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CAS: 111-30-8
MF: C5H8O2
MW: 100.12
EINECS: 203-856-5
Description
Preventol GDA 50 is a well-known sensitizer among cleaners and health workers.
Preventol GDA 50 is also found in X-ray developers products.
Preventol GDA 50 is light yellow liquid.
Preventol GDA 50 is mixes with water.
Preventol GDA 50 is an organic compound with the formula (CH2)3(CHO)2.
The molecule consists of a five carbon chain doubly terminated with formyl (CHO) groups.
Preventol GDA 50 is usually used as a solution in water, and such solutions exists as a collection of hydrates, cyclic derivatives, and condensation products, several of which interconvert.
Because Preventol GDA 50 has two carbonyl group is reactive to primary amine groups (even as its hydrates), it can function as a crosslinking agent for any substance with primary amine groups and develop imine connected link.
Crosslinking rigidifies and deactivates many biological functions, so in this way, glutaraldehyde solutions are used as biocides and as fixative.
Preventol GDA 50 is sold under the brandname Cidex and Glutaral.
As a disinfectant, Preventol GDA 50 is used to sterilize surgical instruments.
In material science Preventol GDA 50 application areas range from polymers to metals and biomaterials.
Preventol GDA 50 is commonly used as fixing agent before characterization of biomaterials for microscopy.
Preventol GDA 50 is a powerful crosslinking agent for many polymers contain primer amine groups.
Preventol GDA 50 also can be used for an interlinking agent to improve the adhesion force between two polymeric coatings.
Preventol GDA 50 is also used to protect against corrosion of undersea pipes.
Preventol GDA 50 solution, 25% in water, is primarily for use as a protein cross-linking agent.
Preventol GDA 50 is not recommended for use as an electron microscopy fixative.
In the laboratory, Preventol GDA 50 solution is commonly used as an amine-reactive homobifunctional crosslinker and as a disinfectant for medical equipment.
Preventol GDA 50 may effectively crosslink amine and hydrazine derivatives to proteins and other amine-containing polymers; biotin hydrazides have been directly coupled to nucleic acids with Preventol GDA 50 in a reaction that is potentially useful for conjugating fluorescent hydrazides and hydroxylamines to DNA.
Biochemistry
Preventol GDA 50 is used in biochemistry applications as an amine-reactive homobifunctional crosslinker and fixative.
Preventol GDA 50 kills cells quickly by crosslinking their proteins.
Preventol GDA 50 is usually employed alone or mixed with formaldehyde as the first of two fixative processes to stabilize specimens such as bacteria, plant material, and human cells.
A second fixative procedure uses osmium tetroxide to crosslink and stabilize cell and organelle membrane lipids.
Another application for treatment of proteins with Preventol GDA 50 is the inactivation of bacterial toxins to generate toxoid vaccines, e.g., the pertussis (whooping cough) toxoid component in the Boostrix Tdap vaccine produced by GlaxoSmithKline.
Preventol GDA 50 is an effective protein crosslinker and finds application in techniques like enzyme immobilisation microscopy, histochemistry and cytochemistry.
Preventol GDA 50 exists in different forms under acidic or neutral conditions.
Preventol GDA 50 is a biocide widely used as a disinfectant in hospitals and industries and is toxic to aquatic organisms.
Preventol GDA 50's allergic nature leads to hypersensitivity reactions.
Contact of glutaraldehyde vapors in endoscopy contributes to Colitis.
Preventol GDA 50 Chemical Properties
Melting point: -15 °C
Boiling point: 100 °C
Density: 1.058 g/mL at 20 °C
Vapor density: 1.05 (vs air)
Vapor pressure: 15 mmHg ( 20 °C)
Refractive index: n20/D 1.450
Fp: 100°C
Storage temp.: Store below +30°C.
Form: Solution
Color: Clear to slight haze
Specific Gravity: 1.06
PH: >3.0 (H2O, 20°C)
Water Solubility: miscible
Merck: 14,4472
BRN: 605390
Exposure limits Ceiling (ACGIH): 0.8 mg/m3 (0.2 ppm).
