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Active Ingredient: 2-methyl-4-isothiazolin-3-one
CAS Registry Number: 2682-20-4
EINCS Number: 2202396
MDL Number: MFCD01742315
APPLICATIONS
ROCIMA 550 is an aqueous-based microbicide which delivers superior performance as a preservative in a variety of industrial applications.
We recommend use of ROCIMA 550 in the following situations:
- As a stand-alone biocide for preservation of aqueous formulations.
- As a co-biocide used in conjunction with some chemicals for preservation of aqueous formulations.
ROCIMA 550 Provides broad spectrum efficacy.
Moreover, ROCIMA 550 exhibits chemical stability in high pH systems.
ROCIMA 550 is recommended for paints, coatings, latex and mineral slurries.
ROCIMA 550 is a isothiazolinone based biocide and preservative used in personal care products.
Also, ROCIMA 550 is used for controlling microbial growth in water-c ontaining solution.
ROCIMA 550 is a potent biocide useful for controlling microbial growth.
ROCIMA 550 (also called 2-methyl-4-isothiazolin-3-one), is a powerful synthetic biocide and preservative within the group of isothiazolinones.
ROCIMA 550 is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, industrial process waters, and air washer systems.
And ROCIMA 550 is incorporated into adhesives, coatings, fuels, metal working fluids, resin emulsions, paints, and various other specialty industrial products as a preservative.
Also ROCIMA 550 is used to control the growth of mold, mildew, and sapstain on wood products.
ROCIMA 550 is generally recommended for use only in rinse-off and leave-on cosmetic products (maximum concentration of 100 ppm) as preservative such as shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps, and detergents.
ROCIMA 550 is a preservative used in cosmetics and beauty products.
ROCIMA 550 is a powerful biocide, or “chemical substance capable of killing living organisms, usually in a selective way.”
Biocides are a general term that includes antimicrobial, germicide, antibiotic, and antifungal.
Ultimately, ROCIMA 550 is used to prevent a wide variety of bacteria and fungi from growing in cosmetics and beauty products, most often in shampoo.
ROCIMA 550 is only approved for use in rinse-off formulas and at low concentrations.
ROCIMA 550 is used in the following products: cosmetics and personal care products, fertilisers, plant protection products and perfumes and fragrances.
Other release to the environment of ROCIMA 550 is likely to occur from: outdoor use as processing aid and indoor use as processing aid.
DESCRIPTION
ROCIMA 550 is approved for use as a biocide in the EEA and/or Switzerland, for: preservation for liquid systems, controlling slimes, preservation for working / cutting fluids.
ROCIMA 550 is being reviewed for use as a biocide in the EEA and/or Switzerland, for: product preservation.
Product Features and Performance Benefits
- Chemically Stable in High pH Systems,
ROCIMA 550 provides an excellent alternative to Benzisothiazolone (BIT).
- Physically Compatible with Polymer Emulsions,
ROCIMA 550 has no negative influence on physical/chemical performance parameters on the finished products.
- Broad Spectrum Efficacy,
ROCIMA 550 is efficacious against gram positive and gram negative bacteria, mold and yeast.
- Free from Volatiles,
ROCIMA 550 is a straight aqueous solution of the active ingredient and does not contribute to VOC.
- Free from Formaldehyde,
ROCIMA 550 does not contain or release formaldehyde.
- Free from Metal Salts,
ROCIMA 550 will not form coagulum (even after undiluted addition).
- Fully Water Soluble,
ROCIMA 550 stays in the aqueous phase, where biological control is needed, resulting in minimal partitioning into the organic phase and improved bio-availability.
- Environmentally Safe,
ROCIMA 550 contains no active halogens, does not contribute to AOX, is biodegradable below microbicidal threshold concentrations, and its metabolites have been identified and are not regarded as ecologically significant.
- Cost Effective,
ROCIMA 550 is effective at low use levels, resulting in a low treatment cost.
Typical Properties of ROCIMA 550
These properties are typical but do not constitute specifications.
