PRODUCTS

POVIDONE K 30 (PVP K 30)

Povidone k 30 (PVP K 30) acts as a stabilizer and film former.
Povidone k 30 (PVP K 30) provides strong and stiff hold.
Povidone k 30 (PVP K 30) is a hygroscopic and amorphous polyvinylpyrrolidone polymer powder.

CAS Number: 9003-39-8
Molecular Formula: CH4
Molecular Weight: 16.04246
EINECS Number: 1312995-182-4

Synonyms: N-VINYL-2-PYRROLIDONE, 88-12-0, 1-vinylpyrrolidin-2-one, 1-Vinyl-2-pyrrolidone, N-Vinylpyrrolidone, 9003-39-8, 1-Vinyl-2-pyrrolidinone, N-Vinyl-2-pyrrolidinone, Povidone, Vinylpyrrolidone, 1-ethenylpyrrolidin-2-one, N-Vinylpyrrolidinone, 2-Pyrrolidinone, 1-ethenyl-, 25249-54-1, 1-Vinylpyrrolidone, Pvpp, Vinylbutyrolactam, Vinylpyrrolidinone, V-Pyrol, Luviskol, Plasdone, 1-Vinylpyrrolidinone, Vinyl-2-pyrrolidone, N-Vinyl pyrrolidone, 1-Ethenyl-2-pyrrolidinone, N-Vinylpyrrolidone-2, 1-Vinyl-2-pyrrolidinone, monomer, 2-Pyrrolidinone, 1-vinyl-, PVP, NSC 10222, MPK 90, PVP 40, DTXSID2021440, 143 RP, AT 717, 1-vinyl-pyrrolidin-2-one, Crospovidone ~40,000, K 15, K 90, PVP-40, CHEBI:82551, MFCD00003197, NSC-10222, 76H9G81541, DTXCID101440, WLN: /T5NVTJ AY1/, MFCD01076626, CAS-88-12-0, K 25, K 115, HSDB 7231, EINECS 201-800-4, BRN 0110513, CCRIS 8581, vinyl pyrrolidone, UNII-76H9G81541, N-vinyl-pyrrolidone, N-vinylpyrrolidinone, 1-vinyl-2-pyrrolidon, POVIDONE MONOMER, VINYLBUTYLOLACTAM, N-vinylpyrrolidin-2-one, ?N-Vinyl-2-pyrrolidone, N-vinyl pyrrolidin-2-one, N-vinyl-pyrrolidin-2-one, EC 201-800-4, SCHEMBL10869, WLN: T5NVTJ A1U1, PVP-K30, Crospovidone (~40,000), POVIDONE MONOMER [MI], USP grade, cross-linked, powder, VINYL PYRROLIDONE (VP), CHEMBL1878943, N-VINYL PYRROLIDONE [INCI], NSC10222, Tox21_202462, Tox21_300073, NSC114022, NSC142693, NSC683040, Polyvinylpyrrolidone (MW ~40,000), AKOS000119985, N-VINYL-2-PYRROLIDONE [IARC], AT18510, CS-W020981, FG-0420, NSC-114022, NSC-142693, NSC-683040, NCGC00166252-01, NCGC00166252-02, NCGC00166252-03, NCGC00254200-01, NCGC00260011-01, 2-PYRROLIDINONE, 1-ETHENYL- [HSDB], NS00002538, V0026, 88-12-0; 9003-39-8 (homopolymer), EN300-19745, C19548, A817742, A843417, Q420628, SR-01000944531, J-015891, SR-01000944531-1, W-100417, 1-Vinyl-2-pyrrolidinone, SAJ first grade, >=99.0%, F8881-5579, Z104475034, InChI=1/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H, 1-Vinyl-2-pyrrolidinone, contains sodium hydroxide as inhibitor, >=99%, 1-Vinyl-2-pyrrolidinone, Pharmaceutical Secondary Standard; Certified Reference Material, 1-Vinyl-2-pyrrolidone (stabilized with N,N'-Di-sec-butyl-p-phenylenediamine).

Povidone k 30 (PVP K 30) forms clear, hard, shiny and glossy films.
Povidone k 30 (PVP K 30) also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.
Povidone k 30 (PVP K 30), is a synthetic polymer made from the monomer N-vinylpyrrolidone.

Shows excellent compatibility with acrylate thickeners.
Povidone k 30 (PVP K 30) stabilizes foam, emulsions, dispersions and suspensions.
Povidone k 30 (PVP K 30) finds application in formulating hair care products like sprays, mousses, gels, styling lotions/creams, colorants and novelty stylers.

