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EC / List no.: 618-620-0
CAS no.: 9067-32-7
Sodium hyaluronate = sodium salt of hyaluronic acid = Hyaluronic acid
Sodium hyaluronate is the sodium salt of hyaluronic acid, a glycosaminoglycan found in various connective tissue of humans.
Chemistry
Sodium hyaluronate is the sodium salt of hyaluronic acid.
Sodium hyaluronate is a glycosaminoglycan and long-chain polymer of disaccharide units of Na-glucuronate-N-acetylglucosamine.
Sodium hyaluronate can bind to specific receptors for which it has a high affinity.
The polyanionic form, commonly referred to as hyaluronan, is a visco-elastic polymer found in the aqueous and vitreous humour of the eye and in the fluid of articulating joints.
Natural occurrence
Sodium hyaluronate, as hyaluronic acid, is distributed widely in the extracellular matrix of mammalian connective, epithelial, and neural tissues, as well as the corneal endothelium.
Mechanism of action
Sodium hyaluronate functions as a tissue lubricant and is thought to play an important role in modulating the interactions between adjacent tissues.
Sodium hyaluronate forms a viscoelastic solution in water.
Mechanical protection for tissues (iris, retina) and cell layers (corneal, endothelium, and epithelium) are provided by the high viscosity of the solution.
Elasticity of the solution assists in absorbing mechanical stress and providing a protective buffer for tissues.
In facilitating wound healing, it is thought that it acts as a protective transport vehicle, taking peptide growth factors and other structural proteins to a site of action.
Sodium hyaluronate is then enzymatically degraded and active proteins are released to promote tissue repair.
Pharmacokinetics
Sodium hyaluronate is cleared within hours of injection but appears to have residual effects on contacted cells.
In the eye it is eliminated via the canal of Schlemm.
Adverse effects
Adverse effects are relatively rare when used to treat the joints.
When used in ophthalmological procedures, sodium hyaluronate may cause postoperative inflammation, corneal edema or decompensation, and short-term increases in intraocular pressure.
Medical uses
Intra-articular injection
Sodium hyaluronate is used to treat knee pain in patients with osteoarthritis who have not received relief from other treatments.
Sodium hyaluronate is injected into the joint capsule, to act as both a shock absorber and a lubricant for the joint.
Thus sodium hyaluronate is used as a viscosupplement, administered through a series of injections into the knee, increasing the viscosity of the synovial fluid, which helps lubricate, cushion and reduce pain in the joint.
Sodium hyaluronate is generally used as a last resort before surgery and provides symptomatic relief, by recovering the viscoelasticity of the articular fluid, and by stimulating new production from synovial fluid.
Use of sodium hyaluronate may reduce the need for joint replacement.
Injections appear to increase in effectiveness over the course of four weeks, reaching a peak at eight weeks and retaining some effectiveness at six months, with greater benefit for osteoarthritis than oral analgesics.
Sodium hyaluronate may also be effective when used with the ankle joint.
Intraocular viscoelastic injection
Sodium hyaluronate is used as an aid in ophthalmic surgery acting as aqueous and vitreous humor, e.g. in cataract extraction (intra- and extracapsular), intraocular lens implantation, corneal transplant, glaucoma filtration, and retina attachment surgery and in the treatment of dry eyes.
In surgical procedures in the anterior segment of eyeball, instillation of sodium hyaluronate its viscoelasticity enables maintenance of a deep chamber during surgical manipulation since the solution does not flow out of the open anterior chamber, allowing for efficient manipulation with less trauma to the corneal endothelium and other surrounding tissues.
Its viscoelasticity also helps to push back the vitreous face and prevent formation of a postoperative flat chamber.
In posterior segment surgery, sodium hyaluronate serves as a surgical aid to gently separate, maneuver, and hold tissues. Sodium hyaluronate creates a clear field of vision, facilitating intra-operative and post-operative inspection of the retina and photocoagulation.
