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CAS NUMBER: 63449-41-2
MOLECULAR FORMULA: C21H38NCl
MOLECULAR WEIGHT: 340.0
DESCRIPTION:
Preventol RI 50 is a type of cationic surfactant.
Preventol RI 50 is an organic salt classified as a quaternary ammonium compound.
Preventol RI 50 has three main categories of use: as a biocide, a cationic surfactant, and a phase transfer agent.
Preventol RI 50 is a mixture of alkylbenzyldimethylammonium chlorides, in which the alkyl group has various even-numbered alkyl chain lengths.
Preventol RI 50 is widely used as a preservative in eye-drops, in higher concentrations it is used as an antiseptic and disinfectant.
In a randomized crossover study two concentrations of Preventol RI 50, 0.1% and 0.4%, used as a sanitary wipe were compared with a 62% ethyl alcohol emollient gel for safety and acceptability in male genital antisepsis.
Preventol RI 50 is an antiseptic.
Preventol RI 50 is used prior to surgical procedures or for minor wound care to reduce risks of infection.
Preventol RI 50 may be used for cold sore care.
Preventol RI 50 is a chemical compound belonging to the quaternary ammonium group that is used as a skin antiseptic or spray disinfectant for surface sanitisation.
Preventol RI 50 has bactericidal action against Gram-positive and Gram-negative bacteria.
Preventol RI 50 is an aqueous solution of Preventol RI 50 (ca. 50%).
Applications are the formulation of disinfectants or disinfecting cleaning agents of the medical, veterinary and cosmetic sectors, the food processing industry, agriculture and households, water treatment (algae prevention in cooling water and swimming pools) an for the elimination of fungi, algae and lichens (substrate pre-treatment agent) and for the fungicidal treatment of insulating material based on recycled textiles.
Preventol RI 50 is a concentrated liquid preparation of quaternary ammonium salts with a broad spectrum of activity covering fungi, bacteria and algae.
Preventol RI 50 is used for the production of disinfectant solutions to be applied to stone materials, plasters, wood, ceramics in aqueous solutions with concentrations ranging from 2 to 10%.
Preventol RI50 is a restoration biocide for removing algae, fungi, lichen and moss on mineral building materials and water resistant surfaces.
Preventol RI 50 is also used for preventive treatment to create an “active ingredient depot”.
Preventol RI 50 is a liquid concentrated preparation of quaternary ammonium salts with a wide spectrum of action against fungi, bacteria and algae.
Preventol RI 50 is used for the production of disinfectant solutions for stone materials, plasters, wood, ceramics in aqueous solutions, in concentrations from 2 to 10%.
Preventol RI 50 is a liquid biocidal preparation composed of quaternary ammonium salts with a broad spectrum of activity against fungi, bacteria and algae.
Preventol RI 50 is primarily used as a preservative and antimicrobial agent, and secondarily used as a surfactant.
Preventol RI 50 works by killing microorganisms and inhibiting their future growth, and for this reason frequently appears as an ingredient in antibacterial hand wipes, antiseptic creams and anti-itch ointments.
In cosmetics, its antimicrobial properties are employed to protect products from spoiling.
Preventol RI 50’s mostly used in personal care products like rash creme, foot odor powder, facial lotion, cleanser, makeup and sunscreen.
Preventol RI 50 is an organic salt used in cleaning agents, classified as a quaternary ammonium cationic detergent.
Preventol RI 50 can be used as an antiseptic and preservative in personal care, healthcare, household, pharmaceutical, and industrial products.
Preventol RI 50 is a powerful antiseptic for pharmaceutical applications and a cationic surfactant.
Preventol RI 50 (BZK, BKC, BAK, BAC), also known as alkyldimethylbenzylammonium chloride, is an anti-bacterial/antimicrobial ingredient.
Preventol RI 50 is a type of cationic surfactant, and an organic salt.
Preventol RI 50 works well in hand sanitizer and hand wash formulations, and can even be used as a surfactant and preservative.
