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Povidone K90 is commonly used as binders for the development of tablet formulations, whether manufactured by wet granulation, dry granulation, or direct compression.
Povidone K90 is used in solid dispersion formulations to enhance the solubility of active pharmaceutical ingredients and increase bioavailability.
Povidone K90 is also used to inhibit recrystallization in liquid soft gels.
CAS Number: 9003-39-8
Molecular Formula: CH4
Molecular Weight: 16.04246
EINECS Number: 1312995-182-4
Synonyms: N-VINYL-2-PYRROLIDONE, 88-12-0, 1-vinylpyrrolidin-2-one, 1-Vinyl-2-pyrrolidone, N-Vinylpyrrolidone, 9003-39-8, 1-Vinyl-2-pyrrolidinone, N-Vinyl-2-pyrrolidinone, Povidone, Vinylpyrrolidone, 1-ethenylpyrrolidin-2-one, N-Vinylpyrrolidinone, 2-Pyrrolidinone, 1-ethenyl-, 25249-54-1, 1-Vinylpyrrolidone, Pvpp, Vinylbutyrolactam, Vinylpyrrolidinone, V-Pyrol, Luviskol, Plasdone, 1-Vinylpyrrolidinone, Vinyl-2-pyrrolidone, N-Vinyl pyrrolidone, 1-Ethenyl-2-pyrrolidinone, N-Vinylpyrrolidone-2, 1-Vinyl-2-pyrrolidinone, monomer, 2-Pyrrolidinone, 1-vinyl-, PVP, NSC 10222, MPK 90, PVP 40, DTXSID2021440, 143 RP, AT 717, 1-vinyl-pyrrolidin-2-one, Crospovidone ~40,000, K 15, K 90, PVP-40, CHEBI:82551, MFCD00003197, NSC-10222, 76H9G81541, DTXCID101440, WLN: /T5NVTJ AY1/, MFCD01076626, CAS-88-12-0, K 25, K 115, HSDB 7231, EINECS 201-800-4, BRN 0110513, CCRIS 8581, vinyl pyrrolidone, UNII-76H9G81541, N-vinyl-pyrrolidone, N-vinylpyrrolidinone, 1-vinyl-2-pyrrolidon, POVIDONE MONOMER, VINYLBUTYLOLACTAM, N-vinylpyrrolidin-2-one, ?N-Vinyl-2-pyrrolidone, N-vinyl pyrrolidin-2-one, N-vinyl-pyrrolidin-2-one, EC 201-800-4, SCHEMBL10869, WLN: T5NVTJ A1U1, PVP-K30, Crospovidone (~40,000), POVIDONE MONOMER [MI], USP grade, cross-linked, powder, VINYL PYRROLIDONE (VP), CHEMBL1878943, N-VINYL PYRROLIDONE [INCI], NSC10222, Tox21_202462, Tox21_300073, NSC114022, NSC142693, NSC683040, Polyvinylpyrrolidone (MW ~40,000), AKOS000119985, N-VINYL-2-PYRROLIDONE [IARC], AT18510, CS-W020981, FG-0420, NSC-114022, NSC-142693, NSC-683040, NCGC00166252-01, NCGC00166252-02, NCGC00166252-03, NCGC00254200-01, NCGC00260011-01, 2-PYRROLIDINONE, 1-ETHENYL- [HSDB], NS00002538, V0026, 88-12-0; 9003-39-8 (homopolymer), EN300-19745, C19548, A817742, A843417, Q420628, SR-01000944531, J-015891, SR-01000944531-1, W-100417, 1-Vinyl-2-pyrrolidinone, SAJ first grade, >=99.0%, F8881-5579, Z104475034, InChI=1/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H, 1-Vinyl-2-pyrrolidinone, contains sodium hydroxide as inhibitor, >=99%, 1-Vinyl-2-pyrrolidinone, Pharmaceutical Secondary Standard; Certified Reference Material, 1-Vinyl-2-pyrrolidone (stabilized with N,N'-Di-sec-butyl-p-phenylenediamine).
A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.
Povidone K90 used for the matrix of dropping pill matrix is odorless, tasteless, white to pale yellow waxy solid with the relative density being 1.062, and its 5% aqueous solution pH being 3 to 7.
Povidone K90 is hygroscopic and of good thermal stability, and can be dissolved in various kinds of organic solvents, and has high melting point.
