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PVP
CAS Number: 9003-39-8
Linear Formula: (C6H9NO)n
PVPK series can be used as firm-forming agent, viscosity-enhancement agenr, lubricaror and adhesive.
POVIDONE K15 is the key component of hair spray, mousse gels and lotions & solution.
POVIDONE K15 is also convenience assistant in skin-care product, hair-drying reagent, shampoo, eye makeup, lipstick, deodorant, sunscreen and dentifrice.
POVIDONE K15 forms clear, hard, shiny and glossy films.
POVIDONE K15 provides strong and stiff hold.
POVIDONE K15 shows excellent compatibility with acrylate thickeners.
POVIDONE K15 stabilizes foam, emulsions, dispersions and suspensions.
POVIDONE K15 finds application in formulating hair care products like sprays, mousses, gels, styling lotions/creams, colorants and novelty stylers.
POVIDONE K15 polymer is a hygroscopic, amorphous polymer.
POVIDONE K15 is a linear nonionic polymer that is soluble in water and organic solvents, and pH stable.
POVIDONE K15 forms hard glossy transparent films and has adhesive and cohesive properties.
POVIDONE K15 is considered to be physiologically inert.
POVIDONE K15 applications take advantage of one or more properties inherent in the polymer, typically due to the lactam ring.
High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.
Dispersancy, where components in a mixture are uniformly distributed through the use of polyvinylpyrrolidone.
POVIDONE K15 is a hygroscopic, amorphous polyvinylpyrrolidone.
POVIDONE K15 used in industrial, specialty and imaging coatings and paints, and as a media component in digital ink jet-printing.
POVIDONE K15 offers high polarity, dispersancy, hydrophilicity, adhesion, cohesivity and high glass transition temperature.
POVIDONE K15 can be plasticized with water and most common organic plasticizers.
POVIDONE K15 30% Solution is a film former in hair styling products.
POVIDONE K15 is an emulsion stabilizer in creams and lotions.
POVIDONE K15 can also be a dispersant for hair colorants.
POVIDONE K15 is available as 100% powder and as 30% aqueous solution.
As a food additive, PVP is a stabilizer and has E number E1201.
PVPP (crospovidone) is E1202.
POVIDONE K15 is also used in the wine industry as a fining agent for white wine and some beers.
In molecular biology, PVP can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer.
POVIDONE K15 is also exceptionally good at absorbing polyphenols during DNA purification.
Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.
In microscopy, PVP is useful for making an aqueous mounting medium.
PVP can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.
Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.
PVP is available in a range of molecular weights and related viscosities, and can be selected according to the desired application properties.
Uses of POVIDONE K15:
POVIDONE K15 is used in some contact lenses and their packaging solutions.
POVIDONE K15 reduces friction, thus acting as a lubricant, or wetting agent, built into the lens.
POVIDONE K15 is used as a lubricant in some eye drops.
POVIDONE K15 was used as a plasma volume expander for trauma victims after the 1950s.
POVIDONE K15 is not preferred as volume expander due to POVIDONE K15 ability to provoke histamine release and also interfere with blood grouping.
Autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.
The long-term effects of crospovidone or povidone within the lung are unknown.
Cosmetic:
PVPK series can be used as film-forming agent, viscosity-improving agent, lubricant and Glue.
POVIDONE K15 is the key component of hair sprays, mousses, gels and lotions and solution, hair-dying reagent and shampoo-extra-care products.
POVIDONE K15 can be used as skin assistant - care products, eye makeup, lipstick,
Deodorant, sunscreen and toothpaste.
Medicine:
PVPK is a new and excellent drug excipient.
POVIDONE K15 is predominantly binding for tablet, dissolving aid for injection, flow aid for capsule, dispersant for liquid medicine and stain, Enzyme and heat sensitive drug for stabilizer, poor soluble drugs for coprecipitant, lubricant and antitoxic Assistant for eye medicine.
POVIDONE K15 works as excipients in more than a hundred drugs.
POVIDONE K15 is used as a binder in many pharmaceutical tablets.