Povidone k 30 (PVP K 30) is widely used in pharmaceuticals, cosmetics, and industrial applications due to its binding, film-forming, and solubility-enhancing properties.
Povidone k 30 (PVP K 30) acts as a binder in tablet formulations, ensuring that the ingredients hold together properly.
Povidone k 30 (PVP K 30) also serves as a solubilizing agent, improving the dissolution and bioavailability of active pharmaceutical ingredients.

In cosmetics, Povidone k 30 (PVP K 30) is used for its film-forming properties.
It is commonly found in hair sprays, gels, and other styling products, where it helps to hold hair in place.
Povidone k 30 (PVP K 30) is utilized in various industrial applications, such as adhesives, coatings, and as a stabilizer in certain processes.

The "K 30" designation indicates the average molecular weight and viscosity of the polymer.
Specifically, Povidone k 30 (PVP K 30) has a molecular weight of approximately 40,000 daltons.
This affects its solubility and the characteristics of the films it forms.

Povidone k 30 (PVP K 30) is considered safe for use in various applications and is compatible with a wide range of substances, making it a versatile additive in multiple industries.
Povidone k 30 (PVP K 30) exists in white powder or aqueous solution.
Povidone k 30 (PVP K 30) readily dissolve in water, alcohol, amine and halohydrocarbon, but are not dissolved in acetone and aether etc..

Povidone k 30 (PVP K 30) has good solubility, biocompatibility, and physiologically inert, film-forming character, colloid protect ability and compound ability to many organic or inorganic compounds.
Povidone k 30 (PVP K 30) is also steady to acid, salt and heat, so it is widely used.
Povidone k 30 (PVP K 30) exists as white or milk white powder or colorless or slight yellow transparent liquid.

Povidone k 30 (PVP K 30) can dissolve in water and a variety of organic solvents.
It has good hygroscopicity, film-forming capability, complexing ability and physiological compatibility.
Povidone k 30 (PVP K 30) is abbreviated as PVP, and is the polymer of vinylpyrrolidone.

According to the different degree of polymerization, it is further classified into soluble Povidone k 30 (PVP K 30) and insoluble PVPP (polyvinyl polypyrrolidone).
Molecular weight of the soluble Povidone k 30 (PVP K 30) is 8,000 to 10,000.
The soluble Povidone k 30 (PVP K 30) can be used as a precipitating agent which can be settle down through its action with polyphenols.

Using this method, it is easily to have residual Povidone k 30 (PVP K 30) in the alcohol.
Due to the savings effect of Povidone k 30 (PVP K 30) inside the human body, the World Health Organization doesn’t recommend to apply this substance.
In recent years, the use of soluble Povidone k 30 (PVP K 30) has been rare.

Insoluble Povidone k 30 (PVP K 30) system had began to be used in the beer industry since the early 1960s.
Povidone k 30 (PVP K 30) has a relative molecule weight greater than the relative mass greater than 700,000.
It is a insoluble polymer derived from the further cross-linking and polymerization of PVP and can be used as an adsorbent of polyphenols with a good efficacy.

Povidone k 30 (PVP K 30) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.
Povidone k 30 (PVP K 30) has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.
Povidone k 30 (PVP K 30) has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder.

Povidone k 30 (PVP K 30) formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents.
The k number refers to the mean molecular weight of the povidone.
Povidone k 30 (PVP K 30)s with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights.

The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body.
The best-known example of povidone formulations is povidone-iodine, an important disinfectant.
Povidone k 30 (PVP K 30) is one of the three major pharmaceutical new excipients and can be used as the co-solvent of tablets, granules, and injection, as the glidant of capsules, as the dispersant agent of liquid preparations and the colorant, as the stabilizer of enzyme and heat sensitive drug, as the co-precipitating agent of poorly soluble drugs, and as the detoxicant of ophthalmic drugs and lubricants.

Povidone k 30 (PVP K 30) is industrially used as expanded polystyrene additive, as the gelling agents for suspension polymerization, stabilizer, and fiber treating agents, paper processing aids, adhesives, and thickening agents.
Povidone k 30 (PVP K 30) and its copolymers CAP is an important raw material of cosmetics, mainly used for hair retaining agent.
The film it formed in the hair is elastic and shiny, and has excellent carding property as well as being free of dust.

Adopting different category of resin can meet various kinds of relative humidity climatic conditions.
Therefore, it is an indispensable raw material in styling hair cream, hair gel, and mousse.
Povidone k 30 (PVP K 30) can also be used for the cosmetics of skin moisturizing agents and the dispersants for grease based hair dying, also as foam stabilizers, and can improve the consistency of the shampoo.