Adding certain natural or synthetic polymers or organic compounds can effectively adjust the Povidone K90’s hygroscopicity and softness.
Povidone K90 is not prone to have chemical reaction. Under normal storage conditions, dry PVP is quite stable.
Povidone K90 has excellent physical inertia and biocompatibility and has not stimulation to skin, eyes no stimulation with no allergic reactions and being non-toxic.
Because of the hydrogen bonding or complexation effect, Povidone K90’s viscosity is increased and this further inhibits the formation and growth of crystallized nuclei of drugs, making the drug being in the amorphous state.
The dropping pill whose matrix is Povidone K90 can enhance the dissolution and bioavailability of poorly soluble drugs.
Povidone K90 itself has no microbicidal activity.
Povidone K90-iodine exhibits rapid, potent, broad-spectrum antimicrobial properties.
Povidone K90 and its copolymers CAP is an important raw material of cosmetics, mainly used for hair retaining agent.
Adopting different category of resin can meet various kinds of relative humidity climatic conditions.
Adding certain natural or synthetic polymers or organic compounds can effectively adjust the PVP’s hygroscopicity and softness.
In general, the greater the PVP amount, the higher dissolution and solubility of drug in the medium.
Susana et al have studied the dissolution of the PVP solid dispersant of the slightly soluble drug albendazole.
The increased amount of Povidone K90 can increase the dissolution rate and efficiency of drug inside the solid dispersant.
Teresa et al have studied the dissolution of the poorly soluble drugs, flunarizine in PVP solid dispersant and obtained similar conclusion.
Povidone K90 also found that the higher the content, the more significant increase in dissolution.
IR has showed that flunarizine and PVP has no chemical reaction except in some cases that a best dissolution efficacy is obtained only in certain ratio between some drugs with the Povidone K90.
Tantishaiyakul et al has found that: when the ratio of piroxicam: Povidone K90 is 1:5 and 1:6, the dissolution of the solid dispersant is the largest with a 40 times as high as that of single drug within 5min.
Povidone K90 can also be dissolved in another molten dropping pill matrix, such as polyethylene glycol (PEG), polyoxyethylene monostearate (S40), poloxamer and stearyl acid, glyceryl monostearate, etc for making complex matrix.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Cosmetics and industrial Povidone K90 is not easy to have chemical reaction. When stored at normal conditions, dry PVP is quite stable.
Solution undergone mildew treatment is also stable.
When heated in air to 150 °C or mixed with ammonium persulfate to heat at 90 °C for 30min, Povidone K90 will be exchanged to become a waterinsoluble compound.
In the presence of azo compound or a dichromate oxidizing agent, light will cause PVP solution to become gel.
The co-heating of PVP solution with strong base (such as sodium silicate or trisodium phosphate) will generate precipitation.
Many different compounds can generate complexes with PVP.
For example, the complexes of Povidone K90 and iodine is very stable and have a good bactericidal effect and can reduce its toxicity; Adding the copolymers of the polyacrylic acid, tannic acid or methyl vinyl ether and maleic acid to the aqueous solution of Povidone K90 will generate insoluble complexes which are insoluble in water, alcohols and ketones.
But when being treated with base for neutralize the poly-acid can reverse the reaction; complexation between Povidone K90 and toxins, drugs and toxic chemicals can reduce their toxicity; some kinds of dyes can also form a strong complex with PVP, which is the basis for using PVP as a dye bleaching agent.
Povidone K90 is a polymer that is amorphous and hygroscopic.
Povidone K90 is a water-soluble polymer of a non-ionic type that has a stable pH level.
The film-forming properties of this ingredient make it effective in many cosmetic products.
Povidone K90 forms a hard glossy film on your skin that can be removed upon becoming sufficiently dry.
Povidone K90 also possesses cohesive and adhesive properties.
As it is available in a fine powdered form of white color, you can add it in different formulas conveniently.
Povidone K90 holds the hair in place irrespective of the climate, making it a great ingredient in hair styling products.
Povidone K90 also gives a glossy texture and appearance to your hair.
Povidone K90 proves to be effective as a dispersant in hair coloring solutions.
Cosmetics and personal care products such as lotions, toothpaste, etc. can be made to be of sparkling white color by using this as one of the primary ingredients.
Povidone K90 is also available in the form of crystals or flakes but Powdered Povidone K90 is the best and convenient to use as it can be easily mixed and added to formulas in different stages.