InChIKey: SXRSQZLOMIGNAQ-UHFFFAOYSA-N
CAS DataBase Reference: 111-30-8(CAS DataBase Reference)
NIST Chemistry Reference: Preventol GDA 50(111-30-8)
EPA Substance Registry System: Preventol GDA 50 (111-30-8)
Preventol GDA 50 is a colorless liquid with a pungent odor, which readily changes to a glossy polymer.
The Odor Threshold is 0.04 ppm (NY) and 0.2 ppm (NJ).
Preventol GDA 50 is miscible in water and organic solvents.
Preventol GDA 50 may be incompatible with strong oxidizers and strong bases.
Preventol GDA 50 should be noted that alkaline solutions containing glutaraldehyde may react with alcohol, ketones, amines, hydrazines, and proteins.
Uses
Preventol GDA 50 is used as a disinfectant and medication.
Usually applied as a solution, Preventol GDA 50 is used to sterilize surgical instruments and other areas.
As a medication Preventol GDA 50 is used to treat plantar warts.
For Preventol GDA 50, a 10% w/v solution is used.
Preventol GDA 50 dries the skin, facilitating physical removal of the wart.
Preventol GDA 50 is also used in the treatment of hyperhidrosis under the control of dermatologists.
Preventol GDA 50 solution is an effective agent to treat palmar and plantar hyperhidrosis as an alternative to tannic acid and formaldehyde.
As broad-spectrum antimicrobial cold sterilant/disinfectant for hospital equipment; as tanning agent for leather; as tissue fixative; as cross-linking agent for proteins; as preservative in cosmetics; as therapeutic agent for warts, hyperhidrosis, and dermal mycotic infections; in X ray processing solutions and film emulsion; as a disinfectant in the beauty industry
Preventol GDA 50 is commonly used in the medical industry in cold sterilization and in the X-ray development process.
Preventol GDA 50 can also be encountered in the leather industry as a tanning ingredient and in mortuary workers.
There are no reports which indicate that Preventol GDA 50 is a naturally occurring compound.
Cidex and Acusol, 2% buffered solutions, use Preventol GDA 50 as an active ingredient.
Sodium bicarbonate is required to activate the solution, which then has a shelf life of 1–2 weeks.
Despite health hazards involved with Preventol GDA 50's use, glutaraldehyde is one of the most effective biocides used.
Preventol GDA 50 is particularly effective against bacteria and viruses, including the human immunodeficiency virus.
Preventol GDA 50 is used to disinfect medical and dental equipment.
Preventol GDA 50 is also used for industrial water treatment and as a preservative.
Preventol GDA 50 is used as a cold sterilizingdisinfectant, as fixatives for tissues, in tanning,and in cross-linking proteins.
Preventol GDA 50 is used as a cross linking agent for gelatin, poly(vinyl alcohol) and polyheptapeptides.
Preventol GDA 50 is also used as a fixative for electron microscopy and as disinfectants.
Preventol GDA 50 provides water resistance to protein and polyhydroxy compounds by reacting through cross linking.
Preventol GDA 50 acts as an intermediate for the production of resins, dyestuffs, pharmaceuticals, photographic films and for stabilization of proteins on agarose beads, activation of polystyrene and glass for immobilization of antibodies and antigens and coupling peptides onto carrier proteins.
