PRODUCTS

SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE)

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is commonly used in cosmetic and personal care products, particularly in soap and detergent formulations.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is also used for the treatment of water-vapor related respiratory problems and cataracts, as well as for the prevention of renal stone formation.

CAS Number: 1562-00-1
EC Number: 216-343-6
MDL number: MFCD00007534
Molecular Formula: C2H6NaO4S+
Molecular Weight: 149.12 g/mol

SYNONYMS:
ISETHIONIC ACID SODIUM SALT, phonic acid, 2-HydroxyethanesuL, ISETHIONIC ACID SODIUM, 2-hydroxyethyl sulfonate, Sodiumhydroxyethylsulfonate, 2-HYDROXYETHANESULFONIC ACID, SODIUM 2-HYDROXYETHANESULFONATE, HYDROXYETHYLSULFONIC ACID SODIUM SALT, 2-HYDROXYETHANESULFONIC ACID SODIUM SALT, 2-Hydroxyethanesulphonic acid sodium salt , Sodium isethionate , Sodium hydroxyethyl sulphonate, 2-Hydroxyethanesulfonic acid sodium salt, Ethanesulfonic acid, 2-hydroxy-, monosodium salt, Ethanesulfonic acid, 2-hydroxy-, sodium salt, Isethionic acid sodium salt, Sodium 1-hydroxy-2-ethanesulfonate, Sodium 2-hydroxy-1-ethanesulfonate, Sodium 2-hydroxyethanesulfonate, Sodium 2-hydroxyethyl sulfonate, Sodium 2-hydroxyethylsulfonate, Sodium beta-hydroxyethanesulfonate, Sodium hydroxyethylsulfonate, Sodium Isethionate, 1562-00-1, Isethionic acid sodium salt, Sodium 2-hydroxyethanesulfonate, 2-Hydroxyethanesulfonic acid sodium salt, Sodium hydroxyethylsulfonate, Ethanesulfonic acid, 2-hydroxy-, monosodium salt, Sodium beta-hydroxyethanesulfonate, 2-Hydroxyethanesulfonic acid, sodium salt, 3R36J71C17, Ethanesulfonic acid, 2-hydroxy-, sodium salt (1:1), Sodium 2-hydroxyethanesulphonate, Sodium 1-hydroxy-2-ethanesulfonate, Sodium 2-hydroxy-1-ethanesulfonate, Sodium 2-hydroxyethanesulfonate, Sodium 2-hydroxyethylsulfonate, HSDB 5838, NSC-124283, Sodium 1-hydroxy-2-ethanesulfonate, EINECS 216-343-6, MFCD00007534, NSC 124283, sodium,2-hydroxyethanesulfonate, ISETHIONATE, SODIUM SALT, UNII-3R36J71C17, Ethanesulfonic acid, 2-hydroxy-, sodium salt, isethionic acid sodium, 2-hydroxy-ethanesulfonate, DSSTox_CID_7413, EC 216-343-6, sodium hydroxyethyl sulfonate, DSSTox_RID_78445, DSSTox_GSID_27413, Isethionic acid, sodium salt, Istethionic Acid Sodium Salt, SCHEMBL125497, CHEMBL172191, DTXSID7027413, Sodium 2-Hydroxy-Ethanesulfonate, SODIUM ISETHIONATE, Isethionic acid sodium salt, 98%, HY-Y1173, 2-hydroxyethanesulfonic acid, sodium, Tox21_200227, AKOS015912506, NCGC00257781-01, CAS-1562-00-1, SODIUM 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Acid, Isethionic Acid Monoammonium Salt, Isethionic Acid Monopotassium Salt, Isethionic Acid Monosodium Salt, Sodium Isethionate, Sodium isethionate, Sodium 2-hydroxyethanesulfonate, Isethionic acid sodium salt, Ethanesulfonic acid, 2-hydroxy-, sodium salt, Sodium hydroxyethylsulfonate, 2-Hydroxyethanesulfonic acid sodium salt, Isethionic acid, sodium salt, Sodium 2-hydroxyethyl sulfonate, sodium;2-hydroxyethanesulfonic acid, Sodium .beta.