Povidone K90 is also used in pharmaceutical products especially as an adhesive to bind the ingredients of tablets.
Povidone K90 Powder possesses cleansing properties as well due to which it is also used in surface cleaners, home cleaners, dishwashing solutions, laundry detergents, and much more.
Povidone K90 is a nonionic, water-soluble polymer with the following features.
It can be suitable for the usage of various applications and fields.
Povidone K90 by Ashland Specialty Chemical acts as a film former.
It stabilizes emulsions, dispersions and suspensions.
Povidone K90 forms clear, hard & glossy film.
Povidone K90 is suggested for use in hair styling formualations.
Povidone K90 is a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms.
Povidone K90 is commonly used as binders for the development of tablet formulations, whether manufactured by wet granulation, dry granulation, or direct compression.
Povidone K90 is used in solid dispersion formulations to enhance the solubility of active pharmaceutical ingredients and increase bioavailability.
Povidone K90 is also used to inhibit recrystallization in liquid soft gels.
Povidone K90, also known as K90 is a water-soluble polymer with good bio-stability.
It is chemically stable, has low toxicity and is biocompatible.
Hence, Povidone K90 is useful in a variety of applications such as cosmetics, tissue engineering, and biomedical engineering.
Povidone K90, also known as Povidone or by its various grades like PVP K15, PVP K17, PVP K25, PVP K30, and PVP K90, is a versatile polymer widely used in numerous industrial applications.
As a leading PVP supplier in the EU, SoleChem Chemicals offers top-quality Povidone K90 tailored to meet diverse industrial needs.
Povidone K90 is synthesized through the free radical polymerization of the monomer N-vinylpyrrolidone.
The process is carefully controlled to produce different molecular weights, resulting in various grades like PVP K15, K17, K25, K30, and K90, each with its unique applications.
Povidone K90 finds its use in several sectors due to its excellent binding, film-forming, and stabilizing properties.
Povidone K90 form is used in the cosmetic industry.
The purpose of using Povidone K90 in the cosmetics industry is to benefit from its ability to form a dispersing agent, a hard and at the same time bright transparent film.
In the adhesive industry, in the manufacture of pressure sensitive adhesives, as an emery stone binder, as a viscosity modifier in the manufacture of ceramic-type products prepared at high temperatures.
Povidone K90 used in the manufacture of adhesives used to bond rubber to metal.
Povidone K90 used as a protective colloid and leveling agent in digital printing coating materials, ballpoint inks and emulsion polymers.
In the electronics industry, it is used as a binder in cathode ray tubes, printed circuits and storage batteries.
Povidone K90 used to disperse titanium dioxide used in the textile industry.
Povidone K90 used in the manufacture of the coating component used on the surface of aluminum, copper, zinc and nickel metals in the coating industry.
Povidone K90 an excipient used to disperse and suspend drugs in pharmaceutical products.
Povidone K90 is used in the production of pills used to relieve the common cold.
In addition, in this application, Povidone K90 is used as a binder and with Xanthan Gum as a thickening agent.
Povidone K90 is used as the adhesive chemical for transdermal systems.
Povidone K90 used as a binder for tablets and capsules.
Povidone K90 is a polymer that is amorphous and hygroscopic.
Povidone K90 a water-soluble polymer of a non-ionic type that has a stable pH level.
The film-forming properties of this ingredient make it effective in many cosmetic products.
Povidone K90 forms a hard glossy film on skin that can be removed upon becoming sufficiently dry.
Apart from that, Povidone K90 also possesses cohesive and adhesive properties.
As Povidone K90 available in a fine powdered form of white color, can add it in different formulas conveniently.
Povidone K90 hold the hair in place irrespective of the climate makes it a great ingredient in hair styling products.
Povidone K90 also gives a glossy texture and appearance to your hair.
Povidone K90 proves to be effective as a dispersant in hair coloring solutions.
Cosmetics and personal care products such as lotions, toothpaste, etc. can be made to be of sparkling white color by using this as one of the primary ingredients.
Povidone K90 is also available in the form of crystals or flakes but powdered Povidone K90 is the best and convenient to use as it can be easily mixed and added to formulas in different stages.
Povidone K90 is also used in pharmaceutical products especially as an adhesive to bind the ingredients of tablets.
Povidone K90 possesses cleansing properties as well due to which it is also used in surface cleaners, home cleaners, dishwashing solutions, laundry detergents.
The film it formed in the hair is elastic and shiny, and has excellent carding property as well as being free of dust.