Insoluble Povidone k 30 (PVP K 30) is the stabilizer of beer and juice which can improve its transparency, color, and flavor.
Povidone k 30 (PVP K 30) is a water soluble polyamide.
Commercially available Povidone k 30 (PVP K 30) is divided into four viscosity grades according to its press K value (Fikentscher K value): K-15, K-30, K-60, K-90, with the average molecular weight being 10,000, 40000,160000, and 360000, respectively. K value or molecular weight is an important factor which decides the various properties of PVP.

Povidone k 30 (PVP K 30) is dissolved in water, chlorinated solvents, alcohol, amine, nitro-paraffin and low molecular weight fatty acids, and is mutually soluble with most inorganic salts and a variety of resin; insoluble in acetone and ether.
Povidone k 30 (PVP K 30) used for the matrix of dropping pill matrix is odorless, tasteless, white to pale yellow waxy solid with the relative density being 1.062, and its 5% aqueous solution pH being 3 to 7.
Povidone k 30 (PVP K 30) is hygroscopic and of good thermal stability, and can be dissolved in various kinds of organic solvents, and has high melting point.

Adding certain natural or synthetic polymers or organic compounds can effectively adjust the PVP’s hygroscopicity and softness.
Povidone k 30 (PVP K 30) is not prone to have chemical reaction. Under normal storage conditions, dry PVP is quite stable.
Povidone k 30 (PVP K 30) has excellent physical inertia and biocompatibility and has not stimulation to skin, eyes no stimulation with no allergic reactions and being non-toxic.

Because of the hydrogen bonding or complexation effect, Povidone k 30 (PVP K 30)’s viscosity is increased and this further inhibits the formation and growth of crystallized nuclei of drugs, making the drug being in the amorphous state.
The dropping pill whose matrix is Povidone k 30 (PVP K 30) can enhance the dissolution and bioavailability of poorly soluble drugs.
In general, the greater the Povidone k 30 (PVP K 30) amount, the higher dissolution and solubility of drug in the medium.

Susana et al have studied the dissolution of the Povidone k 30 (PVP K 30) solid dispersant of the slightly soluble drug albendazole.
The increased amount of Povidone k 30 (PVP K 30) can increase the dissolution rate and efficiency of drug inside the solid dispersant.
Teresa et al have studied the dissolution of the poorly soluble drugs, flunarizine in Povidone k 30 (PVP K 30) solid dispersant and obtained similar conclusion.

Povidone k 30 (PVP K 30) also found that the higher the content, the more significant increase in dissolution.
IR has showed that flunarizine and Povidone k 30 (PVP K 30) has no chemical reaction except in some cases that a best dissolution efficacy is obtained only in certain ratio between some drugs with the PVP.
Tantishaiyakul et al has found that: when the ratio of piroxicam: Povidone k 30 (PVP K 30) is 1:5 and 1:6, the dissolution of the solid dispersant is the largest with a 40 times as high as that of single drug within 5min.

Povidone k 30 (PVP K 30) can also be dissolved in another molten dropping pill matrix, such as polyethylene glycol (PEG), polyoxyethylene monostearate (S-40), poloxamer and stearyl acid, glyceryl monostearate, etc for making complex matrix.
Povidone k 30 (PVP K 30) is water-soluble and is usually polymerized in aqueous solution at about 50??C with ammonia and hydrogen peroxide.
The polymer is also water-soluble and is isolated by spray-drying.

Commercial grades of Povidone k 30 (PVP K 30) have average molecular weights (Mv) ranging from about 10000 up to 360000.
The largest use of Povidone k 30 (PVP K 30) is in cosmetic formulations, especially hair lacquers.
In the latter applications, Povidone k 30 (PVP K 30) is the preferred film-former on account of good adhesion to hair, lustre of the film and ease of removal on washing.

The polymer is also used as a binder in pharmaceutical tablets.
Povidone k 30 (PVP K 30) also finds use in the textile industry, particularly in colour stripping operations, where the great affinity of the polymer for dyestuffs is utilized.
An interesting application of Povidone k 30 (PVP K 30) is in aqueous solution as a blood plasma substitute; such material was extensively used in Germany during the Second World War.

Povidone k 30 (PVP K 30), also commercially known as K30, is a water soluble polymer.
Povidone k 30 (PVP K 30) has a hygroscopic nature with good adhesive properties.
Povidone k 30 (PVP K 30) has a stable pH and has the ability to form transparent films.

Povidone k 30 (PVP K 30) has a wide range of usage such as:an adhesive for making gluesticks and metal adhesivesa dispersant for ceramicscoatings and inksformation of synthetic fibres...
Povidone k 30 (PVP K 30) is a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms.
Povidone k 30 (PVP K 30) is commonly used as binders for the development of tablet formulations, whether manufactured by wet granulation, dry granulation, or direct compression.

