PVP K-30 SOLUTION

PVP K 30 SOLUTION

CAS NO: 9003-39-8 / 25249-54-1
EC NO: 618-363-4

SYNONYMS

Polyvinyl pyrrolidone K 30; Polyvidonum; Disadine; Povidone(usan); Povidone, BAN, USAN; PVP10_SIAL; PVP40_SIAL; 1-Ethenyl-2-pyrrolidinone homopolymer, 9CI; MPK 90; Polividone; 1-Vinyl-2-pyrrolidinone cross-linked insoluble polymer; PVP; PVPP; Crospovidone; Polyvidone; PNVP; Poly[1-(2-oxo-1-pyrrolidinyl)ethylen]; 1-Ethenyl-2-pyrrolidon homopolymer; C6H9NO;  1-Vinyl-2-pyrrolidinon-Polymer; 2-Pyrrolidinone, 1-ethenyl-, homopolymer; -Pyrrolidinone, 1-vinyl-, polymers (8CI); Poly(1-vinyl-2-pyrrolidinone) homopolymer; K60; K60 (polymer);  Poly(1-(2-oxo-1-pyrrolidinyl)-1,2-ethanediyl), alpha-hydro-omega-((4-(iodo-(sup 131)I)phenyl)methyl)-; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.1; K30; K30 (polymer); K90; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.2; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.3; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.4; K15; K25; K25 (polymer);  Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.5; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.6; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.7; Polyvinylpyrrolidone; 1-Ethenyl-2-pyrrolidinone homopolymer; 1-Ethenyl-2-pyrrolidinone polymers; 1-Ethenyl-2-pyrrolidinone, homopolymer; 1-Vinyl-2-pyrrolidinone homopolymer; 1-Vinyl-2-pyrrolidinone polymer;  1-Vinyl-2-pyrrolidone polymer; 143 RP; 2-Pyrrolidinone, 1-ethenyl, homopolymer; 2-Pyrrolidinone, 1-vinyl-, polymers; 2-Pyrrolidinone, 1-vinyl-, polymers, compd. with aluminum acetate; alpha-Hydro-omega-(p-iodobenzyl)poly(1-(2-oxo-1-pyrrolidinyl)ethylene)-(sup 131)I; alpha-Hydro-omega-(p-iodobenzyl)poly(1-(2-oxo-1-pyrrolidinyl)ethylene)-(sup 131)I. (A small part of the iodine is the radioactive isotope, (sup 131)I.); Crospovidonum; EPA Pesticide Chemical Code 079033; Hemodesis; Hemodez; HSDB 205; K 115 (polyamide); K 115 (VAN); K 15; K 25 (polymer); K 25 (VAN); K 30 (polymer); K 30 (VAN); K 60 (polymer);  K 60 (VAN); K 90; K115; K115 (polyamide); N-Vinyl-2-pyrrolidone polymer; N-Vinylbutyrolactam polymer; N-Vinylpyrrolidinone polymer; N-Vinylpyrrolidone polymer; NCI-C60582; Neocompensan; NSC 114022; NSC 142693; Polividone [DCIT]; Poly(1-(2-oxo-1-pyrrolidinyl)-1,2-ethanediyl), alpha-hydro-omega-((4-(iodo-(sup 131)I)phenyl)methyl)-; Poly(1-(2-oxo-1-pyrrolidinyl)ethylene); Poly(1-ethenyl-2-pyrrolidinone); Poly(1-vinyl-2-pyrrolidinone); Poly(1-vinyl-2-pyrrolidinone) homopolymer; Poly(1-vinyl-2-pyrrolidone); Poly(1-vinylpyrrolidinone); Poly(N-vinyl-2-pyrrolidinone);
Poly(N-vinyl-2-pyrrolidone); Poly(N-vinylbutyrolactam); Poly(N-vinylpyrrolidinone); Poly(N-vinylpyrrolidone); Poly(vinylpyrrolidinone); Poly-N-vinyl pyrrolidone; Polyvinylpyrrolidone;  Povidon; Povidone (usp xix); Povidone K 30; PVP; PVP 1; PVP 2; PVP 3; PVP 4; PVP 40; PVP 5; PVP 6; PVP 7; PVP K 3; PVP-K 15; PVP-K 30; PVP-K 60; PVP-K 90; PVPP; UNII-2S7830E561; UNII-333AG72FWJ;
UNII-40UAA97IT9; UNII-68401960MK; UNII-6B46OH7T95; UNII-C67P1734QJ; UNII-E54VE15114; UNII-FZ989GH94E; UNII-H7AGY1OJO8; UNII-K0KQV10C35; UNII-RDH86HJV5Z; UNII-SZR7Z3Q2YH; UNII-U725QWY32X;  Vinisil; Vinylpyrrolidinone polymer; Polyvinylpolypyrrolidone; Polyvinyl polypyrrolidone; PVPP; Crospovidone, Crospolividone; E1202; Copovidone; (C6H9NO)n; povidone; PVP; PVP-K; PVP-K17;  PVP-K25; Polyvinylpyrrolidine; PVP-K30; PVP K 30; PVP-K90; poly vinyl pyrrolidone; K-30; Crospovidone; Polyinylpyrrolidone; Polyvinglpyrrolidone; CAS NO: 9003-39-8 / 25249-54-1; EC NO: 618-363-4; 1-Ethenyl-2-pyrrolidoinone homopolymer (IUPAC); Poly[1-(2-oxo-1-pyrrolidinyl)ethylene]; polyvidone; polyvinylpyrrolidone; PVP; 1-vinyl-2-pyrrolidinone polymer