-hydroxyethanesulfonate, NSC124283, ethanesulfonic acid, 2-hydroxy-, monosodium salt, ethanesulfonic acid, 2-hydroxy-, sodium salt, ethanesulfonic acid, 2-hydroxy-, sodium salt (1:1), 2- hydroxyethanesulfonic acid sodium salt, 2- hydroxyethanesulfonic acid, sodium salt, isethionic acid sodium salt, sodium 1-hydroxy-2-ethanesulfonate, sodium 2-hydroxy-1-ethanesulfonate, sodium 2-hydroxyethane sulfonate, sodium 2-hydroxyethanesulfonate, sodium 2-hydroxyethanesulphonate, sodium 2-hydroxyethyl sulfonate, sodium beta-hydroxyethanesulfonate, sodium hydroxyethylsulfonate, sodium;2-hydroxyethanesulfonate, Sodium isethionate, 1562-00-1, Isethionic acid sodium salt, Sodium 2-hydroxyethanesulfonate, 2-Hydroxyethanesulfonic acid sodium salt, Sodium hydroxyethylsulfonate, Ethanesulfonic acid, 2-hydroxy-, monosodium salt, Sodium beta-hydroxyethanesulfonate, 2-Hydroxyethanesulfonic acid, sodium salt, DTXSID7027413, Ethanesulfonic acid, 2-hydroxy-, sodium salt (1:1), 3R36J71C17, Sodium 1-hydroxy-2-ethanesulfonate, Sodium 2-hydroxy-1-ethanesulfonate, Sodium 2-hydroxyethanesulfonate, Sodium 2-hydroxyethylsulfonate, Sodium 2-hydroxyethanesulphonate, HSDB 5838, NSC-124283, Sodium 1-hydroxy-2-ethanesulfonate, Sodium 2-hydroxy-1-ethanesulfonate, C2H5NaO4S, EINECS 216-343-6, MFCD00007534, NSC 124283, sodium;2-hydroxyethanesulfonate, UNII-3R36J71C17, Ethanesulfonic acid, 2-hydroxy-, sodium salt, 2-hydroxy-ethanesulfonate, EC 216-343-6, sodium hydroxyethyl sulfonate, Isethionic acid, sodium salt, SCHEMBL125497, CHEMBL172191, DTXCID007413, ISETHIONATE, SODIUM SALT, Sodium 2-Hydroxy-Ethanesulfonate, Sodium isethionate [HSDB], Sodium isethionate [INCI], LADXKQRVAFSPTR-UHFFFAOYSA-M, Isethionic acid sodium salt, 98%, HY-Y1173, 2-hydroxyethanesulfonic acid; sodium, Tox21_200227, AKOS015912506, NCGC00257781-01, CAS-1562-00-1, SODIUM 2-HYDROXYETHANESULFONIC ACID, CS-0017163, FT-0627314, H0241, A809723, J-009283, Q1969744, F1905-7166, 2-Hydroxyethanesulfonic Acid Sodium Salt Isethionic Acid Sodium Salt, sodium 2-hydroxyethanesulfonate, Sodium Isethionate (SI), Sodium isethionate (SHES), 2-Hydroxyethanesulfonic acid sodium salt (SHES), Isethionic acid sodium salt 98%, 2-Hydroxyethanesulfo, 2-hydroxyethyl sulfonate, sodium hydroxyethyl, sodium hydroxyethyl sulfonates, ISETHIONIC ACID SODIUM SALT, HYDROXYETHYLSULFONIC ACID SODIUM SALT, SODIUM 2-HYDROXYETHANESULFONATE, SODIUM ISETHIONATE, 2-HYDROXYETHANESULFONIC ACID, 2-HYDROXYETHANESULFONIC ACID SODIUM SALT, 2-Hydroxyethanesulphonic acid sodium salt, Hydroxyethanes

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is a white to colorless crystalline solid or fine powder.
Partition Coefficient of Sodium 2-hydroxyethyl sulfonate (sodium isethionate): Log K_ow highly negative (~-5.50), indicating strong water affinity and low lipid solubility.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) decomposes on heating; no defined boiling point under normal conditions.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is stable under normal storage; non-flammable, not oxidizing.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is the sodium salt of 2-hydroxyethane sulfonic acid (isethionic acid).