Povidone k 30 (PVP K 30) is used in solid dispersion formulations to enhance the solubility of active pharmaceutical ingredients and increase bioavailability.
Povidone k 30 (PVP K 30) is also used to inhibit recrystallization in liquid soft gels.
A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.

Povidone k 30 (PVP K 30) itself has no microbicidal activity.
Povidone k 30 (PVP K 30)-iodine exhibits rapid, potent, broad-spectrum antimicrobial properties 2.
WQaThe clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application 1.

Povidone k 30 (PVP K 30) is a water-soluble complex that mediates a bactericidal or virucidal action following the gradual liberation of free iodine from the complex at the application site to react with the pathogen 1.
Please refer to the drug entry for Povidone-iodine for the full mechanism of action of the complex.
Povidone k 30 (PVP K 30), also commonly called polyvidone or povidone, is a water-soluble polymer compound made from the monomer N-vinylpyrrolidone.

Povidone k 30 (PVP K 30) is available in a range of molecular weights and related viscosities, and can be selected according to the desired application properties.
There are high-purity injectable grades of PVP available on the market, for specific use in intravenous, intramuscular, and subcutaneous applications.
Povidone k 30 (PVP K 30) is used as a binder in many pharmaceutical tablets; it simply passes through the body when taken orally.

Povidone k 30 (PVP K 30) added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.
This complex is used in various products such as solutions, ointment, pessaries, liquid soaps, and surgical scrubs.
Povidone k 30 (PVP K 30) is sold under the trade names Pyodine and Betadine, among others.

It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions).
For this purpose, Povidone k 30 (PVP K 30) is as effective and safe as talc, and may be preferred because of its easy availability and low cost.
Povidone k 30 (PVP K 30) is used in some contact lenses and their packaging solutions.

Povidone k 30 (PVP K 30) reduces friction, thus acting as a lubricant, or wetting agent, built into the lens.
Examples of this use include Bausch & Lomb's Ultra contact lenses with MoistureSeal Technology and Air Optix contact lens packaging solution (as an ingredient called "copolymer 845").
Povidone k 30 (PVP K 30) is used as a lubricant in some eye drops, e.g. Bausch & Lomb's Soothe.

Povidone k 30 (PVP K 30) was used as a plasma volume expander for trauma victims after the 1950s.
Povidone k 30 (PVP K 30) is not preferred as a volume expander due to its ability to provoke histamine release and also interfere with blood grouping.
Autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.

The long-term effects of crospovidone or povidone within the lung are unknown.
Povidone k 30 (PVP K 30) is a water-soluble polymer composed of N-vinylpyrrolidone units.
The "K" value refers to the molecular weight, which in the case of K 30 is about 40,000 daltons.

Povidone k 30 (PVP K 30) is usually available as a white to off-white powder or aqueous solution.
Povidone k 30 (PVP K 30) is hygroscopic, meaning it readily absorbs moisture from the environment.
Highly soluble in water and in various organic solvents, such as alcohols and chloroform.

Chemically stable across a wide pH range and temperature conditions, making it suitable for various formulations.
Povidone k 30 (PVP K 30) is synthesized through the free radical polymerization of N-vinylpyrrolidone in the presence of a suitable initiator.
The process can be controlled to produce polymers of different molecular weights (indicated by the K value).

Povidone k 30 (PVP K 30) acts as a binding agent, ensuring the tablet's structural integrity and proper dissolution of active ingredients.
Enhances the disintegration of tablets in the digestive tract, improving the release and absorption of active ingredients.
Increases the solubility of poorly soluble drugs, enhancing their bioavailability.

Stabilizes suspensions and prevents crystallization of drugs in liquid formulations.
Povidone k 30 (PVP K 30) provides strong film-forming properties, contributing to the hold and shape of hair in gels and sprays.
Skin Care Products: Acts as a thickening agent, stabilizer, and film-former in creams, lotions, and gels.
Contact Lens Solutions: Used as a lubricant and wetting agent to enhance comfort for contact lens wearers.
Industrial Applications:

Adhesives: Serves as a binder in adhesives, improving their strength and flexibility.
Coatings and Films: Used in protective coatings and films due to its excellent film-forming properties.
Employed as a sizing agent to protect fibers during weaving.

Povidone k 30 (PVP K 30) is generally considered safe and non-toxic when used within prescribed limits.
Povidone k 30 (PVP K 30) is well tolerated in pharmaceuticals and cosmetics.
Approved by various regulatory bodies worldwide, including the FDA (U.S. Food and Drug Administration) and EMA (European Medicines Agency), for use in food, pharmaceuticals, and cosmetics.

