PRODUCTS

PVP/VA E-635

PVP/VA E-635 is commonly used as a reactive diluent for radiation curing in UV-coating, UV-inks, and UV adhesives.
PVP/VA E-635 is used as a monomer to produce water soluble polyvinylpyrrolidone (PVP) with uses in pharmaceuticals, oil field, cosmetics, food additives & adhesives.
PVP/VA E-635 is used in the manufacture of copolymers with, for example, acrylic acid, acrylates, vinyl acetate and acrylonitrile and in the synthesis of phenolic resins.

CAS Number: 88-12-0
Molecular Formula: C6H9NO
Molecular Weight: 111.14
EINECS Number: 201-800-4

Synonyms: N-VINYL-2-PYRROLIDONE, 88-12-0, 1-vinylpyrrolidin-2-one, 1-Vinyl-2-pyrrolidone, N-Vinylpyrrolidone, N-Vinyl-2-pyrrolidinone, 1-Vinyl-2-pyrrolidinone, Povidone, Vinylpyrrolidone, 1-ethenylpyrrolidin-2-one, N-Vinylpyrrolidinone, 2-Pyrrolidinone, 1-ethenyl-, 25249-54-1, 1-Vinylpyrrolidone, Plasdone, Pvpp, Vinylbutyrolactam, Vinylpyrrolidinone, V-Pyrol, Luviskol, 1-Vinylpyrrolidinone, Vinyl-2-pyrrolidone, N-Vinyl pyrrolidone, 1-Ethenyl-2-pyrrolidinone, N-Vinylpyrrolidone-2, 1-Vinyl-2-pyrrolidinone, monomer, 2-Pyrrolidinone, 1-vinyl-, PVP, PVP 40, NSC 10222, MPK 90, DTXSID2021440, 143 RP, AT 717, MFCD00003197, 1-vinyl-pyrrolidin-2-one, Crospovidone ~40,000, K 15, K 90, PVP-40, CHEBI:82551, NSC-10222, 76H9G81541, DTXCID101440, WLN: /T5NVTJ AY1/, MFCD01076626, CAS-88-12-0, K 25, K 115, HSDB 7231, EINECS 201-800-4, BRN 0110513, CCRIS 8581, vinyl pyrrolidone, UNII-76H9G81541, N-vinyl-pyrrolidone, N -vinylpyrrolidinone, 1-vinyl-2-pyrrolidon, POVIDONE MONOMER, VINYLBUTYLOLACTAM, N-vinylpyrrolidin-2-one, N-vinyl pyrrolidin-2-one, N-vinyl-pyrrolidin-2-one, Polyvinylpyrrolidone, K17, EC 201-800-4, SCHEMBL10869, WLN: T5NVTJ A1U1, PVP-K30, Crospovidone (~40,000), POVIDONE MONOMER [MI], VINYL PYRROLIDONE (VP), CHEMBL1878943, Polyvinylpyrrolidone (MW 8,000), 1-Vinyl-2-pyrrolidone(stabilized with 200ppm Ammonium hydroxide), NSC10222, Polyvinylpyrrolidone (MW 10,000), Polyvinylpyrrolidone (MW 40,000), Polyvinylpyrrolidone (MW 58,000), Tox21_202462, Tox21_300073, NSC114022, NSC142693, NSC683040, Polyvinylpyrrolidone (MW ~40,000), AKOS000119985, N-VINYL-2-PYRROLIDONE [IARC], AT18510, CS-W020981, FC35103, FG-0420, FP31696, FP45428, FV54838, NSC-114022, NSC-142693, NSC-683040, NCGC00166252-01, NCGC00166252-02, NCGC00166252-03, NCGC00254200-01, NCGC00260011-01, Polyvinylpyrrolidone (MW 1,300,000), DA-56977, 2-PYRROLIDINONE, 1-ETHENYL- [HSDB], NS00002538, V0026, 88-12-0; 9003-39-8 (homopolymer), EN300-19745, C19548, N-Vinyl-2-pyrrolidone - Stabililzed with MEHQ, 1-Vinyl-2-pyrrolidinone;1-Vinylpyrrolidin-2-one, Polyvinylpyrrolidone - K30 average Mw 40,000, A817742, A843417, Q420628, SR-01000944531, Poly(vinylpolypyrrolidone), <= 50 mm particle size, SR-01000944531-1, 1-Vinyl-2-pyrrolidinone, SAJ first grade, >=99.0%, Poly(vinylpolypyrrolidone), 50-300 mm particle size, F8881-5579, Z104475034, N-Vinyl-2-pyrrolidoneStabililzed with hydroquinone methyl ether, InChI=1/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H, 1-Vinyl-2-pyrrolidinone, contains sodium hydroxide as inhibitor, >=99%, Polyvinyl polypyrrolidone;crospolividone;Polyvinylpyrrolidone cross-linked, 1-Vinyl-2-pyrrolidinone, Pharmaceutical Secondary Standard; Certified Reference Material, 1-Vinyl-2-pyrrolidone (stabilized with N,N'-Di-sec-butyl-p-phenylenediamine), 1-VINYL-2-PYRROLIDINONE, 99+%;N-Vinyl-2-pyrrolidone, stabilized with Kerobit;N-Vinyl-2-pyrrolidone, stabilized, 98%;N-VINYL-2-PYRROLIDINONE;N-VINYL-2-PYRROLIDONE;N-VINYLPYRROLIDONE;N-VINYLBUTYROLACTAM;1-ethenyl-2-pyrrolidinon

