PRODUCTS

QUATERNIUM-15

CAS NO:4080-31-3
EC NO:223-805-0

Quaternium-15 (systematic name: hexamethylenetetramine chloroallyl chloride) is a quaternary ammonium salt used as a surfactant and preservative in many cosmetics and industrial substances.
Quaternium-15 acts as an antimicrobial agent because it acts as a formaldehyde releaser, though doing so can also cause contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin.

Quaternium-15 can be found under a variety of names, most commonly those of the Dow Chemical Company: Dowicil 200 (cis isomer only), Dowicil 75 and Dowicil 100 (both a mix of cis and trans isomers).

Synthesis
Quaternium-15 can be prepared by reacting hexamethylenetetramine with 1,3-dichloropropene to produce the product as a mixture of cis and trans isomers.

Applications
The isolated cis-compound is used primarily in cosmetic applications, with a maximum permitted concentration in the EU of 0.2%. The mixed product (cis- and trans-) is used in a wider range of formulations such as: emulsifiable metal-cutting fluids; latex and emulsion paints; liquid floor polishes and floor waxes; glues and adhesives.

What is quaternium-15 and where is it found?
Quaternium-15 is a formaldehyde-releasing preservative.
Quaternium-15 is used in many cosmetics and pharmaceutical preparations.
Quaternium-15 is also used as a preservative in many commercial and industrial products. The table below shows some of the products that may contain quaternium-15.

Cosmetics
Foundations, powders, concealers
Eye makeup (liners, shadows, mascara)
Facial makeup (blushes)
Bronzes
Makeup removers

Self-hygiene/pharmaceutical products
Foundations, powders, concealers
Eye makeup (liners, shadows, mascara)
Facial makeup (blushes)
Bronzes
Makeup removers
Shampoos
Soaps
Moisturizing lotions and creams
Shaving products
Body powders
Sunscreens
Cleansers and other skin care products
Disinfectants

Commercial/industrial products
Adhesives
Floor wax and polish
Paper and paperboard
Water-based inks
Latex paints
Industrial cutting fluid
Laundry starch
Joint cement
Printing pastes

Quaternium-15, a known skin toxicant and allergen, may be especially dangerous for hairdressers and janitors, who are sometimes exposed to this formaldehyde-releasing chemical at regular doses for long periods of time.

FOUND IN: Hair conditioners, hair styling products, creams, lotions, cleansers, shaving products, eye drops contact solutions and household cleaning products.

WHAT TO LOOK FOR ON THE LABEL: Benzalkonium chloride, benzethonium chloride, quaternium-15, centrimonium bromide, polyquaternium – followed by a number (i.e. polyquaternium-7).

WHAT IS POLYQUATERNIUM: Polyquaternium refers to any polymer that has been modified by a process called quaternization. This process results in changes to molecules that improve the performance of body care products. Polyquaternium may also be referred to as quaternary ammonium compounds (QACs) or simply quats.

Quaternium-15 is an odorless, colorless, water-soluble, antimicrobial agent that is active against bacteria more so than yeast and molds.

Quaternium-15 is a quaternary ammonium salt used as a surfactant and preservative in many products including cosmetics.
Quaternium-15 is an anti-microbial agent by virtue of being a formaldehyde releaser, however this can also cause contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin.
In 2005, Quaternium-15 was named in the top 15 most frequently positive allergens identified in patch tests by the North American Contact Dermatitis Group (NACDG). Sensitivity to Quaternium-15 may be identified with a clinical patch test.

Where is quaternium 15 found?
Quaternium-15 is commonly used in personal care products such as cosmetics, soaps, and shampoos.
Quaternium-15 also is found in industrial polishes, waxes, inks, paints, and metal working fluids.
Quaternium-15 belongs to a group of preservatives known as formaldehyde-releasing agents.

