Quick Search
Povidone, PVP K-90 is abbreviated as PVP, and is the polymer of vinylpyrrolidone.
According to the different degree of polymerization, Povidone, PVP K-90 is further classified into soluble Povidone, PVP K-90 and insoluble PVPP (polyvinyl polypyrrolidone).
Molecular weight of the soluble PVP is 8,000 to 10,000.
CAS: 9003-39-8
MF: CH4
MW: 16.04246
EINECS: 1312995-182-4
Synonyms
toxobin;vinisil;vinylpyrrolidinonepolymer;vinylpyrrolidonepolymer;PVP K30 USP24;PVP K120;K30 PVP K30;K 30 POVIDONE K 30 BP/USP;2-Pyrrolidinone,1-ethenyl-,homopolymer;2-Pyrrolidinone,1-vinyl-,polymers;Albigen A;Kollidon;Luviskol K 30;Plasdone;Plasdone 4;Polyvidone;Poly(1-vinyl-2-pyrrolidinone);Povidone;PVP;Subtosan;Vinisil;Poly(N-vinylpyrrolidinone);Poly(vinylpyrrolidone);Poly(vinylpyrrolidinone);Poly(N-vinylpyrrolidone);Peviston;Polyclar AT;Vinylpyrrolidinone polymer;Peregal ST;Luviskol K 90;Periston;Agent AT 717;Poly(N-vinylbutyrolactam);Poly(1-vinyl-2-pyrrolidone);Poly(N-vinyl-2-pyrrolidinone);N-Vinylpyrrolidinone polymer;N-Vinylpyrrolidone polymer;PVP-K 90;Vinylpyrrolidone polymer;K 60;K 115 (vinyl polymer);N-Vinylbutyrolactam polymer;Periston N;Poly(N-vinyl-2-pyrrolidone);PVP-K 3;Antaron P 804;Poly(N-vinyl-γ-butyrolactam);PVP 40;143RP;Bolinan;Plasmosan;Protagent;1-Vinyl-2-pyrrolidone polymer;N-Vinyl-2-pyrrolidone polymer;Kollidon 17;Neocompensan;Hemodez;K 115;MPK 90;AT 717;Kollidon 30;Polyclar H;Polyclar L;PVP 50;Plasdone K 29-32;K 15 (polymer);Plasdone XL;PVP-K 30;PVP-K 60;K 25;Hemodesis;Ganex P 804;K 60 (polymer);Poly(1-vinylpyrrolidinone);Polyplasdone XL;Kollidon 25;PVPP;Aldacol Q;Kollidon 90;Polyvidon;Plasdone C;Povidone K 29-32;PVP-K 25;K 15;Plasdone C 15;Kollidon K 25;SD 13 (polymer);SD 13;PVP 1230;Kollidon K 30;Kollidon CE 50/50;B 7509;K 90;Kollidon 12PF;PVP-K 15;Luviskol K 17;Luviskol K 25;PVP-K 40;NPK 15;NPK 90;Antitox Vana;NP-K 30;Kollidon 17PF;Povidone K 30;Plasdone K 15;9015-62-7;9080-59-5;29386-94-5;41724-41-8;53026-73-6;53026-74-7;53200-27-4;61932-72-7;65931-56-8;111214-46-1;116404-61-6;121414-75-3;132778-04-2;132778-05-3;132834-20-9;153631-61-9;170473-90-2;496908-06-6;730985-60-1;862983-74-2;878051-55-9;956148-96-2;1173909-53-9;1229193-79-6;1234714-82-9;1303541-78-7;1310675-91-2;1337987-71-9;1394151-52-0;1431958-26-7;1694674-42-4;1918127-90-8;2062651-26-5;2083718-66-3;2083718-67-4;2088158-90-9;2100274-29-9;2169285-59-8
The soluble Povidone, PVP K-90 can be used as a precipitating agent which can be settle down through its action with polyphenols.
Using this method, Povidone, PVP K-90 is easily to have residual PVP in the alcohol.
Due to the savings effect of Povidone, PVP K-90 inside the human body, the World Health Organization doesn’t recommend to apply this substance.
