PREVENTOL MPT 11-40

Preventol MPT 11-40 is a broad-spectrum antimicrobial preservative, commonly used as a biocide and fungicide in industrial and material protection applications.
Preventol MPT 11-40 is a commercial formulation rather than a single pure compound.
Preventol MPT 11-40 belongs to the class of isothiazolinone-based preservatives.

CAS Number: 148-79-8
Molecular Formula: C10H7N3S
Molecular Weight: 201.25
EINECS Number: 205-725-8

Synonyms:Thiabendazole, 148-79-8, Tiabendazole, Mintezol, 2-(4-Thiazolyl)benzimidazole, Omnizole, Equizole, Minzolum, Lombristop, Thiabenzole, Thibenzole, Tiabendazol, Bovizole, Mintesol, Nemapan, Thiabendazol, Eprofil, Mertect, Thiaben, Thibenzol, Triasox, Bioguard, Pitrizet, Tebuzate, Tiabenda, Mertec, Mycozol, Polival, Storite, Testo, Tobaz, Tbdz, Thibenzole att, Top Form Wormer, 2-(4-Thiazolyl)-1H-benzimidazole, APL-luster, Thibendole, Cropasal, Ormogal, Sistesan, Thibenzole 200, Tecto rph, Hokustar HP, Mertect 160, Tecto, Tecto 10P, Tecto 40F, Tecto 60, 1H-Benzimidazole 2-(4-thiazolyl), Sanaizol 100, Thiabendazolum, Tiabendazolum, Chemviron TK 100, Drawipas, Mintezole, Thiabendole, Biogard, 2-(1,3-Thiazol-4-yl)-1H-benzimidazole, 4-(2-Benzimidazolyl)thiazole, Mertect lsp, Equizole A, E-Z-Ex, Captan T, TBZ 60W, Metasol TK 100, Helmindrax octelmin, Thiabendazole, Thiprazole, Arbotect, 2-(Thiazol-4-yl)benzimidazole, 2-(1,3-thiazol-4-yl)-1H-1,3-benzodiazole, Mertect 340f, 2-Thiazole-4-ylbenzimidazole, Syntol M100, Metasol TK-100, Tecto B, MK 360, Tibimix 20, Rival, MK-360, RTU Flowable Fungicide, TBZ 6, Benzimidazole 2-(4-thiazolyl), 2-(4'-Thiazolyl)benzimidazole, 5-(4-Thiazolyl)benzimidazole, G 491, DTXSID0021337, NSC-90507, NSC-525040, N1Q45E87DT, DTXCID401337, CHEBI:45979, RefChem:6300, E233, D01AC06, P02CA02, 205-725-8, CCRIS 4510, HSDB 2027, EINECS 205-725-8, BRN 0611403, UNII-N1Q45E87DT, CHEMBL625, MFCD00005587, CAS-148-79-8, STORITE;TBZ(R);TECTO;TECTO(R);THIBENZOLE(R);THIABENDAZOLE (TM);THIABENDAZOL;THIABENDAZOLE

Preventol MPT 11-40 typically contains isothiazolinone derivatives (such as methylisothiazolinone-type compounds) dissolved in a carrier system.
Preventol MPT 11-40s are highly active against microorganisms.
The exact composition is proprietary.

Physically, it is usually supplied as a clear to slightly yellow liquid solution.
Preventol MPT 11-40 is miscible with water and compatible with many formulations.
It has a mild characteristic odor.

Preventol MPT 11-40 exhibits strong antimicrobial activity against bacteria, fungi, and algae.
Preventol MPT 11-40 disrupts cellular metabolism and enzyme systems.
This prevents microbial growth and contamination.

Preventol MPT 11-40 functions as a preservative in aqueous systems, protecting products from spoilage.
Preventol MPT 11-40 is effective at low concentrations.
This improves efficiency.

Preventol MPT 11-40 shows good stability under typical storage and formulation conditions, though it may be sensitive to extreme pH or temperature.
Proper handling ensures performance.
Preventol MPT 11-40 should be stored according to guidelines.

Preventol MPT 11-40 is widely used in industrial formulations such as coatings, adhesives, and construction materials.
It helps extend product shelf life.
Preventol MPT 11-40 is best described as a highly effective antimicrobial preservative used to protect materials and formulations from microbial degradation, especially in industrial systems.