Preventol RI 50 is used in formulas for preservatives, surface cleaners and sterilizing agents.
The chemical properties of Preventol RI 50 make it a good candidate for persistent antimicrobial activity in mammalian tissue.
Preventol RI 50 is an antibacterial ingredient used in a wide range of products, including household cleaners, personal care products and soaps.
Preventol RI 50's a known skin irritant, and research is being undertaken to understand its potential for causing antibacterial resistance in harmful bacteria.
Preventol RI 50 is a synthetic chemical produced by reacting fatty acids with benzyl chloride.
Commercially this ingredient is typically comprised of several compounds with varying alkyl chain lengths, ranging from C8 to C18.
While effective against bacteria, fungi, and viruses, Preventol RI 50 is associated with severe skin, eye, and respiratory irritation and allergies particularly for people with conditions such as asthma and eczema.
PHYSICAL AND CHEMICAL PROPERTIES:
- Active principle: Alkyl Dimethylbenzylammonium Chloride (Preventol RI 50)
- Assay: 50%
- Appearance: colourless to straw-yellow liquid
- Density: 0.99 kg/l at 20°C
- pH: 7 - 7,5
SOLUBILITY AND PHYSICAL PROPERTIES:
Depending on purity, Preventol RI 50 ranges from colourless to a pale yellow (impure).
Preventol RI 50 is readily soluble in ethanol and acetone.
Dissolution in water is ready, upon agitation.
Aqueous solutions should be neutral to slightly alkaline. Solutions foam when shaken.
Concentrated solutions have a bitter taste and a faint almond-like odour.
Standard concentrates are manufactured as 50% and 80% w/w solutions, and sold under trade names such as BC50, BC80, BAC50, BAC80, etc.
The 50% solution is purely aqueous, while more concentrated solutions require incorporation of rheology modifiers (alcohols, polyethylene glycols, etc.) to prevent increases in viscosity or gel formation under low temperature conditions.
Preventol RI 50 also possesses surfactant properties, dissolving the lipid phase of the tear film and increasing drug penetration, making it a useful excipient, but at the risk of causing damage to the surface of the eye.
-Laundry detergents and treatments.
-Softeners for textiles.
BIOACTIVE AGENT:
Especially for its antimicrobial activity, Preventol RI 50 is an active ingredient in many consumer products:
-Pharmaceutical products such as eye, ear and nasal drops or sprays, as a preservative.
-Personal care products such as hand sanitizers, wet wipes, shampoos, soaps, deodorants and cosmetics.
-Skin antiseptics and wound wash sprays, such as Bactine.
-Throat lozenges and mouthwashes, as a biocide
-Spermicidal creams.
-Cleaners for floor and hard surfaces as a disinfectant, such as Lysol and Dettol antibacterial spray and wipes.
-Algaecides for clearing of algae, moss, lichens from paths, roof tiles, swimming pools, masonry, etc.
Preventol RI 50 is also used in many non-consumer processes and products, including as an active ingredient in surgical disinfection.
A comprehensive list of uses includes industrial applications.
An advantage of Preventol RI 50, not shared by ethanol-based antiseptics or hydrogen peroxide antiseptic, is that it does not cause a burning sensation when applied to broken skin.
USES:
-Medicine:
Preventol RI 50 is a frequently used preservative in eye drops; typical concentrations range from 0.004% to 0.01%.
Stronger concentrations can be caustic and cause irreversible damage to the corneal endothelium.
Avoiding the use of Preventol RI 50 solutions while contact lenses are in place is discussed in the literature.
Due to its antimicrobial activity when applied to skin, some topical medications for acne vulgaris have Preventol RI 50 added to increase the products’ efficiency or shelf-life.
Preventol RI 50 is scientifically proven to be a successful spermicide.
Tablets are inserted vaginally, or a gel is applied, resulting in local spermicidal contraception.
Preventol RI 50 is not a wholly reliable method, and can cause irritation.