In recent years, the use of soluble Povidone, PVP K-90 has been rare.
Insoluble PVPP system had began to be used in the beer industry since the early 1960s.
Povidone, PVP K-90 has a relative molecule weight greater than the relative mass greater than 700,000.
Povidone, PVP K-90 is a insoluble polymer derived from the further cross-linking and polymerization of Povidone, PVP K-90 and can be used as an adsorbent of polyphenols with a good efficacy.
A vinyl polymer composed of repeating -CH2-CR- units where R is a 2-oxopyrrolidin-1-yl group.
Povidone, PVP K-90, also commonly called povidone, is a water-soluble polymer compound made from the monomer N-vinylpyrrolidone.
Povidone, PVP K-90 is available in a range of molecular weights and related viscosities, and can be selected according to the desired application properties.
Povidone, PVP K-90 Chemical Properties
Melting point: >300 °C
Boiling point: 90-93 °C
Density: 1,69 g/cm3
Tg: 175
Bulk density: 330kg/m3
Refractive index: (25) 1.5300
Refractive index: 1.5300
Storage temp.: 2-8°C
Solubility H2O: soluble100mg/mL
Form: powder
Color: White to yellow-white
PH: 3.0-5.0
Biological source: synthetic (oragnic)
Water Solubility: Soluble in water.
Sensitive: Hygroscopic
Merck: 14,7697
Stability: Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.
InChI: InChI=1S/C8H15NO/c1-3-7(2)9-6-4-5-8(9)10/h7H,3-6H2,1-2H3
InChIKey: FAAHNQAYWKTLFD-UHFFFAOYSA-N
IARC: 3 (Vol. 19, Sup 7, 71) 1987
EPA Substance Registry System: Povidone, PVP K-90 (9003-39-8)
Povidone, PVP K-90 is the cross-linked homopolymer of pure vinylpyrrolidone.
Povidone, PVP K-90 is hygroscopic and free-flowing white or off-white powder.
Povidone, PVP K-90 has a slight foul smell.
Povidone, PVP K-90 is insoluble in common solvents such as water, ethanol and ether.
So its molecule weight range can’t be measured.
However, Povidone, PVP K-90 has ability to form complex with various kinds of substances (such as “Hu” class substance which can lead to the discoloration of a variety of wines and beverages discoloration).
Also Povidone, PVP K-90 is easily to be removed after filtration because of its insolubility.
Povidone, PVP K-90 is soluble in water and other polar solvents.
For example, Povidone, PVP K-90 is soluble in various alcohols, such as methanol and ethanol, as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).
When dry Povidone, PVP K-90 is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water.
In solution, Povidone, PVP K-90 has excellent wetting properties and readily forms films.
This makes Povidone, PVP K-90 good as a coating or an additive to coatings.
A 2014 study found fluorescent properties of PVP and its oxidized hydrolyzate.
The molecular formula of Polyvinylpyrrolidone
Povidone, PVP K-90 is one of the three major pharmaceutical new excipients and can be used as the co-solvent of tablets, granules, and injection, as the glidant of capsules, as the dispersant agent of liquid preparations and the colorant, as the stabilizer of enzyme and heat sensitive drug, as the co-precipitating agent of poorly soluble drugs, and as the detoxicant of ophthalmic drugs and lubricants.
Povidone, PVP K-90 is industrially used as expanded polystyrene additive, as the gelling agents for suspension polymerization, stabilizer, and fiber treating agents, paper processing aids, adhesives, and thickening agents.
Povidone, PVP K-90 and its copolymers CAP is an important raw material of cosmetics, mainly used for hair retaining agent.
The film Povidone, PVP K-90 formed in the hair is elastic and shiny, and has excellent carding property as well as being free of dust.
Adopting different category of resin can meet various kinds of relative humidity climatic conditions.
Therefore, Povidone, PVP K-90 is an indispensable raw material in styling hair cream, hair gel, and mousse.
Povidone, PVP K-90 can also be used for the cosmetics of skin moisturizing agents and the dispersants for grease based hair dying, also as foam stabilizers, and can improve the consistency of the shampoo.