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is a mild, anionic surfactant derived from isethionic acid and sodium salts, valued for its gentle cleansing properties and suitability for sensitive skin, including baby care formulations.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) contributes to a rich, creamy lather without the harshness associated with traditional sulfates, minimizing skin irritation while maintaining the skin’s natural moisture barrier.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is a biodegradable surfactant widely used in personal care products, such as shampoos, body washes, and facial cleansers, due to its effective cleaning power and compatibility with various ingredients.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is most commonly available in the form of its sodium salt (Sodium 2-hydroxyethyl sulfonate (sodium isethionate)).

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is the sodium salt of isethionic acid.
The chemical structure of isethionic acid includes a hydroxyl group (OH) and a sulfonic acid group (SO3H).
Sodium 2-hydroxyethyl sulfonate (sodium isethionate), short chain alkane sulfonate containing hydroxy group, is a water soluble, strongly acidic liquid used in the manufacture of mild, biodegradable and high foaming anionic surfactants which provides gentle cleansing and soft skin feel.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is made through electrochemical impedance spectroscopy of taurine in reaction solution with phosphorus pentoxide.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is widely distributed in animal species and in a few red algal species.

Higher plasma levels of Sodium 2-hydroxyethyl sulfonate (sodium isethionate) have been shown to be protective against type 2 diabetes.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is an organosulfur compound.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is widely distributed in animal species and in a few red algal species.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is a fine white powder derived from the fatty acids in coconut oil and isethionic acid, a type of sulfonic acid.
Coconuts grow on cocos nucifera trees and are widely cultivated to produce: Fibers, Building materials, Natural ingredients.

In some formulations, Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is included in toothpaste.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is foaming and cleansing properties can contribute to the effectiveness of toothpaste in removing plaque and debris from the teeth.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can help to adjust and stabilize the pH of a formulation.
Maintaining the appropriate pH is crucial for the stability and performance of many cosmetic and personal care products.
The production of Sodium 2-hydroxyethyl sulfonate (sodium isethionate) involves the reaction of ethylene oxide with sodium bisulfite.

Understanding the manufacturing process is crucial for ensuring the quality and purity of the final ingredient.
Ongoing research in the cosmetic and personal care industry may lead to the exploration of alternative ingredients with similar or improved properties compared to Sodium 2-hydroxyethyl sulfonate (sodium isethionate).

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is recognized by its International Nomenclature of Cosmetic Ingredients (INCI) name, which is the standardized system for naming cosmetic ingredients globally.
Formulators may need to consider the compatibility of Sodium 2-hydroxyethyl sulfonate (sodium isethionate) with different packaging materials to ensure the stability and integrity of the product during storage and use.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is an organosulfur compound containing a short chain alkane sulfonate linked to a hydroxyl group.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is a water-soluble liquid used in the manufacture of mild, biodegradable, and high-foaming anionic surfactants.

These surfactants provide gentle cleansing and a soft skin feel.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is most commonly available in the form of its sodium salt (Sodium 2-hydroxyethyl sulfonate (sodium isethionate)).

This drug is made through electrochemical impedance spectroscopy of taurine in reaction solution with phosphorus pentoxide.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is widely distributed in animal species and in a few red algal species.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) forms a colourless, syrupy, and strongly acidic liquid that can form detergents with oleic acid.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) via taurine through a possible enzymatic deamination process.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can be found in both human plasma and urine.
Higher plasma levels of Sodium 2-hydroxyethyl sulfonate (sodium isethionate) have been shown to be protective against type 2 diabetes.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is an organosulfur compound.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is widely distributed in animal species and in a few red algal species.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is generally considered to be biodegradable.