What are some products that may contain quaternium 15?
Baby Products
• Baby oil
• Baby shampoo
• Baby wash
• Bubble bath
• Cleansing pads
Body Washes
Cosmetics
• Blush
• Bronzer
• Eye shadow
• Foundation
• Loose powder
• Mascara
Industrial Uses
• Inks
• Metal work
• Paints
• Polishes
• Waxes
Pet Shampoos and Conditioners
Shampoos
Shaving Cream and Gels
Sunscreens

QUATERNIUM-15 is classified as :
Preservative

Application/Recommended for
Creams, lotions & gels
Decorative cosmetics/Make-up
Hair care (Shampoos, Conditioners & Styling)
Skin care (Facial care, Facial cleansing, Body care, Baby care)
Sun care (Sun protection, After-sun & Self-tanning)

WHERE IS QUATERNIUM-15 FOUND?
At work, you may find quaternium-15 or formaldehyde-releasing agents in:
• Urea-formaldehyde foam insulation
• Electrode attachment gels used in healthcare
• Embalming and preserving fluids
• Pressed wood such as particleboard, medium density fiberboard, plywood, and
oriented strandboard
• Urea-formaldehyde resins
• Metal-working fluids and coolants
• Glues, inks, toners and paints
• Cleaning products, waxes and polishes

Quaternium-15 is a commonly used in personal care products such as cosmetics, soaps and shampoos.
Quaternium-15 belongs to a group of preservatives known as formaldehydereleasing agents.

Quaternium-15 is a cream colored powder with a pungent odor.
Quaternium-15 is readily soluble in water and practically insoluble in mineral oil.
Quaternium-15 is included in cosmetic formulations as an antimicrobial
agent.
Quaternium-15 is used as a preservative in adhesives and food packaging
materials and is regulated by the FDA as an indirect food additive.
Quaternium-15 is also utilized as an antimicrobial agent in water-based metalworking fluids.

Quaternium-15 is a preservative found in many cosmetics and industrial substances that releases formaldehyde.
Quaternium-15 can be found in numerous sources, including but not limited to: mascara, eyeliner, moisturizer, lotion, shampoo, conditioner, nail polish, personal lubricants, soaps, body wash, baby lotion or shampoo, facial cleanser, tanning oil, self-tanning cream, sunscreen, powder, shaving products, ointments, personal wipes or cleansers, wipes, paper, inks, paints, polishes, waxes and industrial lubricants.
Quaternium-15 can cause contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin, on an infant's skin, or on sensitive areas such as the genitals.

Quaternium-15s chemical formula is C9H16Cl2N4.
Quaternium-15 can be found under a variety of names, including: Dowicil 75; Dowicil 100; Dowco 184; Dowicide Q; 1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride; N-(3-chloroallyl) hexaminium chloride; hexamethylenetetramine chloroallyl chloride; 3,5,7-Triaza-1-azoniaadamantane; 1-(3-chloroallyl)-chloride.

Quaternium-15s CAS number is [4080-31-3] and its SMILES structure is ClC=C/C[N+]23CN1CN(C3)CN(C2)C1.[Cl-].

Quaternium-15 doesn't occur naturally in the environment.
Quaternium-15 may be used in some self-care products (cosmetics, natural health products, over-the-counter drugs), cleaning products, paints and coatings.
Quaternium-15 's also used in the automotive, aircraft and transportation industry.

Quaternium-15 can be found in products, such as:

self-care products:
shampoo
sunscreen lotion
body moisturizers
hair styling products
cleaning products:
stain remover
bleach cleaners
toilet bowl cleaners
furniture and vehicle cleaning wipes
paints and coatings
pest control products
Quaternium-15 may also be used in some materials used to package foods.

Quaternium-15 is a formaldehyde releasing preservative used in personal care products usually cosmetics.
Quaternium-15 is also used as a biocide in household and industrial products.

Quaternium-15 is found in many cosmetics, shampoos and skin care products, as well as in household and industrial products. Examples of cosmetic products and toiletries are lotions, creams, moisturizers, emollients, foundations, powders, concealers, bronzers, self-tanners, makeup removers, blushes, eye shadows, eyeliners, eyebrow makeup and mascaras and sunscreens as well as shampoos, soaps etc. Adhesives, paper, paperboard, inks, polishes and latex paints may contain Quaternium-15. Industrial cutting fluid may contain Quaternium-15 as a preservative.

Formaldehyde-releasing preservative used in cosmetics.
Quaternium-15 can aggravate skin, as can all preservatives, although quaternium-15’s ability to do so is very low if the amount in a product is less than 0.2%.

Quaternium-15 is a quaternary ammonium salt used as a surfactant and preservative in many products including cosmetics.

Its functions (INCI)
Antimicrobial: Helps slow the growth of microorganisms on the skin and opposes the growth of microbes
Preservative: Inhibits the development of microorganisms in cosmetic products.

