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RETINYL RETINOATE

RETINYL RETINOATE
(retinoic acid = retinyl ester)
CAS: 15498-86-9
Molecular Formula: C₄₀H₅₆O₂


Retinyl Retinoate is basically a Retinol molecule linked to a Retinoic Acid molecule. 
Retinyl Retinoate is a retinoic acid ester.
Retinyl Retinoate (RR) is a less well known but super interesting member of the retinoids (vitamin A derivatives), aka the "royal family of skincare".  
Retinoids affect almost every aspect of how skin functions
Retinoic acid is highly effective against photo aging.
Retinyl retinoate is a derivative of retinoic acid, falling under the entry for "Tretinoin or its salts or derivatives" of the Prescription Drug List.


Retinyl retinoate has been shown, in limited but promising research (most coming from the same team of Korea-based researchers), to be less sensitizing than retinoic acid (prescription-strength) and cosmetic retinol. 
Retinyl retinoate may be less sensitizing than pure retinol because of its slower conversion in skin to retinoic acid. 
Retinyl retinoate is a skin-restoring A-vitamin derivative.
Retinyl retinoate was found to be a new novel hybrid vitamin derivative – retinyl retinoate, which had a higher improvement of fine wrinkles, excellent stability.
Retinyl retinoate is a hybrid molecule made by fusing Retinoic Acid (eg. Retin-A, Tretinoin etc.) with Retinol. 
Retinyl retinoate exhibits properties of both Retinoic Acid and Retinol. 
 

Retinyl is a retinoid molecule that has a retinol part attached to a retinoic acid part. 
Retinyl retinoate is a synthetic molecule meaning that it has been not (at least yet) found in nature. 
Retinyl retinoate is more stable than retinol.


There are first in-vivo studies (done with human volunteers) that suggest that retinyl retinoate can be more effective than retinol in reducing wrinkles. 
Retinyl retinoate is also most likely as effective as retinol in reducing acne, clogged pores, and evening out the skin tone. 
Retinol is one specific type of retinoid—the most common and proven retinoid sold over-the-counter. 
Dermatologists often refer to retinol as the "gold standard" anti-aging ingredient because it is widely available and has decades of research demonstrating its effectiveness.
Retinyl retinoate is a member of a new generation of well-tolerated synthetic retinoids used as a topical retinoid treatment. 


Retinyl retinoate is a hybrid vitamin A compound made with a condensing reaction of retinol and retinoic acid.
This new form of vitamin A, listed in the same class as other natural non aromatic retinoids, is a cosmetic ingredient freely available without a prescription.
Retinoic acid (tretenoin), also known as vitamin A acid, is a medicine for acne, also used by many as the ultimate wrinkle buster. 
Retinyl retinoate is an extremely effective skin-restoring molecule.
Retinyl retinoate is a molecule that is produced by chemically joining the molecules of retinoic acid and retinol in the body. 


Just one metabolic step is required to split retinyl retinoate back into retinoic acid and retinol, at which point retinoic acid is immediately active, whereas retinol can be converted to additional retinoic acid later on. 
Biological activity of retinyl retinoate in the skin is reportedly higher than that of retinol (and possibly even retinaldehyde) and may be approaching that of retinoic acid itself
Retinyl retinoate is reported to be more resistant to inactivation by sunlight than retinol and most other forms of vitamin A.
Retinyl retinoate is the gold standard of anti-ageing and works in a number of ways. 


Retinyl retinoate blocks the production of collagen-degrading enzymes, meaning collagen does not get broken down as quickly in the skin. After prolonged use
Retinyl retinoate has also been shown to stimulate the production of type I and type III collagen, reducing wrinkles and improving skin firmness. 
Retinyl retinoate has been shown to protect against UV-induced damage, as well as reducing the appearance of hyperpigmentation in the skin. 
Retinyl Retinoate increases collagen and cell turnover to resurface the skin and improve elasticity
Retinyl Retinoate is photostable, it’s possible to apply the cream during the day without the Vitamin A breaking down when exposed to sunlight.
Retinol retinoate is more stable than retinol.


Retinyl retinoate is a hybrid of traditional retinol and clinical strength retinoic acid.
Retinyl retinoate has been proven to be photostable, meaning it doesn’t break down in sunlight like traditional forms of vitamin A.
Retinol retinoate is more effective at stimulating hyaluronan production than both retinol and retinoic acid. 
Retinyl retinoate is a hybrid molecule made by linking retinol with retinoic acid. 
Retinyl retinoate increases collagen, cell turnover and decreases the enzyme that breaks down collagen. 
Retinyl retinoate increases skin smoothness with visibly reduced fine lines and wrinkles, improved tone, texture and brightness. 
Pigmentation is reduced and the overall skin surface uniformity is restored with the help of retinyl retinoate. 