Appearance: Colorless to pale yellow liquid
Odor: Mild
pH, as is: 3 to 6
Specific Gravity, at 25°C: 1.02
Vapor pressure: 0.062 torr
Flash Point: N.A.
Solubility in water: infinite
Solubility in organic solvents: Miscible in a wide range of water
Stability: Stable as supplied for at least one year at typical ambient temp. (20°C); 6 months @ 50°C
Efficacy
Minimum Inhibitory Concentration (MIC)
The minimum concentrations is given below in parts per million (ppm) of ROCIMA 550 active ingredient, which inhibit the growth of various microorganisms under laboratory conditions in nutrient rich growth media.
These data demonstrate the broad spectrum antimicrobial activity of ROCIMA 550.
It should be noted that the MIC concentration will vary according to the growth media used and the test conditions.
Escherichia coli: 31 ppm
Pseudomonas aeruginosa: 15 ppm
Pseudomonas fluorescens: 31 ppm
Pseudomonas putida: 13 ppm
Desulfovibrio desulfuricans: 16 ppm
Enterobacter cloaca: 25 ppm
Citrobacter freundii: 25 ppm
Fusarium solani: 13 ppm
Acremonium strictum: 16 ppm
Directions for Use
Plant processing conditions vary widely in both technology and chemistry types.
This makes it difficult to predict accurately the stability and, therefore, the efficacy of a biocide.
It is therefore recommended that stability and efficacy testing be carried out to optimize ROCIMA 550 dosing.
Typical use concentrations for ROCIMA 550 are in the range of 50 - 150 ppm active ingredient.
This is equivalent to a dosage rate of 0.5 - 1.5 kg of ROCIMA 550 as supplied per tonne of product to be preserved (0.5 - 1.5 lb. of ROCIMA 550 as supplied per 1000 lb. of product to be preserved).
NOTE: No preservative can make up for lack of manufacturing hygiene.
All recommendations on active ingredient use level are based on the assumption that ROCIMA 550 is introduced into a microbiologically clean product.
Generally good manufacturing practices should be applied and equipment, pipes and storage tanks should be sanitized regularly.
Safe Handling Information
NOTE: Always Wear Protective Equipment When Handling Concentrated Biocide Like other industrial biocides, ROCIMA 550 must be handled using proper safety procedures.
As supplied, the product is corrosive to skin/eyes and is a potential sensitizer.
Users should avoid any direct contact with ROCIMA 550 as supplied.
The Material Safety Data Sheet (MSDS) and the product label for ROCIMA 550 contain specific recommendations for safe handling of the product.
Additional safe handling training materials are available.
The use of engineering controls (for example, a closed dosing system) can help minimize the chance of worker exposure to chemicals.
If you need engineering advice regarding handling equipment for ROCIMA 550.
After the shipping containers of ROCIMA 550 have been emptied, they may still contain considerable amounts of concentrated preservative.
To minimize the effect of accidental exposure, the containers should be rinsed at least three times with water before they are discarded.
The best way to handle the rinse water (and the biocide it contains) is to charge it to the product to be preserved; otherwise, the rinse liquids and empty containers should be disposed of as specified by local regulations.
It is recommended that any unused amounts of the preservative be deactivated prior to disposal.
Spill Cleanup Procedures
NOTE: Always Wear Protective Equipment When Handling Concentrated Biocide
Spills should be absorbed with spill pillows or spongy inert solid materials such as vermiculite; the contaminated absorbent should then be transferred to closed containers and disposed of in accordance with local regulations.
After the supernatant biocide has been removed by absorption, the affected spill area should then be chemically decontaminated.
In such cases, an aqueous solution of 5% sodium bicarbonate and 5% sodium hypochlorite should be applied to the site of the spill to deactivate the remaining ROCIMA 550.
The general rule is to apply 10 times the volume of deactivating solution for each estimated volume of residual ROCIMA 550.
After the deactivating solution has been applied, it should be allowed to stand for 30 minutes.
The spill site should then be flushed with copious amounts of water.
The aqueous residue from this flushing process should then be drained into a chemical sewer (provided that local and national regulations permit this).
