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Sodium ascorbyl phosphate has been used as medium supplement in Dulbecco′s Modified Eagle Medium (DMEM) for adipose-derived stem cells, human mesenchymal stem cells and osteoblast cells.
Sodium ascorbyl phosphate is a stable, water-soluble form of vitamin C made from combining ascorbic acid with a phosphate and a salt, compounds which work with enzymes in skin to cleave (split) the ingredient and release pure ascorbic acid, which is the most researched form of vitamin C.
When used in higher amounts, Sodium ascorbyl phosphate can be effective for brightening a dull skin tone, smoothing wrinkles, visibly firming skin, and reducing discolourations.
CAS: 66170-10-3
MF: C6H9O9P.3Na
MW: 325.07
EINECS: 425-180-1
Synonyms
L-Ascorbic acid 2-phosphate trisodium salt, Sodium L-ascorbyl-2-phosphate;Sodium L-ascorbyl-2-;SodiuM (R)-5-((S)-1,2-dihydroxyethyl)-4-hydroxy-2-oxo-2,5-dihydrofuran-3-yl phosphate;L-Ascorbicacid, 2-(dihydrogen phosphate), sodiuM salt (1:3);L-Ascorbic-2-Phosphate;2-PHOSPHO-L-ASCORBIC ACID TRISODIUM;2-(Dihydrogen phosphate)-L-ascorbic acid sodium salt;Vitamin C sodium phosphate;Sodium L-ascorbic acid 2-phosphate;Sodium L-Ascorbyl-2-Phosphate;66170-10-3;VCP-NA;CHEBI:81687;L-Ascorbic acid 2-phosphate (trisodium);2-Phospho-L-ascorbic acid (trisodium);s5115;C18341
The sodium salt form of skincare superstar, vitamin C.
If you do not know what the big fuss about vitamin C is, you are missing out and you have to click here and read all the geeky details about it.
Pure vitamin C (aka ascorbic acid, AA) is great and all, but its lack of stability is a big challenge for the cosmetics industry.
One solution is to create stable derivatives that can be absorbed into the skin, convert there to AA and do all the magic AA is proven to do (which is being an antioxidant, a collagen booster, and a skin brightener).
Sodium Ascorbyl Phosphate is a powerful and effective antioxidant that protects the skin cells against damage caused by free radicals.
Sodium Ascorbyl Phosphate is a stable, water-soluble Vitamin C derivative which not only protects the skin but also improves it appearance.
Sodium ascorbyl phosphate is a highly stable form of vitamin C that has been chemically stabilised with salt.
This stabilisation enables for easy penetration into the skins lipid barrier, where, once absorbed, it quickly converts into ascorbic acid, the pure form of vitamin C.
This quick absorption means sodium ascorbyl phosphate is less irritating than other forms of vitamin C and is suitable for those with sensitive skin.
This stabilisation also means that the benefits of the vitamin C remain potent and effective throughout the use of the product.
This is a key advantage over pure vitamin C, which is known to quickly oxidise and degrade upon external exposure.
Sodium ascorbyl phosphate has powerful antioxidant benefits that fight signs of ageing, preventing the appearance of fine lines and wrinkles by stimulating the production of collagen and protecting against environmental aggressors.
Sodium ascorbyl phosphate also helps diminish discolouration and age spots by inhibiting the production of melanin, resulting in an even, brighter complexion.
A unique benefit of sodium ascorbyl phosphate compared to alternative forms of vitamin C is that it can be used as an effective acne treatment.
As well as having antimicrobial properties, Sodium ascorbyl phosphate reduces sebum oxidation (the process whereby oil on the surface of the skin reacts with oxygen) which results in clogged pores and encourages the formation of blackheads.
By inhibiting this process, skin imperfections are reduced.
As derivative of ascorbic acid (vitamin C), sodium ascorbyl phosphate can rapidly digested by phosphatase to free ascorbic acid in the human body, and is stable.
Therefore, sodium ascorbyl phosphate can play the function of ascorbic acid, and overcome the shortcoming.
Application
Sodium ascorbyl phosphate can be widely used in skin care products.
As an effective water-soluble antioxidant, Sodium ascorbyl phosphate is stable in cosmetic formulations.
Oil-soluble vitamin E acetate, together with water-soluble vitamin C sodium phosphate, is an ideal antioxidant system in all skin care formulations to resist the skin damage caused by daily environmental stress.
Other important application are in fields of sunscreen formulations, wrinkle-resistant products, body emulsions, day creams, evening creams and whitening products.
Sodium ascorbyl phosphate Chemical Properties
Melting point: 260 °C
Density: 1.94[at 20℃]
Storage temp.: Inert atmosphere,Room Temperature
Solubility: Acidic DMSO (Slightly), Water (Slightly)
Form: Solid
Color: White to Off-White
PH: 9.0-9.5 (25℃, 30g/L in H2O)
Odor: at 100.00?%. bland
Water Solubility: 789g/L at 20℃
Stability: Hygroscopic
InChIKey: YRWWOAFMPXPHEJ-OFBPEYICSA-K
CAS DataBase Reference: 66170-10-3(CAS DataBase Reference)
Uses
Sodium ascorbyl phosphate is a long-lasting vitamin C derivative used in studies of gene repression.
Maximizes the benefical properties of vitamins C for personal care and a main active ingredient in medicated cosmetics for whitening.
Also, Sodium ascorbyl phosphate is substrate in the chromoamperometric method to detect tungsten in water.
Vitamin C is a well-known skin-whitening agent.
Sodium ascorbyl phosphate can promote the synthesis of ossein and restrain the oxidation of the lipid.
However, Sodium ascorbyl phosphate's colour is easily changed by oxidation, so the use of Vitamin C is limited.
Sodium ascorbyl phosphate can overcome this shortcoming.
stability of the product is highly improved. Once Brillian-300 is absorbed by skin, Sodium ascorbyl phosphate quickly decomposes into Vitamin C, and exerts the physiological action of Vitamin C.
Sodium ascorbyl phosphate is used as a research reagent and is widely used in molecular biology, pharmacology, and other scientific research fields.
Sodium ascorbyl phosphate is strictly prohibited from being used in the human body.
Sodium ascorbyl phosphate is used for biocatalytic dephosphorylation, for power generation and electrochemical detection.
Sodium ascorbyl phosphate can be used for cell differentiation and tissue engineering applications.
Sodium ascorbyl phosphate is an excellent additive for modern functional whitening cosmetics.
As a cosmetic additive, Sodium ascorbyl phosphate has the following benefits:
1. Inhibit tyrosinase activity, reduce melanin, and have the effect of removing spots and whitening.
2. After entering the body,Sodium ascorbyl phosphate can eliminate oxygen free radicals, thereby having wrinkle-removing and anti-aging functions.
3. Sodium ascorbyl phosphate has a synergistic effect with vitamin E.
4. Sodium ascorbyl phosphate can also be used as a nutritional supplement, feed additive and antioxidant.
Biochem/physiol Actions
Sodium ascorbyl phosphate is used in biocatalytic dephosphorylation for electric power generation and electrochemical detection assays.
Sodium ascorbyl phosphate may be used in cell differentiation and tissue engineering applications.
Sodium ascorbyl phosphate is used in studies of gene repression, such as the repression of dihydrotestosterone-induced dickkopf-1 expression.
