SARKOSYL

SARKOSYL = SODIUM LAUROYL SARCOSINATE = N-DODECANOYL-N-METHYLGLYCINE = SODIUM (N-METHYLDODECANAMIDO)ACETATE

CAS Number: 137-16-6
EC-Number : 205-281-5
Linear Formula: CH3(CH2)10CON(CH3)CH2COONa / C15H28NNaO3

Sarkosyl, also known as Sodium Lauroyl Sarcosinate, is a surfactant derived from vegetable fatty acids and Sarcosine (natural amines, an amino acid found naturally in the body).
Sarkosyl is often used as a secondary surfactant to increase and improve lather in body gels, but Sarkosyl also has great benefits in shampoos or conditioners as Sarkosyl is antistatic and improves hair flexibility.
Sarkosyl is a mild yet powerful hypoallergenic, non-irritating surfactant with excellent synergistic effect with other surfactants and exceptional creamy foaming properties. 

Sarkosyl Reduces irritation and offers moisture.
Sarkosyl is Suitable Vegan, its origin is vegetable and it is Biodegradable.
Sarkosyl is derived from sarcosine, a natural amino acid found in the human body and just about every type of biological material from animals to plants. 

The recommendations for use range from 1% to 5% depending on the cosmetic, but Sarkosyl can go up to 40%.
Sarkosyl is a cleanser and foaming agent that helps with the effectiveness and feel of our toothpaste.
We chose Sarkosyl because it’s very mild, but also very effective. 
Sarkosyl is an anionic surfactant derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products.

This surfactant, Sarkosyl, is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate. 
Since the nitrogen atom is in an amide linkage, the nitrogen is not pH active and is neutrally charged in all aqueous solutions regardless of pH. 
The carboxylate has a pKa of about 3.6 and is therefore negatively charged in solutions of pH greater than about 5.5.
pH-sensitive vesicles can be prepared using this surfactant with another cationic or water-insoluble amphiphiles such as 1-decanol.

Addition of an mixture of equal parts of Sarkosyl and the non-ionic surfactant sorbitan monolaurate (S20) to water led to the formation of micelle-like aggregates, even though neither surfactant formed micelles when present alone. 
Such aggregates can help carry other small molecules, such as drugs, through the skin.
Sarkosyl is a detergent that is structurally related to SDS, except that Sarkosyl has an additional polar and rigid peptide bond linkage within the hydrophobic backbone. 

Such rigidity added to the N-terminus of the hydrophobic chain could lead to a decrease in Sarkosyl's ability to be inserted freely into hydrophobic membrane bilayers and proteins. 
This could explain why Sarkosyl is milder than SDS in its ability to denature and disrupt membrane and protein structures. 
Because of a similar difference in side-chain structure, the bile acid detergent CHAPS is rendered milder than the strongly denaturing sodium cholate, which inactivates integral membrane proteins, such as the serotonin 1A receptor. 

Sarkosyl is mild, biodegradable anionic surfactants derived from fatty acids and sarcosine (amino acid). 
These compounds features lather building and resistance to sebum delathering in cleaners, polymers, industrial chemicals, petroleum and lubricant products. 
As Sarkosyl has good biodegrability, it is in  accordance with the requirement of environmental protection.
Sarkosyl is an anionic surfactant from the group of amino-acid surfactants with. 

Sarkosyl is produced basing on biomimetics, which are raw materials imitating naturally occurring chemical compounds and fatty acids (raw materials of plant origin). 
Sarkosyl is provided as an aqueous solution with the active substance content of approx. 30%. 
Sarkosyl, A mild, biodegradable cleansing agent that is also a very good team-player next to other cleaning agents. 
Sarkosyl is known for its good foam-boosing abilities while improving the mildness of the formula. 
Sarkosyl belongs to anionic surfactant of amino acid category. 

Sarkosyl is quite mild with superior foaming capacity, and its skin feeling is mild, smooth and comfortable.
Sarkosyl, Sulfate-free anionic surfactant, providing dense lather and aiding foam stability. 
Sarkosyl Can be used in clear formulations and is stable over a wide pH range. Ideal co-surfactant.
Foam stability is better in the weakly acid than in the alkaline pH range. 
Sarkosyl is excellent foaming power in electrolyte-containing solutions. 

Sarkosyl is soluble in water in any ratio and forms clear solutions. 
Sarkosyl is the salt of lauroyl sarcosine (produced by the breakdown of creatine or caffeine), a modified fatty acid.
Sarkosyl is very mild, but also very effective. 
What’s more, FDA approved as an indirect food additive, and CIR approved when used in rinse-off products, or in leave-on products at concentrations of 5% or less.

