PRODUCTS

SODIUM ETHYL PARABEN

CAS NUMBER: 35285-68-8

EC NUMBER: 252-487-6

MOLECULAR FORMULA: C9H9NaO3

MOLECULAR WEIGHT: 188.16 g/mol

IUPAC NAME: Ethyl 4-hydroxybenzoate

Sodium Ethyl Paraben is a water-soluble antiseptic mainly used as a safe,high efficiency,broad-spectrum antibiotic for cosmetic.
Sodium Ethyl Paraben is in the paraben family of preservatives used by the food.
Sodium Ethyl Paraben can be used as a food additive and as an antifungal preservative.
Sodium Ethyl Paraben is used in studying the effect of tobacco ingredients (flavorings and additives) on smoke chemistry.

Sodium Ethyl Paraben is also a useful reagent in synthesis of Poly(bis(4-carboxyphenoxy)phosphazene).
Sodium Ethyl Paraben is a Sodium salt of ethylparaben.
Sodium Ethyl Paraben is widely applied in medical industry, food industry, textile industry.

Storage of Sodium Ethyl Paraben: preserved in cool and dry place sealed,shelf life is 24 months.
Sodium Ethyl Paraben is used in Food, Beverage, Pharmaceutical, Health & Personal care products, Agriculture/Animal Feed/Poultry.
Sodium Ethyl Paraben is a paraben preservative used in cream, cream, honey, shampoo and other personal care products.
Sodium Ethyl Paraben is often used as a preservative and anti-fungal agent to prevent molding and to provide a much longer shelf life to chips.

Sodium Ethyl Paraben is a White or almost white, hygroscopic, crystalline powder.
Sodium Ethyl Paraben is manufactured and/or imported in the European Economic Area in 1 - 10 tonnes per year.
Sodium Ethyl Paraben is used by consumers and in formulation or re-packing.

Sodium Ethyl Paraben is used in the following products: cosmetics and personal care products.
Other release to the environment of Sodium Ethyl Paraben is likely to occur from: indoor use as processing aid.
Sodium Ethyl Paraben is used in the following products: cosmetics and personal care products.
Release to the environment of Sodium Ethyl Paraben can occur from industrial use:formulation of mixtures.
Sodium Ethyl Paraben is used as an antifungal preservative.
As a food additive, it has E number E214.

Sodium Ethyl para-hydroxybenzoate, the sodium salt of ethylparaben, has the same uses and is given the E number E215.
Sodium Ethyl Paraben was used to study the in-situ derivatisation solid-phase microextraction procedure for determining parabens.
Sodium Ethyl Paraben was used to study its retention property.
Sodium Ethyl Paraben has high extraction efficiency towards the compounds tested owing to the electrostatic interaction.
Sodium Ethyl Paraben is one of the parabens family.

SOME SPECIFICATIONS:
-Assay: 95.0 - 102.0 %
-Assay (HPLC): 95.0 - 102.0 %
-Identity (IR-spectrum): passes test
-Identity (wet chemistry): passes test
-Appearance of solution (100 g/l, CO₂-free water): clear and not more intense in color than reference solution BY₆
-pH-value (1 g/l in CO₂-free Water): 9.5 - 10.5
-Chloride (Cl): ≤ 350 ppm
-Sulfate (SO₄): ≤ 300 ppm
-Related substances: passes test
-4-Hydroxy benzoic acid: ≤ 3.0 %
-Sum of all impurities : ≤ 1.0 %
-Largest unspecified impurity: ≤ 0.5 %
-Related substances: passes test
-4-Hydroxy benzoic acid (NF): ≤ 3.0 %
-Sum of all impurities: ≤ 1.0 %
-Largest unspecified impurity (NF): ≤ 0.5 %
-Methanol (HS-GC): ≤ 3000 ppm
-Acetone (HS-GC): ≤ 5000 ppm
-Ethanol (HS-GC): ≤ 5000 ppm
-Other residual solvents: excluded by manufactoring process
-Water (according to Karl Fischer): ≤ 5.0 %

Sodium Ethyl Paraben, also known as e-214 or aseptin a, belongs to the class of organic compounds known as p-hydroxybenzoic acid alkyl esters.
Sodium Ethyl Parabens are aromatic compounds containing a benzoic acid.
Sodium Ethyl Paraben is a potentially toxic compound.
Sodium Ethyl Paraben belongs to the class of organic compounds known as p-hydroxybenzoic acid alkyl esters.
Sodium Ethyl Paraben IUPAC Name is sodium;4-ethoxycarbonylphenolate.