Povidone K90 is considered safe for use in various applications and is compatible with a wide range of substances, making it a versatile additive in multiple industries.
Povidone K90 has a relative molecule weight greater than the relative mass greater than 700,000.
Povidone K90 and its copolymers CAP is an important raw material of cosmetics, mainly used for hair retaining agent.
Adopting different category of resin can meet various kinds of relative humidity climatic conditions.
Therefore, it is an indispensable raw material in styling hair cream, hair gel, and mousse.
Povidone K90 can also be used for the cosmetics of skin moisturizing agents and the dispersants for grease based hair dying, also as foam stabilizers, and can improve the consistency of the shampoo.
Insoluble Povidone K90 is the stabilizer of beer and juice which can improve its transparency, color, and flavor.
Povidone K90 is a water soluble polyamide.
Povidone K90 exists in white powder or aqueous solution.
The film it formed in the hair is elastic and shiny, and has excellent carding property as well as being free of dust.
Povidone K90 a insoluble polymer derived from the further cross-linking and polymerization of PVP and can be used as an adsorbent ofcpolyphenols with a good efficacy.
Povidone K90 industrially used as expanded polystyrene additive, as the gelling agents for suspension polymerization, stabilizer, and fiber treating agents, paper processing aids, adhesives, and thickening agents.
Povidone K90 is one of the three major pharmaceutical new excipients and can be used as the co-solvent of tablets,cgranules, and injection, as the glidant of capsules, as the dispersant agent of liquid preparations and the colorant, as the stabilizer ofcenzyme and heat sensitive drug, as the co-precipitating agent of poorly soluble drugs, and as the detoxicant of ophthalmic drugs andclubricants.
Povidone K90, also commercially known as K30, is a water soluble polymer.
Povidone K90 has a hygroscopic nature with good adhesive properties.
Povidone K90 has a stable pH and has the ability to form transparent films.
Povidone K90 has a wide range of usage such as:an adhesive for making gluesticks and metal adhesivesa dispersant for ceramicscoatings and inksformation of synthetic fibres.
Povidone K90 is a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms.
The clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound
healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application.
Povidone K90 is a water-soluble complex that mediates a bactericidal or virucidal action following the gradual liberation of free iodine from the complex at the application site to react with the pathogen.
Povidone K90, also commonly called polyvidone or povidone, is a water-soluble polymer compound made from the monomer N-vinylpyrrolidone.
Commercially available Povidone K90 is divided into four viscosity grades according to its press K value (Fikentscher K value): K-15, K-30, K-60, K-90, with the average molecular weight being 10,000, 40000,160000, and 360000, respectively.
K value or molecular weight is an important factor which decides the various properties of Povidone K90.
Povidone K90 is dissolved in water, chlorinated solvents, alcohol, amine, nitro-paraffin and low molecular weight fatty acids, and is mutually soluble with most inorganic salts and a variety of resin; insoluble in acetone and ether.
Povidone K90 is industrially used as expanded polystyrene additive, as the gelling agents for suspension polymerization, stabilizer, and fiber treating agents, paper processing aids, adhesives, and thickening agents.
Povidone K90 by Ashland Specialty Chemical acts as a stabilizer and film former.
Povidone K90 forms clear, hard, shiny and glossy films.
Melting point: >300 °C
Boiling point: 90-93 °C
Density: 1,69 g/cm3
storage temp.: 2-8°C
solubility: H2O: soluble100mg/mL
form: powder
color: White to yellow-white
PH: 3.0-5.0
Water Solubility: Soluble in water.
Sensitive: Hygroscopic
Merck: 14,7697
Stability: Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.
Povidone K90 forms molecular adducts in solution with sulfathiazole, sodium salicylate, salicylic acid, phenobarbital, tannin, and other compounds.
The efficacy of some preservatives, e.g. thimerosal, may be adversely affected by the formation of complexes with povidone.
Povidone K90 is widely applied in a wide range of hair care, skin care and oral care products.
Povidone K90 is particularly suitable for formulations where viscosity modification and film forming properties are required.
Povidone K90 is especially suitable for hair styling products.
Medium molecular weights such as Povidone K90 is preferred at critical points in viscosity such as spray.
High molecular weight products such as Povidone K90 are a better choice when high viscosity is required in applications.
Povidone K90 is widely used in cosmetic products such as hair gel, hair mousses, liquid hair preparation preparations, pump sprays.