Preventol MPT 11-40 is a benzimidazole derivative introduced as a veterinary drug during the 1960s and later as a human anthelminthic drug. 
Preventol MPT 11-40 has a broad spectrum anthelminthic activity being effective against various types of nematode infections. 
Preventol MPT 11-40 is both ovicidal and larvicidal. 

Preventol MPT 11-40 is also highly effective against many saprophytic and pathogenic fungi in vitro and has also shown anti-inflammatory, antipyretic and analgesic properties in laboratory animals. 
Clinically, it is primarily used against Strongyloides stercoralis and cutaneous larva migrans.
Preventol MPT 11-40 is a broad-spectrum anthelmintic that is active against a variety of helminths. 

Preventol MPT 11-40 also inhibits production of eggs and disrupts larval development. 
Preventol MPT 11-40 inhibits fumarate reductase in helminths, which inhibits succinate formation, and therefore energy production through the citric acid cycle. 
Preventol MPT 11-40 also inhibits methionine aminopeptidase in E. coli (Ki = 40 nM; IC50 = 47.2 nM). 

Melting point: 298–301°C
Boiling point: 446.0±37.0 °C (Predicted)
Density: 1.2271 (rough estimate)
vapor pressure: Negligible at room temperature
refractive index: 1.5500 (estimate)
storage temp.: Sealed in dry, Room Temperature
solubility: Soluble in methanol and dimethyl sulfoxide
form: powder
pKa: pKa 4.7 (Uncertain)
color: light yellow
Water Solubility: 0.005 g/100 mL
Merck: 14,9289
BRN: 611403
Cosmetics Ingredients Functions: ANTIMICROBIAL
InChI: 1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
InChIKey: WJCNZQLZVWNLKY-UHFFFAOYSA-N
SMILES: c1ccc2[nH]c(nc2c1)-c3cscn3
LogP: 2.470

Preventol MPT 11-40 is primarily indicated in infections with Strongyloides stercoralis and cutaneous larva migrans. 
Preventol MPT 11-40 may also prove useful against Capillaria philippinensis, Trichostrongylus species and alleviate symptoms during the invasion stage of trichinosis.
Preventol MPT 11-40 exhibits broad-spectrum antimicrobial efficacy, meaning it is effective against bacteria, fungi (molds and yeasts), and algae.

Preventol MPT 11-40 targets multiple types of microorganisms.
This makes it highly versatile.
The active components (isothiazolinones) act by disrupting microbial enzyme systems and cellular metabolism.

They interfere with essential biochemical pathways.
This leads to rapid microbial inactivation.
Preventol MPT 11-40 shows high activity at very low concentrations, often in the ppm range.

Small amounts provide effective preservation.
This improves cost efficiency.
Preventol MPT 11-40 is particularly suited for aqueous systems, where microbial growth risk is high.

Preventol MPT 11-40 protects water-based formulations.
This is important in many industrial products.
The formulation provides long-lasting preservation, maintaining effectiveness over time.

Preventol MPT 11-40 helps prevent contamination during storage and use.
This enhances product stability.
It demonstrates good compatibility with many formulation components, including polymers, pigments, and fillers.

Preventol MPT 11-40 can be incorporated into complex systems.
This increases formulation flexibility.
Preventol MPT 11-40 can influence shelf life and product durability, by preventing microbial degradation.

It helps maintain performance properties.
This improves reliability.
Preventol MPT 11-40 may be sensitive to extreme pH, high temperatures, or strong reducing agents, which can reduce its effectiveness.

Proper formulation conditions are required.
This ensures optimal performance.
Preventol MPT 11-40 is a highly efficient, low-dose antimicrobial system that provides long-lasting protection in water-based formulations, making it essential in industrial preservation.

Preventol MPT 11-40 is a kind of fungicide and parasiticide. 
As a fungicide, it can be used for the treatment of mold, blight and many other fungal diseases occurring in fruits and vegetable. 
As an antiparasitic, it is capable of treating roundworms, hookworms, and other kinds of helminth species that can attack wild animals, livestock and humans. 

Preventol MPT 11-40 also has effects of inhibiting the angiogenesis of cells. 
Preventol MPT 11-40 has found that Thiabendazole is capable of suppressing the helminth-specific mitochondrial enzyme fumarate reductase, further inhibiting the citric acid cycle, mitochondrial respiration and ATP production, leading to helminth’s death. 
Preventol MPT 11-40 may also inhibit the microtubule polymerization processes.