Sodium Ethyl Paraben EU Food Improvement Agents: C9H9NaO3.
Sodium Ethyl Paraben is produced naturally and found in several fruits and insects, where it acts as an antimicrobial agent.
Sodium Ethyl Paraben is mainly used as antiseptics in cosmetics, food and medicine.

Sodium Ethyl Paraben is also can be used as feed preservatives and antiseptic for bacteria.
Sodium Ethyl Paraben is readily absorbed from the gastrointestinal tract or through the skin.
Sodium Ethyl Paraben is hydrolyzed to p-hydroxybenzoic acid and rapidly excreted in urine without accumulating in the body.
Under the Federal Food, Drug, and Cosmetic Act (FD&C Act), cosmetic products and ingredients, other than color additives, do not need FDA approval before they go on the market.

Description: Belongs to the class of organic compounds known as p-hydroxybenzoic acid alkyl esters.
These are aromatic compounds containing a benzoic acid, which is esterified with an alkyl group and para-substituted with a hydroxyl group.

Class: Benzene and substituted derivatives
Sub Class: Benzoic acids and derivatives
Direct Parent: p-Hydroxybenzoic acid alkyl esters
Alternative Parents:
-Benzoyl derivatives
-1-hydroxy-2-unsubstituted benzenoids
-Carboxylic acid esters
-Monocarboxylic acids and derivatives
-Organooxygen compounds
-Organic oxides
-Hydrocarbon derivatives

Substituents:
-P-hydroxybenzoic acid alkyl ester
-Benzoyl
-1-hydroxy-2-unsubstituted benzenoid
-Phenol
-Carboxylic acid ester
-Monocarboxylic acid or derivatives
-Carboxylic acid derivative
-Organic oxygen compound
-Organic oxide
-Hydrocarbon derivative
-Organooxygen compound
-Aromatic homomonocyclic compound

Sodium Ethyl Paraben is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries pharmaceuticals.
Sodium Ethyl Paraben is suitable to preserve both rinse- off and leave- on formulations.
Sodium Ethyl Paraben is effective against bacteria, molds and yeast.

Sodium Ethyl Paraben has a characteristic Odor
Sodium Ethyl p-hydroxybenzoate is widely used in food and pharmaceutical and textile industry for its antiseptic property.
Sodium Ethyl Paraben is also can be used in industries such as cosmetics, feed and so on
Sodium Ethyl Paraben is a water-soluble antiseptic mainly used as a safe, high efficiency, broad-spectrum antibiotic for cosmetics.

Sodium Ethyl Paraben is in the Paraben family of preservatives used by the food, pharmaceutical, and personal care product industries.
Sodium Ethyl Paraben is important to note that, at the target pH of the formulation, the Parabens will exist as the free esters and not as salts and, therefore, the solubility will also be that of the free esters.
Use of the sodium salts will facilitate introduction of the Parabens; it will not allow higher concentrations to be used compared with the free esters.

Appearance: White powder
pH: 9.5- 10.5
Water content: max. 5.0 %
Assay by non aqueous titration: 99 - 102 %
Solubility:Water up to 50 %
Appearance :Powder
Active Substance (ca.): 100%
INCI-Name: Sodium Ethyl Paraben

Uses: Sodium Ethyl Paraben is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries pharmaceuticals.
Sodium Ethyl Paraben is suitable to preserve both rinse- off and leave- on formulations.
Sodium Ethyl Paraben is effective against bacteria, molds and yeast.
The recommended use level of Nipagin A Sodium to preserve most product types is normally in the range of 0.1- 0.3 % based on the total weight of the finished product.
The Paraben esters have many advantages as preservatives,like broad spectrum antimicrobial activity, effective at low use concentrations, compatible with a wide range of cosmetic ingredients, colourless, odourless, well documented toxicological and dermatological acceptability based on human experience (used in cosmetics, food and pharmaceuticals since 1930ies), p-Hydroxybenzoic Acid and a number of its esters occur naturally in a variety of plants and animals, stable and effective over a wide pH- range, etc.

