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Povidone K 90 is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.
Povidone K 90 has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.
Povidone K 90 is industrially used as expanded polystyrene additive, stabilizer and gelling agent for fiber processing agents, paper processing aids, adhesives and thickeners.
CAS Number: 9003-39-8
EC Number: 201-800-4
MDL Number: MFCD01076626
Molecular Formula: (C6H9NO)n
SYNONYMS:
Poly[1-(2-oxo-1-pyrrolidinyl)ethylene], PVP, Povidone K-90, n-vinyl-2-pyrrolidone, n-vinylpyrrolidone, 1-vinyl-2-pyrrolidone, 1-vinyl-2-pyrrolidin-2-one, n-vinyl-2-pyrrolidinone, vinylpyrrolidone, 2-pyrrolidinone, 1-ethenyl, 1-vinyl-2-pyrrolidinone, n-vinylpyrrolidinone, 1-vinylpyrrolidone, 1-ethenylpyrrolidin-2-one, Polyvidone 360,000, Polyvidone K90, Polyvinylpyrrolidon K90, Polyvinylpyrrolidone 360,000, PVP 360,000, PVP K90, PVP360, PVP, K-30, PVP-K, PVP-K30, PVP-K17, PVP-K25, PVP-K90, Povidone, PVP K 30, Crospovidone, Polyinylpyrrolidone, Polyvinylpyrrolidine, Polyvinylpyrrolidone, Polyvinglpyrrolidone, Polyvinyl pyrrolidone, poly vinyl pyrrolidone, PVP, Povidone K-90, Poly[1-(2-oxo-1-pyrrolidinyl)ethylene], PVP, Povidone, Polyvinylpyrrolidone, Povidone K 90, Polyvinylpyrrolidone, cross-linked
Povidone K 90 is a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms.
Povidone K 90 is commonly used as binders for the development of tablet formulations, whether manufactured by wet granulation, dry granulation, or direct compression.
Plasdone K polymers are used in solid dispersion formulations to enhance the solubility of active pharmaceutical ingredients and increase bioavailability.
Plasdone K grades are also used to inhibit recrystallization in liquid soft gels.
The molecular weight of Povidone K 90 is about 600,000, which belongs to high K value in homopolymer series products.
Povidone K 90 is a white or milky white powder, colorless or slightly yellow liquid.
Povidone K 90 is white to milky white powder; Odorless or slightly odorous, tasteless; With hygroscopicity.
Povidone K 90 is soluble in water, ethanol, isopropanol or chloroform, and insoluble in acetone or ether.
Povidone K 90 is a white powder, with slightly odor.
Povidone K 90 is hygroscopic.
Povidone K 90 is soluble in water, ethanol, ether and other organic solvents.
Povidone K 90 has a variety of substances have a strong ability to complex adsorption.
Povidone K 90 is supplied in various viscosity grades as a powder and/or aqueous solution.
The industrial applications of Povidone K 90 include, in adhesives to improve strength and toughness; in paper manufacture to increase strength and as a coating resin; and in synthetic fibers to improve dye receptivity.
Povidone K 90 is also widely employed in inks, imaging, lithography, detergents and soaps, the textile, ceramic, electrical and metallurgical industries and as a polymerization additive.
The full line of Povidone K 90 is also available for personal care applications such as film forming, emulsion stabilization and colorant dispersion.
Povidone K 90, also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.
Povidone K 90 is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds.
Povidone K 90 has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder.
Povidone formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents.
The k number refers to the mean molecular weight of the povidone.
Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights.
The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body.
The best-known example of povidone formulations is povidone-iodine, an important disinfectant.
Povidone K 90 is a free flowing, white powder, good stability, non-irritant,soluble in water and ethnol,safer and easier to use.
Povidone K 90 is effective in killing bacillus,viruses & epiphytes.
Povidone K 90 is compatible with most surface.
Povidone K 90 exists as free-flowing, redish-brown powder,non-irritant with good stability, dissolves in water and alcohol, insoluble in diethyl ether and chloroform.