Sodium hyaluronate is also used to coat the bladder lining in treating interstitial cystitis.
Skin injections in plastic surgery
Sodium hyaluronate is injected to reduce wrinkles on the face. As of 2017, the FDA had approved 13 hyaluronate preparations as so called dermal fillers.
They are also used as a filler of lips or in other parts of the body, though not FDA approved.
The filling effect is temporary and lasts for about six months or longer in most people.
Topical application
Topically applied sodium hyaluronate can facilitate the absorption of biomacromolecules, i.e. pharmaceuticals, and function like a nanocarrier.
Its effects on skin depend on the hyaluronate formulation and skin health: In barrier-deficient skin it restricted the delivery of biomacromolecules to the stratum corneum and viable epidermis.
In normal skin, low-molecular weight hyaluronate (5 kDa) enhanced penetration into the epidermis.
Transepidermal water loss increased by 55.5% with low-molecular weight, and was reduced by 28% with crosslinked resilient, and by 16% with HMW.
The addition to skin creams became popular in the second millennium.
Its efficacy against wrinkles has not been tested in clinical trials.
After instillation into the lung, higher molecular weight hyaluronate appears to persist longer in the lung but if > 215 kD there was poor lung penetration and mucociliary clearance. Hyaluronate could allow access to lymph nodes draining the pulmonary bed.
Sodium hyaluronate in skin care
As a derivative of HA, sodium hyaluronate has similar benefits to HA. It’s been proven to:
Moisturize the skin
Sodium hyaluronate is hydrophilic, meaning it easily mixes with water.
When applied topically, it attracts moisture in skin cells.
This reduces dryness and flaking by increasing skin hydration.
Compared to high molecular weight HA, sodium hyaluronate can provide a greater hydrating effect.
This is due to its low molecular weight, according to a 2019 report.
Reduce appearance of wrinkles
Dry skin makes fine lines and creases more noticeable. But as sodium hyaluronate hydrates the skin, it improves the appearance of wrinkles.
In a 2014 studyTrusted Source, formulas with sodium hyaluronate decreased wrinkle depth and improved elasticity.
The researchers linked this effect to the hydrating properties of HA.
Reduce skin inflammation
Sodium hyaluronate can also soothe skin inflammation.
In a 2013 study, an HA sodium salt cream reduced symptoms of rosacea in adults. Rosacea is an inflammatory skin condition that causes redness, burning, and bumps.
According to the study, low molecular weight HA promotes the production of beta-defensin 2 (DEFβ2,) a compound that promotes tissue healing.
Sodium hyaluronate also controls the activity of inflammatory cells.
Similarly, in a 2014 studyTrusted Source, HA sodium salt gel improved an inflammatory skin disorder called seborrheic dermatitis.
Heal wounds
In a 2017 case reportTrusted Source, HA sodium salt gel helped heal a recurring skin ulcer.
According to the researchers, this was due to HA’s ability to promote cell multiplication and tissue repair.
The rise in DEFβ2 also played a role. DEFβ2 has antimicrobial effects, which protects wounds from infection.
These properties, combined with the anti-inflammatory activity of sodium hyaluronate, can help support proper wound healing.
Other medical benefits of sodium hyaluronate
Beyond skin care, sodium hyaluronate has other medical benefits.
Knee osteoarthritis
As mentioned earlier, it’s naturally found in joint fluid and cartilage.
However, in osteoarthritis, levels of sodium hyaluronate in the joints become low.
If you have osteoarthritis in the knee, an injection of sodium hyaluronate can help.
The treatment is directly injected in the knee, which decreases pain in the area.
Eye surgery
Sodium hyaluronate is also an ophthalmic viscosurgical device (OVD).
As an OVD, sodium hyaluronate protects the eye and creates space for surgery.
It’s useful in procedures like:
corneal transplant surgery
glaucoma filtration surgery
secondary intraocular lens implantation
cataract surgery
Dry eye syndrome
Thanks to its anti-inflammatory and moisturizing effects, sodium hyaluronate can soothe dry eyes.
