PRODUCTS

PREVENTOL P 100 B

Preventol P 100 B is a synthetic compound commonly used as a preservative in cosmetic and personal care products.
Preventol P 100 B is effective in preventing the growth of bacteria, fungi, and yeast, thereby extending the shelf life of formulations.
Preventol P 100 B functions by releasing small amounts of formaldehyde, which acts as an antimicrobial agent.

CAS Number: 52-51-7
EC Number: 200-143-0
Chemical Name: Bronopol
IUPAC Name: 2-Bromo-2-nitropropane-1,3-diol
Chemical Formula: C3H6BrNO4 / HOCH2CBr(NO2)CH2OH / C3H6O4BrN
Molecular Weight: 199.99 g/mol

SYNONYMS:
bronopol, 52-51-7, 2-Bromo-2-nitro-1,3-propanediol, 2-Bromo-2-nitropropane-1,3-diol, Bronosol, Bronocot, Bronotak, Bronidiol, Bronopolu, Lexgard bronopol, Onyxide 500, Bronopolum, 1,3-Propanediol, 2-bromo-2-nitro-, 2-Nitro-2-bromo-1,3-propanediol, beta-Bromo-beta-nitrotrimethyleneglycol, DTXSID8024652, 2-bromo-2-nitro-propane-1,3-diol, NSC-141021, 6PU1E16C9W, 2-Bromo-2-nitropropan-1,3-diol, DTXCID904652, Remain Silver, Remain Gold, Gold-Bloc, Soft Tuch, Gil Sani-Guard, Bronopol Teat Dip, QM Gold, Medic Booster Barrier, RefChem:5619, GlyTouCan:G47426ZE, ULTRA-SOFT BARRIER DIP, TDX-84, G47426ZE, AST Inc. PRO-4 BARRIER TEAT DIP, AST Inc. PRO-4 SANITIZING TEAT DIP, SFP INC. TD-44 SANITIZING TEAT DIP, SFP INC. TD-44 BARRIER SANITIZING POST TEAT DIP, 200-143-0, C3H6BrNO4, MFCD00007390, BNPD, NSC 141021, CHEBI:31306, NCGC00164057-01, Bronopolu [Polish], Caswell No. 116A, Bioban, Bronopolum [INN-Latin], Myacide AS plus, Myacide BT, CAS-52-51-7, Bronopol [INN:BAN:JAN], Myacide Pharma BP, Canguard 409, HSDB 7195, EINECS 200-143-0, UN3241, EPA Pesticide Chemical Code 216400, BRN 1705868, UNII-6PU1E16C9W, AI3-61639, Bronopol (Standard), BNPD,BNPK, Bronopol (JAN/INN), BRONOPOL [HSDB], BRONOPOL [INN], BRONOPOL [JAN], BRONOPOL [MI], BRONOPOL [VANDF], BRONOPOL [MART.], WLN: WNXE1Q1Q, 1, 2-bromo-2-nitro-, 2-Bromo-2-nitropropane-1,3-diol (Bronopol), BRONOPOL [WHO-DD], EC 200-143-0, SCHEMBL23260, orb1310205, orb3025832, SCHEMBL5984823, Bioban BNPD-40 (Salt/Mix), CHEMBL1408862, SCHEMBL15295432, SCHEMBL16556987, HY-B1217R, LVDKZNITIUWNER-UHFFFAOYSA-, HMS5083H11, 2-Bromo-2-nitropropane-1,3-diol [UN3241] [Flammable Solid], ALBB-031641, HY-B1217, MSK21088, Tox21_112079, Tox21_300126, BDBM50248122, BR1092, EBC-26186, NSC141021, s4553, SBB000393, 2-bromanyl-2-nitro-propane-1,3-diol, AKOS003606838, CCG-213823, CS-4699, DB13960, FB01194, NCGC00164057-02, NCGC00164057-03, NCGC00253984-01, AS-11889, ST041068, 2-Bromo-2-nitro-1,3-propanediol, 98%, .beta.-Bromo-.beta.-nitrotrimethyleneglycol, DB-027831, Bronopol, PESTANAL(R), analytical standard, NS00003792, 52B517, D01577, E85247, EN300-141420, SBI-0653499.0001, AB01563195_01, A829125, SR-01000944249, Q2462902, SR-01000944249-1, BRD-K33457401-001-01-1, InChI=1/C3H6BrNO4/c4-3(1-6,2-7)5(8)9/h6-7H,1-2H2, 1,3-Propanediol, 2-bromo-2-nitro-, Bronocot, Onyxide 500, 2-Bromo-2-nitro-1,3-propanediol, 2-Bromo-2-nitropropane-1,3-diol, Bronosol, 2-Nitro-2-bromo-1,3-propanediol, 2-Bromo-2-nitropropan-1,3-diol, β-Bromo-β-nitrotrimethyleneglycol, Bronopolu, Bronotak, Bioban, Bronidiol, Canguard 409, Lexgard bronopol, Myacide AS plus, Myacide BT, NSC 141021, Myacide Pharma BP, 2-Bromo-2-nitro-1,3-propanediol, 2-Bromo-2-nitropropan-1,3-diol, 2-Bromo-2-nitropropane-1,3-diol, 2-Nitro-2-bromo-1,3-propanediol, Acticide L 30, BE 6, BE 6 (bactericide), BNPD, BNPK, Bactrinashak, Bactrinol 100, Bactronol, Bioban, Bioban BP Plus, Bronidiol, Bronocot, Bronopol, Bronotak, Busan 1144, Canguard 409, Myacide AS, Myacide AS Plus, Myacide BT, Myacide Pharma BP, N 25, N 25 (antimicrobial), NSC 141021, Nalco 92RU093, Onyxide 500, Preventol P 100, Protectol BN 98, Protectol BN 99, Pyceze, Topcide 2520, Ultra-Fresh SAB, 2-Bromo-2-Nitropropane-1,3-diol, Bronopol, b-Bromo-b-nitrotrimethyleneglycol, 2-nitro-2-bromo-1,3-propanediol, 2-Bromo-2-nitro-1,3-propanediol, 2-Bronopol, -Bromo-nitrotrimethyleneglycol, Bronopol, 2-Bromo-2-nitropropane-1,3-diol, 2-Bromo-2-nitro-1,3-propanediol, 2-Nitro-2-bromo-1,3-propanediol, BNPD, Bronocot, Myacide BT, Pyceze, Onyxide 500, Bropol, 2-Bromo-2-nitropropane-1,3-diol preservative, Nitro-bromopropanediol, Preventol P 100, Preventol P 100 B antimicrobial, Preventol P-100 preservative