Quaternium-15 is a broad-spectrum preservative found in many cosmetics and personal care products.
Quaternium-15 is one of the formaldehyde-releasing preservatives that include imidazolidinyl urea, diazolidinyl urea, 2-bromo-2-nitropropane-l,3-diol, DMDM (dimethylolmethyl)hydantoin, and tris (hydroxymethyl) nitromethane. Although quaternium-l 5 does release small amounts of formaldehyde, not all patients who are allergic to quaternium-15 are allergic to formaldehyde and vice versa.

Uses
Adhesives
Construction materials
Cosmetics ‹(creams, lotions, shampoos, soaps, etc.)
Inks
Jointing cements
Latex paints
Metal working fluids
Over-the-counter topical medicaments
Paper or paperboard
Polishes

Quaternium-15 is being reviewed for use as a biocide in the EEA and/or Switzerland, for: product preservation, controlling slimes, preservation for working / cutting fluids.

Definition
ChEBI: A quaternary ammonium salt derived from hexamethylenetetramine; used as a preservative in many cosmetics and industrial substances. Also acts as a disinfectant and allergenic agent.

General Description
Cream-colored powder.

Air & Water Reactions
Dust may form an explosive mixture in air. Water soluble.

Reactivity Profile
1-(3-CHLOROALLYL)-3,5,7-TRIAZA-1-AZONIAADAMANTANE CHLORIDE is basic. May react with strong reducing agents to give flammable gases. Possible vigorous combination with strong oxidizing agents.

Quaternium-15 is a preservative used in cosmetics and in many industrial applications including latex paints, polishes and waxes, metalworking fluids, adhesives, paper, inks, etc. [Marks, 121-2] Dowicil 75 is one of the biocides commonly used in metalworking fluids. [Occupational Exposure to Metalworking Fluids. DHHS (NIOSH) Publication No. 98-102, 1998, Table 4-1] Used as a formaldehyde releaser in cleaning agents, paints, soaps, metalworking fluids, polishes, paper products, textile finishes, joint cements, and photocopier toner; [Kanerva, p. 405]

What is Quaternium-15?
Quaternium-15 is a quaternary ammonium salt prepared by reaction of hexamethylenetetramine and 1,3-dichloropropene.
Quaternium-15 is a cream-colored powder with a pungent odor. In addition to its use in cosmetic products, it is also used in the formulation of metal cutting fluids, paints, adhesives, and glues.

Use & Benefits:
Quaternium-15 is used in a wide variety of cosmetic products as a surfactant and preservative. As a surfactant, it lowers the surface tension between two components of the product like two liquids or a liquid and a solid. Lower the surface tension, better mixing capability of that particular ingredient.
Quaternium-15 contains a water-loving end and fat-loving core in a single molecule.
Quaternium-15 attracts dirt, oil, and other impurities accumulated on the surface of the skin with an oil-loving end which then can be washed off easily with water via a water-loving end.
Quaternium-15 also possesses anti-microbial properties.
Quaternium-15 kills the microorganism and stops them from coming back by stopping reproduction.
Quaternium-15 inhibits the growth of molds and fungus in cosmetic products.
Quaternium-15 is also used as an anti-static agent.
Quaternium-15 prevents the build of static charge in the product because of its special chemical structure.
Quaternium-15 is used in formulations of creams, lotions, gels, make-up products, shampoos, baby products, and other skin and hair care products.

Quaternium-15 is a preservative found in a variety of cosmetics, topical pharmaceutical preparations, and industrial substances. As a preservative, it has activity against bacteria, fungi, and molds.

Quaternium-15 is most frequently found in hair-care products such as conditioners, rinses, and shampoos as well as several popular moisturizing lotions and a number of cosmetic products.

Quaternium-15 is commonly used in personal care products such as cosmetics, soaps, and shampoos.
Quaternium-15 also is found in industrial polishes, waxes, inks, paints, and metal working fluids.
Quaternium-15 belongs to a group of preservatives known as formaldehyde-releasing agents.

Quaternium-15 uses and applications include: Antimicrobial, preservative in adhesives, latex emulsions, paints, cutting fluids, topical pharmaceuticals; preservative in cosmetics, food packaging adhesives, food-contact PU resins; preservative for pigment slurries and latexes used as pigment binders in food-contact paperpaperboard

CLASS
Specialty Chemicals

FUNCTIONS
Antimicrobial, Resins, Preservative

INDUSTRY
Cosmetic, Pharmaceutical, Adhesives

Quaternium-15 is a quaternary ammonium salt used as a preservative in many cosmetics and industrial substances.
Quaternium-15 acts as a formaldehyde releaser.
Quaternium-15 can cause contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin, on an infant's skin, or on sensitive areas such as the genitals.