Povidone K90 is available in white powder or aqueous solution.
Povidone K90 is easily soluble in water, alcohol, amine and halohydrocarbon but insoluble in acetone and aether.
Povidone K90 has good solubility, biocompatibility and physiologically inert, film-forming, colloid retain ability and compound ability of many organic or inorganic compounds.
Povidone K90 is also acid, salt and heat resistant, so it is widely used.
Povidone K90 is available as white or milky white powder or colorless or slightly yellow transparent liquid.
Povidone K90 can be dissolved in water and various organic solvents.
Povidone K90 has hygroscopic, film-forming, complexing ability and physiological compatibility.
Povidone K90 is a kind of new excellent drug excipient.
It is mainly used as binder for tablet and granule, co-solvent for injection, flow aid for capsule, dispersant for liquid medicine and pigment, stabilizer of enzyme and heat sensitive drug, co-precipitant for poorly soluble drugs, lubricant and antitoxic excipient for eye medicines.
Povidone K90 has been used as an excipient in over a hundred drugs.
Povidone K90 has excellent adhesive, film-forming, dispersing and thickening properties and is widely used in the pharmaceutical industry.
Povidone K90 is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.
Low molecular weight Povidone K90 is commonly used as a solubilizing agent, crystallization inhibitor and suspension stabilizer in injection and ophthalmic formulations.
Medium Molecular such as Povidone K90, as a binder in tablets, capsules and granules, as a stabilizer in oral suspensions, filmforming agents, solubilizing agents, dispersing agent for pigments, enzyme stabilizer and increase bioavailability.
High molecular PVP-K, like PVP K90, works as a highly effective binder.
Povidone K90 is often used as a stabilizer, thickener, hydraulic agent, etc. in oral and topical suspensions.
Povidone K90 has good compatibility with a variety of good propellant and also has corrosion resistance.
Povidone K90 is widely used in hair styling, as the film former in combing products, as the creatinine and stabilizer of skin care lotions and creams, as the base stock material for eye and facial cosmetics and lipstick base, and also as hair dye dispersants and shampoo foam stabilizer.
Povidone K90 has detoxification effect and can reduce the irritation effects of other preparation on the skin and eyes.
Povidone K90 is also used as toothpaste detergents, gelling agents and antidotes.
The main drawback of PVP is its sensitivity to moisture.
However, this issue can be tackled by using its vinyl acetate copolymer in order to mitigate the effects of moisture and humidity.
In addition, Povidone K90 also has wide application in the pharmaceutical, beverage and textile industries.
All soluble grades of Povidone K90 is supplied in the form of an almost white free-flowing powder.
They have a slight characteristic odor and are practically tasteless.
Because of its solubility in water and in many organic solvents, its high binding power and ability to form complexes, soluble Povidone K90 occupies a special position among the synthetic colloids.
Povidone K90 is compatible in solution with a wide range of inorganic salts, natural and synthetic resins, and other chemicals.
Uses Of Povidone K90:
Povidone K90 is widely applied in a wide range in hair care, skin care & oral care products.
Povidone K90 is particularly suitable for formulations where viscosity modification and film forming properties are needed.
Povidone K90 is particularly suited to hair styling products.
The medium molecular weights such as Povidone K90 is preferred where viscosity is critical in applications, for example, spray.
The higher molecular weight products such as Povidone K90 is better choice where high viscosity are needed in applications.
Therefore, can use it for making a wide range of cosmetic and skincare products.
However, don't add a huge amount of this powder as it might make your emulsions and final products too thick.
Povidone K90 is mostly used in hair styling applications like hair gels, pomades, etc. because of its ability to retain the form and hardness of hair irrespective of the weather conditions.
Povidone K90 capacity to resist heat and humidity makes it one of the best ingredients for hair styling products.
Moisturizing: Due to its hygroscopic properties, Povidone K90 is widely used in skincare products like lotions and moisturizers.
Povidone K90 retains the moisture content of your skin for a long time and rejuvenates your skin deeply to make it soft, plump, and smooth.
Povidone K90 is used as a dispersant in pigments and it is also effective as a stabilizer for oral care products (suspensions).
Moreover, it also proves to be effective in improving the bioavailability of solutions.
As a stabilizer, it proves to be useful in enhancing the overall shelf-life of cosmetic products.
As it has a higher molecular weight than other forms of PVP, it is used as a viscosity enhancer for cosmetic products.