-Beekeeping:
It is used in beekeeping for the treatment of rotten diseases of the brood.
DEGRADATION:
Preventol RI 50 degradation follows consecutive debenzylation, dealkylation, and demethylation steps producing benzyl chloride, an alkyl dimethyl amine, dimethylamine, a long chain alkane, and ammonia.
The intermediates, major, and minor products can then be broken down into CO2, H2O, NH3, and Cl–.
The first step to the biodegradation of BAC is the fission or splitting of the alkyl chain from the quaternary nitrogen as shown in the diagram.
This is done by abstracting the hydrogen from the alkyl chain by using a hydroxyl radical leading to a carbon centered radical.
This results in dimethylbenzylamine as the first intermediate and dodecanal as the major product.
From here, dimethylbenzylamine can be oxidized to benzoic acid using the Fenton process.
The trimethyl amine group in dimethylbenzylamine can be cleaved to form a benzyl that can be further oxidized to benzoic acid.
Preventol RI 50 uses hydroxylation (adding a hydroxyl group) to form p-hydroxybenzoic acid.
Preventol RI 50 can then be converted into ammonia by performing demethylation twice, which removes both methyl groups, followed by debenzylation, removing the benzyl group using hydrogenation.
The diagram represents suggested pathways of the biodegradation of Preventol RI 50 for both the hydrophobic and the hydrophilic regions of the surfactant.
Since stearalkonium chloride is a type of Preventol® RI 80, the biodegradation process should happen in the same manner.
APPLICATION:
Preventol RI 50 is used in pharmaceuticals such as leave-on skin antiseptics.
Preventol RI 50 is used as antiseptic in Bactine to safely treat childhood scrapes and cuts.
Preventol RI 50 is used in advanced, next generation hand sanitizers.
Preventol RI 50 is used in hygienic towelettes and wet wipes.
Preventol RI 50 is used in cosmetics such as eye and nasal drops, as a preservative.
Preventol RI 50 is used in cleaners for floor and hard surfaces as a disinfectant.
Preventol RI 50 is used in high-level surgical instrument sterilizing and disinfection solutions.
Preventol RI 50 is used in air and surface sprayable disinfectants.
Preventol RI 50 available as a textile dyeing and finishing industry of fungicides and softeners, antistatic agents, emulsifiers, conditioner, etc.
For the formulation of disinfectants or disinfecting cleaning agents for the medical, veterinary and cosmetic sectors, the food processing industry, agriculture and households. For water treatment (algae prevention in cooling water and swimming pools) and for the elimination of fungi, algae and lichens (substrate pre-treatment agent).
Preventol RI 50 and RI 50 have a broad spectrum of activity covering mould fungi, algae and lichens along with slime forming organisms, bacteria and yeasts.
They are ideal active ingredients for disinfectants for use in households and in the food processing industry.
Preventol RI 50 and RI 50 are odourless and are miscible in any ratio with water and lower alcohols.
Diluted solutions of Preventol RI 50 is therefore ideal for eliminating fungi, algae and lichens from finished coatings, plaster and stone and concrete surfaces.
Preventol RI 50 greatly reduces the surface tension of water, good wetting and penetration are guaranteed when using substrate pre-treatment agents based on these products.
A mould-infested substrate must also be pre-treated with a penetrating fungicidal agent even when the coating applied afterwards is itself fungicidal.
To ensure that this coating-bonds effectively (no flaking), it is advisable to wash with water after a solution containing.
Preventol RI 50 has been applied or not to apply a coat to the treated surfaces until they have dried (after approx. 24 hours) pre-tests are recommended.