Rarely causes allergic reactions, making it suitable for sensitive applications.
Its solubility, binding capacity, and film-forming properties make it a multipurpose additive.
Non-toxic and compatible with a wide range of substances.

Maintains its properties under various conditions, ensuring consistent performance in formulations.
Its tendency to absorb moisture can be a drawback in certain formulations, requiring careful packaging and storage.
May interact with some active ingredients or excipients, necessitating compatibility testing in formulations.

Melting point: >300 °C
Boiling point: 90-93 °C
Density: 1,69 g/cm3
storage temp.: 2-8°C
solubility: H2O: soluble100mg/mL
form: powder
color: White to yellow-white
PH: 3.0-5.0
Water Solubility: Soluble in water.
Sensitive: Hygroscopic
Merck: 14,7697
Stability: Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.

Commonly used Povidone k 30 (PVP K 30) level in the cosmetic industry is K-30.
Commercialized Povidone k 30 (PVP K 30) is white and free flowing powder or solids with its content in the mass fraction of 20%, 30%, 45% and 50% aqueous solution.
Povidone k 30 (PVP K 30) is soluble in water and is hygroscopic with a moisture equilibrium being 1/3 of the relative humidity of the environment.

Povidone k 30 (PVP K 30) is not easy to have chemical reaction.
When stored at normal conditions, dry Povidone k 30 (PVP K 30) is quite stable.
Solution undergone mildew treatment is also stable.

When heated in air to 150 °C or mixed with ammonium persulfate to heat at 90 °C for 30min, Povidone k 30 (PVP K 30) will be exchanged to become a water-insoluble compound.
In the presence of azo compound or a dichromate oxidizing agent, light will cause PVP solution to become gel.
The co-heating of PVP solution with strong base (such as sodium silicate or trisodium phosphate) will generate precipitation.

Many different compounds can generate complexes with PVP.
For example, the complexes of Povidone k 30 (PVP K 30) and iodine is very stable and have a good bactericidal effect and can reduce its toxicity; Adding the copolymers of the polyacrylic acid, tannic acid or methyl vinyl ether and maleic acid to the aqueous solution of Povidone k 30 (PVP K 30) will generate insoluble complexes which are insoluble in water, alcohols and ketones.

But when being treated with base for neutralize the poly-acid can reverse the reaction; complexation between PVP and toxins, drugs and toxic chemicals can reduce their toxicity; some kinds of dyes can also form a strong complex with Povidone k 30 (PVP K 30), which is the basis for using PVP as a dye bleaching agent.
In the early 1950s, older, with shellac and oil-based hairspray had been rapidly replaced by PVP sprays which are still widely used until now.
Povidone k 30 (PVP K 30) can form wet, transparent film on the hair which is shiny and has good lubrication effect.

Povidone k 30 (PVP K 30) has good compatibility with a variety of good propellant and also has corrosion resistance.
Povidone k 30 (PVP K 30) is widely used in hair styling, as the film former in combing products, as the creatinine and stabilizer of skin care lotions and creams, as the base stock material for eye and facial cosmetics and lipstick base, and also as hair dye dispersants and shampoo foam stabilizer.
Povidone k 30 (PVP K 30) has detoxification effect and can reduce the irritation effects of other preparation on the skin and eyes.

Povidone k 30 (PVP K 30) is also used as toothpaste detergents, gelling agents and antidotes. The main drawback of PVP is its sensitivity to moisture.
However, this issue can be tackled by using its vinyl acetate copolymer in order to mitigate the effects of moisture and humidity.
In addition, Povidone k 30 (PVP K 30) also has wide application in the pharmaceutical, beverage and textile industries.

All soluble grades of Povidone k 30 (PVP K 30) is supplied in the form of an almost white free-flowing powder.
They have a slight characteristic odor and are practically tasteless.
Because of its solubility in water and in many organic solvents, its high binding power and ability to form complexes, soluble polyvinylpyrrolidone occupies a special position among the synthetic colloids.

Povidone k 30 (PVP K 30) is compatible in solution with a wide range of inorganic salts, natural and synthetic resins, and other chemicals.
Povidone k 30 (PVP K 30) forms molecular adducts in solution with sulfathiazole, sodium salicylate, salicylic acid, phenobarbital, tannin, and other compounds.
The efficacy of some preservatives, e.g. thimerosal, may be adversely affected by the formation of complexes with povidone.