Povidone K 90, also known as polyvinylpyrrolidone (PVP) K-90, is a polymer with various applications in pharmaceuticals, cosmetics, and other industries
Povidone K 90 is considered safe for use in pharmaceuticals and cosmetics when used as directed.
However, as with any ingredient, Povidone K 90’s essential to adhere to recommended usage levels and formulations to ensure product safety and efficacy.
Povidone K 90 has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder.
Povidone K 90 formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents.
The k number refers to the mean molecular weight of the Povidone.
Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights.
The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body.
The best-known example of povidone formulations is povidone-iodine, an important disinfectant.
Povidone is a synthetic linear polymer consisting of 1-vinyl-2-pyrrolidinone groups in different degrees of polymerisation and molecular weights.
Each grade is characterized by its viscosity in aqueous solution, relative to that of water, expressed as a K – value, typically in the 10 – 120 range.
Povidone occurs as a fine, white to creamy white coloured, odourless hygroscopic powder.
Povidone with K- values equal to or lower than 30 are manufactured by spray–drying and occur as spheres.
Povidones with >K 90 are manufactured by drum drying and occur as plates.
Povidone K 90 has a molecular weight of approx. 1000000.
Povidone K 90 is a white or creamy white powder.
Povidone K 90 is odorless, non-toxic, non-irritating.
Solubility: Povidone K 90 is easily soluble in water, alcohol, amine and many other organic solvents.
USES and APPLICATIONS of POVIDONE K 90:
Industrial Applications: Povidone K 90 is also used in various industrial applications, including adhesives, coatings, and inks, where its adhesive and film-forming properties are beneficial.
Povidone K 90 is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.
Povidone K 90 has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.
Povidone K 90 is industrially used as expanded polystyrene additive, stabilizer and gelling agent for fiber processing agents, paper processing aids, adhesives and thickeners.
Povidone K 90 and its copolymers CAP are an important raw material of cosmetics, widely applied for hair care.
Povidone K 90 film formed on the hair is elastic and glossy, has excellent carding property as well as dust free.
The adoption of different resin category can meet various relative humidity climatic conditions.
Therefore, Povidone K 90 is an indispensable raw material in the shaping of hair conditioner, hair gel and mousse.
Povidone K 90 can also be used in cosmetics of skin moisturizing agents and dispensaries for oil-based hair dyeing, as foam stabilizers and can increase the consistency of shampoo.
Povidone K 90 is one of the new 8 main pharmaceutical excipients. Povidone K 90 can be applied as solubilizer of capsules, as co-solvent of tablets, granules and injection, as dispersing agent of liquid preparations and coloring agent, as stabilizer of enzyme and heat-sensitive drug, as co-precipitating agent of poorly soluble drugs and as detoxifier of ophthalmic drugs and lubricants.
Povidone K 90 is widely used in the field of pharmaceuticals, which has excellent solubility, flexibility, chemical stability, physiological inertness and cementation.
Povidone K 90 is used binder and dissolution rate enhancer in solid dosage forms (wet granulation and direct compression)
Povidone K 90 is used solubiliser, suspending and viscosity increasing agent in oral formulations (suspensions and solutions).
Povidone K 90 is used tablet film coating polymer
Povidone K 90 is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.
Povidone K 90 has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.
Insoluble Povidone K 90 is a stabilizer of beer and fruit juice, which can improve its transparency, color and flavor.
Povidone K 90 can be used as pigment, printing, ink, textile printing and dyeing, surface coating agent, dispersant, thickening agent and viscosity agent in color picture tube, and can improve the bonding agent to metal, glass, plastic and other materials.
Povidone K 90 has bonding performance.
In addition, Povidone K 90 is also widely used in the developing high-tech fields such as separation membranes, medical polymer materials, photo-curable resins, photo-curable coatings, optical fibers and laser disks.
Povidone K 90 is widely used in the cosmetics industry.