The Sodium Parabens, like Sodium Ethyl Paraben have several additional advantages:
- Nipagin A Sodium is highly soluble in cold water for ease of addition.
- No heating stage required for incorporation, thus saving energy and plant occupancy.
- Increased antimicrobial activity at alkaline pH.

PHYSCIAL PROPERTIES OF SODIUM ETHYL PARABEN:

-Molecular Weight: 188.16

-Exact Mass: 188.04493843

-Monoisotopic Mass: 188.04493843

-Topological Polar Surface Area: 49.4 Å²

-Physical Description: White, crystalline hygroscopic powder

-Melting Point: 213 °C-217 °C

Applications: Sodium Ethyl Paraben is designed for preservation of a wide range of cosmetics and toiletries.
Sodium Ethyl Paraben is suitable to preserve both rinse- off and leave- on formulations.
Formulations which are prone to bacteria contamination an additional antibacterial preservative, like Nipaguard DMDMH might be necessary to add as Sodium Ethyl Paraben provides a higher efficacy against fungi than against bacteria.

Sodium Ethyl Paraben is a highly water-soluble short-chain Paraben in sodium salt form.
The major benefit offered by the sodium salts is their high solubility in cold water, thereby enabling the introduction of Parabens without heating or pre-dissolving in solvents.
Sodium Ethyl Paraben, also known as Ethyl Paraben or Ethyl parahydroxybenzoate, can be used as a food additive and as an antifungal preservative

Benefits:
-Sodium Ethyl Paraben has high solubility in cold water
-Sodium Ethyl Paraben performs broad spectrum of activity against bacteria and fungi
-Sodium Ethyl Paraben shows effectiveness at low concentrations
-Sodium Ethyl Paraben has stability over a broad pH-range

Incorporation:
Sodium Ethyl Paraben is highly soluble in water and so easily incorporated into cosmetic formulations.
Sodium Ethyl Paraben is important to note that, whilst the aqueous solubility in alkaline solution is high, if the pH of the formulated product is acidic the sodium salt reverts to the ester and the low solubility is regained.

Microbial activity:
Sodium Ethyl Paraben has a broad spectrum of activity which includes the following common spoilage organisms.

Microorganisms MIC level (%):
Gram-negative bacteria
-Pseudomonas aeruginosa: 0.113
-Escherichia coli: 0.056
-Klebsiella pneumoniae: 0.056
-Serratia marcescens: 0.056
-Proteus vulgaris: 0.068
-Salmonella enteritidis: 0.046
Gram-positive bacteria:
-Staphylococcus aureus: 0.079
-Streptococcus haemolyticus: 0.068
-Bacillus cereus: 0.028

Applications:
Aqueous concentrates may be prepared up to 40% in strength.
The concentrate may then be added to the process, preferably slowly and with rapid mixing.
Due to the high pH of aqueous solutions of sodium Parabens, the pH of the final product requires adjustment.
The aqueous solution should be used within a short time of preparation as prolonged storage will result in alkaline hydrolysis of the esters.

pH stability:
Sodium Ethyl Paraben remains fully stable over a wide pH range from 3.0- 11.0.
Aqueous solutions of Nipagin A Sodium are not long- term stable at alkaline pH.

Temperature stability:
The recommended maximum handling temperature is 80°C.

Storage instructions:
Sodium Ethyl Paraben is stable in sealed original containers.
Further information on handling, storage and dispatch is given in the EC safety data sheet.