PVP/VA E-635 is a colorless to yellow liquid, with a characteristic odor.
Its melting point is around 13.5oC and boils at about 90-92oC. VP is completely miscible in water and in most organic solvents but partially miscible in aliphatic hydrocarbons.
Industrial production of PVP/VA E-635 with acetylene at high pressure and temperature has been reported.

The vinylation process proceeds in liquid phase and is catalyzed by 3-pyrrolidone -potassium hydroxide.
PVP/VA E-635 is stable toward alkalis at room temperature.
Above 0 ℃ it is cleaved by aqueous mineral acids into acetaldehyde and 2-pyrrolidone; the latter reacts with an excess of NVP to give 1,1'-ethylidene-bis-2- pyrrolidone.

Protic compounds such as amides, thiols, alcohols, and phenols add to the double bond according to the Markovnikov rule, for example, N-(1-phenoxyethyl)-2-pyrrolidone is formed with phenol.
Catalytic hydrogenation produces N-ethyl-2-pyrrolidone.
Hydroformylation on rhodium catalysts forms PVP/VA E-635 as the major product.

On prolonged standing, particularly in warm conditions, NVP tends to polymerize.
Industrially, PVP/VA E-635 is converted into polyvinylpyrrolidone using radical initiators.
PVP/VA E-635 Copolymer is the ingredient found in most mainstream hair care products that provides the hold factor.

So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams.
PVP/VA E-635 is a synthetic ingredient that is derived from petroleum.
PVP/VA E-635 was the main ingredient in the rst really successful hairsprays in the early 1950s.

This polymer worked as a hairspray because it was soluble in water.
This meant it could be rinsed out when you wash your hair.
PVP/VA E-635 tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties.

This was xed with the help of another polymer, a silicone called polydimethylsiloxane.
To understand how this silicone made a better hairspray, it helps to understand how the hairspray works in the rst place.
PVP/VA E-635 on, the polyvinylpyrrolidone forms a thin coating on the hair.

This coating is PVP/VA E-635 and keeps the hair from moving around.
PVP/VA E-635 Copolymer Series of copolymers covering a range of VP/VA ratios.
PVP/VA E-635 is a white powder while the others are 50% solutions in ethanol (E), isopropanol (I) or water (W).

