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POVIDONE K 17

CAS Number: 9003-39-8
MDL number: MFCD00149016
Linear Formula: (C6H9NO)n

Povidone K 17 has biocompatibility, low toxicity, adhesive characteristics, complexing stability, relatively inert behavior, and is resistant to thermal degradation.
Povidone K 17 is readily prepared by the polymerization of N-vinyl-2-pyrrolidone or by the Reppe synthesis technique.
Soluble in water, ethanol, ether and other organic solvents.

Povidone K 17 is white to milky white powder.
Odorless or slightly odorous, tasteless, with hygroscopicity.
Povidone K 17 is soluble in water, ethanol, isopropanol or chloroform, and insoluble in acetone or ether.
Povidone K 17 , also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone

Povidone K 17 is homopolymer.
Povidone K 17 exists as powder or aqueous solution.
Povidone K 17 can dissolve in water and variety of organic solvent.
Povidone K 17 CAS 9003-39-8 is a hygroscopic polymer with a molecular weight ranging from 45000 to 58000, available as a white or creamy white powder.

Excellent hygroscopic, film-forming, adhesive, chemical stability and toxicological safety characters in water and many other organic solvents.
Povidone K 17 is a non-ionic high molecular polymer.
PVP is classified according to its average molecular weight.
PVP is customarily used to indicate the K value.

Different K values represent different PVP average molecular weight ranges.
The K value is actually a characteristic value related to the relative viscosity of the PVP aqueous solution, and the viscosity is a physical value related to the molecular weight of the high molecular polymer.
Therefore, the K value can be used to characterize the average molecular weight of PVP.
Generally, the K value is more Large, the greater the viscosity.

Povidone K 17, also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.
Povidone K 17 exists as white or milk white powder or colorless or slight yellow transparent liquid.
Povidone K 17 can dissolve in water and a variety of organic solvents.

Povidone K 17 has good hygroscopicity, film-forming capability, complexing ability and physiological compatibility.
Polyvinylpyrrolidone is a hygroscopic, amorphous polymer supplied as a white, free-flowing powder or a clear aqueous solution. Available in several molecular weight grades, they are characterized by K-value, and used in a great variety of applications.
What the different is we use K value to distinguish different PVP.

The K value of PVP is actually the characteristic value associated with the relative viscosity of the PVP aqueous solution, and the viscosity is the physical quantity associated with the molecular weight of the polymer.
Therefore, the average molecular weight of the PVP can be characterized by the K value.
Usually the greater the K value, the greater the viscosity, the stronger the adhesion.

Molecular weight of polymer is generally expressed as weight average(Mw), number average and viscosity average.
The most commonly used expression is weight average molecular weight, which is measured by light scattering method.
Mw Values of PVP-K series products are shown as following:
PVP-K12   2,000-------------------3,000
PVP-K17   7,000--------------1,1000
PVP-K25   28,000-----------------34,000
PVP-K30   44,000-----------------54,000
PVP-K60   320,000---------------380,000
PVP-K90   1,000,000-----------1,500,000
PVP-K120 1,600,000-----------2,000,000
Besides, different K value of PVP have different characteristics and applications.

Povidone K 17 in solid drugs can be used not only as a binder, solubilizer, disintegrating agent, extend agent, but also as a film coat and capsules and controlled release film.
Povidone K 17 exists as white or milk white powder or colorless or slight yellow transparent liquid.
Povidone K 17 can dissolve in water and a variety of organic solvents.

Povidone K 17 has good hygroscopicity, film-forming capability, complexing ability and physiological compatibility.
Povidone K 17 Technical Grade is a Homopolymer of vinylpyrrolidone (Polyvinylpyrrolidone) in a powder form.
Povidone K 17 has a low molecular weight.

Suitable for use in styling formulas in liquid form, such as in spray form by giving natural styling (natural-hold) not stiff, used to catch curls.
Can be dissolved in water up to 20%, can withstand heat up to 80 degrees for a period of not more than 15 minutes.
White free flouring hygroscopic powder, freely soluble in ethanol, methanol, slightly soluble in acetone.