Sodium Ethyl Paraben is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries pharmaceuticals.
Sodium Ethyl Paraben is suitable to preserve both rinse- off and leave- on formulations.
This product is highly soluble in cold water, which adds to its ease of addition to formulations.

Sodium Ethyl Paraben provides a broad spectrum of activity against bacteria & fungi.
Sodium Ethyl Paraben is a short-chain Paraben in sodium salt form.
Sodium Ethyl Paraben exhibits effectiveness at low concentrations.
Sodium Ethyl Paraben shows good biodegradability at environmental concentrations.
Sodium Ethyl Paraben is used in all kinds of personal care products.

CHEMICAL PROPERTIES OF SODIUM ETHYL PARABEN

-Hydrogen Bond Donor Count: 0

-Hydrogen Bond Acceptor Count: 3

-Rotatable Bond Count: 3

-pH: 9,9-10,3 (0,1 % aqueous solution)

-Heavy Atom Count: 13

-Formal Charge: 0

-Complexity: 153

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 0

-Undefined Atom Stereocenter Count: 0

-Defined Bond Stereocenter Count: 0

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 2

-Compound Is Canonicalized: Yes

Sodium Ethyl Paraben is Preservative for the cosmetic industry.
Sodium Ethyl p-Hydroxybenzoate, designed for preservation of a wide range of cosmetics and toiletries.
Sodium Ethyl Paraben is suitable to preserve both rinse- off and leave- on formulations.
Formulations which are prone to bacteria contamination an additional antibacterial preservative might be necessary to add as it provides a higher efficacy against fungi than against bacteria.

Sodium Ethyl Paraben is broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries pharmaceuticals.
Sodium Ethyl Paraben is suitable to preserve both rinse- off and leave- on formulations.
Sodium Ethyl Paraben is effective against bacteria, molds and yeast.
Sodium Ethyl Paraben's usage level to preserve most product types is normally in the range of 0.1- 0.3 % based on the total weight of the finished product.

OTHER PROPERTIES:

-Melting Point: 116 °C
-Boiling Point: 298.00 °C
-Water Solubility: 0.88 mg/mL at 25 °C
-LogP: 2.47
-Water Solubility: 2.49 g/L
-logP: 10(2.76) g/L
-logP: 10(2.03) g/L
-logS: 10(-1.8) g/L
-pKa (Strongest Acidic): 8.5
-pKa (Strongest Basic): -6.1
-Physiological Charge: 0
-Hydrogen Acceptor Count: 2
-Hydrogen Donor Count: 1
-Polar Surface Area: 46.53 Å²
-Rotatable Bond Count: 3
-Refractivity: 44.81 m³·mol⁻¹
-Polarizability: 17.23 Å³
-Number of Rings: 1
-Bioavailability: Yes
-Rule of Five: Yes
-Ghose Filter: Yes
-Veber's Rule: No
-MDDR-like Rule: No

Sodium Ethyl Paraben is soluble in cold water for ease; No heating stage required for incorporation, thus saving energy and plant occupancy; Increased antimicrobial activity at alkaline pH.pH stability; remains fully stable over a wide pH range from 3.0- 11.0.
Aqueous solutions are not long- term stable at alkaline pH.max. temperature 80°C.

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol.
They are largely used as biocides in cosmetics and toiletries, medicaments, or food.
They have synergistic power with biocides.

Sodium Ethyl Paraben is a water-soluble antiseptic mainly used as a safe, high efficiency, broad-spectrum antibiotic for cosmetics.
Sodium Ethyl Paraben is in the paraben family of preservatives used by the food, pharmaceutical, and personal care product industries.
Sodium Ethyl Paraben by Sharon Laboratories acts as a preservative.
Exhibits the same antimicrobial activity as regular parabens.

Sodium Ethyl Paraben is characterized by its high solubility in cold water.
Sodium Ethyl Paraben is used in hair styling gels, hair care products, toothpaste and oral care products.
Sodium Ethyl Paraben has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics.
Sodium Ethyl Parabencan be combined with other parabens like methyl 4-hydroxybenzoate or propyl 4-hydroxybenzoate.
The sodium salt provides improved solubility in water compared to standard ethyl 4-hydroxybenzoate.