Its crude product comes from the polymerization of Povidone k 30 (PVP K 30) under basic catalyst or the existence of N, N'-divinyl amidine and further cross-inking reaction.
Then use water, 5% acetic acid and 50% ethanol for reflux to until extract ≤50mg/kg (for over 3h).
The 30% to 60% aqueous solution of the purified 1-vinyl-2-pyrrolidone, in the presence of ammonia or amines and also with hydrogen peroxide as the catalyst, has cross-linking and homo-polymerization reaction at a temperature of 50 °C and subject to further purification to obtain the final product.

Povidone k 30 (PVP K 30) is manufactured by the Reppe process.
Acetylene and formaldehyde are reacted in the presence of a highly active copper acetylide catalyst to form butynediol, which is hydrogenated to butanediol and then cyclodehydrogenated to form butyrolactone.
Povidone k 30 (PVP K 30) is produced by reacting butyrolactone with ammonia.

This is followed by a vinylation reaction in which Povidone k 30 (PVP K 30) and acetylene are reacted under pressure.
The monomer, Povidone k 30 (PVP K 30), is then polymerized in the presence of a combination of catalysts to produce povidone.
Povidone k 30 (PVP K 30), a polymer of vinylpyrrolidinone, is an excipient used as a suspending and dispersing agent.

Injectable preparations containing polymers with a molecular weight in the order of 12,000 have caused painful local granulomatous lesions.
This has led to the withdrawal of Povidone k 30 (PVP K 30) from such preparations in some countries.
Povidone k 30 (PVP K 30) was formerly also used as a plasma expander but, because it was sequestered within the liver and spleen, this use has been discontinued.

However, Povidone k 30 (PVP K 30) remains widely used as a vehicle for ophthalmic preparations, and as the major component of artificial tears.
Povidone k 30 (PVP K 30) is soluble in water and other polar solvents.
For example, Povidone k 30 (PVP K 30) is soluble in various alcohols, such as methanol and ethanol, as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).

When dry Povidone k 30 (PVP K 30) is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water.
In solution, Povidone k 30 (PVP K 30) has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings.
Povidone k 30 (PVP K 30) was first synthesized by BASF chemist Walter Reppe, and a patent was filed in 1939 for one of the derivatives of acetylene chemistry.

Povidone k 30 (PVP K 30) was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production.
Povidone k 30 (PVP K 30) continues to make PVP, including a pharmaceutical portfolio under the brand name of Kollidon.

Storage Of Povidone k 30 (PVP K 30):
Povidone k 30 (PVP K 30) darkens to some extent on heating at 150°C, with a reduction in aqueous solubility.
Povidone k 30 (PVP K 30) is stable to a short cycle of heat exposure around 110–130°C; steam sterilization of an aqueous solution does not alter its properties.

Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives.
Povidone k 30 (PVP K 30) may be stored under ordinary conditions without undergoing decomposition or degradation.
However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.

Uses Of Povidone k 30 (PVP K 30):
Povidone k 30 (PVP K 30) is mainly used as pharmaceutical excipient, blood compatibilizer, cosmetics thickening agents, latex stabilizers, and clarifying agent of beer brewing.
Although Povidone k 30 (PVP K 30) is used in a variety of pharmaceutical formulations, it is primarily used in solid-dosage forms.
In tableting, Povidone k 30 (PVP K 30) solutions are used as binders in wet-granulation processes.

Povidone k 30 (PVP K 30) is also added to powder blends in the dry form and granulated in situ by the addition of water, alcohol, or hydroalcoholic solutions.
Povidone k 30 (PVP K 30) is used as a solubilizer in oral and parenteral formulations, and has been shown to enhance dissolution of poorly soluble drugs from solid-dosage forms.
Povidone k 30 (PVP K 30) solutions may also be used as coating agents or as binders when coating active pharmaceutical ingredients on a support such as sugar beads.

Povidone k 30 (PVP K 30) is widely used as is in cosmetics such as hair care products and in medical products.
It acts as iodophor in iodine-polyvinylpyrrolidone.
Povidone k 30 (PVP K 30) is an irritant and has been claimed as the allergen in some cases of dermatitis from iodine-polyvinylpyrrolidone (although iodine is more likely the hapten).

It may cause type I contact urticaria or anaphylaxis.
Povidone k 30 (PVP K 30) is additionally used as a suspending, stabilizing, or viscosity-increasing agent in a number of topical and oral suspensions and solutions.
The solubility of a number of poorly soluble active drugs may be increased by mixing with Povidone k 30 (PVP K 30).