Because of Povidone K 17's solubility in water and in many organic solvents, Povidone K 17's high binding power and ability to form complexes, soluble polyvinylpyrrolidone occupies a special position among the synthetic colloids.
Povidone K 17 can not only improve the hydrophilicity of the membrane, but also control the pore size and distribution of the membrane by selecting PVP with different molecular weights and controlling the amount of addition.

Due to Povidone K 17's low molecular mass, Povidone K 17 is rapidly dissolved in water and most polar solvents.
Therefore, Povidone K 17 improves the solubility of materials in polar solvents.
Povidone K 17 is necessary to prevent particles from clumping and crystallization.
This property is particularly applicable to solid and liquid antibiotics.

PVPs with higher K-Value, because of higher molecular mass cannot be used in injectable materials.
Povidone K 17 exists as white or yellowish powder and aquous solution.
Povidone K 17 can dissolve in water and a variety of organic solvents.
Povidone K 17 has good hygroscopicity, film-forming capability, complexing ability and physiology compatibility.

Povidone K17 K30 K90 exists as white or milk white powder or colorless or slight yellow transparent liquid.
Povidone K 17 can dissolve in water and a variety of organic solvents.
Povidone K 17 has good hygroscopicity, film-forming capability, complexing ability and physiological compatibility.
PVP K17 exists in white powder or aqueous solution.

Povidone K 17 has good solubility, biocompatibility, and physiologically inert, film-forming character, colloid protect ability and compound ability to many organic or inorganic compounds.
Povidone K 17 is also steady to acid, salt and heat, so it is widely used.

USES and APPLICATIONS of Povidone K 17:
-Low molecular weight Povidone K 17, often used as a solubilizing agent, crystallization inhibitor and suspension stabilizer in injection.
-Povidone K 17 possess excellent adhesive,film-forming,dispersing and thickening properties,and are widely used in the pharmaceutical industry.
-Use in styling formulas by acting as a hair fixative

-Industrial applications of Povidone K 17 include use as an adhesive to improve strength and thickness; increase strength in paper production; use as a resin coating; improve dye coloration in synthetic fibers; also commonly used in inks, imaging, lithography, detergents and soaps , textiles, pottery, electricity, metallurgy, and as a polymerization additive.
-Povidone K 17 is also widely used in the pharmaceutical industry due to its excellent adhesion, film formation, dispersion and thickening properties.

-Povidone K 17 has excellent adhesive, film-forming, dispersion and thickening properties and is widely used in the pharmaceutical industry.
-Povidone K 17 is a polymer used as a pharmaceutical aid, complexing agent, and solubilizer.
-Povidone K 17 was used as a plasma volume expander for trauma victims.
-Povidone K 17 acts as diluent, solvent and cleaning agent in various kinds of industries.

-Povidone K 17 also acts as an adjuvant, emulsifier, filtering aid, tableting aid, thickener.
-Povidone K 17 possess excellent adhesive,film-forming, dispersing and thickening properties, which are widely used in the pharmaceutical industry.
-Low molecular weight Povidone K 17, for use as a solubilizing agent,crystallization inhibitor and suspension stabilizer in injectables and ophthalmic formulations

-Used for styling formulas or a face mask (peel-off) to harden the texture.
-Both hair styling products And mask products should use different levels of PVP together in order to obtain a suitable formula
-Povidone K 17 is a kind of new excellent pharmaceutical excipient.

-Povidone K 17 is mainly used as binder for tablet and granule, dissolving assistant for injection, flow assistant for capsule, dispersant for liquid medicine and pigment, stabilizer for enzyme and heat-sensitive drug, coprecipitant for poorly soluble drugs, lubricator and antitoxic assistant for eye drug.
-Povidone K 17 has been used as excipient in more than one hundred drugs.

