POVIDONE

Povidone is a synthetic, water-soluble polymer widely used in pharmaceuticals, cosmetics, and industrial applications for its binding, film-forming, and solubilizing properties.
Povidone is known for its excellent safety profile, chemical stability, and ability to improve the bioavailability of poorly soluble drugs.
Povidone is utilized in various dosage forms, including tablets, capsules, topical solutions, and ophthalmic preparations.

CAS Number: 9003-39-8
EC Number: 232-911-6
Molecular Formula: (C6H9NO)n
Molecular Weight: Variable (typically 10,000–700,000 Da, depending on grade)

Synonyms: Povidone, Polyvinylpyrrolidone, PVP, PVP K-30, PVP K-90, Kollidon, Polyvidone, E1201, Pharmaceutical PVP, Solubilizing Polymer, Povidone USP, PVP for Cosmetics, Povidone, Polyvinylpyrrolidone, PVP, Polyvidone, Poly[1-(2-oxo-1-pyrrolidinyl)ethylene], N-vinylpyrrolidone polymer, Poly-N-vinylpyrrolidone, Kollidon, Crospovidone, Crovol, PVP K30, Povidone K30, PVP-iodine component, Povidone-iodine carrier, PVP-I, Polyvinylpyrrolidone-iodine complex, Iodopovidone, Povidone–iodine, Betadine base polymer, Povidone vehicle, Pharmaceutical binder Povidone, Tablet binder Povidone, Film-forming polymer Povidone, Adhesive additive Povidone, Emulsifier Povidone, Disintegrant Povidone, Stabilizer Povidone, Suspending agent Povidone, Thickening agent Povidone, Viscosity modifier Povidone, Lubricant Povidone, Wetting agent Povidone, Solubilizer Povidone, Hair spray ingredient Povidone, Eye drop lubricant Povidone, Contact lens lubricant Povidone, Plasma expander Povidone, Inactive ingredient Povidone, GRAS food-grade Povidone, Wine-fining agent Povidone, PVP K90, PVP720, Povidone USP grade, Povidone EP grade

APPLICATIONS

Povidone is used as a binder in tablet and capsule formulations to ensure cohesive and durable dosage forms.
Povidone acts as a solubilizer for poorly water-soluble drugs, enhancing their dissolution and bioavailability.
Povidone is employed as a film-former in topical and transdermal drug delivery systems.

Povidone is used in ophthalmic solutions to increase viscosity and improve eye retention time.
Povidone serves as a stabilizer and dispersing agent in suspensions and emulsions.
Povidone is incorporated into oral lozenges and chewable tablets for improved mouthfeel and structural integrity.

Povidone is used in wound care products, such as iodine-based antiseptics, due to its film-forming and water-binding properties.
Povidone is a key ingredient in Povidone-Iodine, a widely used topical antiseptic.
Povidone is employed in dermatological preparations for its non-irritating and moisturizing characteristics.

Povidone is included in cosmetic products, such as hair sprays, gels, and creams, to provide hold, texture, and moisture retention.
Povidone improves the texture and application of facial masks, foundations, and makeup removers.
Povidone is used in skin care products for its humectant and thickening effects.

Povidone is used in industrial applications as a dispersant in inks, dyes, and coatings.
Povidone acts as a thickener in adhesives and glues.
Povidone is employed in water treatment as a stabilizer and chelating agent.

Povidone is used in veterinary medicine for oral, topical, and injectable drug formulations.
Povidone enhances the solubility of animal medications and nutritional supplements.
Povidone is employed in animal wound care and antiseptic sprays.

Povidone is included in food processing as a clarifying agent in beverages such as wine and beer.
Povidone is used in biotechnology as a stabilizing agent for enzymes and sensitive biological compounds.
Povidone is applied in diagnostic assays to enhance reagent stability and reaction consistency.

Povidone is used as a binder in tablet formulations for pharmaceuticals.
Povidone is employed as a film-forming agent in wound healing products.

Povidone is used in ophthalmic solutions to enhance viscosity.
Povidone is incorporated in mouthwashes as a stabilizer.
Povidone is used in lozenges to bind active ingredients.

Povidone is used in oral suspensions for improving solubility.
Povidone is applied in nasal sprays as a mucoadhesive.

Povidone is used in transdermal patches as a matrix carrier.
Povidone is utilized in hydrogels for skin treatment.

Povidone is included in hand sanitizers as a skin-friendly thickener.
Povidone is used in veterinary formulations for tablet cohesion.

Povidone is employed in injectable drugs as a solubilizing agent.
Povidone is used in topical creams for consistent texture.

Povidone is incorporated in suppositories for improved dispersion.
Povidone is used in diagnostic test strips for reagent stabilization.
Povidone is applied in toothpaste as a binding and film-forming agent.

Povidone is used in hair sprays to provide hold and gloss.
Povidone is included in hair gels for firm consistency.

Povidone is used in cosmetics as a thickening and binding agent.
Povidone is utilized in sunscreens to improve water resistance.

Povidone is used in facial masks for adherence and uniform application.
Povidone is applied in shaving creams for smoother texture.
Povidone is used in skin serums to stabilize active ingredients.

Povidone is employed in moisturizers for non-greasy film formation.
Povidone is included in deodorants to control product consistency.