Povidone k 30 (PVP K 30) is mainly used for beer clarifying and quality stabilizing (reference amount 8~20g/100L, maintained for 24h and remove it by filtration), and can also be applied in combination with enzymes (protease) and protein adsorbents.
Povidone k 30 (PVP K 30) is also used to clarify the wine and as a stabilizer to prevent discoloration (reference amount 24~72g/100L).
Clarifying agents; stabilizers; thickeners agent; tablet fillers; dispersants; Povidone k 30 (PVP K 30) of molecular weight 360,000 are often used as the clarifying agent of beer, vinegar, and grape wine.

Povidone k 30 (PVP K 30) is used as the fixing liquid for gas chromatography.
Povidone k 30 (PVP K 30) is used as a colloidal stabilizer and clarifying agent for beer clarification.
Apply proper amount according the demands of production.

Povidone k 30 (PVP K 30) can be used for pharmacy, aquaculture, and livestock disinfectant for the sterilization of the skin and mucous.
Povidone k 30 (PVP K 30) molecule has an amide bond for absorbing the hydroxyl groups located in polyphenol molecule to form hydrogen bonds, and therefore, can be used as the stabilizer of beer, fruit wine/grape wine, and drinking wine to extend their shelf life and improve the transparency, color and taste.
The products have two specifications: disposable type and regeneration type.

Disposable products are suitable for application by SMEs; renewable products demand the purchase of special filtration equipment; but since it is recyclable, it is suitable for large breweries for recycle application.
In daily cosmetics, Povidone k 30 (PVP K 30) and its copolymer has good dispersion property and filming property, and thus being able to be used as a setting lotion, hair spray and styling mousse, as opacifiers for hair care agents, as the stabilizer of shampoo foam, as wave styling agent and as the dispersants and affinity agents in hair dye.
Adding Povidone k 30 (PVP K 30) to cream, sunscreen, and hair removal agent can enhance wetting and lubricating effect.

Taking advantage of the excellent properties of Povidone k 30 (PVP K 30) such as surface activity, film-forming and non-irritating to the skin, no allergic reactions, etc., has broad prospects in its application in hair care and skin care products.
Povidone k 30 (PVP K 30) is used as an adhesive in glue sticks; an emulsifier and a disintegrant for solution polymerization; an additive to Doro's RNA extraction buffer; as a liquid-phase dispersion enhancing agent in diffusion-ordered spectroscopy (DOSY) NMR and as a thickening agent in tooth whitening gels.
Povidone k 30 (PVP K 30) finds use in personal care products like shampoos and toothpastes, in ink for inkjet printers as well as in contact lens solutions.

Povidone k 30 (PVP K 30) is used as a food additive and in the wine industry as a fining agent for white wine.
Povidone k 30 (PVP K 30) is used as a capping agent to synthesize silver nanowires through a polyol process.
Povidone k 30 (PVP K 30) binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers.

Povidone k 30 (PVP K 30) is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes.
It has also been used in contact lens solutions and in steel-quenching solutions.
Povidone k 30 (PVP K 30) is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.

As a food additive, Povidone k 30 (PVP K 30) is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202.
Povidone k 30 (PVP K 30) is also used in the wine industry as a fining agent for white wine and some beers.
In in-vitro fertilisation laboratories, Povidone k 30 (PVP K 30) is used to slow down spermatozoa in order to capture them for e.g. ICSI.

In molecular biology, Povidone k 30 (PVP K 30) can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer.
Povidone k 30 (PVP K 30) is also exceptionally good at absorbing polyphenols during DNA purification.
Povidone k 30 (PVP K 30) is common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.

In microscopy, Povidone k 30 (PVP K 30) is useful for making an aqueous mounting medium.
Povidone k 30 (PVP K 30) can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.
Povidone k 30 (PVP K 30), also known as polyvinylpyrrolidone or polyvidone, is a polymer and used as a binder in pharmaceutical tablets.

Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.
Povidone k 30 (PVP K 30) is a kind of new excellent pharmaceutical excipient.
Povidone k 30 (PVP K 30) is mainly used as binder for tablet and granule, dissolving assistant for injection, flow assistant for capsule, dispersant for liquid medicine and pigment, stabilizer for enzyme and heat-sensitive drug, coprecipitant for poorly soluble drugs, lubricator and antitoxic assistant for eye drug.

Povidone k 30 (PVP K 30) has been used as excipient in more than one hundred drugs.
With excellent adhesive, film-forming, dispersing and thickening properties, Povidone k 30 (PVP K 30) is widely used in the pharmaceutical industry.
Povidone k 30 (PVP K 30) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.

Low molecular weight Povidone k 30 (PVP K 30), like PVP K12,K15,K17, are usually used as a solubilizing agent, crystallization inhibitor and suspension stabilizer in injection and ophthalmic formulations.
Povidone k 30 (PVP K 30), like PVP K25,K30, are often used as binder in tablets, capsules and granules, as a stabilizer for oral suspensions, film-forming agent, solubilizing agent, dispersant for pigments, as an enzyme stabilizer and to improve bioavailability.
High molecular Povidone k 30 (PVP K 30), like PVP K90, work as highly effective binder.