-Application in industrial fields:
* Suspension, dispersion and emulsifier
* Glass fiber
* detergent
* Plastics and resin
* Ink, paint and coating
* Textile dyeing and printing
* Film and adhesive
* TV tube

-Application in Cosmetics:
--Povidone K 17 is widely used in a wide range of hair care, skin care and oral care products.
--Povidone K 17 are particularly suitable for formulations where viscosity modification and film forming properties are required.
--Povidone K 17 are especially suitable for hair styling products.
--Povidone K 17 is widely used in cosmetics as below
* Hair Gels
* Hair foam
* Liquid hair fixing preparations
* Pump Sprays

-In pill crushing, Povidone K 17 is commonly used as a tablet binder to make the pills strong and not easy to break.
-Low molecular weight Povidone K 17 is often used as a solubilizing agent, crystallization inhibitor and suspension stabilizer in injection, and ophthalmic formulations.

-Dishwashing liquids
-Dishwashing and laundry tablets
-Laundry detergents
-Hard surface cleaners

-Home care features and benefits:
*Acts as rheology modifier
*Is a highly adhesive tablet binder
*Stabilizes emulsion and structures liquid products
*Provides anti-soil redeposition, enzyme stabilization and dye transfer inhibition
*Functions as binder and protective coating for enzymes
*Provides surface shine enhancement
*Forms hard, transparent, glossy films
*Home care applications

-Povidone K 17 is used as a colloidal stabilizer and clarifier, can be used for the clarification of beer, according to the production needs of the appropriate amount of use.
-Povidone K 17 is one of the constituents used in the synthesis and coating of silver nanocubes.
-Povidone K 17 serves as a reducing agent and colloidal stabilizer in the synthesis of palladium nanobars and nanoplates.

-Povidone K 17 is also used as a capping agent in the synthesis of silver nanospheres.
-General applications of Povidone K 17 are: in pharmaceutical, food, beverage, cosmetic, toiletry and photographic industries.
-Used as stationary liquid for gas chromatography

-Povidone K 17 can be used as a protective colloid and thickening agent in adhesive dispersions.
-Povidone K 17 is used in adhesive sticks, wettable gums for postage stamps, envelopes and in pick-up adhesives for bonds that can be broken and remade several times.
-Povidone K 17 is used in paints, coatings, inks, textile dying and printing.

-Povidone K 17 is used in hair styling formulations by acting as a hair fixative
-Povidone K 17 is used in facial mask formulas by acting as a thickener / film former
-For a variety of substances, Povidone K 17 have a strong ability to complex adsorption.

-Povidone K 17 is used in the following applications:
*Membranes:
Hydrophilicity, pore size formation, biocompatibility, non toxic
*Specialty paper / Films / Ink-jet media / Inks:
Viscosity modifier, binder, complex formation, fixation

-Povidone K 17 can not only improve the hydrophilicity of the membrane, but also control the pore size and distribution of the membrane by selecting PVP with different molecular weights and controlling the amount of addition.
-Povidone K 17 has applications in the fields of new materials such as drag reduction materials, optical fibers, laser discs, photo-curable resins, and photosensitive materials.

-Electronics industry:
*Povidone K 17 is used in the Mickey glue in the picture tube to increase the contrast and resolution of the color tube.
*Povidone K 17 can also be used in nickel-chromium and lithium batteries, as a dispersant and thickener in conductive paste; and in printed circuit boards; The additives in the capacitor electrolyte can significantly extend the life of the capacitor.

-Agriculture:
*Adding a certain amount of Povidone K 17 to pesticides not only plays a role in solubilization, but also improves the adhesion of pesticides to plants and enhances the insecticidal effect.
*Adding an appropriate amount of Povidone K 17 to the fertilizer can increase the utilization rate of the active ingredients in the fertilizer.
*Seed coating can prevent frostbite of seeds and prevent the invasion of mold.

-Povidone K 17 grade is widely used as a cosolvent in veterinary injection drugs.
-Because of Povidone K 17's chemical structure (the presence of a lactam ring), Povidone K 17 can form a complex of many hydrogenated substances such as phenols and carboxylic acids, in particular mineral salts and anionic colors.
-Povidone K 17 is also used in water treatment and dyeing applications.

-Applications:
• In the industry of animal and human pharmaceutical
• Production of various membranes with various applications such as dialysis, purification of water and
• As a color stabilizer and leveling agent in the textile and fiber industry
• Helping to release pharmaceutical more efficiently

-Povidone K 17 is widely used in tabletting, coating, pharmaceutical, cosmetics, ink, painting,coating and other industrial applictions.
-Povidone K 17, In Pharmaceutical industry, is used as aid to produce finished drugs.
-Povidone K 17 is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.