Sodium hyaluronate may reduce symptoms like:
dryness
burning
itching
Rhinitis
When used as a nasal spray, sodium hyaluronate can relieve symptoms of rhinitis.
This condition occurs when the inside of your nose becomes inflamed.
The spray may help:
nasal congestion
swelling
runny nose
Sodium hyaluronate forms
Sodium hyaluronate is available in many forms:
Sodium hyaluronate injection
A sodium hyaluronate injection is used to treat osteoarthritis knee pain.
It’s given by a medical provider in a clinical setting.
Sodium hyaluronate eye drops
Eye drops are used to treat dry eyes. They’re also called artificial tears.
The drops, which are available at drugstores, can be used at home.
You place the drops directly in your eyes.
Sodium hyaluronate nasal spray
This is a liquid that contains sodium hyaluronate.
Sodium hyaluronate comes in a bottle with a spray attachment, which you use to mist the liquid into your nostril.
Like eye drops, nasal sprays are available at drugstores.
Sodium hyaluronate face wash
A face wash with sodium hyaluronate can help hydrate your skin while removing makeup, dirt, and excess oil.
The product is applied to wet skin, then rinsed off.
Sodium hyaluronate serum
A serum is a product with a high concentration of beneficial ingredients.
To use it, you spread the formula on your face after cleansing.
Sodium hyaluronate lotion
Sodium hyaluronate is available as a lotion or cream, which is applied directly on your skin.
Sodium hyaluronate may be formulated for your face, body, or both.
You can also buy sodium hyaluronate cream for undereye skin.
Sodium hyaluronate gel
The ingredient also comes in gel form. You spread the gel on your skin until it’s absorbed.
What Is Sodium Hyaluronate?
According to both dermatologists, sodium hyaluronate is a water-soluble salt that's derived from hyaluronic acid, which can be found naturally in the body.
Like hyaluronic acid, sodium hyaluronate is incredibly hydrating, but this form can penetrate deeper into the skin and is more stable (meaning it will last longer) in cosmetic formulation.
Weinstein describes sodium hyaluronate as a fiber- or cream-like powder, which can be found in moisturizers and serums. As a humectant, sodium hyaluronate works by pulling in moisture from the environment and the underlying layers of your skin into the epidermis.
As Weinstein puts it, sodium hyaluronate "serves as a water reservoir in the skin, helping it to regulate the moisture content."
Benefits of Sodium Hyaluronate for Skin
Sodium hyaluronate has incredible hydrating benefits that address a number of skin concerns caused by a lack of moisture in the skin.
Combats skin dryness:
As a humectant, it pulls in water from the air and helps to retain moisture to keep your skin hydrated and flake-free.
Repairs a compromised moisture barrier:
It's essential for restoring and maintaining a healthy barrier to prevent transepidermal water loss (TEWL), which can lead to inflammatory conditions.
Improves signs of aging: Sodium hyaluronate works to replace lost moisture and hyaluronic acid naturally found in the skin that lessens with age.
This added hydration, in turn, may smooth texture created by fine lines and wrinkles.
Improves breakout-prone skin:
According to Shah, it could help your acne by rebalancing the skin if you are overly drying it with harsh exfoliants, cleansers, and treatments.
It's also generally considered to be non-comedogenic, which means it won't clog pores.
Plumps: Sodium hyaluronate provides structure and volume and can create temporary but instantaneous plumpness in the skin.
Leaves a non-greasy glow:
Sodium hyaluronate has a lightweight feel and imparts a dewy finish without leaving a thick, greasy residue.
Helps eczema:
Since the ingredient is so gentle, it's safe to use on sensitive skin and can be beneficial for severely dry skin types.
Restores skin post-procedure:
Weinstein and Shah both recommend the use of sodium hyaluronate to hydrate after in-office procedures, such as lasers or micro-needling, which make the skin vulnerable.
Sodium hyaluronate is a water-soluble form of hyaluronic acid.