USES and APPLICATIONS of SARKOSYL:
-Sarkosyl is an anionic detergent used for cell lysis during the extraction of RNA
-Sarkosyl is also suitable for the solubilization of membrane protein
-Sarkosyl is an ionic detergent that is reportedly an inhibitor of hexokinase. 
-Sarkosyl Solution is used as a 10% Sterile Solution for cell lysis in RNA purification protocols and membrane solubilization.
-Sarkosyl is used as a detergent, foaming agent, and antienzyme for dentifrices; 
-Permitted for use as an inert ingredient in non-food pesticide products
-These surfactants have good foaming properties, also at a higher pH range. 
Amino-acid surfactants have good tolerance to highly alkaline environment and may be used as aids in foam formation, even at high pH values that in case of other surfactants decrease foaming efficiency. 
-Sarkosyl is an ionic surfactant derived from sarcosine, used as a foaming and cleansing agent in shampoo, shaving foam and foam wash products. 
-In molecular biology experiments, sarkosyl is used to inhibit the initiation of DNA transcription.
-Sarkosyl is widely used in various industries (cosmetics, detergents, household and industrial cleaning, agro-chemicals, textiles processing).
-Sarkosyl is an ionic detergent used to denature proteins in hybridization, nucleic acid purification, and electrophoresis.
-Sarkosyl is used in concentrated salt solutions as a detergent because SDS is insoluble in concentrated salt solutions.
-Sarkosyl (Anionic) used to solubilise proteins. 
-Hydrophobic membrane proteins are suited to more non ionic detergents.
-Sarkosyl is used mild baby shampoo, facial cleansers, liquid soaps, shaving product or toothpaste.
-Sarkosyl is an anionic surfactant derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products.
-Cosmetic Uses of Sarkosyl: antistatic agents, cleansing agents, foaming agents, hair conditioning, skin conditioning, surfactants, surfactant - emulsifying, and viscosity controlling agents.
-Sarkosyl is used shampoos, especially very mild baby shampoos, body washing liquids, shower gels, bath lotion, bubble baths,
gentle liquid soaps, materials for face cleaning and care, toothpastes, shaving foams, household and industrial cleaning product, and glass cleaning concentrates.
-Sarkosyl is used Anionic surfactant, especially resistant to chlorine. 
-Sarkosyl is used as a secondary surfactant in cosmetics-detergent due to its foam-increasing feature. 
Sarkosyl is used Consistent bleach (2-5%), Detergent and Cosmetics (3-10%), Baby shampoo (3-8%). 
-Sarkosyl can reduce the irritation caused by the residue of traditional surfactants on the skin with it's good compatibility properties.
-Sarkosyl and sodium lauroyl sarcosinate are surfactants used as ingredients in shampoos, baby and face cleansers, bath lotions and toothpastes; 
-Sarkosyl is used in household and professional detergents for hard surface cleaning, in particular for car cleaning, too. 
-For the manufacture of hair shampoos and body cleansing products Sarkosyl is often best combined as mild Co-surfactant with alkyl ether sulphates.
-Sarkosyl can be combined with other anionic surfactants commonly used in cosmetics and improves skin compatibility.
-Sarkosyl is often seen in shampoos, bath, cleansing and shaving products as a foaming agent, surfactant, and hair conditioning agent.
-Sarkosyl has the ability to enhance the appearance and feel of hair by improving body, suppleness and sheen, especially in hair that is chemically damaged. 
-Sarkosyl also serves to clean skin and hair by mixing with oil and dirt and enabling them to be rinsed away. 
-As a modified fatty acid, Sarkosyl is thought to be more soluble, and have increased crystallinity and acidity compared to its original fatty acid composition.
-Sarkosyl is an anionic specialty surfactant.  
Sarkosyl is particularly mild, and is suitable for sensitive skin and sensitive areas.  
-Sarkosyl improves foam and thickening properties of formulations. 
-Sarkosyl is Suitable for shampoos, foam baths, shower gels, syndet bars, detergents, creamy shower products, and baby products.  
-Sarkosyl is A powerful anionic surfactant that confers mild detergency, excellent foaming and lathering characteristics. 
Sarkosyl Displays synergy with other detergents. 
Sarkosyl is Wetting agent. 
Sarkosyl is Enzyme inhibitor in oral care. 
Sarkosylv is Corrosion inhibitor.
-Powerful yet mild anionic surfactant produced from a natural fatty acid and the amino acid sarcosine, supplied as the sodium salt at 30% activity.

ADVANTAGES of of SARKOSYL:
*anionic surfactant very gentle for skin,
*very good foaming properties,
*reduces the irritant effect of other surfactants on skin,
*excellent cleaning properties,
*provides Provides the skin long-term comfort and softness sensation,
*due to high absorbtion on the surface of hair, reduction of static electricity and binding, provides the hair soft and silky sensation,
*it is easily biodegradable,
*based on renewable raw materials of plant-origin,
*contains no preservatives,
*may be used in the presence of oxidizing agents.