PVP/VA E-635 is a copolymer that combines polyvinylpyrrolidone (PVP) with vinyl acetate (VA) in a specific ratio, often used in various industries for its versatile properties.
This copolymer is typically utilized as a film-forming agent, binder, and stabilizer in products such as cosmetics, personal care formulations, and food applications.
PVP/VA E-635 is valued for its ability to enhance the texture, appearance, and performance of formulations, contributing to better product stability and improved sensory characteristics.

PVP/VA E-635 is commonly used in hair sprays, shampoos, and skin creams, where it provides film-forming properties that help to improve the durability of the product on the skin or hair.
Its versatile nature also makes it useful in the pharmaceutical and industrial sectors, where it serves as an excipient, adhesive, or emulsifier in various formulations.
PVP/VA E-635 Ashland Specialty Chemical acts as a film forming agent.
PVP/VA E-635 forms transparent, flexible and oxygen permeable films which adhere to glass, plastic and metal.

PVP/VA E-635 offers strong & stiff hold, enhanced high humidity curl retention and good propellant compatibility.
PVP/VA E-635 finds application in formulating alcohol-free and hair care products like hairsprays, colorants, mousses, gels, styling lotions/creams and novelty stylers.
PVP/VA E-635 is a 50% solution of linear and random polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer in water.

PVP/VA E-635 is produced by the free-radical polymerization of monomers in the ratio of 60/40 (VP/VA).
PVP/VA E-635 is a synthetic polymer that is produced by the copolymerization of polyvinylpyrrolidone (PVP) and vinyl acetate (VA), creating a material with distinct properties derived from both components.
This copolymer is primarily known for its ability to enhance the solubility and stability of active ingredients, especially in water-based formulations.

In the cosmetic and personal care industry, PVP/VA E-635 is often found in hair styling products, such as gels and sprays, where it serves as a film-forming agent, providing hold and maintaining the desired shape without leaving a sticky residue.
PVP/VA E-635 also enhances the longevity and consistency of the product’s application.

Melting point: 13-14 °C
Boiling point: 92-95 °C (11 mm Hg(lit.))
Density: 1.04 g/mL at 25 °C (lit.)
Vapor density: 3.8 (vs air)
Vapor pressure: 0.1 mm Hg (24 °C)
Refractive index: n20/D 1.512 (lit.)
Flash point: 201 °F
Storage temp.: Store below +30°C.
Solubility: 52.1g/l soluble
Form: Liquid
pKa: -0.34±0.20 (Predicted)
Color: Clear colorless to yellow
pH: 9-10 (100g/l, H2O, 20℃)
Explosive limit: 1.4-10% (V)
Viscosity: 2.07 cp (25°C)
Water Solubility: Miscible
Merck: 14,7697
BRN: 110513
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey: WHNWPMSKXPGLAX-UHFFFAOYSA-N
LogP: 0.4 at 25℃

PVP/VA E-635 is an important precursor and intermediate for process auxiliaries and additives.
The main areas of use are the production of polyvinylpyrrolidone and copolymers, the preferred comonomers being vinyl acetate and methyl acrylate.
10–15% of the monomer is used in the pharmaceutical industry for the production of a polyvinylpyrrolidone–iodine complex used as a disinfectant.

PVP/VA E-635 is also used as a reactive solvent for UV-curable resins for the production of printing inks and paints as paper and textile auxiliaries, and as an additive in the cosmetics industry.
PVP/VA E-635 is widely used in skin care products, where it acts as a binder and stabilizer, contributing to the smooth texture and ease of application.
The copolymer also functions in medical and pharmaceutical formulations, such as controlled-release drug systems, due to its ability to form stable films and coatings.

Furthermore, in food industries, PVP/VA E-635 can be utilized as an emulsifier or stabilizing agent in certain food products, enhancing their texture and shelf life.
PVP/VA E-635 is utilized in various industrial processes, including as an adhesive in manufacturing, in textiles, and even in the production of coatings and paints.
Its unique combination of properties, such as film formation, water solubility, and non-toxic nature, makes it highly versatile for both consumer and industrial products.

