persistent irritation, redness, pain, rash, or another adverse response develops.
Eye Contact
Potassium Salicylate eye exposure should be rinsed immediately and continuously with clean water for at least 15 minutes while the eyelids are held open.
Potassium Salicylate eye exposure requires contact-lens removal when easy and urgent medical attention because serious eye injury can occur.
Ingestion
Potassium Salicylate accidental ingestion should be followed by thorough rinsing of the mouth without inducing vomiting unless directed by medical personnel.
Potassium Salicylate ingestion requires prompt contact with a physician or poison information center because harmful systemic salicylate exposure can develop.
Note to Physicians
Potassium Salicylate exposure should be treated symptomatically with appropriate supportive care and assessment of acid-base and electrolyte status when clinically indicated.
Potassium Salicylate ingestion assessment should consider nausea, vomiting, tinnitus, sweating, rapid breathing, confusion, quantity, exposure time, and salicylate sensitivity.
HANDLING AND STORAGE
Handling
Potassium Salicylate should be handled using methods that minimize dust generation, moisture uptake, and unnecessary skin or eye contact.
Potassium Salicylate should be kept away from food, drink, strong acids, strong oxidizing agents, and incompatible processing chemicals.
Ventilation
Potassium Salicylate powder-handling areas should have effective general ventilation and local dust extraction where necessary.
Potassium Salicylate respiratory protection should be used when engineering controls cannot adequately limit airborne dust.
Storage
Potassium Salicylate should be stored in tightly closed and moisture-resistant containers within a cool, dry, and well-ventilated area.
Potassium Salicylate should be protected from humidity, direct sunlight, excessive heat, contamination, strong acids, and damaged packaging.
Spill and Leak Procedures
Potassium Salicylate spills should be collected using filtered vacuum equipment or another recovery method that minimizes airborne dust.
Potassium Salicylate should be prevented from entering drains or surface water in bulk quantities, and collected waste should be placed in labeled containers.
Handling Precautions
Potassium Salicylate handling should include chemical-resistant gloves, protective clothing, and tightly fitting safety goggles.
Potassium Salicylate processing should follow the current grade-specific Safety Data Sheet, exposure controls, and applicable pharmaceutical, cosmetic, or industrial regulations.