-Disinfection
-Agriculture
-Food & Feed
-Leather & Textiles
-Cosmetics & Personal Care
-Pharma & Life Science
-Water Treatment
CHARACTERISTICS:
-Density (20 °C): approx. 0.98 g/cm3
-Vapour pressure (50 °C): approx. 54 mbar
-Solidification point: approx. 6 °C
-Boiling point: approx. 100 °C
-Flash point: > 100 °C (EN ISO 2719)
-Ignition temperature: approx. 345 °C (DIN 51794)
-Solubility (20 °C): miscible in any ratio with water, alkalis, lower alcohols and ketones
-Stability range: pH approx. 1 - 12
GENERAL PROPERTIES:
-Physical form: Colorless to pale yellow liquid
-CAS No.: 63449-41-2
-Active Content: 50%; 80%(±1%)
-pH(10%Aq.Soln.): 6-8
-Specific Gravity at 25°C(±2): 0.90–0.95
-Free Amine Hydrochloride: NMT3.0%; NMT6.0%;
-Solubility: Easily soluble in water and alcohol
-Alkalinity/Acidity: NMT 0.1 ml
PRECAUTION:
Preventol RI 50 / RI 50 are clear, viscous liquids. Contact of the skin with the product and the inhalation of vapours should be avoided.
The precautions generally recommended for handling chemicals should be observed, e. g. wearing of protective clothing, safety goggles and protective gloves.
If the product comes into contact with skin, the affected area should be washed off immediately with plenty of water and soap; splashes in the eyes should be rinsed out immediately with plenty of water.
If irritation persists, medical attention should be obtained.
Contaminated or soaking clothing should be changed at once.
STORAGE:
If correctly stored and kept in the original sealed package, the products have a shelf life of 1 year.
Preventol RI 50 is corrosive.
It is recommended that this product is stored between 30 - 40 °C.
SYNONYM:
Preventol P 91
2-Bromo-2-nitro-1,3-propanediol
52-51-7
2-Bromo-2-nitropropane-1,3-diol
Bronosol
Bronocot
Bronidiol
Preventol P 91u
Bronotak
1,3-Propanediol, 2-bromo-2-nitro-
Onyxide 500
Lexgard Preventol P 91
2-Nitro-2-bromo-1,3-propanediol
BNPD
MFCD00007390
beta-Bromo-beta-nitrotrimethyleneglycol
NSC 141021
CHEBI:31306
NSC-141021
6PU1E16C9W
NCGC00164057-01
Preventol P 91um
DSSTox_CID_4652
DSSTox_RID_77484
DSSTox_GSID_24652
Preventol P 91u [Polish]
Caswell No. 116A
Bioban
Preventol P 91um [INN-Latin
Myacide AS plus
Myacide BT
CAS-52-51-7
Preventol P 91 [INN:BAN:JAN]
Myacide Pharma BP
Canguard 409
BNP
HSDB 7195
EINECS 200-143-0
UN3241
EPA Pesticide Chemical Code 216400
BRN 1705868
UNII-6PU1E16C9W
AI3-61639
2-Bromo-2-nitropropan-1,3-diol
2-bromo-2-nitro-propane-1,3-diol
Preventol P 91
Preventol P 91
Preventol P 91
Preventol P 91
Preventol P 91
Preventol P 91
Preventol P 91
WLN: WNXE1Q1Q
1, 2-bromo-2-nitro-
2-Bromo-2-nitropropane-1,3-diol (Preventol P 91)
Preventol P 91 [WHO-DD]
EC 200-143-0
SCHEMBL23260
Bioban BNPD-40 (Salt/Mix)
CHEMBL1408862
DTXSID8024652
SCHEMBL16556987
LVDKZNITIUWNER-UHFFFAOYSA-
2-bromo-2nitro-1,3-propanediol
AMY8948
2-bromo-2-nitro-1,3-propandiol
2-Bromo-2-nitropropane-1,3-diol [UN3241] [Flammable Solid]
ALBB-031641
HY-B1217
ZINC1088216
Tox21_112079
Tox21_300126
BDBM50248122
NSC141021
s4553
2-bromanyl-2-nitro-propane-1,3-diol
AKOS003606838
CCG-213823
CS-4699
DB13960