-Catalogue Number: E 975118
-Chemical Name: E 215
-CAS Number: 35285-68-8
-Alternate CAS -Free Acid: 120-47-8
-Appearance: White to Off-White Solid
-Melting Point: >273°C
-Molecular Weight: 188.16
-Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
-Solubility: DMSO (Slightly), Methanol (Slightly)
-Category: Building Blocks; Miscellaneous;
-Applications: E 215 is used in studying the effect of tobacco ingredients (flavorings and additives) on smoke chemistry.
Sodium Ethyl Paraben is also a useful reagent in synthesis of Poly(bis(4-carboxyphenoxy)phosphazene)

-Average Molecular Weight: 166.1739
-Monoisotopic Molecular Weight: 166.062994186
-Traditional Name: ethylparaben
-CAS Registry Number: 120-47-8
-SMILES: CCOC(=O)C1=CC=C(O)C=C1
-InChI Identifier: InChI=1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3
-InChI Key: NUVBSKCKDOMJSU-UHFFFAOYSA-N

STORAGE OF SODIUM ETHYL PARABEN:

Sodium Ethyl Paraben should be stored under an inert atmosphere.
Sodium Ethyl Paraben should be stored in Cool place.
Sodium Ethyl Paraben should be stored in dry place.

Sodium Ethyl Paraben is kept sealed
Sodium Ethyl Paraben has a shelf life of 24 months.
Sodium Ethyl Paraben is stable in closed original containers.

Sodium Ethyl Paraben should not be stored at very low or very high temperatures.
Sodium Ethyl Paraben should not be stored in the same place as reagents.
Sodium Ethyl Paraben should be stored in ventilated environment.
Sodium Ethyl Parabenshould be stored in a moisture free environment.

SYNONYMS:

Sodyum EtilParaben 4-hydroxy-;
Sodyum EtilParaben methyl ester (7CI);
Sodyum EtilParaben UNII:Z0D00IVA10;
Ethyl 4-hydroxybenzoate (ethylParaben);
Ethyl 4-hydroxybenzoate;
p-Hydroxybenzoic acid ethyl ester sodium salt;
35285-68-8;
Sodium ethylParaben;
Sodium 4-(ethoxycarbonyl)phenolate;
ethylParaben sodium;
Sodium ethyl p-hydroxybenzoate;
Sodium 4-ethoxycarbonylphenoxide;
EthylParaben, sodium salt;
Ethyl p-hydroxybenzoate, sodium salt;
Sodium Ethyl Parahydroxybenzoate;
EthylParaben Sodium Salt;
C9H9NaO3;
EthylParaben sodium (NF);
Q3963917; ethyl ester; sodium salt;
Ethyl 4-hydroxybenzoate sodium salt;
4-Hydroxybenzoic Acid Ethyl Ester Sodium Salt;
Ethyl 4-Hydroxybenzoate Sodium Salt;
Ethyl p-Hydroxybenzoate Sodium Salt;
Sodium Ethyl Parahydroxybenzoate;
EthylParaben sodium salt;
SODIUM ETHYL 4-HYDROXYBENZOATE; s
odium 4-ethoxycarbonylphenoxide;
benzoicacid,4-hydroxy-,ethylester,sodiumsalt;
Benzoicacid,p-hydroxy-,ethylester,sodiumderiv.;
ETHYL-P-HYDROXYBENZOATE SODIUM SALT;
ETHYL-4-HYDROXYBENZOIC ACID SODIUM SALT;
Sodyum EtilParaben Ethyl 4-hydroxybenzoate,sodium salt;
Sodium Ethyl Paraben;
Ethyl Paraben Sodium;
Sodium 4-(ethoxycarbonyl);
SODIUM ETHYL 4-HYDROXYBENZOATE;
Benzoic acid; SODIUM ETHYL PARABEN;
Sodium Ethyl Parahydroxybenzoate;
Sodium Ethyl Paraben,Ethyl 4-hydroxybenzoate (ethylParaben);