PVP K 30 SOLUTION

Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.

The K value of PVP is actually the characteristic value related to the relative viscosity of PVP aqueous solution, and the viscosity is the physical quantity related to the molecular weight of polymer, so the K value can be used to characterize the average molecular weight of PVP.

PVP K-30 30% Solution is a film former in hair styling products. It has an average molecular weight of 60,000 in Daltons.

PVP is an emulsion stabilizer in creams and lotions. PVP can also be a dispersant for hair colorants. PVP K-30 is available as 100% powder and as 30% aqueous solution.

The K30 Solution provides a firm, clear film while maintaining softness.

Physical state
liquid

Colour
light yellow

pH
4.0 - 8.0

Concentration
5 %

Melting point/freezing point
27.1 °F / -2.7 °C

Boiling point/boiling range
> 212 °F / > 100 °C

Density
1.062 g/cm3 (25 °C)

Water solubility
soluble

Polyvinylpyrrolidone (PVP) is a linear polymer of 1-vinyl-2-pyrrolidone monomers used as a binder, emulsion stabilizer, film former, hair fixative, and suspending agent-nonsurfactant. The molecular weight of the polymer ranges from 10,000 to 700,000. PVP K-30, with an average molecular weight of 40,000, is typically used in cosmetic formulations. The highest concentration reported to be used is 35%. There was no significant absorption of PVP K-30 given orally to rats, and the acute oral LD50 was >100 g/kg for rats and guinea pigs. Neither toxic effects nor gross lesions were found in rats maintained for two years on a diet containing 10% PVP K-30. Short-term PVP inhalation studies produced mild lymphoid hyperplasia and fibroplasia in rats, but no inflammatory response. In animal studies, no evidence of significant ocular irritation, skin irritation, or skin sensitization was found at PVP-iodine solution concentrations of 10%. While PVP-iodine is not a cosmetic ingredient, these negative findings were considered to support the safety of the PVP component. Undiluted PVP K-30 was not a dermal irritant or sensitizer in clinical tests. No developmental toxicity was seen in vehicle controls where PVP was used as a vehicle for another agent. In certain assay systems, PVP was genotoxic, but was negative in the majority of studies. Orally administered PVP significantly decreased the rate of bladder tumors in mice exposed to bracken fern. Several studies tested the carcinogenicity of subcutaneous implants of particulate PVP in rats, mice, and rabbits. Although the majority of these studies conducted in rats were positive, tumors (sarcomas) were localized to the site of implantation. Based on the available data, it was concluded that PVP is safe as used in cosmetics.

