PRODUCTS

S-PANTOPRAZOLE

CAS NO: 142678-35-1
EC/LIST NO:-

S-isomer (S) pantoprazole is known to be more effective and less dependent on cytochrome 2C19 than R-isomer (R)-pantoprazole.

S-Pantoprazole is an anti-ulcer medicine used to treat conditions where the stomach produces too much acid.
Stomach and duodenal ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome are certain problems caused by high levels of stomach acid.
S-Pantoprazole relieves stress ulcers and also acidity due to the intake of painkillers.

S-Pantoprazole interferes with the final step of acid release in the stomach.
Thus, acidity in the stomach is decreased and the ulcer healing process is fastened.
Common side effects of S-Pantoprazole are nausea, vomiting, headache, stomach pain, diarrhoea, and dizziness.
Do not use this medicine if you are previously allergic to it.

You may have to take S-Pantoprazole one hour before a meal.
Avoid spicy and fatty foods, alcohol, and reduce caffeinated drinks or beverage such as coffee, tea and cola while using this medicine.
Eat a healthy and balanced diet. Always try to finish your dinner three hours before heading to bed.

S-Pantoprazole is used to treat damage from gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus (the tube between the throat and stomach) in adults and children 5 years of age and older.
S-Pantoprazole is used to allow the esophagus to heal and prevent further damage to the esophagus in adults with GERD.
S-Pantoprazole is also used to treat conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome in adults.
S-Pantoprazole is in a class of medications called proton-pump inhibitors.
S-Pantoprazole works by decreasing the amount of acid made in the stomach.

S-Pantoprazole is used to treat certain stomach and esophagus problems (such as acid reflux).
S-Pantoprazole works by decreasing the amount of acid your stomach makes.
This medication relieves symptoms such as heartburn, difficulty swallowing, and persistent cough.
S-Pantoprazole helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus.
S-Pantoprazole belongs to a class of drugs known as proton pump inhibitors

S-Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

S-Pantoprazole is used to treat erosive esophagitis (damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or GERD) in adults and children who are at least 5 years old.
S-Pantoprazole is usually given for up to 8 weeks at a time while your esophagus heals.

S-Pantoprazole is also used to treat Zollinger-Ellison syndrome and other conditions involving excess stomach acid.

S-Pantoprazole is not for the immediate relief of heartburn symptoms.

Heartburn is often confused with the first symptoms of a heart attack.
Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

Long-term treatment with S-Pantoprazole may also make it harder for your body to absorb vitamin B-12, resulting in a deficiency of this vitamin.
Talk with your doctor if you need long-term S-Pantoprazole treatment and you have concerns about vitamin B-12 deficiency.

S-Pantoprazole can cause kidney problems.
Tell your doctor if you are urinating less than usual, or if you have blood in your urine.

Diarrhea may be a sign of a new infection.
Call your doctor if you have diarrhea that is watery or has blood in it.

S-Pantoprazole may cause new or worsening symptoms of lupus.
Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.

You may be more likely to have a broken bone while taking this medicine long term or more than once per day.

S-Pantoprazole reduces the amount of acid your stomach makes.

S-Pantoprazole used for heartburn, acid reflux and gastro-oesophageal reflux disease (GORD) – GORD is when you keep getting acid reflux.
S-Pantoprazole also taken to prevent and treat stomach ulcers.

Sometimes, S-Pantoprazole is taken for a rare condition caused by a tumour in the pancreas or gut called Zollinger-Ellison syndrome.

S-Pantoprazole comes as tablets.

All types of S-Pantoprazole are available on prescription.
You can also buy lower-strength 20mg tablets from pharmacies for heartburn or acid reflux.

S-Pantoprazole oral tablet is a prescription drug that’s available as the brand-name drug Protonix.
S-Pantoprazole also available as a generic drug. Generic drugs usually cost less than the brand-name version.
In some cases, they may not be available in all strengths or forms as the brand-name drug.

S-Pantoprazole comes in three forms: an oral tablet, an oral liquid suspension, and an intravenous (IV) form that’s injected into your vein by a healthcare provider.