Biodegradability is an important consideration in the formulation of personal care products to minimize environmental impact.
Ongoing research and development in the cosmetic industry may lead to the discovery of new applications or formulations involving Sodium 2-hydroxyethyl sulfonate (sodium isethionate), as well as potential improvements in Sodium 2-hydroxyethyl sulfonate (sodium isethionate)’s performance or environmental impact.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) for synthesis is a high-quality product widely used in various industries.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is mild on the skin, and non-drying.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) works equally well in soft or hard water.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is also an anti-static agent in shampoos.

USES and APPLICATIONS of SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE):
The main use of Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is the production of the isethionate class of surfactants.
These are readily foaming and particularly mild, making them suitable for cleaning sensitive skin and are therefore mainly used in baby soaps and shampoos.

Because of its pronounced skin compatibility, Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is added to soaps and liquid skin cleansers with up to 15 parts by weight.
From Sodium 2-hydroxyethyl sulfonate (sodium isethionate) the so-called biological buffers such as HEPES, MES, PIPES etc. are easily accessible.

The addition of 2-hydroxyethyl sulfonate to electroplating baths allows higher current densities and lower concentrations than the much more expensive methane sulphonic acid with improved appearance.
Intermediate for Mild Surfactants: Key building block in forming acyl isethionates (e.g., sodium cocoyl isethionate), which are mild, foaming anionic surfactants popular in high-end and sensitive skin products.

Pharmaceutical & Research: Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is utilized as an excipient or buffer component in drug formulations or chemical studies; included in research for biological buffers and synthesis intermediates.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is used as a hydrophilic head group in washing-active surfactants, known as isethionates (acyloxyethanesulfonates) due to its strong polarity and resistance to multivalent ions.

Cosmetic Uses of Sodium 2-hydroxyethyl sulfonate (sodium isethionate) : antistatic agents, cleansing agents, hair conditioning, and skin conditioning.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is commonly used in cosmetic and personal care products, particularly in soap and detergent formulations.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is also used for the treatment of water-vapor related respiratory problems and cataracts, as well as for the prevention of renal stone formation.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) functions as a surfactant, which means it helps to reduce the surface tension of liquids and allows them to spread more easily.

In skincare products, Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can contribute to the formation of a stable lather and enhance the cleansing properties of the product.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can be used as an anionic detergent and has anti-settlement activity against Balanus amphitrite.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) forms a colourless, syrupy, and strongly acidic liquid that can form detergents with oleic acid.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is frequently used in the industrial production of taurine.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can be used as an anionic detergent and has anti-settlement activity against Balanus amphitrite
Known for Sodium 2-hydroxyethyl sulfonate (sodium isethionate)’s superior quality and excellent performance, it is extensively used in the production of chemicals and pharmaceuticals for its exceptional properties and wide range of applications.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can have antistatic properties, which are beneficial in hair care products.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) helps reduce static electricity, making hair more manageable and less prone to frizz.
Some surfactants may not perform well in hard water, but Sodium 2-hydroxyethyl sulfonate (sodium isethionate) tends to be more compatible.

This makes Sodium 2-hydroxyethyl sulfonate (sodium isethionate) suitable for formulations in areas where hard water is prevalent.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate)’s versatility extends to its compatibility with various formulation types, such as liquid cleansers, solid bars, shampoos, and other personal care products.

In addition to its cleansing properties, Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can contribute to a pleasant skin feel in cosmetic formulations, enhancing the overall sensory experience of the product.
As consumer demand for sustainable and eco-friendly products increases, there may be ongoing efforts within the industry to explore and develop more sustainable alternatives or production methods for ingredients like Sodium 2-hydroxyethyl sulfonate (sodium isethionate).

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is commonly found in shampoos and hair care products.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is surfactant properties help in removing oils and dirt from the hair and scalp, contributing to the overall cleansing performance of the product.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is often used in the formulation of syndet bars, which are synthetic detergent bars.
These bars are considered milder than traditional soap bars and are popular for cleansing without causing excessive dryness.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is generally considered to be biodegradable.