Plant Hygiene
Effective preservation of aqueous products can only be achieved through a combination of
1. Use of an effective microbicide, and
2. Good manufacturing practices.
Biocide addition should not be used to replace good plant hygiene; it is complementary to good manufacturing practice, not a substitute for it.
Some of the key aspects of preventing microbial contamination are given below.
- Raw Materials
-confirm whether they are susceptible to microbial contamination
-regularly monitor their microbiological quality
-set a microbiological specification for them
- Process Water
-monitor the microbial contamination level
-regularly clean and sanitize water treatment units
-treat stored water prior to use
- Storage and Handling
-flush and drain lines when not in use
-clean and sanitize lines and equipment regularly
-try to minimize non-draining areas
-avoid entry of ambient air into storage tanks
-minimize tank headspace and/or provide microbe free headspace
- Cleaning and Sanitization
-establish protocols for cleaning and sanitizing of tanks and equipment
Toxicology
ROCIMA 550 is considered safe at recommended use levels. Based on assessment of extensive toxicological data,
experts conclude that the active ingredient in ROCIMA 550 is:
- non-genotoxic
- not carcinogenic
- not teratogenic
- non-sensitizing at use levels
Like other biocides, ROCIMA 550 must be handled properly.
The product, as supplied, is corrosive to the skin/eyes and is a potential sensitizer.
Please refer to the Material Safety Data Sheet for details on proper handling procedures.
Environmental Fate
There is no shortcut to environmental safety:
The studies demonstrate that, at normal use/dilution levels, ROCIMA 550 has minimal environmental impact because of the following properties:
- ROCIMA 550 is used at very low dose levels
- Rapid degradation to non-toxic, non-persistent substances
- Degradation does not produce chlorine or chlorinated organics
- ROCIMA 550 is unlikely to adversely affect legally accepted routine disposal procedures of equipment rinses (white water) or the aqueous phases after splitting of the emulsion, respectively.
This combination of properties makes ROCIMA 550 an environmentally sound choice for a preservative.
SYNONYMS
1-(4-CHLOROPHENYL)-3-(3,4-DICHLOROPHENYL)UREA
2-METHYL-3(2H)-ISOTHIAZOLONE
2-METHYL-4-ISOTHIAZOLIN-3-ONE
2-METHYL-4-ISOTHIAZOLINE-3-ONE
3,4,4 TRICHLOROCARBANILIDE
3,4,4'-TRICHLOROCARBANILIDE
3,4,4'-TRICHLORODIPHENYLUREA
CUTISAN
N-(3,4-DICHLOROPHENYL)-N'-(4-CHLOROPHENYL)UREA
N-(4-CHLOROPHENYL)-N-(3,4-DICHLOROPHENYL)-UREA
N-METHYL-3-OXODIHYDRO ISOTHIAZOLE
TCC
TRICHLOROCARBANILIDE
TRICLOCARBAN
2-methyl-3(2h)-isothiazolon
Isothiazolone,2-methyl-
Methylisothiazolinone
Skycide 100
2-methyl-2H-isothiazol-3-one
2-Methylisothiazolin-3-one
2-Methyl-4-isothiazolin-3-one
2682-20-4
Methylisothiazolinone
2-methylisothiazol-3(2h)-one
2-Methyl-4-isothiazoline-3-one
2-Methyl-3(2H)-isothiazolone
3(2H)-Isothiazolone, 2-methyl-
2-methyl-1,2-thiazol-3-one
N-Methyl-3-oxodihydroisothiazole
2-methyl-3-isothiazolone
2-methyl-1,2-thiazol-3(2H)-one
UNII-229D0E1QFA
229D0E1QFA
CHEBI:53620
n-methylisothiazolin-3-one
2682-20-4 (free base)
Neolone
Caswell No. 572A
2-METHYL-2H-ISOTHIAZOL-3-ONE
Microcare MT
Kordek MLX
EINECS 220-239-6
MIT (biocide)
Acticide M 10
Acticide M 20
Bestcide 600
Kordek 50