-Features and advantages of Povidone K 17:
*Precisely processed
*Safely packed
*Free from contaminants

-Povidone K 17 is also used in many technical applications:
*as an adhesive in glue stick and hot-melt adhesives
*as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process
*as an emulsifier and disintegrant for solution polymerization to increase resolution in photoresists for cathode ray tubes (CRT) in aqueous metal quenching
*for production of membranes, such as dialysis and water purification filters

*as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating
*as a thickening agent in tooth whitening gels
*as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and *as an inhibitor of recrystallisation

*as an additive to Doro's RNA extraction buffer
*as a liquid-phase dispersion enhancing agent in DOSY NMR
*as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly
*as a stabilizing agent in all inorganic solar cells

-Povidone K 17 binds to polar molecules exceptionally well, owing to its polarity.
-Povidone K 17 has application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers.
-Povidone K 17 is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes.

-Povidone K 17 has also been used in contact lens solutions and in steel-quenching solutions.
-Povidone K 17 is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.
-Povidone K 17 is also used in the wine industry as a fining agent for white wine and some beers.

-In molecular biology, Povidone K 17 can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer.
-Povidone K 17 is also exceptionally good at absorbing polyphenols during DNA purification.
-Povidone K 17 are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.

-In microscopy, Povidone K 17 is useful for making an aqueous mounting medium.
-Povidone K 17 can be used to screen for phenolic properties.
-Povidone K 17 is also widely used in the pharmaceutical industry due to its excellent adhesion, film formation, dispersion and thickening properties.

-In Pharmaceutical Industry:
Povidone K 17 and PVP K30 K90 (Pharmaceutical grade) is a kind of new excellent pharmaceutical excipient.
-Povidone K 17 is mainly used as binder for tablet and granule, dissolving assistant for injection, flow assistant for capsule, dispersant for liquid medicine and pigment, stabilizer for enzyme and heat-sensitive drug, coprecipitant for poorly soluble drugs, lubricator and antitoxic assistant for eye drug.

-Povidone K 17 has been used as excipient in more than one hundred drugs.
-With excellent adhesive, film-forming, dispersing and thickening properties, Povidone K 17 is widely used in the pharmaceutical industry.
-Povidone K 17 is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.
-Low molecular weight Povidone K 17, is usually used as a solubilizing agent, crystallization inhibitor and suspension stabilizer in injection and ophthalmic formulations.

-In Cosmetic Industry:
*Povidone K 17 is widely applied in a wide range in hair care, skin care & oral care products.
*Povidone K 17 is particularly suitable for formulations where viscosity modification and film forming properties are needed.
*Povidone K 17 is particularly suited to hair styling products.

-Povidone K 17 is widely used in cosmetics such as Hair Gels, Hair mousses, Liquid hair setting preparations, Pump Sprays.
-Povidone K 17 Series is widely used in pharmaceutical fields, thanks to Povidone K 17’s excellent solubility,film-formingcapability, chemical stability,physiologicalinertia and cementability.

-Povidone K 17 and/or its liquid products used in agriculture as binder and complexation agent for crop protection,Primary film former in seed treatment and coatings.
-Dye transfer inhibition in detergents using Povidone K 17 and/or Povidone K 17's liquid product to complex fugitive.

PREPARATION METHOD of Povidone K 17:
Povidone K 17 is obtained by polymerizing pyrrolidone and ethylene under pressure to form a vinyl pyrrolidone monomer by the action of a catalyst.
1-vinyl-2-pyrrolidone homopolymer having an average molecular weight of 3.8x 104 and a molecular formula of (C6H9NO)n, where n represents the average number of 1-vinyl-2-pyrrolidone moieties.
Povidone K 17 is obtained by polymerizing n-vinyl-2-pyrrolidone in the presence of a basic catalyst or N,N'-vinyltriazole, followed by purification.