Biodegradability is an important consideration in the formulation of personal care products to minimize environmental impact.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is commercially available and is used by cosmetic and personal care product manufacturers worldwide.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is availability contributes to its widespread use in various formulations.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is the sodium salt of 2-hydroxyethane sulfonic acid (isethionic acid), it is used as a hydrophilic head group in washing-active surfactants, known as isethionates (acyloxyethanesulfonates) due to its strong polarity and resistance to multivalent ions.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) contributes to the stability of formulations by preventing phase separation or changes in texture over time, enhancing the overall shelf life of the product.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is also used for the treatment of water-vapor related respiratory problems and cataracts, as well as for the prevention of renal stone formation.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is commonly used in cosmetic and personal care products, particularly in soap and detergent formulations.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) functions as a surfactant, which means it helps to reduce the surface tension of liquids and allows them to spread more easily.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is frequently used in the industrial production of taurine.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can be used as an anionic detergent and has anti-settlement activity against Balanus amphitrite.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is commonly found in shampoos and hair care products.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) has surfactant properties help in removing oils and dirt from the hair and scalp, contributing to the overall cleansing performance of the product.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can be included in facial cleansers and exfoliating scrubs to help cleanse the face and remove dead skin cells, contributing to a smoother complexion.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is sometimes used in combination with other surfactants to achieve specific performance characteristics.

This synergistic effect allows formulators to tailor the properties of the final product.
In addition to cleansers, Sodium 2-hydroxyethyl sulfonate (sodium isethionate) may be included in creams and lotions to contribute to their emulsifying properties and enhance the spreadability of the product on the skin.

In hair care formulations, Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can act as a pH adjuster, helping to maintain the desired pH level for optimal performance of the product.
As consumer demand for sulfate-free products increases, Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can be part of formulations designed to be sulfate-free while still providing effective cleansing.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is generally considered biodegradable, which is an important factor for formulators and consumers concerned about the environmental impact of cosmetic ingredients.
In some formulations, Sodium 2-hydroxyethyl sulfonate (sodium isethionate) may be included in hand sanitizers to contribute to the cleansing properties of the product.

Ongoing research in the cosmetic industry may lead to the discovery of new applications or improved formulations involving Sodium 2-hydroxyethyl sulfonate (sodium isethionate).
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) works as an amphoteric detergent and can also be used as an intermediate in preparing surfactants derived from fatty acid sulfoalkyl esters (acyloxy ethane sulfonate).

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) increases the formulation’s stability, improves the detergency in hard water, and is smooth to the skin.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is used in cleaning/washing agents, disinfectants, cosmetics, surface-active agents, shampoos, and bubble baths.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is used as a key raw material in the manufacturing of Igepon type surfactants which are ethanesulfonated detergent bars.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is used in the following products: cosmetics and personal care products, pH regulators and water treatment products, polymers and textile treatment products and dyes.

Release to the environment of Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can occur from industrial use: formulation of mixtures and formulation in materials.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is used in the following products: metal surface treatment products, pH regulators and water treatment products, pharmaceuticals, polymers and textile treatment products and dyes.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) has an industrial use resulting in manufacture of another substance (use of intermediates).
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is used for the manufacture of: chemicals, textile, leather or fur and metals.
Release to the environment of Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is an amphoteric detergent used in detergent bar soaps.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) makes a dense lather in addition to the lather made by the soap.

-Chemical & Industrial Uses of Sodium 2-hydroxyethyl sulfonate (sodium isethionate):
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is used in detergent formulations including dishwashing and laundry liquids where mildness and foaming are desirable.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) acts in some industrial processes (e.g., electroplating, textile dyeing) as a chelating component or leveling agent (not the primary use).

-Personal Care & Cosmetics use of Sodium 2-hydroxyethyl sulfonate (sodium isethionate) :
Ingredient or intermediate in surfactants, especially in the production of isethionate surfactants used in mild cleansing products.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is used in soap bars, syndet bars, liquid hand washes, shampoos, bubble baths, shower gels, and sensitive-skin cleansers due to its compatibility and low irritation.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) can appear directly as a conditioner or skin-feel enhancer in formulations.

WHAT DOES SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE) DO IN A FORMULATION?
*Antistatic
*Cleansing
*Hair conditioning
*Skin conditioning

PROPERTIES of SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE):
Solid Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is a colorless, free-flowing, non-hygroscopic solid.
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) dissolves readily in water and has good biodegradability.
Due to the method of synthesis samples often contain traces of sodium sulfite or sodium hydrogen sulfite causing aqueous solution to possess a mildly alkaline pH of about 10.