Povidone K 90 is very suitable as an auxiliary material in shampoo, hair care, beauty and skin care, hair dye, shampoo, lipstick, sunscreen, toothpaste, etc.
Povidone K 90 is also frequently used in the coating of medicines and seeds.
Povidone K 90 plays a role in preventing moisture, light, odor in the medicine package and controlling release.
Povidone K 90 also plays a role in preventing disease and insects in the seedling stage, drought resistance and cold protection in seed coating.
Reduce the amount of pesticides and other effects.
The glue used in PVP solid glue sticks is Povidone K 90.
Povidone K 90 is used tablet binding, modified release, viscosifier, and tissue engineering scaffolds.
Povidone K 90 is used as a binder in pharmaceutical tablets.
Povidone K 90 is widely used in medical products, hair care products and cosmetics.
Povidone K 90 is used as a solubilizer and complexing agent.
Povidone K 90 is used as a binder in pharmaceutical tablets.
Povidone K 90 is used as stationary liquid for gas chromatography
Povidone K 90 is used as a colloidal stabilizer and clarifier, can be used for the clarification of beer, according to the production needs of the appropriate amount of use.
-Cosmetics uses of Povidone K 90:
Povidone K 90 is used in cosmetic formulations for its film-forming and stabilizing properties.
Povidone K 90 can be found in products such as hair sprays, mousses, and gels, where it helps to provide hold and durability to styling products.
PHARMACEUTICALS USES OF POVIDONE K 90:
Povidone K 90 is widely used in the pharmaceutical industry for its various properties, including:
*Binder:
Povidone K 90 is used as a binder in the formulation of tablets and granules.
As a binder, Povidone K 90 helps to hold the active pharmaceutical ingredients together, ensuring the uniformity and integrity of the dosage form.
*Disintegrant:
Povidone K 90 can also act as a disintegrant in tablets, facilitating the rapid breakup of the tablet into smaller particles when in contact with fluids, thereby aiding in drug release.
*Solubilizer:
Povidone K 90 is used as a solubilizing agent to enhance the solubility of poorly water-soluble drugs in aqueous solutions, improving their bioavailability.
*Stabilizer:
Povidone K 90 is used as a stabilizer in oral and topical formulations to prevent the degradation of active ingredients caused by oxidation or light exposure.
*Vehicle for Drug Delivery:
Povidone K 90 can serve as a carrier or vehicle for drug delivery systems, such as oral suspensions and topical gels.
FEATURES AND BENEFITS OF POVIDONE K 90:
*highly adhesive polymer- excellent tablet binding capacity at low concentrations producing hard, non-friable tablets
*excellent solubility in water and non-polar solvents- can be added as an aqueous or non-aqueous solution to wet granulation tablet processes
*dissolves quickly- does not delay disintegration or dissolution
*low solution viscosity- workable solution viscosity at high polymer levels makes it easy to use in granulation and other manufacturing equipment
*non-ionic- solution- viscosity is not affected by changes in pH or the presence of electrolytes, will not form complexes or interact with ionic drug actives
*interfacially active- acts as a drug solubilizer, inhibits crystallization of drug actives and inactive ingredients, stabilizes suspensions, dispersions and emulsions
*Highly versatile excipient
*Non-irritant, pH stable and temperature resistant
*Hygroscopic and freely soluble in water and hydro-alcoholic solutions
PREPARATION METHOD OF POVIDONE K 90:
Povidone K 90 is obtained by polymerizing n-vinyl-2-pyrrolidone in the presence of a basic catalyst or N,N'-vinyltriazole, followed by purification.
CHEMICAL COMPOSITION OF POVIDONE K 90:
Chemical Structure:
Povidone K 90 is a water-soluble polymer composed of repeating vinylpyrrolidone units.
Chemical Formula:
(C6H9NO)n, where n represents the number of repeating units in the polymer chain.