Preventol P 100 B is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria).
Preventol P 100 B oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity.
Preventol P 100 B is also a formaldehyde releaser.

Preventol P 100 B is an industrial antimicrobial preservative based on bronopol, a nitro-alcohol compound widely used as a bactericide and microbicide.
Preventol P 100 B has a broad antimicrobial spectrum, including activity against Gram-positive and Gram-negative bacteria, as well as sulfate-reducing and anaerobic bacteria.

Due to its broad-spectrum efficacy, Preventol P 100 B is often found in products such as lotions, creams, and shampoos.
Understanding Preventol P 100 B's properties and regulatory status is essential for both formulators and consumers concerned about the safety and effectiveness of cosmetic ingredients.

Preventol P 100 B (full name 2-Bromo-2-nitro-1,3-propanediol) is a broad-spectrum antimicrobial preservative.
First developed in the 1960s, Preventol P 100 B is highly effective against bacteria and fungi even at low concentrations.
Because of this property, Preventol P 100 B is used as a preservative in cosmetics, pharmaceuticals, detergents, and industrial products.

Preventol P 100 B, also known as 2-bromo-2-nitro-1,3-propanediol, is an organic compound with the chemical formula C3H6BrNO4.
Preventol P 100 B is a white crystalline solid with a slightly bitter taste and is commonly used as a preservative and antimicrobial agent.
Preventol P 100 B appears as white crystals.

Preventol P 100 B is a nitro compound.
The evidence at hand indicates Preventol P 100 B to be safe as a cosmetic ingredient at concentrations up to and including 0.1 percent except under circumstances where its action with amines or amides can result in the formation of nitrosamines or nitrosamides.

Preventol P 100 B, or 2-Bromo-2-nitro-1,3-propanediol, is an organic compound with wide-spectrum antimicrobial properties.
First synthesized in 1897, Preventol P 100 B was primarily used as a preservative for pharmaceuticals and was registered in the United States in 1984 for use in industrial bactericides, slimicides and preservatives.