Povidones are available in different molecular weights. The higher the molecular weight, the greater the viscosity and consequently the adhesive strength. The K-value denotes the intrinsic viscosity of the polymer related to the molecular weight, and is derived from the relative viscosity of the aqueous solution measured at 25°C. The direct correlation between the molecular weight and properties enables the appropriate grade to be used in each formulation in the appropriate concentration in order to achieve the optimum effect.  

Polyvinylpyrrolidone is a hygroscopic, amorphous polymer supplied as a white, free-flowing powder or a clear aqueous solution. Available in several molecular weight grades, they are characterized by K-value, and used in a great variety of applications. Polyvinylpyrrolidone can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert: 

-Applications take advantage of one or more properties inherent in the polymer, typically due to the lactam ring.
-High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.
-Dispersancy, where components in a mixture are uniformly distributed through the use of polyvinylpyrrolidone.
-Hydrophilicity, where the substantial water solubility of polyvinylpyrrolidone is its dominant feature and frequently a factor along with other properties valuable to numerous applications.
-Adhesion, taking advantage of the higher molecular weight polyvinylpyrrolidones formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application.
-Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques.

Polyvinylpyrrolidone is cross-linkable to a water insoluble, swellable material either in the course of vinylpyrrolidone polymerization, by addition of an appropriate multifunctional comonomer or by post-reaction, typically through hydrogen abstraction chemistry.

Home Care Features and Benefits

- acts as rheology modifier
- is a highly adhesive tablet binder
- stabilizes emulsion and structures liquid products
- provides anti-soil redeposition, enzyme stabilization and dye transfer inhibition
- functions as binder and protective coating for enzymes
- provides surface shine enhancement
- forms hard, transparent, glossy films

Home Care Applications

- dishwashing liquids
- dishwashing and laundry tablets
- laundry detergents
- hard surface cleaners

Features & Benefits:
-Strong, stiff hold
-Stabilizes emulsions, dispersions and suspensions
-Foam stabilizer
-Excellent compatibility with acrylate thickeners
-Shine

Applications:
Ideal for gels, mousses, styling creams/lotions, hair colorants, pomades, waxes, pastes, hairspray.

While PVP is used as a film former in hair styling products, it can also be used as an emulsion stabilizer in creams and lotions and as a dispersant for hair colorants.

PVP was used as a plasma volume expander for trauma victims after the 1950s. It is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping.

It is used as a binder in many pharmaceutical tablets; it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption. The long-term effects of crospovidone or povidone within the lung are unknown).

PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties. This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others.

It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.

PVP is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. 

PVP is used as a lubricant in some eye drops.

PVP is also used in many technical applications:

as an adhesive in glue stick and hot-melt adhesives
as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process
as an emulsifier and disintegrant for solution polymerization
to increase resolution in photoresists for cathode ray tubes
in aqueous metal quenching
for production of membranes, such as dialysis and water purification filters
as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating
as a thickening agent in tooth whitening gels
as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation
as an additive to Doro's RNA extraction buffer
as a liquid-phase dispersion enhancing agent
as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly
as a stabilizing agent in all inorganic solar cells

PVP binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers.

PVP is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions. PVP is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.

As a food additive, PVP is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers.

In molecular biology, PVP can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.

In microscopy, PVP is useful for making an aqueous mounting medium.

PVP can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.

PVP is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol, as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea. When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings.

Povidone itself has no microbicidal activity. Povidone-iodine exhibits rapid, potent, broad-spectrum antimicrobial properties. The clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application.