HOW IS IT USED?
Cosmetics; used as an antimicrobial preservative in cosmetic, soaps and shampoos. International restrictions 0.1 to 1% - other use; surfactant, hair conditioning, adhesives, binding, lacquers and varnishes.

Commerical use; cutting fluids, lubricants, hydraulic fluids, additives, cleaning, pesticides, bacteriasides, food additives, paper, pharmaceuticals (antiarrhythmic and anticonvulsant agents).

Quaternium-15 is a quaternary ammonium salt derived from hexamethylenetetramine; used as a preservative in many cosmetics and industrial substances. Also acts as a disinfectant and allergenic agent.
Quaternium-15 has a role as a disinfectant, an antibacterial agent, a hapten and an allergen.
Quaternium-15 is a quaternary ammonium salt and an organochlorine compound.
Quaternium-15 derives from a hexamethylenetetramine.
Quaternium-15 is an antimicrobial agent used in cosmetics as a cosmetic preservative and antistatic agent.

Uses:
Formaldehyde-releasing preservative in hand creams, lotions, face creams, shampoos, latex paints, topical medicaments, polishes, metal working fluids, adhesives, inks, etc

Quaternium-15 is used as a preservative and antistatic agent in cosmetics.
Quaternium-15 can be found in a wide variety of products, including eye shadows, foundations, facial powders, body washes, mascaras, shampoos, conditioner, hair colors, facial cleansers, bronzers and nail treatments.

Quaternium-15 is a quaternary ammonium salt used as a preservative in many cosmetics and industrial substances.
Quaternium-15 acts as a formaldehyde releaser.
Quaternium-15 can cause contact dermatitis in sensitive individuals.
Quaternium-15's toxicity is also due to it's ability to react and release formaldehyde and nitrosamines, both of which are believed to be carcinogenic.
Quanternium-15 is a type of preservative which is widely used in many cosmetic and industrial products.

IUPAC names
1-(3-chloroprop-2-en-1-yl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.1~3,7~]decane chloride
3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane,1-(3-chloro-2-propenyl)-, chloride
3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane,1-(3-chloro-2-propenyl)-, chloride (9CI)
3,5,7-TRIAZA-1-AZONIATRICYCLODECANE-1-(3-CHLORO-2-PROPENYL)-,CHLORIDE
CHLOROALLYLTRIAZAAZONIAADAMANTANE CHLORIDE
Methenamine 3-chloroallylochloride
methenamine 3-chloroallylochloride

SYNONYMS:
1-(3-Chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane Chloride
1-[(2E)-3-Chlor-2-propen-1-yl]-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decanchlorid [German] [ACD/IUPAC Name]
1-[(2E)-3-Chloro-2-propen-1-yl]-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane chloride [ACD/IUPAC Name]
1-[(2E)-3-Chloroprop-2-en-1-yl]-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane chloride
1-[(2E)-3-chloroprop-2-en-1-yl]-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane chloride
2W5B4VJ152
3,5,7-Triaza-1-azoniaadamantane, 1- (3-chloroallyl)-, chloride
3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane, 1-[(2E)-3-chloro-2-propen-1-yl]-, chloride (1:1) [ACD/Index Name]
3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane, 1-[(2E)-3-chloro-2-propenyl]-, chloride
3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane, 1-(3-chloro-2-propenyl)-, chloride
4080-31-3 [RN]
Chlorure de 1-[(2E)-3-chloro-2-propén-1-yl]-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]décane [French] [ACD/IUPAC Name]
Dowicil75
Quaternium-15 [Wiki]
QUATERNIUM-15 TRANS-FORM
1-((Z)-3-Chloroallyl)-1,3,5,7-tetraazaadamantan-1-ium chloride
1-(3-Chloroallyl)-1,3,5,7-tetraazaadamantan-1-ium chloride
1-(3-CHLOROALLYL)-3,5,7-TRIAZA-1-AZONIAADAMANTANECHLORIDE
1-(3-Chloroallyl)-3,5,7-triazo-1-azoniaadamantane chloride
3,5,7-Triaza-1-azoniaadamantane, 1-(3-chloroallyl)-, chloride
3,5,7-Triaza-1-azoniatricyclo(3.3.1.13,7)decane, 1-(3-chloro-2-propenyl)-, chloride
51229-78-8 [RN]