It’s used in skin care to help firm, hydrate, and encourage moisture retention.
Sodium hyaluronate penetrates deeper than hyaluronic acid.
Look for it in serums and moisturizers.
Sodium hyaluronate can be applied morning and night.
It’s good for dry, acne-prone, and dull skin.
Too much sodium hyaluronate can cause dryne
What is sodium hyaluronate?
Sodium hyaluronate (HA) is essentially a water-soluble salt form of hyaluronic acid.
It’s found naturally in the body acting as a lubricant and a hydrator for you joints, hair, eyes, skin, and nerves.
HA is the hydration holy grail and can hold up to 1000 times its weight in water.
Both sodium hyaluronate and hyaluronic acid work by binding to water molecules and drawing water into the cells, leaving your skin looking plump and hydrated.
Sodium hyaluronate (also known as hyaluronic acid or hyaluronan) is a natural substance.
Sodium hyaluronate is present in the body wherever moisture is stored or lubrication between layers of tissue is required to eliminate friction.
Examples are the vitreous body of the eye itself, the tear film, the joint cartilage, the synovial fluid in the joints, all the mucuous membranes of the body, but also the basic substance of the skin which consists of up to 55% sodium hyaluronate.
Sodium hyaluronate takes on a variety of functions:
Storage: it absorbs and stores moisture in enormous quantities
Lubrication
Transport medium for nutrients
Filter for inflammatory molecules.
Sodium Hyaluronate is the ideal molecule in eye lubrication
As a result of their unique physical and chemical properties, sodium hyaluronate (SH) solutions are similar to natural tears:
Viscoelasticity
The most important property of SH solutions is their viscoelasticity, which combines the viscous properties of a liquid with the elastic properties of a solid, depending on the shear stress applied. When used as an ocular lubricant, the unique viscoelastic properties of SH increase the stability of the pre-corneal tear film and maximize tear film residence time.
Before using sodium hyaluronate
To make sure this is the right treatment for you, before you start using the eye drops it is important that your doctor or pharmacist knows:
If you wear soft contact lenses.
If you have ever had an allergic reaction to a preservative in eye drops.
How to use sodium hyaluronate eye drops
Wash your hands well before you use the drops.
Remove the cap from the bottle (or the tip of the unit if you are using a single-use unit).
Tilt your head back a little and pull the lower lid of your eye downwards to form a pocket.
Hold the bottle (or single-use unit) upside down near to your eye. Try not to touch your eye as you do this.
Apply enough pressure to release one drop into your eye. Only use a second drop if the first drop missed going into your eye.
Close your eye for a minute or two, and press gently on the side of your nose where the corner of your eye meets your nose. This helps to stop the drop from draining away and keeps it in your eye.
Repeat the process in your other eye if you have been told to use the drops in both eyes.
Replace the cap (or if you are using a single-use dose unit, throw the used unit away).
What is sodium hyaluronate?
Sodium hyaluronate is similar to the fluid that surrounds the joints in your body.
This fluid acts as a lubricant and shock absorber for the joints.
Sodium hyaluronate is used to treat knee pain caused by osteoarthritis.
Sodium hyaluronate is usually given when other arthritis medications have not been effective.
Sodium hyaluronate may also be used for purposes not listed in this medication guide.
WHAT IS SODIUM HYALURONATE USED FOR?
When added to cosmetic formulations, Sodium Hyaluronate helps to increase the final product’s stability and to reduce the probability of oxidization.
Cleansers and moisturizers that are enriched with this hydrating agent will not leave the skin with an oily residue.