Polyvinyl pyrrolidone is used as a powder and solution in the production of pharmaceutical tablets because of its adhesion properties.

This product is completely compatible and does not interact to other tablet components.

Since PVP K30 quickly forms a clear solution, it is suitable for producing high-solubility tablets. This product can be used as a solubility enhancer in polar solvents for topical and oral applications.

In addition, PVP K30 also plays an important role in emulsion stability and anti-sedimentation.

Polyvinyl pyrrolidone, due to its chemical structure (the presence of a lactam ring), can form a complex with many molecules containing functional groups such as hydroxyl, carboxylic and amine.

Applications:
• As a binder in a variety of oral tablets.
• Film forming in coated tablets.
• Contribute to the uniform distribution of pigment, stabilization and preservation of the composition of the percentage of pigments in the coating
• Stabilization of suspensions.

It finds use in detergents as an anti-redeposition agent(especially on carbonaceous soil) and as an anti-dyetransfer agent, where it complexes and solubilizes vagrant
dyes keeping clothes more color-pure.

• Essential or auxiliary material in a variety of liquid, glue stick and wound adhesives
• Production of various types of membranes for various applications such as dialysis, water specialization 
• Containing film in seed veneers to create antimicrobial coating or seed protection 
• Color stabilizer and leveling agent for dyeing of all kinds of polyester, woolen
• Anti- crystallization in syrups
• Stabilizing enzymes and thermally sensitive agents

Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. It has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.

Povidone k30 has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder. Povidone formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents. The k number refers to the mean molecular weight of the povidone. Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights. The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body. The best-known example of povidone formulations is povidone-iodine, an important disinfectant.

Polyvinylpyrrolidone (PVP) gives products an extra fixative power: it forms a thin coating over the hair that helps to maintain it in the position you wish. PVP promotes the dispersion of pigments, making it a very effective ingredient for creating well spread out makeup products.

Polyvinylpyrrolidone (PVP) PVP or povidone is a hygroscopic, amorphous, synthetic polymer consisting of linear 1-vinyl-2-pyrrolidinone groups. As a binder, PVP is used in the concentration range of 0.5%–5% w/w. Different degrees of polymerization of PVP resulted in polymers of various molecular weights.

PVP is commonly used as a surfactant or structure directing reagent in the chemical process to regulate nucleation and crystal growth, reduced surface tension and stabilized metal nanoparticles.

In the macromolecule structure of PVP, it has both a hydrophilic and hydrophobic group. It is highly soluble in water and ethanol. During the cocrystallization process, PVP will not precipitate from the solution due to its high solubility and low amount of addition.

FIRST AID MEASURES

General advice: No hazards which require special first aid measures.

If inhaled: If breathed in, move person into fresh air. If unconscious, place in recovery position and seek medical advice. If symptoms persist, call a physician.

In case of skin contact: First aid is not normally required. However, it is recommended that exposed areas be cleaned by washing with soap and water.

In case of eye contact: Remove contact lenses. Protect unharmed eye.

If swallowed: Do not give milk or alcoholic beverages. Never give anything by mouth to an unconscious person. If symptoms persist, call a physician.

Most important symptoms and effects, both acute and delayed: May cause an allergic skin reaction.

FIREFIGHTING MEASURES

Suitable extinguishing media: Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Water spray
Foam
Carbon dioxide (CO2)
Dry chemical

Specific hazards during firefighting: Do not allow run-off from fire fighting to enter drains or water courses.

Hazardous combustion products:
carbon dioxide and carbon monoxide
Nitrogen oxides (NOx)

Specific extinguishing methods:
Product is compatible with standard fire-fighting agents.

Further information:
Standard procedure for chemical fires.

ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures: Persons not wearing protective equipment should be excluded from area of spill until clean-up has been completed.

Environmental precautions: Prevent further leakage or spillage if safe to do so.