Synonyms
glutaraldehyde
Pentanedial
Glutaral
111-30-8
Glutaric dialdehyde
Cidex
1,5-Pentanedial
Sonacide
Glutardialdehyde
Glutaric acid dialdehyde
Glutaric aldehyde
Pentane-1,5-dial
Glutaraldehyd
Glutaralum
Glutarol
Ucarcide
Aldesan
Alhydex
Hospex
1,3-Diformylpropane
Gluteraldehyde
1,5-Pentanedione
Aldesen
Novaruca
Sporicidin
Sterihyde L
Aldehyd glutarowy
NCI-C55425
Glutaclean
Sterihyde
Aqucar
Veruca-sep
Relugan GT
Relugan GTW
component of Cidex
Glutarex 28
NSC 13392
Sonacide (TN)
Cidex 7
Ucarcide 250
Relugan GT 50
Sterihyde L (TN)
Coldcide-25 microbiocide
NSC-13392
Glutaral (JAN/USP/INN)
Potentiated acid glutaraldehyde
CHEBI:64276
T3C89M417N
1, 5-Pentanedial
MFCD00007025
NCGC00091110-01
DSSTox_CID_5355
DSSTox_RID_77761
DSSTox_GSID_25355
Glutaraldehyde Solution, 25%
Caswell No. 468
Glutaraldehyd [Czech]
Glutaraldehyde solution
1,3-Diformyl propane
Diswart
Gludesin
Glutaralum [INN-Latin]
Glutarol-1,5-pentanedial
Polyglutaraldehyde
Aldehyd glutarowy [Polish]
Glutaral [USAN:INN:JAN]
CAS-111-30-8
Poly(glutaraldehyde)
CCRIS 3800
HSDB 949
EINECS 203-856-5
EPA Pesticide Chemical Code 043901
BRN 0605390
pentandial
Dioxopentane
Glutural
Ucarset
Verucasep
Glutaraldehyde solution, for electron microscopy, ~25% in H2O
Virsal
UNII-T3C89M41N
Glutaral(usan)
glutaric dihydride
Glutaral [USAN:USP:INN:JAN]
GLUTARALDEHYDE, 25% SOLN
Glutaral concentrate
Bactron K31
Ucarcide 225
Glutaraldehyde solution (50% or less)
Glutaraldehyde solution, 25% in water
Pentanedial, homopolymer
GLUTARAL [HSDB]
GLUTARAL [INCI]
GLUTARAL [USAN]
pentane-1,5-dialdehyde
GLUTARAL [INN]
GLUTARAL [JAN]
Glutaral, INN, USAN
GLUTARAL [MART.]
Protectol GDA, GT 50
SCHEMBL836
WLN: VH3VH
GLUTARAL [WHO-DD]
EC 203-856-5
GLUTARALDEHYDE [MI]
GLUTARALDEHYDE [FCC]
4-01-00-03659 (Beilstein Handbook Reference)
BIDD:ER0299
GLUTARALDEHYDE [VANDF]
Glutaraldehyde Solution, 50%
GLUTARAL [USP IMPURITY]
CHEMBL1235482
DTXSID6025355
AMY3308
Bio1_000462
Bio1_000951
Bio1_001440
NSC13392
STR01121
ZINC1729593
Tox21_111083
Tox21_201742
Tox21_303295
STL281872
AKOS008967285
Glutaraldehyde (50per cent in water)
DB03266
Glutaric dialdehyde, 25%sol. In water
Glutaric dialdehyde, 25% sol. in water
NCGC00091110-02
NCGC00091110-03
NCGC00257231-01
NCGC00259291-01
GLUTARAL CONCENTRATE [USP MONOGRAPH]
Glutaraldehyde solution, 25 wt. % in H2O
Glutaraldehyde solution, 50 wt. % in H2O
FT-0626730
G0067
G0068
EN300-18037
D01120
Glutaraldehyde solution, for synthesis, 25.0%
Glutaraldehyde solution, Grade II, 25% in H2O
A802339
Q416475
Glutaraldehyde solution, for in vitro diagnostic use
Q-201162
Glutaric dialdehyde solution, 50 wt. % in H2O, FCC
F2191-0161
Glutaraldehyde solution, SAJ first grade, 20.0-26.0%
Glutaraldehyde solution, technical, ~25% in H2O (2.6 M)
Glutaraldehyde solution, technical, ~50% in H2O (5.6 M)
Glutaraldehyde solution, 1.2 % (w/v) glutaraldehyde in H2O
Glutaraldehyde solution, for electron microscopy, ~50% in H2O
Glutaraldehyde solution, for electron microscopy, ~8% in H2O
Glutaraldehyde solution, 50% in H2O, suitable for photographic applications
Glutaraldehyde solution, Grade I, 25% in H2O, specially purified for use as an electron microscopy fixative
Glutaraldehyde solution, Grade I, 50% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
Glutaraldehyde solution, Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
Glutaraldehyde solution, Grade I, 8% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