POVIDONE K15 simply passes through the body when taken orally.
POVIDONE K15 added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.
POVIDONE K15 is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs.
POVIDONE K15 is known under the trade names Pyodine and Betadine, among a plethora of others.
POVIDONE K15 is used in pleurodesis (fusion of the pleura because of incessant pleural effusions).
For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.
Technical Uses of POVIDONE K15:
POVIDONE K15 is Also Used in Many Technical Applications:
As an adhesive in glue stick and hot-melt adhesives,
As a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process,
As an emulsifier and disintegrant for solution polymerization,
To increase resolution in photoresists for cathode ray tubes (CRT),
In aqueous metal quenching,
For production of membranes, such as dialysis and water purification filters,
As a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating,
As a thickening agent in tooth whitening gels,
As an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation,
As an additive to Doro's RNA extraction buffer,
As a liquid-phase dispersion enhancing agent in DOSY NMR,
As a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly,
As a stabilizing agent in all inorganic solar cells.
Other Uses of POVIDONE K15:
Paint and coating, plastic and resin, adhesives, glass, which is also used as an assistant in the field.
Fiber, Film, ink, TV tube, detergent, biocide, tabulating, textile dying and printing, etc.
POVIDONE K15 binds to polar molecules exceptionally well, owing to POVIDONE K15 polarity.
This has led to POVIDONE K15 application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers.
POVIDONE K15 is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes.
POVIDONE K15 has also been used in contact lens solutions and in steel-quenching solutions.
POVIDONE K15 is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.
Features and Benefits of POVIDONE K15:
Home Care Features and Benefits:
Acts as rheology modifier
Is a highly adhesive tablet binder
Stabilizes emulsion and structures liquid products
Provides anti-soil redeposition, enzyme stabilization and dye transfer inhibition
Functions as binder and protective coating for enzymes
Provides surface shine enhancement
Forms hard, transparent, glossy films
Applications of POVIDONE K15:
Technical grade PVP are being used in Textiles/Fibers, Adhesives, Coatings/paintings, Laundry/Household detergent, inks, seramics and other hi-tech industries.
Povidone is one of the most important excipient in the worldwide for pharmaceutical industry,whatever for human health care products and animal health care products.
POVIDONE K15's more and more used as:
Binder for tables,capsule.
Sugar coatings and films.
Thickening agent.
Solubility Improver for poorly soluble drugs.
Bioavailability Enhancer for drug's active ingredients.
Pore-forming for membrane products.
Home Care Applications:
Dishwashing liquids
Dishwashing and laundry tablets
Laundry detergents
Hard surface cleaners
Functions of POVIDONE K15:
POVIDONE K15 is a film former in hair styling products.
POVIDONE K15 is an emulsion stabilizer in creams and lotions.
POVIDONE K15 is also a dispersant for hair colorants, foam stabilizer and de-stainer and gelling agent in toothpastes.
History of POVIDONE K15:
PVP was first synthesized by BASF chemist, Walter Reppe, and a patent was filed in 1939 for one of the derivatives of acetylene chemistry.
PVP was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production.
BASF continues to make PVP, including a pharmaceutical portfolio under the brand name of Kollidon.
Storage of POVIDONE K15:
Keep POVIDONE K15 container tightly closed in a cool well-ventilated area.
POVIDONE K15 is a hygroscopic material.
Safety of POVIDONE K15:
The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses, and POVIDONE K15 is generally recognized as safe (GRAS).
PVP is including in the Inactive Ingredient Database for use in oral, topical, and injectable formulations.
However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP has come in contact with autologous serum (internal blood fluids) and mucous membranes.
Examples of Documented Allergic Reactions:
A boy had an anaphylactic response after application of PVP-Iodine for treatment of impetigo.
He was found to be allergic to the PVP component of the solution.
A woman had experienced urticaria (hives) from various hair products, later found to contain PVP.
The woman had an anaphylactic response after povidone-iodine solution was applied internally during a surgery.
She was found to be allergic to PVP.
A man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP.
Additionally, Povidone is commonly used in conjunction with other chemicals.