When applied to the skin, Sodium Hyaluronate is reputed to…
Easily and deeply penetrate the skin to help it retain moisture for increased firmness and suppleness, resulting in a revitalized appearance
Remove loose flakes from dry skin
Relieve itching due to dehydrated and irritated skin
Smoothe the appearance of wrinkles and generally improve the texture of skin
Enhance the absorption and benefits of other nourishing ingredients in a formulation
Be gentle enough for use on most skin types, including acne-prone types
Replace the skin’s natural Hyaluronic Acid content, which diminishes with age, exposure to UV radiation, and various other environmental factors that lead to gradual moisture loss
Promote the look of replenished facial volume by causing the skin to appear swollen/plumper, which helps reduce the look of fine lines
HOW IS SODIUM HYALURONATE USED?
To use Sodium Hyaluronate in skincare, simply add it to the suggested phases of formulations for the following products:
Face Wash:
Due to its inclination to form clumps when introduced to water, SH can first be blended with Glycerine before being added to water.
This will prevent clumping and encourage a smooth blend.
Alternatively, it can simply be added directly to water, covered, and given time to hydrate, after which it can be mixed well.
When making larger volumes, SH can be added to water and blended in with a stick (immersion) blender until its consistency thickens.
Home / Ingredients /
Sodium Hyaluronate vs Hyaluronic Acid: Differences, Benefits, Skin Care Uses
October 7, 2019 • By Ana Gotter
Sodium hyaluronate is the salt form of hyaluronic acid, which makes it water-soluble and allows it to penetrate the skin deeper.
Sodium hyaluronate is commonly used to improve skin firmness, smooth wrinkles, and hydrate skin.
Sodium hyaluronate comes in multiple forms, including serums, moisturizers, powders, and oral supplements, and it’s safe to use for most skin types.
Hyaluronic acid is one of the most popular ingredients in the cosmetic industry today, offering powerful absorption and hydration properties.
Sodium hyaluronate, on the other hand, is the salt form of hyaluronic acid, and though they’re often referred to interchangeably, there are differences between the two that can make sodium hyaluronate more effective in some cases.
What Is Sodium Hyaluronate?
What’s the Difference Between Sodium Hyaluronate and Hyaluronic Acid?
Sodium Hyaluronate Skin Care Benefits
Skin care uses and complementary ingredients
Sodium Hyaluronate Safety and Side Effects
Takeaway
What Is Sodium Hyaluronate?
Sodium hyaluronate is a sodium salt that’s been synthesized by scientists to be stable and resistant to oxidation.
It’s a water-binding ingredient that allows for improved hydration.
Skin care uses
It’s often used in cosmetic products to help the skin absorb and retain more moisture, which can create a plumping effect that results in smooth, supple skin.
Sodium hyaluronate is typically added to moisturizing serums, creams, and lotions, allowing the skin to more easily absorb the hydrating benefits of the product.
Other uses
In addition to being a popular ingredient in skin care products, sodium hyaluronate is also used in numerous other products, too:
Eye drops to prevent dryness
Joint injections to act as a shock absorber between joints with low cartilage or in those with osteoarthritis
Treatment to coat the bladder lining when treating conditions like interstitial cystitis.
Sodium Hyaluronate Skin Care Benefits
Sodium hyaluronate has multiple skin care benefits that can result in healthier, glowing skin and an improved complexion.
Improves firmness of skin
When sodium hyaluronate is applied directly to the skin, its water-binding properties allow it to sink deeply into the skin between connective tissues to better absorb and retain moisture.
s a result, the skin will look and feel firmer to the touch, offering a smooth, youthful complexion.
Smooths wrinkles and fine lines
As the hydration penetrates deeply into the skin and results in a firmer appearance, the skin becomes plumper.
This reduces the visibility of fine lines and wrinkles, and moisturized skin can help prevent further wrinkles from developing.
Hydrates Skin Without Clogging Pores
Sodium hyaluronate is gentle, so it offers hydration without irritating sensitive skin in most cases.
It’s also non-comedogenic, meaning that it can offer significant hydration and moisturization benefits without clogging pores, unlike a large number of other products on the market.
A word about acne
Many people with acne-prone skin need to be particularly careful with the products they use to prevent breakouts or irritation. Sodium hyaluronate is particularly gentle, and since it won’t clog pores, it won’t result in additional breakouts.