S-Pantoprazole oral tablet is used to reduce the amount of stomach acid your body makes.
S-Pantoprazole helps treat painful symptoms caused by conditions such as gastroesophageal reflux disease (GERD).
With GERD, gastric juices flow upward from your stomach and into the esophagus.

S-Pantoprazole oral tablet is also used to treat other conditions in which the stomach makes excess acid, such as Zollinger-Ellison syndrome.

S-Pantoprazole is in a class of drugs called proton pump inhibitors (PPIs), which block the production of acid by the stomach.
Other drugs in the same class include lansoprazole (Prevacid), omeprazole (Prilosec) and rabeprazole (Aciphex).
Proton pump inhibitors are used for the treatment of stomach conditions such as duodenal and peptic ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome that are caused by stomach acid.

S-Pantoprazole, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid.
By blocking the enzyme, the production of acid is decreased, and this allows the stomach and esophagus to heal.

S-Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

S-Pantoprazole is also used to treat Zollinger-Ellison syndrome and other conditions involving excess stomach acid.

S-Pantoprazole is not for immediate relief of heartburn.

S-Pantoprazole may also be used for purposes not listed in this medication guide.

S-Pantoprazole is used to treat certain conditions in which there is too much acid in the stomach.
S-Pantoprazole is used to treat erosive esophagitis or "heartburn" caused by gastroesophageal reflux disease (GERD), a condition where the acid in the stomach washes back up into the esophagus.
This medicine may also be used to treat Zollinger-Ellison syndrome, a condition where the stomach produces too much acid.

S-Pantoprazole is a proton pump inhibitor (PPI).
S-Pantoprazole works by decreasing the amount of acid produced by the stomach.

This medicine is available only with your doctor's prescription.

S-Pantoprazole (pan TOE pra zole) prevents the production of acid in the stomach.
S-Pantoprazole is used to treat gastroesophageal reflux disease (GERD), inflammation of the esophagus, and Zollinger-Ellison syndrome.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

S-Pantoprazole reduces the amount of acid produced in your stomach.
S-Pantoprazole belongs to a group of medicines known as proton pump inhibitors (PPIs).
They are used to treat a number of conditions associated with high stomach acid affecting your stomach and gut, such as indigestion, reflux and ulcers.
S-Pantoprazole can prevent ulcers from forming, or help the healing process where damage has already occurred.

S-Pantoprazole can be given together with antibiotics to get rid of Helicobacter pylori, a bacteria found in the stomach that can cause ulcers.

S-Pantoprazole can be used to prevent ulcers caused by medicines such as non-steroidal anti-inflammatory drugs (NSAIDs).
Examples of NSAIDs are diclofenac, ibuprofen and naproxen.

S-Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zollinger-Ellison (ZE) Syndrome.
S-Pantoprazole can also be found in quadruple regimens for the treatment of H. pylori infections along with other antibiotics including amoxicillin, clarithromycin, and metronidazole, for example.
1023 S-Pantoprazole efficacy is considered similar to other medications within the PPI class including omeprazole, esomeprazole, lansoprazole, dexlansoprazole, and rabeprazole.

S-Pantoprazole exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme at the secretory surface of gastric parietal cell.
This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus.
As the binding of S-Pantoprazole to the (H+, K+)-ATPase enzyme is irreversible and new enzyme needs to be expressed in order to resume acid secretion, S-Pantoprazole's duration of antisecretory effect persists longer than 24 hours.

Due to their good safety profile and as several PPIs are available over the counter without a prescription, their current use in North America is widespread.
Long term use of PPIs such as S-Pantoprazole have been associated with possible adverse effects, however, including increased susceptibility to bacterial infections (including gastrointestinal C. difficile), reduced absorption of micronutrients including iron and B12, and an increased risk of developing hypomagnesemia and hypocalcemia which may contribute to osteoporosis and bone fractures later in

PPIs such as S-Pantoprazole have also been shown to inhibit the activity of dimethylarginine dimethylaminohydrolase (DDAH), an enzyme necessary for cardiovascular health.
DDAH inhibition causes a consequent accumulation of the nitric oxide synthase inhibitor asymmetric dimethylarginie (ADMA), which is thought to cause the association of PPIs with increased risk of cardiovascular events in patients with unstable coronary syndromes.