Some of these, such as iodine, are blamed for allergic responses.
Yet subsequent testing results in some patients show no signs of allergy to the suspect chemical.
Allergies attributed to these other chemicals may possibly be caused by the PVP instead.
There are high-purity injectable grades of PVP available on the market, for specific use in intravenous, intramuscular, and subcutaneous applications.
Skin Protection:
Handle POVIDONE K15 with gloves.
Gloves must be inspected prior to use.
Use proper glove removal technique (without touching glove’s outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Properties of POVIDONE K15:
POVIDONE K15 is soluble in water and other polar solvents.
For example, POVIDONE K15 is soluble in various alcohols, such as methanol and ethanol, as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).
When dry POVIDONE K15 is a light flaky hygroscopic powder, readily absorbing up to 40% of POVIDONE K15 weight in atmospheric water.
In solution, POVIDONE K15 has excellent wetting properties and readily forms films.
This makes POVIDONE K15 good as a coating or an additive to coatings.
A 2014 study found fluorescent properties of PVP and POVIDONE K15 oxidized hydrolyzate.
Physical Properties of POVIDONE K15:
POVIDONE K15 exists as powder or aqueous solution.,and being supplied in a wide molecular weight range.
POVIDONE K15 can dissolve in water and a variety of organic solvents.
They are highly hygroscopicity,excellent film-forming capacity,adhesiveness and chemical stability,none toxicity.
Typical Properties of POVIDONE K15:
Product Number: P0471
Molecular Formula / Molecular Weight: (C6H9NO)n
Physical State (20 deg.C): Solid
Store: Store under inert gas
CAS RN: 9003-39-8
PubChem Substance ID: 87574662
Merck Index (14): 7697
MDL Number: MFCD01076626
Melting point/freezing point: 165°C (329°F)
Appearance: White or off-white powder
Specifications of POVIDONE K15:
Storage Temperature: +20°C
Shipping Temperature: Ambient
Harmonised Tariff Code: 39059990
CAS: 9003-39-8
MF: (C6H9NO)n
Pharmacopoeia Specifications of POVIDONE K15:
Conforms to USP.
Specification Version: 1.0
Sulphated Ash: ≤ 0.1%
Vinylpyrrolidone: ≤ 10ppm
Viscosity: 12.0 .18.0 (K-value)
Water: ≤ 5.0%
pH: 3.0 .5.0 (5% in water)
Synonyms of POVIDONE K15:
Polyvinylpyrrolidone
Polyvinyl pyrrolidone
PVP
Polyvidone
1-Ethenylpyrrolidin-2-one
Copovidone
PVPP
kollidon
kollidon 17
kollidon 25
kollidon 30
luviskol
luviskol K 17
luviskol K 25
luviskol K 30
MPK 90
neocompensan
N-vinyl,polymer
Nvinylbutyrolactam polymer
N-vinylbutyrolactam,polymer
N-vinylpyrrolidinone polymer
Nvinylpyrrolidinone,polymer
N-vinylpyrrolidone polymer
N-vinylpyrrolidone,polymer
P.V.P
albigen A
aldacol Q
AT 717
bolinan
ganex P 804
hemodesis
hemodez
Hueper's polymer No. 1
Hueper's polymer No. 2
Hueper's
polymer No. 3
Hueper's polymer No. 4
Hueper's polymer No. 5
Hueper's polymer No. 6
Hueper's polymer No. 7
K 115
K 115 (polyamide)
K 115,polyamide
K 15
K 25
143 RP
1-ethenyl-2-pyrrolidinone polymers
1-ethenyl-2-pyrrolidinone,polymers
1-ethenyl-2-pyrrolidone,polymer
1-vinyl-2-pyrrolidinone,polymers
1-vinyl-2-pyrrolidone polymers
2-pyrrolidinone, 1-ethenyl, homopolymer
2-pyrrolidinone, 1-vinyl-, polymers
agent AT 717
agrimer
peragal ST
peregal ST
periston
periston-N
peviston
plasdon K-26/28
plasdon XL
plasdone
plasdone C