They are often used as stabilizer in oral and topical suspension, as a thickener, hydropylizing agent, etc.
Povidone k 30 (PVP K 30) is widely applied in a wide range in hair care, skin care & oral care products.
Povidone k 30 (PVP K 30) is particularly suitable for formulations where viscosity modification and film forming properties are needed.

Povidone k 30 (PVP K 30) is particularly suited to hair styling products.
The medium molecular weights such as Povidone k 30 (PVP K 30) is preferred where viscosity is critical in applications, for example, spray.
The higher molecular weight products such as Povidone k 30 (PVP K 30) is better choice where high viscosity are needed in applications.

Povidone k 30 (PVP K 30) is used as a binder in tablet and capsule formulations.
Povidone k 30 (PVP K 30) helps to hold the ingredients together, ensuring the tablet maintains its shape and integrity.
Povidone k 30 (PVP K 30) aids in the breakdown of tablets and capsules once they are ingested, facilitating the release and absorption of the active ingredients in the digestive tract.

Povidone k 30 (PVP K 30) enhances the solubility of poorly soluble drugs, improving their bioavailability and therapeutic effectiveness.
It stabilizes suspensions and prevents the crystallization of drugs in liquid formulations, ensuring consistent drug delivery.
Povidone k 30 (PVP K 30) is used in controlled-release formulations to modulate the release rate of the active ingredient.

Povidone k 30 (PVP K 30) is commonly found in hair gels, sprays, and mousses for its strong film-forming properties, which provide hold and shape to hair.
Acts as a thickening agent and film-former in creams, lotions, and gels, contributing to the texture and application of the product.
Povidone k 30 (PVP K 30) is used in mouthwashes and toothpastes for its binding and stabilizing properties.

Serves as a lubricant and wetting agent, enhancing the comfort of contact lenses.
Povidone k 30 (PVP K 30) is used as a binder in adhesives, improving their strength, flexibility, and adhesive properties.
Utilized in protective coatings and films due to its excellent film-forming capabilities.

Povidone k 30 (PVP K 30) provides a protective layer that can enhance durability and resistance to environmental factors.
Employed as a sizing agent in the textile industry to protect fibers during weaving and improve the finish of the fabric.
Povidone k 30 (PVP K 30) is used as an additive to enhance the properties of plastics and polymers, such as improving flexibility and reducing brittleness.

Acts as a dispersant in inks and pigments, ensuring even distribution and stability of the colorants.
Povidone k 30 (PVP K 30) is used as a stabilizer, clarifying agent, and thickener in various food products.
Povidone k 30 (PVP K 30) helps to improve the texture, stability, and shelf life of food items.

Employed in the clarification of beverages like wine and beer to remove impurities and improve clarity.
Povidone k 30 (PVP K 30) is used in the formulation of wound dressings and bandages for its film-forming and protective properties.
Povidone k 30 (PVP K 30) is used in transdermal patches and other drug delivery systems to control the release of medication.

Povidone k 30 (PVP K 30) is used in various laboratory and research applications, including as a stabilizer in biological assays and as a solubilizing agent for proteins and enzymes.
Employed in the development and testing of new pharmaceutical formulations due to its versatility and compatibility with a wide range of substances.
Povidone k 30 (PVP K 30) is used in the formulation of veterinary medications and supplements for its binding and stabilizing properties.

Safety Profile Of Povidone k 30 (PVP K 30):
Povidone k 30 (PVP K 30) has been used in pharmaceutical formulations for many years, being first used in the 1940s as a plasma expander, although it has now been superseded for this purpose by dextran.
Povidone k 30 (PVP K 30) is widely used as an excipient, particularly in oral tablets and solutions.
When consumed orally, povidone may be regarded as essentially nontoxic since it is not absorbed from the gastrointestinal tract or mucous membranes.

Povidone k 30 (PVP K 30) additionally has no irritant effect on the skin and causes no sensitization. exists that povidone may accumulate in the organs of the body following intramuscular injection.
A temporary acceptable daily intake for povidone has been set by the WHO at up to 25 mg/kg body-weight
The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses, and it is generally recognized as safe (GRAS).

Povidone k 30 (PVP K 30) is included in the Inactive Ingredient Database for use in oral, topical, and injectable formulations.
However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the Povidone k 30 (PVP K 30) has come in contact with autologous serum (internal blood fluids) and mucous membranes.