Industrially, PVP/VA E-635 is produced by reacting 2-pyrrolidone with acetylene in highpressure autoclaves at 130–170 ℃ and pressures of up to 2.6 MPa.
Vinylation proceeds in the liquid phase and is catalyzed by 2-pyrrolidone–potassium.
The salt is obtained by adding 1–5% potassium hydroxide or caustic potash solution to fresh pyrrolidone and removing excess water by vacuum distillation (batchwise or continuously).

The vinylation reaction takes place in a liquid-phase tube or loop reactor, or in a gas-phase reactor.
To avoid the danger of acetylene explosions, nitrogen or propane mixtures of acetylene are used instead of pure acetylene.
After the vinylation, the crude product obtained is purified by multistep vacuum distillation. Unreacted 2-pyrrolidone and derivatives can be recycled.

Excess acetylene is removed by distillation and can also be recycled to the process.
Another industrially important synthetic route is based on PVP/VA E-635.
In this process, PVP/VA E-635 is dehydrated in the gas phase in a heterogeneously catalyzed reaction at 320–400 ℃ and 10 kPa.

The obtained crude PVP/VA E-635 is purified by vacuum distillation or crystallization.
PVP/VA E-635 acts as a film former. Offers strong & stiff hold, enhanced high humidity curl retention, hairstyle hold, good propellant compatibility, fixative & styling polymers and vegan suitable.
It is a linear, random copolymer that is formed by the free-radical polymerization of vinyl acetate (VA) and vinylpyrrolidone (VP), which are provided in ethanol, in ratios ranging from 70/30 to 30/70.

It is used in the formulation of hair care products such as hairsprays, colorants, mousses, gels and styling lotions/creams.
Also used in personal care, pomades, waxes and pastes.
PVP/VA E-635 is produced industrially by vinylation of 2-pyrrolidone, i.e. the base-catalyzed reaction with acetylene.

PVP/VA E-635 is the precursor to polyvinylpyrrolidone (PVP), an important synthetic material.
The PVP/VA E-635 monomer is commonly used as a reactive diluent in ultraviolet and electron-beam curable polymers applied as inks, coatings or adhesives.
PVP/VA E-635, also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.

PVP/VA E-635 is the ingredient found in most mainstream hair care products that provides the hold factor.
So it is very common in most Hairsprays but also found in gel's, wax's, pomades and styling creams.
PVP/VA E-635 is a synthetic ingredient that is derived from petroleum.

PVP/VA E-635 (also known as Polyvinylpyrrolidone) was the main ingredient in the rst really successful hairsprays in the early 1950s.
This polymer worked as a hairspray because it was soluble in water.
PVP/VA E-635 tended to absorb water out of the air, giving hair that tacky look that was so common in the sixties.

This coating is sti and keeps the hair from moving around.
Unfortunately no one was aware of the dangers that came with this Polymer.
If particles of PVP/VA E-635 Copolymer are inhaled, it can cause damage to the lungs in sensitive individuals.

PVP/VA E-635 can be considered toxic, since particles may contribute to foreign bodies in the lungs of people.
PVP/VA E-635 was considered safe to use however now it is denitely an ingredient that is better to avoid.

Uses:
PVP/VA E-635 is used in the preparation of NMDA receptor antagonists. Also used in the synthesis of copolymers used to stabilize rhodium nanoclusters.
PVP/VA E-635 was used as a plasma volume expander for trauma victims after the 1950s.
PVP/VA E-635 is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping.

PVP/VA E-635 is used as a binder in many pharmaceutical tablets; it simply passes through thevbody when taken orally.
However, autopsies have found that PVP/VA E-635 contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.
The long-term eects of crospovidone or povidone within the lung are unknown.