Compared to other aliphatic halogen-nitro compounds, Preventol P 100 B is more stable to hydrolysis in aqueous media under normal conditions.
Preventol P 100 B is a chemical compound of bromine and an antimicrobial substance.
Preventol P 100 B (INN; chemical name Preventol P 100 B) is an organic compound that is used as an antimicrobial.

Preventol P 100 B is a white solid although commercial samples appear yellow.
The first reported synthesis of Preventol P 100 B was in 1897.
Preventol P 100 B was invented by The Boots Company PLC in the early 1960s and first applications were as a preservative for pharmaceuticals.

Due to its low mammalian toxicity at in-use levels and high activity against bacteria, especially Gram-negative species, Preventol P 100 B became popular as a preservative in many consumer products such as shampoos and cosmetics.
Preventol P 100 B was subsequently adopted as an antimicrobial in other industrial environments such as paper mills, oil exploration, and production facilities, as well as cooling water disinfection plants.

USES and APPLICATIONS of PREVENTOL P 100 B:
Preventol P 100 B is primarily used to protect aqueous industrial formulations from microbial contamination such as slime-forming bacteria, spoilage organisms, and odor-causing microorganisms.
Because microbial growth in industrial water systems can cause corrosion, odor formation, and product degradation, Preventol P 100 B is widely applied as a preservative in industrial and commercial formulations.

Preventol P 100 B is widely used in industrial and commercial applications.
Industrial Preservation uses of Preventol P 100 B: Water-based paints and coatings, Polymer emulsions and latex dispersions, Adhesives and sealants, Printing inks, Pigment and mineral slurries, Surfactant solutions.

Industrial Water Systems uses Preventol P 100 B: Cooling water systems, Air conditioning and humidifying systems, Oil-field water systems, Paper mill water treatment.
Consumer and Commercial Products use of Preventol P 100 B: Household cleaners and detergents, Disinfectants, Chemical toilet deodorants,Cat litter deodorants.

Other Applications of Preventol P 100 B: Metalworking fluids, Agricultural pesticide formulations, Industrial lubricants, Textile and leather processing chemicals.
These applications rely on Preventol P 100 B's ability to prevent microbial growth in aqueous systems.

Preservative: Preventol P 100 B is widely used as a preservative in various personal care products, such as shampoos, lotions, and cosmetics, to prevent the growth of bacteria and fungi.
Industrial Use: Preventol P 100 B is employed in industrial settings as a preservative in water-based products, such as paints, adhesives, and metalworking fluids.

Medical Applications: Preventol P 100 B is utilized as a disinfectant in medical and healthcare facilities for sterilizing medical equipment and surfaces to prevent the spread of infections.
Water Treatment: Preventol P 100 B is used in water treatment applications to control microbial growth in cooling water systems, swimming pools, and industrial water systems.

Preventol P 100 B is a preservative that can also be found in shampoos, skin care products and makeup.
Preventol P 100 B helps maintain product quality and performance over time.
Some people raise concerns about preservatives, because a small number of individuals have allergies to them, just as some people have allergies to nuts or bees.

But preservatives play a very important role in food, cosmetics and household products.
Without preservatives, many products would not last more than a week or two before being contaminated by bacteria, mold or yeast.
Cosmetics and Personal Care uses of Preventol P 100 B: Preservatives in shampoos, lotions, creams, and liquid soaps.

Detergents and Cleaning Products use of Preventol P 100 B: Additives that prevent the formation of bacteria and mold.
Industrial Applications of Preventol P 100 B: Microbial control in cooling water systems, pulp, oil, and gas production facilities.
Pharmaceutical Industry uses of Preventol P 100 B: Preservative additives in topical formulations.

Preventol P 100 B is used as a microbicide or microbiostat in various commercial and industrial applications, including oil field systems, air washer systems, air conditioning or humidifying systems, cooling water systems, papermills, absorbent clays, metal working fluids, printing inks, paints, adhesives and consumer products.

Preventol P 100 B is used as a preservative in pharmaceuticals, as well as numerous consumer products such as shampoos and cosmetics.
Preventol P 100 B is also used as an antimicrobial in many industrial environments such as paper mills, oil exploration and production facilities, as well as cooling water disinfection plants.