PROPERTIES & BENEFITS of SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE):
*Surfactant Head Group:
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) provides a strong hydrophilic head suitable for forming surfactants when reacted with fatty acids (e.g., forming sodium lauroyl isethionate).

*Foaming & Cleansing:
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) supports the formation of good foam even in hard water when converted into surfactants; improves cleansing efficacy while being mild to skin.

*Mildness & Skin Compatibility:
Isethionate derivatives are known for very low irritation, making them suitable for sensitive skin, baby products, and dermatological cleansers.

*Water Solubility & Biodegradability:
Highly water-soluble and readily biodegradable, reducing environmental persistence.

*Hard Water Resistance:
Due to strong polarity and sulfonate group, performs well in hard water conditions typical of soap bars and syndet products.

CHEMICAL STRUCTURE & NATURE of SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE):
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is the sodium salt of 2-hydroxyethane sulfonic acid (isethionic acid).
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) contains a hydrophilic sulfonate group (-SO₃⁻) and a hydroxyl group (-OH) on an ethyl backbone, giving it strong polarity and water solubility.

PRODUCTION of SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE):
Sodium 2-hydroxyethyl sulfonate (sodium isethionate) is formed by the reaction of ethylene oxide with sodium hydrogen sulfite in aqueous solution.
To avoid contamination and suppress the formation of by-products (which are difficult to remove) the reaction must be performed under careful control of mass ratios and process conditions.

Excess sulfite (SO32−) or bisulfite (HSO3−) lead to an unpleasant odor of the downstream product.
Higher levels of ethylene glycol or glycol ethers (formed by the hydrolysis and ethoxylation of ethylene oxide) give hygroscopic and greasy surfactants.

Concentrated ethylene glycol-containing Sodium 2-hydroxyethyl sulfonate (sodium isethionate) solutions can subsequently mostly be freed from ethylene glycol by continuous extraction with e.g. isopropanol (<0.5%).
Therefore, in the continuous industrial process an aqueous sodium hydrogen sulfite solution is prepared in a first reactor by mixing a sodium hydroxide solution and sulfur dioxide.

In a second reactor the sodium hydrogen sulfite solution is mixed with a slight excess of ethylene oxide to obtain Sodium 2-hydroxyethyl sulfonate (sodium isethionate) in almost quantitative yields at elevated temperature and pressure with a precise control of pH.
The reaction has to take place under the exclusion of oxygen and under precise control of the stoichiometry of the reactants, the temperature, the pH and the throughput.

PHYSICAL and CHEMICAL PROPERTIES of SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE):
Molecular Weight: 148.12
Molecular Weight: 148.12
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 2
Exact Mass: 147.98062409
Monoisotopic Mass: 147.98062409
Topological Polar Surface Area: 85.8 Å²
Heavy Atom Count: 8
Formal Charge: 0
Complexity: 122

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes
Molecular Formula / Molecular Weight: C2H5NaO4S = 148.11
Physical State (20 deg.C): Solid
Store Under Inert Gas: Store under inert gas

Condition to Avoid: Hygroscopic
CAS RN: 1562-00-1
Reaxys Registry Number: 3633992
PubChem Substance ID: 87570669
Melting point: 191-194 °C(lit.)
Density: 1762.7[at 20℃]
storage temp.: Store below +30°C.
solubility: H2O: 0.1 g/mL, clear, colorless
form:Fine Powder
color: White
PH: 7.0-11.0 (20g/l, H2O, 20℃)
Water Solubility: SOLUBLE
BRN: 3633992
Stability: Stable.
Hygroscopic.