DIFFERENTIAL DIAGNOSIS of Povidone K 17:
Take 2ml of this product aqueous solution (1-50), add 2ml of lmol/L hydrochloric acid solution and several drops of potassium dichromate solution, and generate orange-yellow precipitate.
Take 3ml of this product aqueous solution (1-50), add about 15mg of cobalt nitrate and about 75mg of ammonium thiocyanate.
After stirring, add dilute hydrochloric acid Dropwise to make it acidic, which generates light blue precipitate.
Take 3ml of this product aqueous solution (1-50) and add 1-2 drops of test solution to generate brown-red precipitate, which is stirred and dissolved into brown-red solution.

PHYSICAL and CHEMICAL PROPERTIES of Povidone K 17:
Molar Mass :111.143
Density: 1,69 g/cm3
Melting Point: 130℃
Boling Point: 90-93 °C
Solubility: >=10 g/100 mL at 20 C
Melting Point: 130°C
Storage conditions: 2-8°C
Solubility: H2O: soluble100mg/mL

Morphology: powder
Color: White to yellow-white
PH value: 3.0-5.0
Water solubility: Soluble in water.
Sensitivity: Hygroscopic
Merck: 14,7697
stability: Stable.
Solids Content in %: ≥ 95%
K-Value: 15 – 19
NVP in %: 100
Physical state : Solid

Appearance : Solid. Amorphous powder.
Colour : Off-white to light yellow.
Odour : Characteristic odour. Mild odour.
Odour threshold : No data available
pH solution: 5 %
Melting point: 130 °C
Solidification point: No data available
Boiling point: No data available
Flash point: > 250 °C
Relative evaporation rate (butylacetate=1): 0
Flammability (solid, gas): No data available

Explosive limits: No data available
Vapour pressure: < 0.1 hPa (20 °C)
Relative vapour density at 20 °C: No data available
Relative density: 1.2 - 1.3
Density: 1230 - 1290 kg/m³
Solubility: Soluble in water. Soluble in ethanol. Soluble in chloroform. Soluble in chlorinated hydrocarbons.
Water: > 30 g/100ml
Log Pow: No data available
Self ignition temperature: 420 °C

Solubility:
Povidone K 17 readily dissolve in water, alcohol, amine and halohydrocarbon, but is not dissolved in acetone and aether etc..
Povidone K 17 has good solubility, biocompatibility, and physiologically inert, film-forming character, colloid protect ability and compound ability to many organic or inorganic compounds.
Povidone K 17 is also steady to acid, salt and heat, so Povidone K 17 is widely used.

FIRST AID MEASURES of Povidone K 17:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.

*In case of skin contact:
Wash off with soap and plenty of water.

*In case of eye contact:
Flush eyes with water as a precaution.

*If swallowed:
Rinse mouth with water.

-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of Povidone K 17:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.

FIRE FIGHTING MEASURES of Povidone K 17:
-Extinguishing media:
--Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

-Further information: No data available

EXPOSURE CONTROLS/PERSONAL PROTECTION of Povidone K 17:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.

*Skin protection
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min

Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min

*Respiratory protection
Respiratory protection is not required.

-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of Povidone K 17:
-Precautions for safe handling:
--Hygiene measures:
General industrial hygiene practice.

-Conditions for safe storage, including any incompatibilities:
Storage conditions
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.

STABILITY and REACTIVITY of Povidone K 17:
-Reactivity: No data available
-Chemical stability: Stable under recommended storage conditions.
-Possibility of hazardous reactions: No data available
-Conditions to avoid: No data available

SYNONYMS:
Polyvinyl pyrrolidone
Povidone
PVP
PVP-K
PVP-K17
Polyvinylpyrrolidine
poly vinyl pyrrolidone
Crospovidone
Polyinylpyrrolidone
Polyvinglpyrrolidone
PVP, Povidone, Copovidone
PVPP, Crospovidone, Polyvidone
Poly[1-(2-oxo-1-pyrrolidinyl)ethylen]
1-Ethenyl-2-pyrrolidon homopolymer
1-Vinyl-2-pyrrolidinon-Polymere
Polyvinyl pyrrolidone
Povidone
Polyvinylpyrrolidine
poly vinyl pyrrolidone
Crospovidone
Polyinylpyrrolidone
Polyvinglpyrrolidone