Having moisturized skin can even help prevent breakouts.
When the skin is too dry, it may overproduce oil in attempt to rectify the problem, resulting in more breakouts.
Using sodium hyaluronate with a gentle, non-comedogenic moisturizer can keep your skin properly hydrated.
Skin care uses and complementary ingredients
Sodium hyaluronate is often found in serums, moisturizers, and creams.
These can be applied directly to the skin, and it’s not uncommon to find products created specifically for either facial use or full-body use.
In some cases, you may find serums that have sodium hyaluronate as the primary ingredient.
In others, complementary ingredients may be used to strengthen its potential or offer additional benefits.
Common complementary ingredients may include:
Vitamin C, which can promote skin healing
Vitamin E, which may help repair damage caused by UV rays
Vitamin A, for antiaging purposes
Collagen, which also has water-binding properties to improve skin firmness
Glycerin, which is effective for smoothing and moisturizing skin
Powder form & oral supplements
Sodium hyaluronate can be purchased in powder form. You can use this to create an at-home, pure form of hyaluronic acid and apply it to your skin, or add it to food or beverages to consume it directly.
This can be used to improve complexion, hydrate the skin, and possibly treat joint pain, though topical application on the skin and injections for the joints can be more effective.
What is sodium hyaluronate?
Sodium hyaluronate is the salt form of hyaluronic acid.
Sodium hyaluronate is synthesized to create a smaller molecular structure for stability and increased resistance to oxidation.
Its smaller molecular structure and water solubility means that it can penetrate deeper into skin, providing intense hydration beyond the skin’s surface.
Sodium hyaluronate is usually used for anti-aging and moisturizing because of its ability to improve firmness levels, smooth out fine lines, and hydrate the skin.
You can find sodium hyaluronate in many products, including serums and moisturizers. Sodium hyaluronate is also possible to take it as an oral supplement.
Physicochemical property
Sodium hyaluronate is also called Hyaluronic acid sodium, is physiological active substances, which is widely exists in the human body.
Sodium hyaluronate is high molecular weignt straight-chain mucopolysaccharides, which is composed of glucuronic acid and acetyl amino hexose polymerizatio.
its molecular weight is 1 million.
In water, Sodium hyaluronate can form a thick viscoelastic solution, has the physiological ph and ionic strength.
The molecular configuration is variable, so also can be done with a fine needle.
Sodium hyaluronate won't produce inflammatory substances , called Healon.
The 10 mg dissolved in 1 ml saline solution, its thick viscosity is 200000 times higher than aqueous humor or saline water.
Healon protein content is less than 0.5%, and a sterile solution with high purity.
Sodium Hyaluronate Injection
Hyaluronic acid sodium is a class of the non-drug neutral medium. Sodium hyaluronate injection is colorless transparent viscous liquid.
Sodium hyaluronate is the main component of synovial joints , one of the components of cartilage matrix,and plays a role of lubrication in articular cavity, can reduce friction between organization, can play a role of the elastic at the same time and act the buffer effect of stress on articular cartilage, has their physiological function.
High molecular weight, high concentration and high polymer viscoelasticity of sodium hyaluronate can significantly improve the joint inflammatory reaction, strengthen the function of joint fluid sticky and lubrication, protect the articular cartilage, promote the healing and regeneration of the articular cartilage, relieve pain, and increase the motion of Joint.
The common dosage of sodium hyaluronate is: the jaw joints with 1 ml (10 mg), shoulder joint in 2 ml (20 mg), hip and knee with 2.5 ml (25 mg).
Sodium hyaluronate is mainly used in the treatment of degenerative osteoarthritis, traumatic arthritis, chronic rheumatic or rheumatoid arthritis, temporal jaw arthritis, femoral head aseptic necrosis.