S-Pantoprazole doses should be slowly lowered, or tapered, before discontinuing as rapid discontinuation of PPIs such as S-Pantoprazole may cause a rebound effect and a short term increase in hypersecretion.

S-Pantoprazole is a medicine used to treat damage to the esophagus caused by gastroesophageal reflux disease (GERD) — a condition where acid from the stomach flows backwards.
S-Pantoprazole typically given for up to eight weeks at a time while your esophagus heals.

The medicine is also used to treat conditions where the stomach produces too much acid.

S-Pantoprazole is a proton pump inhibitor.
S-Pantoprazole works by decreasing the amount of acid made in your stomach.

S-isomer (S) pantoprazole is known to be more effective and less dependent on cytochrome 2C19 than R-isomer (R)-pantoprazole.

Aim The purpose of this study was to compare the efcacy and safety of S-pantoprazole 20 mg versus S-Pantoprazole 40 mg for treatment of reux esophagitis.
Methods This multi-center, double-blind, randomized trial enrolled patients with endoscopically documented reux esophagitis.
Patients were assigned to receive either 20 mg S-pantoprazole or 40 mg pantoprazole once daily for 4 weeks.
Endoscopy and symptoms were assessed after 4 weeks of treatment.
In patients whose reux esophagitis

was not resolved at 4 weeks, treatment was extended to 8 weeks and symptoms were reassessed. Heartburn, chest pain, acid regurgitation, globus, and overall symptoms were rated.
The primary efcacy endpoint was healing of esophagitis, and secondary endpoints were symptomatic and endoscopic improvement.

Results Sixty-seven patients in the S-pantoprazole group (52 male, mean age 51 years) and 62 in the S-Pantoprazole group (61 male, mean age 50 years) were analyzed per protocol.
The healing rate of reux esophagitis was 85 % at 4 weeks and 94 % at 8 weeks in the S-pantoprazole group, which did not differ from those in the pantoprazole group (84 and 97 %, respectively).
After treatment, individual and overall gastroesophageal reux disease (GERD) symptoms and esophagitis improved compared with baseline inammation in both groups.
Intergroup differences in symptoms and endoscopic healing were not signicant.

S-Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

S-Pantoprazole is also used to treat Zollinger-Ellison syndrome and other conditions involving excess stomach acid.

All proton pump inhibitors (PPIs) are chiral compounds.
Chirality can introduce selectivity and specificity in terms of interactions with receptors or enzyme-binding sites.
This may lead to variations in pharmacokinetic and pharmacodynamic properties, as well as differences in safety and toxicity profiles.
The use of a single isomer offers predictable pharmacokinetics and increased potency.
Esomeprazole, the S-enantiomer of omeprazole, dexrabeprazole, and dexlansoprazole are good examples of racemic PPI switches, which have the clinical advantages of increasing the homogeneity of the treatment response and providing better efficacy with comparable safety compared with racemic compounds.

S-Pantoprazole is a selective and long-acting PPI.
S-pantoprazole, the optical S-isomer of pantoprazole, was developed for the treatment of acid-related disorders.
This agent displays a similar mechanism of action to that of racemic pantoprazole and is a highly effective inhibitor of gastric acid secretion.
S-pantoprazole is subject to less extensive first-pass metabolism than is S-Pantoprazole, resulting in higher systemic bioavailability.

A reduction of the therapeutic dosage by chiral purification decreases the metabolic load on the body.
Animal studies have shown that S-pantoprazole is more potent (1.5-1.9 fold) and effective (3-4 fold) than racemate in inhibiting gastric lesions in several preclinical models.9 S-pantoprazole is associated with less pronounced inter-individual variation of intragastric pH and more effective and longer-lasting inhibition of gastric acid secretion in a human study11; therefore, it may be expected to produce a more consistent clinical response.
S-pantoprazole (20 mg) was more effective than racemic S-Pantoprazole (40 mg) in improving the symptoms of heartburn, acid regurgitation, and bloating and was equally effective in healing esophagitis.
The relative risk reduction was 15-33%.
Another study showed 20 mg S-pantoprazole was effective in healing reflux esophagitis compared to placebo.
There has been no study on the efficacy of low-dose (10 mg) S-pantoprazole for the treatment of gastroesophageal reflux disease (GERD).