PVP/VA E-635 added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.
This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs.
PVP/VA E-635 is known under the trade names Pyodine and Betadine, among a plethora of others.

PVP/VA E-635 is used in pleurodesis (fusion of the pleura because of incessant pleural eusions).
For this purpose, povidone iodine is equally eective and safe as talc, and may be preferred because of easy availability and low cost.
PVP/VA E-635 is used in some contact lenses and their packaging solutions.

PVP/VA E-635 reduces friction, thus acting as a lubricant, or wetting agent, built into the lens.
PVP/VA E-635 is used in as an adhesive in glue stick and hot-melt adhesives.
PVP/VA E-635 is used in as a special additive for batteries, ceramics, berglass, inks, and inkjet paper, and in the chemical-mechanical planarization process.

PVP/VA E-635 is used in as an emulsier and disintegrant for solution polymerization
PVP/VA E-635 is used in increase resolution in photoresists for cathode ray tubes (CRT).
PVP/VA E-635 is used in aqueous metal quenching for production of membranes, such as dialysis and water purication lters.

PVP/VA E-635 is used in as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating.
PVP/VA E-635 is used in as a thickening agent in tooth whitening gels.
PVP/VA E-635 is used in as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation.

PVP/VA E-635 is used in as an additive to Doro's RNA extraction buer.
PVP/VA E-635 is used in as a liquid-phase dispersion enhancing agent in DOSY NMR.
PVP/VA E-635 is used in as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly.

PVP/VA E-635 is used in as a stabilizing agent in all inorganic solar cells.
PVP/VA E-635 is a versatile copolymer that finds widespread application across various industries, particularly in cosmetics, pharmaceuticals, and food processing, due to its unique properties.
In the cosmetics and personal care industry, PVP/VA E-635 is primarily used in hair care products such as styling gels, sprays, and mousses.

PVP/VA E-635 functions as a film-forming agent, providing a strong hold and maintaining hair shape without making it feel stiff or sticky, which helps extend the duration of the hairstyle.
Additionally, PVP/VA E-635 is used in skin care products like moisturizers, lotions, and foundations, where it improves the texture and stability of the product while ensuring smooth application and long-lasting effects.

In the pharmaceutical industry, PVP/VA E-635 is utilized in the formulation of controlled-release drug systems and as a binder in tablet formulations.
Its ability to form films makes it an ideal candidate for creating coatings that control the release rate of active pharmaceutical ingredients, enhancing their effectiveness and providing consistent delivery over time.
Moreover, it is used in wound dressings, as it helps to form protective films over wounds, supporting healing and providing a barrier against infections.

In food processing, PVP/VA E-635 serves as an emulsifier, stabilizer, and thickening agent in various products.
PVP/VA E-635 helps improve the texture and consistency of products like sauces, beverages, and dressings, ensuring a smooth, uniform texture and preventing separation of ingredients.
Additionally, it can extend the shelf life of certain food items by maintaining product stability during storage.

The industrial applications of PVP/VA E-635 are also significant, as it is used in adhesives, coatings, and paints.
PVP/VA E-635 helps to improve the adhesive properties, ensuring stronger bonding, while also providing a smooth, durable finish to painted surfaces.
In textiles, it is used in fabric finishes and as a binder in the production of nonwoven fabrics, enhancing their durability and flexibility.

PVP/VA E-635 continues to be highly valued for its multifunctionality across a wide range of applications.
In the cosmetics industry, it is also used in nail care products such as nail polish, where it serves as a film-forming agent to create a smooth, glossy finish.
This copolymer helps to improve the adhesion of nail products to the nail surface and increases the durability of the manicure, making the nail polish less prone to chipping.

PVP/VA E-635 can also be found in lip glosses, mascaras, and eye makeup, where it enhances the texture and adds a shiny, smooth appearance to the product.
For personal care products, PVP/VA E-635 is utilized in deodorants and antiperspirants, where it helps to improve the formulation's texture and stability.
PVP/VA E-635 assists in creating even application and contributes to long-lasting performance by preventing the product from separating over time.