Insoluble Povidone, PVP K-90 is the stabilizer of beer and juice which can improve its transparency, color, and flavor.
Povidone, PVP K-90 occurs as a fine, white to creamy-white colored, odorless or almost odorless, hygroscopic powder.
Povidones with K-values equal to or lower than 30 are manufactured by spray-drying and occur as spheres.
Povidone, PVP K-90 and higher K-value povidones are manufactured by drum drying and occur as plates.
Uses
In the early 1950s, older, with shellac and oil-based hairspray had been rapidly replaced by Povidone, PVP K-90 sprays which are still widely used until now.
Povidone, PVP K-90 can form wet, transparent film on the hair which is shiny and has good lubrication effect.
Povidone, PVP K-90 has good compatibility with a variety of good propellant and also has corrosion resistance.
Povidone, PVP K-90 is widely used in hair styling, as the film former in combing products, as the creatinine and stabilizer of skin care lotions and creams, as the base stock material for eye and facial cosmetics and lipstick base, and also as hair dye dispersants and shampoo foam stabilizer.
Povidone, PVP K-90 has detoxification effect and can reduce the irritation effects of other preparation on the skin and eyes.
Povidone, PVP K-90 is also used as toothpaste detergents, gelling agents and antidotes.
The main drawback of Povidone, PVP K-90 is its sensitivity to moisture.
However, this issue can be tackled by using its vinyl acetate copolymer in order to mitigate the effects of moisture and humidity.
In addition, Povidone, PVP K-90 also has wide application in the pharmaceutical, beverage and textile industries.
Clarifying agent; pigment stabilizer; colloidal stabilizer; Povidone, PVP K-90 is mainly used for beer clarifying and quality stabilizing (reference amount 8~20g/100L, maintained for 24h and remove it by filtration), and can also be applied in combination with enzymes (protease) and protein adsorbents.
Povidone, PVP K-90 is also used to clarify the wine and as a stabilizer to prevent discoloration (reference amount 24~72g/100L).
Clarifying agents; stabilizers; thickeners agent; tablet fillers; dispersants; Povidone, PVP K-90 of molecular weight 360,000 are often used as the clarifying agent of beer, vinegar, and grape wine.
Used as the fixing liquid for gas chromatography.
Povidone, PVP K-90 is used as a colloidal stabilizer and clarifying agent for beer clarification.
Apply proper amount according the demands of production.
Povidone, PVP K-90 can be used for pharmacy, aquaculture, and livestock disinfectant for the sterilization of the skin and mucous.
PolyFilterTM molecule has an amide bond for absorbing the hydroxyl groups located in polyphenol molecule to form hydrogen bonds, and therefore, can be used as the stabilizer of beer, fruit wine/grape wine, and drinking wine to extend their shelf life and improve the transparency, color and taste.
The products have two specifications: disposable type and regeneration type.
Disposable products are suitable for application by SMEs; renewable products demand the purchase of special filtration equipment; but since Povidone, PVP K-90 is recyclable, it is suitable for large breweries for recycle application.
In daily cosmetics, Povidone, PVP K-90 and its copolymer has good dispersion property and filming property, and thus being able to be used as a setting lotion, hair spray and styling mousse, as opacifiers for hair care agents, as the stabilizer of shampoo foam, as wave styling agent and as the dispersants and affinity agents in hair dye.
Adding Povidone, PVP K-90 to cream, sunscreen, and hair removal agent can enhance wetting and lubricating effect.
Taking advantage of the excellent properties of Povidone, PVP K-90 such as surface activity, film-forming and non-irritating to the skin, no allergic reactions, etc., has broad prospects in its application in hair care and skin care products.
Povidone, PVP K-90 is used as an adhesive in glue sticks; an emulsifier and a disintegrant for solution polymerization; an additive to Doro's RNA extraction buffer; as a liquid-phase dispersion enhancing agent in diffusion-ordered spectroscopy (DOSY) NMR and as a thickening agent in tooth whitening gels.