Moreover, Povidone K90 also added while manufacturing paints, adhesives, inks, and other industrial solvents and lubricants.
Hair gels, pomades, hair styling products, moisturizers, lotions, creams, moisturizers, and other skincare and hair care products contain it as one of the key ingredients.
Povidone K90 was used as a plasma volume expander for trauma victims after the 1950s.
Povidone K90 not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping.
Povidone K90 used as a binder in many pharmaceutical tablets; it simply passes through the body when taken orally.
Povidone K90 added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.
This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs.
Povidone K90 known under the trade names Pyodine and Betadine, among a plethora of others.
Povidone K90 used in pleurodesis (fusion of the pleura because of incessant pleural effusions) or this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.
Povidone K90 is used in some contact lenses and their packaging solutions.
Povidone K90 reduces friction, thus acting as a lubricant, or wetting agent, built into the lens.
Examples of this use include Bausch & Lomb's Ultra contact lenses with MoistureSeal Technologyand Air Optix contact lens packaging solution
Povidone K90 is used as a lubricant in some eye drops
Povidone K90 is also used as a solubilizing agent because of its ability to blend and dissolve a variety of biochemicals and natural ingredients in emulsions.
As it is a stable ingredient you can add it to formulas without worrying about their pH balance.
Also, it is non-ionic and blends with a variety of ingredients.
Povidone K90 can be used for pharmacy, aquaculture, and livestock disinfectant for the sterilization of the skin and mucous.
Povidone K90 is used as a food additive and in the wine industry as a fining agent for white wine.
Povidone K90 is used as a capping agent to synthesize silver nanowires through a polyol process.
As a food additive, Povidone K90 is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202.
Povidone K90 is also used in the wine industry as a fining agent for white wine and some beers.
In in-vitro fertilisation laboratories, Povidone K90 is used to slow down spermatozoa in order to capture them for e.g. ICSI.
In molecular biology, Povidone K90 can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer.
Povidone K90 is also exceptionally good at absorbing polyphenols during DNA purification.
Povidone K90 is common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.
In microscopy, Povidone K90 is useful for making an aqueous mounting medium.
Povidone K90 can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.
Povidone K90, also known as polyvinylpyrrolidone or polyvidone, is a polymer and used as a binder in pharmaceutical tablets.
Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.
Povidone K90 is a kind of new excellent pharmaceutical excipient.
Povidone K90 is mainly used as binder for tablet and granule, dissolving assistant for injection, flow assistant for capsule, dispersant for liquid medicine and pigment, stabilizer for enzyme and heat-sensitive drug, coprecipitant for poorly soluble drugs, lubricator and antitoxic assistant for eye drug.
Povidone K90 has been used as excipient in more than one hundred drugs.
With excellent adhesive, film-forming, dispersing and thickening properties, Povidone K90 is widely used in the pharmaceutical industry.
Povidone K90 is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.
Low molecular weight Povidone K90, like PVP K12,K15,K17, are usually used as a solubilizing agent, crystallization inhibitor and suspension stabilizer in injection and ophthalmic formulations.
Povidone K90, like PVP K25,K30, are often used as binder in tablets, capsules and granules, as a stabilizer for oral suspensions, film-forming agent, solubilizing agent, dispersant for pigments, as an enzyme stabilizer and to improve bioavailability.
High molecular Povidone K90, like PVP K90, work as highly effective binder.
They are often used as stabilizer in oral and topical suspension, as a thickener, hydropylizing agent, etc.
Safety Profile Of Povidone K90:
Povidone K90 is included in the Inactive Ingredient Database for use in oral, topical, and injectable formulations.
However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the Povidone K90 has come in contact with autologous serum (internal blood fluids) and mucous membranes.
Povidone K90 has been used in pharmaceutical formulations for many years, being first used in the 1940s as a plasma expander, although it has now been superseded for this purpose by dextran.
Povidone K90 is widely used as an excipient, particularly in oral tablets and solutions.
When consumed orally, povidone may be regarded as essentially nontoxic since it is not absorbed from the gastrointestinal tract or mucous membranes.
Povidone K90 additionally has no irritant effect on the skin and causes no sensitization exists that povidone may accumulate in the organs of the body following intramuscular injection.
A temporary acceptable daily intake for povidone has been set by the WHO at up to 25 mg/kg body-weight
The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses, and it is generally recognized as safe (GRAS).