Preventol P 100 B's use is declining due to its recognized potential to decompose into carcinogenic nitrosamines.
Preventol P 100 B is also a formaldehyde releaser.

Preventol P 100 B is used in consumer products as an effective preservative agent, as well as a wide variety of industrial applications (almost any industrial water system is a potential environment for bacterial growth, leading to slime and corrosion problems - in many of these systems Preventol P 100 B can be a highly effective treatment).

While Preventol P 100 B is not in itself a nitrosating agent, under conditions where it decomposes (alkaline solution and/or elevated temperatures) it can liberate nitrite and low levels of formaldehyde and these decomposition products can react with any contaminant secondary amines or amides in a personal care formulation to produce significant levels of nitrosamines (due to the toxicity of these substances, the term 'significant' means levels as low as tens of parts per billion).

Manufacturers of personal care products are therefore instructed by regulatory authorities to avoid the formation of nitrosamines which might mean removing amines or amides from the formulation, removing Preventol P 100 B from a formulation, or using nitrosamine inhibitors.
The use of Preventol P 100 B in personal care products (cosmetics, toiletries) has declined since the late 1980s due to the potential formation of nitrosamines.

-Uses of Preventol P 100 B in Cosmetics:
Functional role in cosmetics: Preventol P 100 B is used as a preservative agent in cosmetics.
Other uses: Preventol P 100 B is also used as a surfactant.
Cosmetic Products Containing Preventol P 100 B: Recent products using Preventol P 100 B in their cosmetic formulations and Shampoo and Conditioner.

MECHANISM OF ACTION of PREVENTOL P 100 B:
Preventol P 100 B prevents the multiplication of microorganisms by disrupting cell metabolism.

CHEMICAL CHARACTERISTICS of PREVENTOL P 100 B:
Preventol P 100 B belongs to the nitro-alcohol antimicrobial compounds.
Preventol P 100 B functions primarily as a microbicide and microbiostat, meaning it can either kill microorganisms or inhibit their growth.

Important chemical characteristics include:
*Broad-spectrum antimicrobial activity
*Stable under normal storage conditions in aqueous systems
*Effective against slime-forming bacteria
*Active against sulfate-reducing bacteria responsible for corrosion
*Preventol P 100 B functions as a formaldehyde-releasing preservative in some applications
*Compatible with many water-based industrial formulations
*Preventol P 100 B acts by disrupting microbial metabolism and enzyme systems, leading to inhibition of bacterial growth and microbial spoilage.

BENEFITS of PREVENTOL P 100 B:
*Preventol P 100 B offers several advantages in industrial preservation:
*Broad-spectrum antimicrobial protection
*Effective against bacteria responsible for slime and corrosion
*Preventol P 100 B helps maintain product stability and shelf life
*Prevents odor formation caused by microbial contamination
*Effective in low concentrations
*Compatible with many aqueous formulations and industrial systems
These benefits make Preventol P 100 B a commonly used preservative in industrial water systems and water-based products.

PROPERTIES of PREVENTOL P 100 B:
Important functional properties include:
*Strong bactericidal and microbiostatic activity
*Effective in aqueous and water-rich environments
*High water solubility allowing easy formulation
*Stability in industrial processing conditions
*Synergistic antimicrobial effects when combined with other preservatives
*Ability to inhibit slime formation in industrial water systems
Because microbial contamination can reduce product performance and stability, Preventol P 100 B plays a significant role in industrial preservation systems.

PHYSICAL AND CHEMICAL PROPERTIES of PREVENTOL P 100 B:
*Appearance
Preventol P 100 B is supplied as crystals or crystalline powder, which may vary from white to pale yellow in colour depending on the grade.
The yellow coloration is due to chelation of iron during the manufacturing process.

*Melting point
As a pure material, Preventol P 100 B has a melting point of about 130 °C.
However, due to its polymorphic characteristics, Preventol P 100 B undergoes a lattice rearrangement at 100 to 105 °C and this can often be wrongly interpreted as the melting point.
At temperatures above 140 °C, Preventol P 100 B decomposes exothermically releasing hydrogen bromide and oxides of nitrogen.

*Solubility
Preventol P 100 B is readily soluble in water; the dissolution process is endothermic.
Solutions containing up to 28% w/v are possible at ambient temperature.
Preventol P 100 B is poorly soluble in non-polar solvents but shows a high affinity for polar organic solvents.