FUNCTIONS of of SARKOSYL:
*Sarkosyl is often seen in shampoos, bath, cleansing and shaving products as a foaming agent, surfactant, and hair conditioning agent. 
*Sarkosyl has the ability to enhance the appearance and feel of hair by improving body, suppleness and sheen, especially in hair that is chemically damaged. 
*Sarkosyl also serves to clean skin and hair by mixing with oil and dirt and enabling them to be rinsed away. 
*As a modified fatty acid, Sarkosyl is thought to be more soluble, and have increased crystallinity and acidity compared to its original fatty acid composition.
*Antistatic: Sarkosyl Reduces static electricity by neutralizing the electrical charge on a surface
*Cleaning agent: Sarkosyl Helps keep a surface clean
*Emulsifying agent: Sarkosyl Promotes the formation of intimate mixtures between immiscible liquids by modifying the interfacial tension (water and oil)
*Foaming agent: Sarkosyl Captures small bubbles of air or other gases in a small volume of liquid by changing the surface tension of the liquid
*Hair conditioner: Sarkosyl Leaves hair easy to comb, supple, soft and shiny and/or gives volume, lightness and shine
*Skin conditioning agent: Sarkosyl Keeps the skin in good condition
*Surfactant: Sarkosyl Reduces the surface tension of cosmetics and contributes to the even distribution of the product during use
*Viscosity control agent: Sarkosyl Increases or decreases the viscosity of cosmetics

WHAT DOES SARKOSYL DO IN A FORMULATION?
*Antistatic
*Cleansing
*Emulsifying
*Foaming
*Hair conditioning
*Skin conditioning
*Surfactant
*Viscosity controlling

IN CULTURE:
Sarkosyl was sold as a special ingredient called "Gardol" in Colgate "Dental Cream", as toothpaste was then called, during the 1950s through the mid-1960s in the US and the mid-1970s in France. 
Sarkosyl's current use as a preventive dentifrice is in Arm & Hammer Baking Soda Toothpaste, a Church & Dwight product, where Sarkosyl is used as a surfactant.

PHYSICAL and CHEMICAL PROPERTIES of SARKOSYL:
Molecular Weight: 293.38
Appearance Form: powder
Color: white
Odor: characteristic
Odor Threshold: No data available
pH: ca.8 at 30 g/l at 20 °C
Melting point/freezing point
Melting point: 146 °C 

Initial boiling point and boiling range: 350 - 410 °C at 1.013 hPa - 
Flash point: 267 °C 
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: 0,02 hPa at 20 °C 
Vapor density: No data available
Relative density: No data available
Water solubility: at 20 °C soluble

Partition coefficient: n-octanol/water: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
Viscosity 
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Explosive properties: No data available
Oxidizing properties: No data available

Other safety information: No data available
Chemical formula: C15H28NNaO3
Molar mass: 293.383 g·mol−1
Melting point: 140 °C (284 °F; 413 K)
Assay Percent Range: ≥95 %
Color: White
Molecular Formula: C15H28NNaO3
Linear Formula: NaO2CCH2N(CH3)CO(CH2)10CH3
Melting Point: 45°C

pH: 7.5 to 8.5
Quantity: 500g
Merck Index: 15, 4401
pH: 7-9 (10% solution in water)
Solubility: ≥ 10% (in water at 20°C)
Absorbance of a 1% solution in water
260 nm: < 0.08
280 nm: < 0.06
340 nm: < 0.04

FIRST AID MEASURES of SARKOSYL:
-Description of first-aid measures:
No data available
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of SARKOSYL:
-Environmental precautions:
No data available
-Methods and materials for containment and cleaning up:
No data available

FIRE FIGHTING MEASURES of SARKOSYL:
-Extinguishing media:
No data available
-Advice for firefighters:
No data available
-Further information:
No data available

EXPOSURE CONTROLS/PERSONAL PROTECTION of SARKOSYL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure
Prevent product from entering drains.

HANDLING and STORAGE of SARKOSYL:
-Precautions for safe handling:
*Advice on safe handling:
Ensure all equipment is electrically grounded before beginning transfer operations.
-Conditions for safe storage, including any incompatibilities:
No data available

STABILITY and REACTIVITY of SARKOSYL:
-Reactivity:
No data available
-Chemical stability:
No data available
-Conditions to avoid:
No data available
-Incompatible materials:
No data available

SYNONYMS:
Sodium Lauroyl Sarcosinate
Sarcosyl
Sarkosyl NL
Sodium N-dodecanoyl-N-methylglycinate
Sodium N-lauroylsarcosinate solution
N-Methyl-N-(1-oxododecyl)glycine, sodium salt
Sodium lauroyl sarcosinate
Compound 105
Gardol
Hamposyl L-30; Lauroylsarcosine sodium salt
Maprosyl 30
Medialan LL-99
N-Dodecanoyl-N-methylglycine, sodium salt
N-Lauroylsarcosine, sodium
N-Lauroylsarcosine, sodium salt
Sarcosyl NL
Sarcosyl NL 30
Sarkosyl NL
Sarkosyl NL 100
Sarkosyl NL 30
Sarkosyl NL 35
Sarkosyl NL 97
Sodium N-lauroylsarcosinate
Sodium N-lauroylsarcosine
Sodium lauroylsarcosine
Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt
Sarcosine, N-lauroyl-, sodium salt (8CI)
N-Lauroylsarcosine sodium salt
N-Lauroylsarcosine sodium salt
sodium N-lauroylsarcosinate
sodium lauroylsarcosinate
sarkosyl NL