Retinyl retinoate 8 x stronger than Retinol ( vitamin A ). 
Retinyl retinoate is a hybrid of traditional retinol and clinical strength retinoic acid. 
Retinyl retinoate is able to act directly on the skin without breaking down into parts, the molecule helps to stimulate cellular regeneration and supports collagen synthesis. 
Retinyl retinoate is 8 times more powerful than retinol, 
Retinyl retinoate visibly reduces fine lines and wrinkles, evens skin tone and smoothes skin’s texture for a more youthful-looking complexion.


Retinyl retinoate is an advanced and encapsulated form of r-retinoate which goes to work directly on the nucleus of skin cells 
Retinyl retinoate works faster than retinol 
retinyl retinoate, a pioneering derivative of vitamin A.
Retinyl retinoate: a retinoid alternative for sensitive skin.
Retinyl retionate is a hybrid molecule composed of the fusion of retinoic acid (eg Retin-A, tretinoin etc.) with retinol.

Retinyl retinoate is a new retinoid precursor and derivative of vitamin A that combines high effectiveness, and good stability (compared to other derivatives of vitamin A and retinoids).
Retinyl retinoate is a molecule that is produced by chemically joining the molecules of retinoic acid and retinol. 
The biological activity of retinol retinoate in the skin is supposedly higher than that of retinol (and possibly even retinaldehyde) and may be approaching that of retinoic acid itself.

Retinyl retinoate is more powerful than Retinol, 8 times greater collagen stimulation and therefore “plumps” our skin fighting against wrinkles.
Retinyl retinoate can visibly reduce pigmentation
Retinyl retinoate works quickly - many users have seen results in as little as 6 weeks.

Retinyl retinoate works as an antioxidant and prevents the formation of free radicals.
Retinyl retinoate intervenes in the production of melanin and regulates it, thus reducing skin sun spots.
Retinyl retinoate accelerates the rate of cell renewal. 
Retinyl retinoate promotes the regeneration of the skin, causes a "peeling" effect that makes its upper layers, more damaged, come off more easily and are replaced by newer ones.

The inventors developed a retinyl retinoate by condensing Vitamin A (retinol) and retinoic acid, each of which has a good effect for anti-wrinkles by itself, and then completed the present invention. 
Retinyl retinoate is developed in the present invention has been identified to have better chemical stability, and higher skin regeneration activity than the previous retinol or retinoic acid.

PHYSICAL AND CHEMICAL PROPERTIES
Chemical Name: Retinyl Retinoate
Synonyms: Retinoic Acid Retin-15-yl Ester; Retinoic Acid Ester with Retinol
CAS Number: 15498-86-9
Molecular Formula: C₄₀H₅₆O₂
Appearance: Light Yellow to Yellow Oil to Waxy Solid
Molecular Weight: 568.89
Storage: Amber Vial, -20°C Freezer, Under Inert Atmosphere
Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly), Water (insoluble)
Stability: Photstable
Physical State :Low-Melting Solid
Storage :Store at -20° C Store the products in a dark, cool and dry place.
Appearance:Yellow powder or crystal
Mol.F: 15498-86-9

APPLICATIONS AND USES
Retinyl Retinoate is used in the treatment of skin diseases and disorders such as acne, psoriasis and photoaging.
Retinyl retinoate visibly reduces fine lines and wrinkles, evens skin tone and smoothes rough skin for a more youthful-looking complexion.
Retinyl retinoate had characteristic features of new anti-aging agents, and effectively improved facial wrinkle conditions.
Retinyl retinoate is an especially practicable choice for skin care formulations.


Skin replica analysis indicated significant improvements in retinyl retinoate-treated skin in a study.
Retinyl Retinoate has better anti-aging activity than retinol. 
Retinyl Retinoate is often touted to be 8 times as active as retinol,
Biological activity of retinyl retinoate was in between the properties of retinol and retinoic acid. 
Retinyl retinoate showed higher biological activity than that of retinol, such as RAR activity and collagen synthesis. 
Retinyl Retinoate  has a faster-acting effect. 