Povidone is used in anti-acne gels to enhance formulation spreadability.
Povidone is applied in micellar water to stabilize cleansing ingredients.
Povidone is used in makeup removers to dissolve pigments.

Povidone is included in foundation products for long-lasting wear.
Povidone is used in eyeliner formulations for smudge resistance.

Povidone is employed in lipsticks to improve texture and shine.
Povidone is used in mascara to provide film-forming properties.

Povidone is applied in nail polish for improved adhesion.
Povidone is used in laundry detergents as a dye transfer inhibitor.

Povidone is included in dishwashing liquids for spot prevention.
Povidone is used in inks for improved pigment dispersion.

Povidone is applied in photographic films to improve coating performance.
Povidone is used in adhesives for water solubility control.
Povidone is used in paper coatings to enhance printability.

Povidone is employed in textiles as a sizing agent.
Povidone is used in agriculture for seed coating formulations.

Povidone is incorporated into water-treatment tablets as a binding agent.
Povidone is used in biocidal formulations for stability and binding.
Povidone is applied in medical adhesives for skin-friendly adhesion.

Povidone is used in hydrocolloid dressings to manage wound exudate.
Povidone is used in rapid-dissolving oral films as a structural polymer.

Povidone is employed in food contact coatings due to its inertness.
Povidone is used in fragrance capsules for slow-release delivery.

Povidone is applied in air freshener gels to form stable matrices.
Povidone is used in flavor delivery systems for encapsulation.

DESCRIPTION

Povidone is a white to off-white hygroscopic powder with no odor and a faint taste.
Povidone is synthesized through polymerization of N-vinylpyrrolidone (NVP) and is available in various molecular weights and viscosity grades.
Povidone is highly soluble in water and a range of polar solvents, making it adaptable for aqueous and hydroalcoholic formulations.

Povidone exhibits film-forming, adhesive, and moisture-retaining properties, ideal for pharmaceutical coatings and dermal applications.
Povidone is physiologically inert, non-toxic, and generally recognized as safe (GRAS) for use in food and pharmaceuticals.
Povidone does not exhibit significant reactivity under normal use and is compatible with a wide range of excipients and active ingredients.

Depending on the grade (e.g., K-15, K-30, K-90), Povidone can be tailored for different applications based on molecular weight and viscosity.
Povidone is used in both immediate-release and sustained-release drug delivery systems.
Povidone is not absorbed by the body when applied topically and is mostly excreted unchanged when ingested.

Povidone is a synthetic polymer derived from the monomer vinylpyrrolidone.
Povidone is water-soluble and widely used as a pharmaceutical excipient.

Povidone is known for its binding, film-forming, and dispersing properties.
Povidone has excellent biocompatibility and low toxicity.

Povidone is available in various molecular weights for tailored applications.
Povidone forms clear films that are resistant to cracking.

Povidone is hygroscopic and can retain moisture in formulations.
Povidone is compatible with a wide range of pharmaceutical actives.

Povidone is thermally stable under normal processing conditions.
Povidone is commonly used in both human and veterinary medicine formulations.

PROPERTIES

Chemical Name: Polyvinylpyrrolidone (Povidone)
CAS Number: 9003-39-8
EC Number: 232-911-6
Molecular Formula: (C6H9NO)n
Molecular Weight: Varies (10,000–700,000 Da)
Appearance: White to off-white powder
Odor: Odorless
Density: ~1.2 g/cm³
Melting Point: Not applicable (decomposes)
Boiling Point: Not applicable
Solubility: Soluble in water, ethanol, methanol, and other polar solvents
Viscosity: Depends on grade (K-values range from K-12 to K-90)
pH (1% solution): 3.0–7.0
Reactivity: Stable under normal conditions
Storage Conditions: Store in a dry, cool place away from moisture and heat

FIRST AID

Inhalation:
Move to fresh air if Povidone dust is inhaled.
Seek medical attention if respiratory symptoms persist.
Use respiratory protection in dusty environments.

Skin Contact:
Wash thoroughly with soap and water.
Seek medical attention if irritation or rash develops.
Remove and clean contaminated clothing.

Eye Contact:
Flush eyes with water for at least 15 minutes.
Remove contact lenses if present and easy to do.
Consult a physician if irritation continues.

Ingestion:
Rinse mouth and drink water.
Povidone is considered non-toxic in small quantities, but seek medical advice if symptoms occur.
Do not induce vomiting unless directed by a physician.

Note to Physicians:
Povidone is not metabolized and is excreted unchanged.
Provide supportive care as required.

HANDLING AND STORAGE

Handling:
Avoid generating dust.
Use personal protective equipment such as gloves and safety goggles.
Handle in well-ventilated areas to avoid inhalation of fine particles.

Storage:
Store in a tightly sealed container in a dry, cool, and well-ventilated location.
Protect from moisture, heat, and direct sunlight.
Avoid prolonged exposure to air to prevent caking and loss of performance.

Spill Response:
Sweep up powder without generating dust.
Place in appropriate waste container for disposal.
Avoid discharge into drains or natural water sources.

Disposal:
Dispose of in accordance with local, regional, and national regulations.
Do not incinerate closed containers.