PHYSICAL and CHEMICAL PROPERTIES of POVIDONE K 90:
Appearance Form: powder, crystals, flakes
Average Molecular Wt.: 360,000
Color: beige
Odor: No data available
Odor Threshold: No data available
pH: 5,0 - 8 at 10 g/l at 20 °C
Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available
Flash point: Not applicable
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: No data available
Vapor density: No data available
Density: No data available
Relative density: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Physical State (20 deg.C): Solid
Store Under Inert Gas: Store under inert gas
Molar Mass: 111.143
Density 1,69 g/cm3
Melting Point: 130℃
Boling Point: 90-93 °C
Solubility: >=10 g/100 mL at 20 C
Melting Point: 130°C
Formula: (C6H9NO)n
CAS No.: 9003-39-8
Appearance: Solid
Color: White to off-white
SMILES: O=C1CCCN1C(C[H])[H].[n]
CAS: 9003-39-8
EINECS: 1312995-182-4
Molecular Formula: (C6H9NO)n
Molar Mass: 111.143
Density: 1.69 g/cm³
Melting Point: 130°C
Boiling Point: 90-93 °C
Water Solubility: >=10 g/100 mL at 20 °C
Appearance: White powder
Storage Condition: Room Temperature
Physical and Chemical Properties:
Melting Point: 130°C
Appearance: White or yellowish-white powder
K-Value: 81.0～97.2
pH Value (5% in water): 3.0～7.0
Water %: ≤5.0
Residue on ignition %: ≤0.1
Lead PPM: ≤10
Aldehydes %: ≤0.05
Hydrazine PPM: ≤1
Vinylpyrrolidone %: ≤0.1
Nitrogen %: 11.5~12.8
Peroxides (as H2O2) PPM: ≤400
IUPAC Name: N'-[(Z)-octadec-9-enyl]propane-1,3-diamine
CAS No.: 7173-62-8
CAS Registry Number: 7173-62-8
Unique Ingredient Identifier: 54XL96S8SY
Molecular Formula: C21H44N2
Molecular Weight: 324.6 g/mol
Molecular Weight: 324.58746 g·mol−1
Molar Mass: 324.59
Density: 0.851 g/cm³
Density: 0.851±0.06 g/cm³ (Predicted)
Boiling Point: 435.6 °C at 760 mmHg
Boling Point: 435.6±28.0 °C (Predicted)
Flash Point: 257.5 °C
Water Solubility: 36 mg/L at 23 °C
Vapor Pressure: 0.002 Pa at 20 °C
pKa: 10.67±0.19 (Predicted)
Refractive Index: 1.464
InChI: InChI=1S/C21H44N2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-23-21-18-19-22/h9-10,23H,2-8,11-22H2,1H3/b10-9-
InChI Key: TUFJPPAQOXUHRI-KTKRTIGZSA-N
Canonical SMILES: CCCCCCCCC=CCCCCCCCCNCCCN
Isomeric SMILES: CCCCCCCC/C=CCCCCCCCCNCCCN
DSSTOX Substance ID: DTXSID0027644
EINECS: 230-528-9
Product name: PVP-K90 (Povidone k 90)
Povidone 90 is also known as Povidone K90
CAS NUMBER. ：9003-39-8
Molecular formula: (C6H9NO)n
FIRST AID MEASURES of POVIDONE K 90:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact: rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
-Indication of any immediate medical attention and special treatment needed:
No data available
ACCIDENTAL RELEASE MEASURES of POVIDONE K 90:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up dry.
Dispose of properly.
FIRE FIGHTING MEASURES of POVIDONE K 90:
-Extinguishing media:
*Suitable extinguishing media:
Water Foam Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
EXPOSURE CONTROLS/PERSONAL PROTECTION of POVIDONE K 90:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of POVIDONE K 90:
-Conditions for safe storage, including any incompatibilities:
Storage conditions:
Tightly closed.
Dry
STABILITY and REACTIVITY of POVIDONE K 90:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions: No data available
-Conditions to avoid: no information available