Retinyl Retinoate increases the Hyaluronic acid production more than other retinoids 
Retinyl Retinoate shows promise for treating acne.
Retinyl Retinoate is used in the treatment of skin diseases and disorders such as acne, psoriasis and photoaging.
Retinyl retinoate is used for acne vulgaris therapy, 
Retinyl retinoate was measured in anti-bacterial efficacy 
Retinyl retinoate showed a significant decrease in both inflammatory and non-inflammatory lesions


The application of retinyl retinoate is effective and has no local side effects for acne lesions. 
Retinyl retinoate had somewhat anti-bacterial activity against Propionibacterium acnes (P. acnes). 
Retinyl retinoate can be used as treatment for mild acne or could potentiate the efficiency of an additive anti-acne agent. 
Retinyl retinoate is possible to be suggested as a topical anti-acne treatment with excellent tolerance. 
Retinyl Retinoate promotes the renewal speed of the skin surface, making the skin surface more compact.


Retinyl Retinoate promotes the dermis to accelerate the production of collagen and inhibit the destruction of collagen.
Retinyl Retinoate increases the content of mucopolysaccharides (such as hyaluronic acid, etc.) in the epidermis to make the skin stronger in water retention.
Retinyl Retinoate promotes the metabolism of the stratum corneum, make the stratum corneum firmer and restore the barrier function.
Retinyl Retinoate is used in anti-aging products.
Retinyl Retinoate maintains the collagen in the dermis and prevents the collagen from degrading too fast. 
Retinyl Retinoate is compounded with hyaluronic acid and bio-complex polysaccharide (hydrolyzed myrtle), and the improvement of fine lines can be observed within a week.


Retinyl Retinoate is used in whitening products
Retinyl Retinoate cooperates with VC to inhibit tyrosinase, promote metabolism, and accelerate the disappearance of melanin. 
Retinyl Retinoate is used in sunscreen products
Retinyl Retinoate inhibits the enhancement of MMP activity caused by ultraviolet rays, protects elastin and dermal collagen, and improves wrinkles and fine lines caused by UV irradiation.
Retinyl Retinoate is used in repair products
Retinyl Retinoate promotes the synthesis of hyaluronic acid in the body, reduces the TEWL of the skin, promotes the activity of keratinocytes, increases the thickness of the epidermis, and makes the epidermis stronger.
Retinyl retinoate was found to be a safe cosmetic product that did not lead to allergic or irritant contact dermatitis. 


Retinyl retinoate, which was synthesized via a condensation reaction between retinol (hydroxyl end group) and retinoic acid (carboxyl end group), removed the disadvantage of retinol and retinoic acid for application in the cosmetics industry 
Retinyl retinoate is used as an additive for cosmetics in the prevention and improvement of skin aging and medicines for the treatment of skin problems.
Retinyl retinoate improves the photo-stability, and the in vitro biological activity of the hybrid was analyzed
Retinyl retinoate  has higher inhibitory activity against c-Jun than retinol and showed superior effects on collagen synthesis compared to retinol. 
Retinyl retinoate is used as an additive in cosmetics for prevention and improvement of skin aging and medicines for the treatment of skin troubles due to its excellent stability under severe and accelerated conditions.
Retinyl retinoate dramatically fades lines and wrinkles, while infusing under-eyes with vitality and radiance.
 
Retinyl retinoate is more powerful and it is more photostable than Retinol so it can be used day and night (always still use Sunscreen). 
Retinyl retinoate can visibly reduce pigmentation, it works fast - significant results for most users in as little as 6 weeks.
Retinyl Retinoate needs to be converted into retinoic acid in the body when used. Retinyl Retinoate is more effective at treating periorbital wrinkles.
When Retinyl Retinoate is absorbed into the skin, it is broken down into Retinoic Acid that delivers an immediate effect and into Retinol, which is slowly converted into Retinoic Acid and starts to work later.

Retinoic Acid converts to retinoic acid (active vitamin A) and retinol in one step (and then the retinol further converts later on).
Retinoic Acid clears acne by fighting bacteria and reducing sebum production.
The encapsulation technology along with Vitamin C and Vitamin E makes Retinyl retinoate a powerful age-defying product.
Retinoic Acid will reduce the appearance of fine lines, improve skin tone and firm the skin.


PRODUCTION
Retinyl Retinoate is produced in a Korean lab and frozen at -20 °C before travelling to the UK via cryogenic air freight.

Retinyl Retinoate is a molecule that is created by attaching retinol to retinoic acid. 
The attachment of retinol to retinoic acid makesRetinyl Retinoate more stable (pure retinol is unstable and hard to formulate) as well as more active. 


SYNONYMS
Retinoic acid
3,4-didehydroretinol
 

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