In addition, it is found in cleansers and soaps, where it works as a stabilizing agent to maintain uniform consistency and provide a creamy, smooth texture.
In the pharmaceutical industry, PVP/VA E-635 plays a critical role in the development of drug delivery systems, particularly in the form of hydrogels.
These hydrogels can be used for controlled drug release or topical treatments, as the copolymer helps in forming a gel matrix that controls the release rate of medications over an extended period, making treatments more effective and reducing the frequency of administration.

Moreover, PVP/VA E-635 is used in eye drops and contact lens solutions, where it acts as a stabilizer and lubricant to enhance comfort and promote better hydration.
For food products, PVP/VA E-635 serves as a key ingredient in chewing gum, where it helps maintain the texture and consistency of the gum while enhancing chewability.
In addition, it can be used in confectionery coatings, where it provides a smooth, glossy finish that improves the visual appeal of products such as candy, chocolates, and coated nuts.

The copolymer also plays an important role in beverage production, where it is used as a stabilizer to maintain uniform suspension of solid ingredients, such as fruit pulp, in drinks like smoothies or fruit juices.
In industrial applications, PVP/VA E-635 is widely used in the production of inks and toners for printing, where it enhances the stability and adhesion of the ink on paper or other surfaces.

PVP/VA E-635 ensures smooth printing performance and prevents clogging of the printer nozzles.
PVP/VA E-635 is also found in the manufacture of coatings for electronic components, where it improves the uniformity of the coating and provides protection from environmental elements like dust and moisture.

Storage:
PVP/VA E-635 must be protected from heat and direct sunlight.
Even in closed containers PVP/VA E-635 can only be stored for a limited period because it tends to polymerize.
Stabilizers are therefore added. N,N'-Bis(1-methylpropyl)-1,4-benzenediamine [101-96-2] is an important, NVP-soluble stabilizer that does not interfere with further processing.

Use of this stabilizer allows the product to be stored for ca.
Stabilization with solid sodium hydroxide that can be easily filtered off is not as efficient.
Storage at temperatures close to the melting point results in separation of NVP from the stabilizer due to repeated solidification and melting.

This shortens the shelf life considerably and can lead to uncontrolled polymerization.
Solidified PVP/VA E-635 must therefore be molten carefully in a water bath (max. 40 ℃) or at room temperature (max. 30 ℃) and homogenized by continuous agitation.

Safety Profile:
Confirmed carcinogen moderately toxic by ingestion, inhalation, and skin contact.
A severe eye irritant probably irritating and narcotic in high concentrations.
Combustible when exposed to heat or flame; can react vigorously with oxibzing materials.

To fight fire, use alcohol foam, CO2, dry chemical when heated to decomposition it emits highly toxic fumes of NOx.
PVP/VA E-635 can cause skin irritation or sensitization, especially in individuals with sensitive skin.
Direct contact with the eyes may also cause mild irritation or discomfort, though it is generally considered non-toxic and non-irritating at typical concentrations used in consumer products.

Prolonged or excessive exposure to high concentrations of the copolymer could increase the likelihood of skin irritation or allergic reactions.
PVP/VA E-635 is typically used in solid or liquid forms, inhalation of dust or aerosolized particles, especially in industrial settings, may irritate the respiratory system.
Long-term exposure to inhaled particles can potentially lead to respiratory issues, including coughing, shortness of breath, or throat irritation.

This is more of a concern in manufacturing environments where powders or aerosols are produced during processing.
PVP/VA E-635, leading to reactions such as rashes, swelling, or more severe skin conditions.

These allergic reactions can occur when the compound is used in products that come into prolonged or repeated contact with the skin, such as cosmetics or personal care items.
If irritation or an allergic reaction occurs, it is important to discontinue use and seek medical attention if necessary.