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Provichem 0203 a colorless to slightly yellow solid that melts at approximately 40°F.
Provichem 0203 is very irritating to skin, eyes and mucous membranes.
Provichem 0203 may emit toxic fumes when heated to high temperatures.
CAS: 98-09-9
MF: C6H5ClO2S
MW: 176.62
EINECS: 202-636-6
Provichem 0203 used to make dyes and other chemicals.
Provichem 0203 is an antimicrobial agent that inhibits the enzyme Cox-2.
Provichem 0203 has been shown to be a potent anti-cancer compound in laboratory studies and has been found to have anti-inflammatory properties.
Provichem 0203 may also be effective against metabolic disorders such as obesity, diabetes, and cancer.
The mechanism of action is currently unclear, but Provichem 0203 has been shown to inhibit the activity of human serum xanthine oxidase, which is involved in oxidation reactions.
Provichem 0203 may lead to a decrease in the production of reactive oxygen species (ROS) that are toxic to cells.
The reaction between Provichem 0203 and sulfonyl chloride is as follows: Benzenesulfonyl chloride + Sulfonyl chloride → Benzenesulfonic acid + Chlorosulfonic acid
Provichem 0203 is an organosulfur compound with the formula C6H5SO2Cl.
Provichem 0203 is a colourless viscous oil that dissolves in organic solvents, but reacts with compounds containing reactive N-H and O-H bonds.
Provichem 0203 is mainly used to prepare sulfonamides and sulfonate esters by reactions with amines and alcohols, respectively.
The closely related compound toluenesulfonyl chloride is often preferred analogue because Provichem 0203 is a solid at room temperature and easier to handle.
Provichem 0203 is prepared by the chlorination of benzenesulfonic acid or its salts with phosphorus oxychloride or, less commonly, by a reaction between benzene and chlorosulfuric acid.
Provichem 0203 Chemical Properties
Melting point: 13-15 °C (lit.)
Boiling point: 251-252 °C (lit.)
Density: 1.384 g/mL at 25 °C (lit.)
Vapor pressure: 0.04 mm Hg ( 20 °C)
Refractive index: n20/D 1.551(lit.)
Fp: >230 °F
Storage temp.: Store below +30°C.
Solubility alcohol: soluble
Form: Liquid
Color: Clear
Water Solubility: may decompose
Sensitive: Moisture Sensitive
Merck: 14,1072
BRN: 606926
Stability: Stable. Incompatible with water, strong oxidizing agents, strong bases, methyl formamide, dimethyl sulfoxide.
LogP: 3.39 at 23℃
CAS DataBase Reference: 98-09-9(CAS DataBase Reference)
NIST Chemistry Reference: Provichem 0203 (98-09-9)
EPA Substance Registry System: Provichem 0203 (98-09-9)
Provichem 0203 is a colorless oily liquid with a pungent odor.
Insoluble in water, soluble in ethanol and ether.
Can react with ammonia, amine and alcohol to produce benzenesulfonamide and Provichem 0203 respectively.
Provichem 0203 is toxic, irritates skin, eyes and mucous membranes, corrosive, and can cause burns.
Uses
Provichem 0203 reacts with Grignard reagents to form oxindoles from N-unsubstituted indoles.
Provichem 0203 is widely used to check the assay of thiamine in different food products.
Provichem 0203 is involved in the synthesis of alpha-disulfones, sulfonamides and sulfoante esters as precursor.
Provichem 0203 is a derivatization reagent for the determination of various amines in waste water and surface water at the sub-ppb level by gas chromatography-mass spectrometry.
Provichem 0203 is common reagent used in Hinsberg test for detection and distinguishing the type of amines as primary, secondary and tertiary amines.
Provichem 0203 may be used in thiamine assay for determination of thiamine in different food products.
Air & Water Reactions
Insoluble and stable in cold water.
Decomposes in hot water to produce corrosive and toxic hydrochloric acid and Provichem 0203.
Rate of reaction decreases as temperature decreases.
Reactivity Profile
Provichem 0203 is incompatible with strong oxidizing agents and bases, including amines.
Corrodes metals in the presence of water due to slow formation of hydrochloric acid and Provichem 0203.
May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts.
Preparation Method
First, chlorosulfonic acid was put into a reaction kettle, and then benzene was dripped at 20 to 25 ° C., and the reaction was carried out under heat preservation.
The reaction solution was separated, extracted and distilled under reduced pressure to obtain a Provichem 0203.
The by-product hydrogen chloride gas in the operation should be absorbed into dilute hydrochloric acid with water for later use.
Synonyms
BENZENESULFONYL CHLORIDE
98-09-9
Phenylsulfonyl chloride
Benzene sulfochloride
Benzenesulfonic chloride
Benzene sulfonechloride
Benzenosulfochloride
Benzenesulfonic acid chloride
Benzenosulfochlorek
Benzenesulfochloride
BENZENE SULFONYL CHLORIDE
Benzenesulphonyl chloride
Benzenesulfonic(acid)chloride
Benzenesulfonic (acid) chloride
phenyl sulfonyl chloride
RCRA waste no. U020
NSC 2864
UN2225
benzensulfonyl chloride
benzene sulfonylchloride
Benzene sulphonyl chloride
OI9V0QJV9N
DTXSID1026619
NSC-2864
Benzolsulfochloride
BSC-refine D
Benezenesulfochloride
Benzenosulphochloride
Benzenesulfon chloride
RCRA waste number U020
Benzenosulfochlorek [Polish]
phenylsulfonylchloride
HSDB 6004
EINECS 202-636-6
UNII-OI9V0QJV9N
benzene-1-sulfonyl chloride
BRN 0606926
AI3-18043
benzolsulfonylchlorid
PhSO2Cl
phenylsufonyl chloride
benzenesulfonyichloride
benzenesulfonyl chlorde
benzenesulfonyl choride
benzenesulfonyl cloride
Benzenesulfonylchloride
benzenesulonyl chloride
bezenesulfonyl chloride
benzenesulphonylchloride
benzenesulfonyl-chloride
phenylsulphonyl chloride
benzenesuIfonyl chloride
phenyl-sulfonyl chloride
benzene sulphonylchloride
benzenesulfonoyl chloride
benzene-sulfonyl chloride
phenyl sulphonyl chloride
WLN: WSGR
m-benzenesulfonyl chloride
4-benzenesulfonyl chloride
EC 202-636-6
phenylsulfonic acid chloride
4-benzene sulfonyl chloride
SCHEMBL17223
benzenesulphonic acid chloride
Benzenesulfonyl chloride, 96%
Benzenesulfonyl chloride, 99%
DTXCID706619
CHEMBL1479161
NSC2864
BENZENESULFONYL CHLORIDE KIT
AMY37105
CS-D1402
ZINC8100887
Tox21_200143
AR3950
BENZENESULFONYL CHLORIDE [MI]
MFCD00007426
STL283941
AKOS000118823
UN-2225
CAS-98-09-9
NCGC00090988-01
NCGC00090988-02
NCGC00090988-03
NCGC00090988-04
NCGC00257697-01
AS-14034
B0036
B1211
FT-0622639
EN300-19437
Benzenesulfonyl chloride, for HPLC derivatization
A845807
Benzene sulfonyl chloride [UN2225] [Corrosive]
Benzenesulfonyl chloride, purum, >=97.0% (AT)
J-519686
Q2660596
F2190-0562