Uses Of Preventol MPT 11-40:
Preventol MPT 11-40 is widely used as a post-harvest systemic fungicide on citrus and bananas. 
Preventol MPT 11-40 is active against fruit rots in bananas, citrus, apples and pears; bulb and corm rots in ornamentals; storage rots in sweet potato and potato and is also used to control Dutch elm disease. 
Preventol MPT 11-40 is the original benzimidazole anthelmintic for both human and animal health usages.

Systemic fungicide used for diseases of fruits and vegetables and for control of Dutch elm disease.
Preventol MPT 11-40 occurs as a whitecrystalline substance that is only slightly soluble in waterbut is soluble in strong mineral acids. 
Preventol MPT 11-40 is abasic compound with a pKa of 4.7 that forms complexeswith metal ions.

Preventol MPT 11-40 inhibits the helminth-specific enzymefumarate reductase. 
Preventol MPT 11-40 is not known whether metal ionsare involved or if the inhibition of the enzyme is related tothiabendazole’s anthelmintic effect. 
Preventol MPT 11-40 anthelminticdrugs such as thiabendazole and mebendazolealso arrest nematode cell division in metaphase by interferingwith microtubule assembly. 

They exhibit a highaffinity for tubulin, the precursor protein for microtubulesynthesis.
Preventol MPT 11-40 has broad-spectrum anthelmintic activity.It is used to treat enterobiasis, strongyloidiasis (threadworminfection), ascariasis, uncinariasis (hookworm infection), andtrichuriasis (whipworm infection). 
Preventol MPT 11-40 has also been used torelieve symptoms associated with cutaneous larva migrans(creeping eruption) and the invasive phase of trichinosis. 

Inaddition to its use in human medicine, Preventol MPT 11-40 iswidely used in veterinary practice to control intestinalhelminths in livestock.
Preventol MPT 11-40 is widely used in water-based paints and coatings as a preservative.
It prevents microbial growth during storage and application.

In adhesives and sealants, it acts as a biocide to protect formulations from bacterial and fungal contamination.
Preventol MPT 11-40 ensures product stability over time.
This improves performance.

Preventol MPT 11-40 is applied in construction materials, such as plasters, mortars, and fillers.
It prevents mold and microbial degradation.
This enhances durability.

Preventol MPT 11-40 is used in polymer dispersions and latex systems.
It protects aqueous dispersions from spoilage.
This maintains formulation integrity.

In textile and leather processing, it helps control microbial growth during treatment and storage.
Preventol MPT 11-40 prevents degradation of materials.
This improves product quality.

Preventol MPT 11-40 is used in paper and pulp processing to prevent microbial contamination in water systems and coatings.
It supports process hygiene.
This enhances production efficiency.

In industrial cleaning and maintenance products, it acts as a preservative in liquid formulations.
Preventol MPT 11-40 prevents microbial growth in stored products.
This ensures stability.

Preventol MPT 11-40 is applied in cooling water systems and industrial fluids to control microbial contamination.
It reduces biofouling and slime formation.
Preventol MPT 11-40 is also used in household and institutional products, such as detergents and cleaning solutions.

It maintains product hygiene during storage.
This improves shelf life.
Preventol MPT 11-40 is used wherever broad-spectrum antimicrobial protection in water-based systems is required, especially in coatings, adhesives, construction materials, and industrial fluids.

Safety Profile Of Preventol MPT 11-40:
Moderately toxic by ingestion an experimental teratogen. 
A questionable carcinogen, experimental reproductive effects. 
Mutation data reported when heated to decomposition it emits toxic fumes of SOX and NOX.

Preventol MPT 11-40 presents moderate to high hazards, mainly due to its isothiazolinone-based active ingredients, which are known to be irritating and sensitizing.
It requires careful handling.
Appropriate safety measures are essential.

Skin contact may cause irritation and allergic sensitization.
Repeated exposure can lead to dermatitis.
Protective gloves and clothing are strongly recommended.

Eye contact can cause severe irritation or damage.
Symptoms include redness, pain, and possible injury.
Immediate and thorough rinsing with water is necessary.

Inhalation of vapors or aerosols may cause respiratory irritation.
Symptoms can include coughing, throat irritation, and discomfort.
Adequate ventilation and respiratory protection are recommended.