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Quadrol, also known as Neutrol TE, is a tetrafunctional tertiary amine commonly used as a buffering agent, stabilizer, and emulsifier in various industrial and personal care applications.
Quadrol (Neutrol TE) is highly valued in formulations that require precise pH control, particularly in cosmetic, pharmaceutical, and cleaning applications.
Quadrol (Neutrol TE) is also used as a chelating agent, providing stability and enhancing performance in complex chemical formulations.
CAS Number: 102-60-3
EC Number: 203-041-4
Molecular Formula: C8H20N2O4
Molecular Weight: 208.26 g/mol
Synonyms: Quadrol, Neutrol TE, N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine, Tetrahydroxypropyl Ethylenediamine, THPED, Tetrakis(2-hydroxypropyl)ethylenediamine, 2,2',2'',2'''-(Ethane-1,2-diyldinitrilo)tetra(ethanol), Ethylenediamine Tetrakis(2-propanol), Quadrol Buffer, Polyol Quadrol, Neutrol TE Buffer, Tetrahydroxypropyl Ethylene Diamine, Ethylenediamine Tetrapropanol, Tetrahydroxypropyl Diamine, Tetrahydroxypropyl-ED, Quadrol Tetrahydroxypropyl, TEA-Quadrol, 2-Hydroxypropyl Ethylenediamine Derivative, Tetrafunctional Tertiary Amine, Ethylene Diamine Tetrapropylene Glycol, Emulsifier TE, 2-Hydroxypropyl Tetramine, Quadrol Emulsifying Agent
APPLICATIONS
Quadrol (Neutrol TE) is widely used in cosmetic formulations as a pH buffer and stabilizer, providing precise pH control to maintain product stability and efficacy.
Quadrol (Neutrol TE) is applied in skincare products like creams and lotions, where it helps balance pH levels and enhances the texture and feel of the formulation.
Quadrol (Neutrol TE) is a common ingredient in sunscreens and facial serums, where it provides stability to UV filters and active ingredients, extending shelf life.
Quadrol (Neutrol TE) is incorporated into hair care products, such as shampoos and conditioners, where it serves as a buffering agent and stabilizer, enhancing product consistency.
Quadrol (Neutrol TE) is used in personal care formulations as an emulsifier, ensuring stable emulsions in oil-in-water and water-in-oil formulations.
Quadrol (Neutrol TE) is essential in body washes and soaps, where it maintains pH balance and improves the skin-friendliness of cleansing agents.
Quadrol (Neutrol TE) is found in pharmaceutical formulations, where it stabilizes active ingredients and buffers solutions for optimal therapeutic performance.
Quadrol (Neutrol TE) is included in medical products, such as topical gels and ointments, where it provides pH control and enhances the solubility of active compounds.
Quadrol (Neutrol TE) is used in controlled-release drug formulations, where it ensures stable pH, aiding in the gradual release of active ingredients.
Quadrol (Neutrol TE) is utilized in industrial cleaners and detergents, where it acts as a chelating agent and stabilizer, enhancing cleaning efficacy on hard surfaces.
Quadrol (Neutrol TE) is incorporated into heavy-duty cleaning formulations for automotive and machinery maintenance, providing stability and compatibility with other ingredients.
Quadrol (Neutrol TE) is an ingredient in industrial water treatment processes, where it serves as a chelating agent to control hardness and maintain system integrity.
Quadrol (Neutrol TE) is applied in coating formulations, where it acts as a stabilizer and pH buffer, ensuring consistency and smooth application on various surfaces.
Quadrol (Neutrol TE) is used in agricultural formulations, where it stabilizes pH-sensitive ingredients in pesticides and herbicides, enhancing effectiveness and longevity.
Quadrol (Neutrol TE) is found in textile processing, where it improves dyeing uniformity and helps maintain fiber integrity in fabric treatments.
Quadrol (Neutrol TE) is an essential component in biochemical research, where it serves as a buffering agent in enzymatic reactions, stabilizing the pH of solutions.
Quadrol (Neutrol TE) is employed in protein purification and analysis, where it maintains a consistent environment, improving the accuracy of biochemical assays.
Quadrol (Neutrol TE) is used in electrophoresis and chromatography buffers, where it enhances resolution and provides pH stability in separation techniques.
DESCRIPTION
Quadrol (Neutrol TE) is a multifunctional tertiary amine, known for its buffering, chelating, and stabilizing properties in personal care, pharmaceutical, and industrial applications.
Quadrol (Neutrol TE) is particularly effective in pH-sensitive formulations, helping to maintain product integrity and efficacy across varying conditions.
In personal care applications, Quadrol (Neutrol TE) provides a stable, skin-compatible pH balance, enhancing the feel and performance of lotions, creams, and other skincare products.
Quadrol (Neutrol TE) is biodegradable and generally regarded as safe, making it suitable for use in products with environmental and health considerations.
The tetrafunctional structure of Quadrol (Neutrol TE) allows it to act as both a chelating and buffering agent, contributing to its versatility in complex formulations.
Quadrol (Neutrol TE) is stable over a wide temperature range, ensuring reliable performance in products exposed to high or fluctuating temperatures.
PROPERTIES
Chemical Formula: C8H20N2O4
Molecular Weight: 208.26 g/mol
Common Name: Quadrol (Neutrol TE)
Appearance: Clear to pale yellow liquid or solid (depending on temperature)
Density: Approx. 1.02 g/cm³
Boiling Point: 290°C
Melting Point: Approx. 60°C
Solubility: Highly soluble in water and polar solvents
Flash Point: 150°C
Reactivity: Stable under normal conditions; avoid strong oxidizing agents
Chemical Stability: Stable under recommended storage conditions
Storage Temperature: Store in a cool, dry place away from direct sunlight and moisture
Vapor Pressure: Low
FIRST AID
Inhalation:
If Quadrol (Neutrol TE) vapors or mists are inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.
Skin Contact:
Wash the affected area with soap and water.
If skin irritation or rash develops, seek medical attention.
Eye Contact:
In case of eye contact, flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.
Ingestion:
If Quadrol (Neutrol TE) is ingested, do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.
Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.
HANDLING AND STORAGE
Handling:
Personal Protection:
Wear appropriate personal protective equipment (PPE), such as gloves and safety goggles, when handling large quantities of Quadrol (Neutrol TE).
Use in a well-ventilated area to avoid inhalation of vapors or mists.
Ventilation:
Ensure adequate ventilation when handling Quadrol (Neutrol TE) to control airborne concentrations below occupational exposure limits.
Avoidance:
Avoid direct contact with eyes and prolonged skin contact.
Do not eat, drink, or smoke while handling Quadrol (Neutrol TE).
Wash hands thoroughly after handling.
Spill and Leak Procedures:
Contain spills to prevent further release and minimize exposure.
Absorb with inert material (e.g., sand, vermiculite) and collect for disposal.
Dispose of in accordance with local regulations.
Storage:
Store Quadrol (Neutrol TE) in a cool, dry, well-ventilated area away from incompatible materials such as strong oxidizers.
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and moisture.
Handling Cautions:
Avoid inhalation of vapors and direct contact with skin and eyes.
Use explosion-proof equipment in areas where vapors may be present.