LogP: -4.6 at 20℃
Density: 1762.7[at 20℃]
Melting Point: 191-194°C(lit.)
Water Solubility: SOLUBLE
Solubility: H2O: 0.1g/mL, clear, colorless
Appearance: White crystal
Color: White
Appearance (20°C): Appearance: Crystal-Powder
Color: Off-white
Odor: Odorless
pH: Not available
Melting Point: 194°C
Boiling Point/Boiling Range: Not available
Flash Point: Not available
Explosive Properties: Lower explosive limit not available;
upper explosive limit not available

Density: Not available
Solubility:
Water: Soluble
Other Solvents: Not available
CAS: 1562-00-1
EINECS: 216-343-6
InChI: InChI=1/C2H6O4S/c3-1-2-7(4,5)6/h3H,1-2H2,(H,4,5,6)/p-1
Molecular Formula: C2H5NaO4S
Molar Mass: 148.11 g/mol
Melting Point: 191-194°C (literature value)
Water Solubility: Soluble, 0.1 g/mL, clear, colorless
Appearance: White crystal

BRN: 3633992
pH: 7.0-11.0 (20g/L, H2O, 20°C)
Storage Condition: Store below +30°C
Stability: Stable.
Hygroscopic.
Incompatible with strong oxidizing agents and strong acids.
Sensitive: Easily absorbs moisture
MDL: MFCD00007534
Density: 1.625 g/cm3
Exact Mass: 147.980621 g/mol
PSA (Polar Surface Area): 85.81000
Stability: Stable.
Hygroscopic.
Incompatible with strong oxidizing agents and strong acids.

Common Name:Sodium 2-hydroxyethyl sulfonate
Primary Trade/Common Name:Sodium Isethionate
INCI Name:Sodium Isethionate
CAS Number:1562-00-1
EC / EINECS Number:216-343-6
PubChem CID:517063
ChemSpider ID:14540
Molecular Formula:C₂H₅NaO₄S
Molecular Weight:~148.11 g/mol

Appearance:White to colorless crystalline solid or fine powder
Melting Point:Around 191–194 °C
Solubility:Highly soluble in water at 20 °C (≈650 g/L)
pH in Solution:~7–11 in aqueous solution depending on concentration
Density:Bulk density ~800 kg/m³
Partition Coefficient:Log K_ow highly negative (~-5.50), indicating strong water affinity and low lipid solubility
Vapor Pressure:Extremely low (estimated ~1.3 × 10⁻¹² mm Hg at 25 °C)
Thermal Behavior:Decomposes on heating; no defined boiling point under normal conditions
Stability:Stable under normal storage; non-flammable, not oxidizing

FIRST AID MEASURES of SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE):
-Skin Contact:
Remove/Take off immediately all contaminated clothing.
Wash gently with plenty of soap and water.
-If skin irritation or rash occurs:
Get medical advice/attention.
-Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if convenient and easy to do.
Continue to wash.
-In case of eye irritation:
Get medical advice/attention.
-Ingestion:
Get medical advice/attention if you feel unwell.

ACCIDENTAL RELEASE MEASURES of SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE):
-Environmental Measures:
Prevent from entering sewers.
-Methods and materials for control and cleaning:
Be careful not to scatter.

FIRE FIGHTING MEASURES of SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE):
-Suitable Extinguishing Media:
Dry chemical, foam, water spray, carbon dioxide
-Specific method:
Non-related personnel should be evacuated to a safe place.

EXPOSURE CONTROLS/PERSONAL PROTECTION of SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE):
-Engineering control:
Install showers and eyewash stations .
-Personal protective equipment:
*Respiratory protection:
Follow local and government regulations.
*Hand protection:
Protective gloves.
*Eye Protection:
Safety goggles.
Wear a mask if the situation requires it.
*Skin and Body Protection:
Protective clothing.
Wear protective boots if situation requires.

HANDLING and STORAGE of SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE):
-Handling:
*Technical measures:
Handle in a well-ventilated area.
Wear suitable protective equipment.
Wash hands.
-Storage
Storage Conditions:
Keep container tightly closed.
Store in a cool, dark place.
Store under an inert gas atmosphere.
Moisture-proof.
-Packaging materials:
In accordance with the law.

STABILITY and REACTIVITY of SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE):
-Chemical stability:
Generally stable.
-Possibility of Hazardous Reactions:
No specific reactivity reported.