We performed a multi-center, double-blind, randomized, placebo-controlled phase III trial to evaluate the effect and safety of 10 mg S-pantoprazole in NERD patients and assessed the rate of recurrence after cessation of medication.

Take S-Pantoprazole exactly as prescribed by your doctor.
Follow all directions on your prescription label and read all medication guides or instruction sheets.
Use the medicine exactly as directed.

Use the lowest dose for the shortest amount of time needed to treat your condition.

S-Pantoprazole is taken by mouth (oral) or given as an infusion into a vein (injection).
A healthcare provider may teach you how to properly use the injection by yourself.

S-Pantoprazole tablets are taken by mouth, with or without food.
The oral granules should be taken 30 minutes before a meal.

Do not crush, chew, or break the tablet.
Swallow it whole.

The oral granules should be mixed with applesauce or apple juice and given either by mouth or through a nasogastric (NG) tube.

Read and carefully follow any Instructions for Use provided with your medicine.
Ask your doctor or pharmacist if you have any questions.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.

Call your doctor if your symptoms do not improve or if they get worse while you are using this medicine.

S-Pantoprazole can cause false results with certain medical tests.
Tell the doctor or laboratory staff that you are using this medicine.

S-Pantoprazole may also affect a drug-screening urine test and you may have false results.
Tell the laboratory staff that you use this medicine.

Store this medicine at room temperature away from moisture, heat, and light.

S-Pantoprazole comes as a delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) tablet and as delayed-release granules to take by mouth.
The packets of delayed-release granules must be mixed with applesauce or apple juice and taken by mouth or given through a feeding tube.
For the treatment and maintenance of GERD, S-Pantoprazole is usually taken once a day.
For the treatment of conditions where the stomach produces too much acid, S-Pantoprazole is usually taken twice a day.
The delayed-release tablets are usually taken with or without food, and the granules are usually taken 30 minutes before a meal.
Take S-Pantoprazole at around the same time(s) every day.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Take S-Pantoprazole exactly as directed.
Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.
If your doctor has prescribed the 40 mg tablet and it is too big for you to swallow, ask your doctor to prescribe two of the 20 mg tablets instead.

To take the granules, open the packet and either sprinkle the granules onto one teaspoonful of applesauce or into a cup containing one teaspoonful of apple juice.
Do not mix the granules with water, other liquids, or other foods.
Use all of the granules in the packet; do not divide the granules into smaller doses.
If you sprinkle the granules into apple juice, stir the mixture for 5 seconds.
Swallow the mixture of applesauce or apple juice and medication right away (within 10 minutes) without chewing or crushing the granules.
If you sprinkled the granules on applesauce, take several sips of water to wash the granules down to your stomach.
If you sprinkled the granules into apple juice, rinse the cup once or twice with apple juice and drink the apple juice right away to be sure you swallow any leftover granules.

S-Pantoprazole granules mixed with apple juice may be given through a feeding tube.
If you have a feeding tube, ask your doctor how you should take S-Pantoprazole.

Continue to take S-Pantoprazole even if you feel well.
Do not stop taking S-Pantoprazole without talking to your doctor.
If your condition does not improve or gets worse, call your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

IUPAC NAME :

SYNONYMS:

142678-35-1 [RN]
1H-Benzimidazole, 6-(difluoromethoxy)-2-[(S)-[(1S)-(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]- [ACD/Index Name]
6-(Difluormethoxy)-2-{(S)-[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl}-1H-benzimidazol [German] [ACD/IUPAC Name]
6-(Difluoromethoxy)-2-{(S)-[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl}-1H-benzimidazole [ACD/IUPAC Name]
6-(Difluorométhoxy)-2-{(S)-[(3,4-diméthoxy-2-pyridinyl)méthyl]sulfinyl}-1H-benzimidazole [French] [ACD/IUPAC Name]
S-pantoprazole
102625-70-7 [RN]
pantoprazole [INN] [USAN] [Wiki]
PANTOPRAZOLE, S-
UNII-D8TST4O562