Povidone, PVP K-90 finds use in personal care products like shampoos and toothpastes, in ink for inkjet printers as well as in contact lens solutions.
Povidone, PVP K-90 is used as a food additive and in the wine industry as a fining agent for white wine.
Povidone, PVP K-90 is used as a capping agent to synthesize silver nanowires through a polyol process.
Pharmaceutical Applications
Although povidone is used in a variety of pharmaceutical formulations, Povidone, PVP K-90 is primarily used in solid-dosage forms.
In tableting, povidone solutions are used as binders in wet-granulation processes.
Povidone, PVP K-90 is also added to powder blends in the dry form and granulated in situ by the addition of water, alcohol, or hydroalcoholic solutions.
Povidone, PVP K-90 is used as a solubilizer in oral and parenteral formulations, and has been shown to enhance dissolution of poorly soluble drugs from solid-dosage forms.
Povidone, PVP K-90 solutions may also be used as coating agents or as binders when coating active pharmaceutical ingredients on a support such as sugar beads.
Povidone, PVP K-90 is additionally used as a suspending, stabilizing, or viscosity-increasing agent in a number of topical and oral suspensions and solutions.
The solubility of a number of poorly soluble active drugs may be increased by mixing with povidone.
Medical
There are high-purity injectable grades of Povidone, PVP K-90 available on the market, for specific use in intravenous, intramuscular, and subcutaneous applications.
Povidone, PVP K-90 is a frequently used binder in pharmaceutical tablet formulations.
Pharmacokinetic studies in humans and various laboratory animal models indicate no to very little systemic absorption of PVP following oral administration.
Povidone, PVP K-90 added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.
Povidone, PVP K-90 is used in various products such as solutions, ointment, pessaries, liquid soaps, and surgical scrubs.
Povidone, PVP K-90 is sold under the trade names Pyodine and Betadine, among others.
Povidone, PVP K-90 is used in pleurodesis (fusion of the pleura because of incessant pleural effusions).
For this purpose, Povidone, PVP K-90 is as effective and safe as talc, and may be preferred because of its easy availability and low cost.
PVP is used in some contact lenses and their packaging solutions.
Povidone, PVP K-90 reduces friction, thus acting as a lubricant, or wetting agent, built into the lens.
Examples of this use include Bausch & Lomb's Ultra contact lenses with MoistureSeal Technology, Air Optix contact lens packaging solution (as an ingredient called "copolymer 845"), and Johnson & Johnson's Acuvue contact lenses.
Povidone, PVP K-90 is used as a lubricant in some eye drops, e.g. Bausch & Lomb's Soothe.
Povidone, PVP K-90 was used as a plasma volume expander for trauma victims after the 1950s.
Povidone, PVP K-90 is not preferred as a volume expander due to its ability to provoke histamine release and also interfere with blood grouping.
Autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.
The long-term effects of crospovidone or Povidone, PVP K-90 within the lung are unknown.
Production method
Povidone, PVP K-90's crude product comes from the polymerization of vinylpyrrolidone under basic catalyst or the existence of N, N'-divinyl amidine and further cross-inking reaction.
Then use water, 5% acetic acid and 50% ethanol for reflux to until extract ≤50mg/kg (for over 3h).
The 30% to 60% aqueous solution of the purified 1-vinyl-2-pyrrolidone, in the presence of ammonia or amines and also with hydrogen peroxide as the catalyst, has cross-linking and homo-polymerization reaction at a temperature of 50 °C and subject to further purification to obtain the final product.
Production Methods
Povidone, PVP K-90 is manufactured by the Reppe process. Acetylene and formaldehyde are reacted in the presence of a highly active copper acetylide catalyst to form butynediol, which is hydrogenated to butanediol and then cyclodehydrogenated to form butyrolactone.
Povidone, PVP K-90 is produced by reacting butyrolactone with ammonia.
This is followed by a vinylation reaction in which pyrrolidone and acetylene are reacted under pressure.
The monomer, vinylpyrrolidone, is then polymerized in the presence of a combination of catalysts to produce Povidone, PVP K-90.