*Partition coefficient
Study of the solubility data shows that Preventol P 100 B has a high affinity for polar rather than non-polar environments.
In two-phase systems, Preventol P 100 B partitions preferentially into the polar (usually aqueous) phase.

*Stability in aqueous solution
In aqueous solutions, Preventol P 100 B is most stable when the pH of the system is on the acid side of neutral.
Temperature also has a significant effect on stability in alkaline systems.

*Degradation
Under extreme alkaline conditions, Preventol P 100 B decomposes in aqueous solution and very low levels of formaldehyde are produced.
Liberated formaldehyde is not responsible for the biological activity associated with Preventol P 100 B.
Other decomposition products detected after Preventol P 100 B breakdown are bromide ion, nitrite ion, bromonitroethanol and 2-hydroxymethyl-2-nitropropane-1,3-diol.

PRODUCTION of PREVENTOL P 100 B:
Preventol P 100 B is produced by the bromination of di(hydroxymethyl)nitromethane, which is derived from nitromethane by a nitroaldol reaction.
World production increased from the tens of tonnes in the late 1970s to current estimates in excess of 5,000 tonnes.
Production of Preventol P 100 B today is the business of low cost producers, mainly in China.

PHYSICAL and CHEMICAL PROPERTIES of PREVENTOL P 100 B:
Product Name: Preventol P 100 B
Chemical Name: Bronopol
IUPAC Name: 2-Bromo-2-nitropropane-1,3-diol
Chemical Formula: C₃H₆BrNO₄
Molecular Weight: 199.99 g/mol
Chemical Class: Halogenated nitro compound / antimicrobial preservative
CAS and EC Numbers
CAS Number: 52-51-7
EC Number: 200-143-0
Molecular Weight: 199.99 g/mol

XLogP3-AA: -0.6
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 2
Exact Mass: 198.94802 Da
Monoisotopic Mass: 198.94802 Da
Topological Polar Surface Area: 86.3 Å²
Heavy Atom Count: 9
Formal Charge: 0
Complexity: 107

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Chemical formula: C3H6BrNO4
Molar mass: 199.988 g·mol−1

Appearance: White solid
Density: 1.1 g/cm3
Melting point: 130 °C (266 °F; 403 K)
Boiling point: 140 °C (284 °F; 413 K) (decomposes)
Appearance: White to light yellow crystalline powder
Scent: Slightly sharp/characteristic
Density: ~1.89 g/cm³
Melting Point: ~130 °C
Solubility: Well soluble in water and polar organic solvents.

Stability: It degrades at high temperatures and in alkaline environments.
Chemical Name: 2-Bromo-2-nitro-1,3-propanediol
Trade Name: Bronopol
Molecular Formula: C₃H₆BrNO₄
Molecular Weight: 199.99 g/mol
CAS Number: 52-51-7
Chemical Formula: C3H6BrNO4
CAS Number: 52-51-7
Molecular Weight: 199.99 g/mol

Appearance: White crystalline solid
Melting Point: 130-134°C
Boiling Point: Decomposes at elevated temps.
Solubility: Soluble in water, ethanol
Density: 1.91 g/cm³
Appearance: White to pale yellow crystalline powder or crystals
Odor: Odorless or slight characteristic odor
Physical State: Solid
Color: White or slightly yellow

Molecular Weight: 199.99 g/mol
Density: about 1.9 g/cm³
Melting Point: approximately 125–131 °C
Boiling Point: about 152 °C (decomposes)
Flash Point: ~167 °C
Water Solubility: up to about 280 g/L; readily soluble in water
Solubility in Organic Solvents: soluble in polar organic solvents, poorly soluble in non-polar solvents
Vapor Pressure: ~1.26 × 10⁻⁵ mmHg

pH (1 % solution): approximately 4.7–8.5
Decomposition Temperature: about 140 °C
Self-Accelerating Decomposition Temperature: around 100–110 °C
Structural Chemical Properties
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 2
Topological Polar Surface Area: 86.3 Å²
LogP: −0.6

FIRST AID MEASURES of PREVENTOL P 100 B:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of PREVENTOL P 100 B:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of PREVENTOL P 100 B:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of PREVENTOL P 100 B:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of PREVENTOL P 100 B:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of PREVENTOL P 100 B:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available