Application in Particular Diseases
In Osteoarthritis:
Four intraarticular hyaluronic acid preparations are available for treating pain associated with OA of the knee: sodium hyaluronate (Hyalgan 20 mg/2 mL; Supartz 25 mg/2.5 mL), hylan polymers (Synvisc 16 mg/2 mL), and hyaluronan (Orthovisc 30 mg/2 mL). Hyalgan and Supartz are administered once weekly for five injections, whereas Synvisc and Orthovisc are administered once weekly for three injections.
Injections are well tolerated, but acute joint swelling and local skin reactions (e.g., rash, ecchymoses, or pruritus) have been reported.
These products may be beneficial for OA of the knee that is unresponsive to other therapy, but they are expensive because treatment includes both drug and administration costs.
Pharmacological action
Sodium hyaluronate has the effect of promotinig wound healing.
Sodium hyaluronate can form a macromolecular network barrier on the surface of eye tissue, preventing inflammatory content into the wound and lesion area, and can obviously increase the viscosity of liquids and adhesion, make the drug reserved and concentrated on the surface of the cornea for a long time, achieving long-term, powerful function.
Sodium hyaluronate can stabilize tear film, prolong tear film broken, alleviate symptoms of dry eye.
Sodium hyaluronate is used for keratitis, corneal ulcer, the cornea injury caused by physical factors or other chemical burns.
Pharmacodynamics
(1)Sodium hyaluronate can protect corneal endothelial in surgery, epithelium, iris and retina.
(2)Sodium hyaluronate can be instead of aqueous humor without loss, so it can keep the depth of anterior chamber during the surgery.
(3)Sodium hyaluronate is injected into glass cavity ,helping to reset the retina because of oppression.
(4)Sodium hyaluronate can enter the conjunctiva under the pillow to keep filter pillow uplift in glaucoma surgery.
(5) Sodium hyaluronate can help to reduce the adhesion for separation tissue surface.
Clinical application
Used in the surgeries such as intraocular lens, cataracts, glaucoma, corneal transplantation and retinal detachment .
Usage dosage
The injection is used commonly in anterior chamber, and each 0.5~0.5 ml.
In Intraocular lens implant surgery, using Healon can keep up the entire operation process of the depth of anterior chamber, having wide position for the operation of cataract extraction and intraocular lens implantation, also can keep the shape and position of the tissue in anterior chamber to run the operation smoothly and reduce early post-operational complications.
Healon which is in corneal transplant applicationcan, can protect the corneal endothelium from the tissue damage.
Uses
sodium hyaluronate is used as a humectant to increase moisture in the skin, it may also serve as an emulsifier. Sodium hyaluronate is capable of binding 1,800 times its own weight in water.
Sodium hyaluronate is the sodium salt of hyaluronic acid and is the most commonly used form.
Sodium Hyaluronic is is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues.
antifungal agent
prevents thromboembolic complications
aldosterone antagonist used as an adjunct in the management of chronic heart failure
suitable as substrate for hyaluronidase
Surgical aid (ophthalmological).
Production Methods
Sodium hyaluronate occurs naturally in vitreous humor, serum, chicken combs, shark skin, and whale cartilage; it is usually extracted and purified from chicken combs.
Sodium hyaluronate may also be manufactured by fermentation of selected Streptococcus zooepidemicus bacterial strains; sodium hyaluronate is removed from the fermentation medium by filtration and purified by ultrafiltration.
Sodium hyaluronate is then precipitated with an organic solvent and dried.
Pharmaceutical Applications
Sodium hyaluronate is the predominant form of hyaluronic acid at physiological pH.
The name hyaluronan is used when the polysaccharide is mentioned in general terms, and in the literature the terms hyaluronic acid and sodium hyaluronate are used interchangeably.
Hyaluronan is used therapeutically to treat osteoarthritis in the knee, and is an effective treatment for arthritic pain.
Crosslinked hyaluronan gels are used as drug delivery systems.
Hyaluronan is the most common negatively charged glycosaminoglycan in the human vitreous humor, and is known to interact with polymeric and liposomal DNA complexes, where hyaluronan solutions have been shown to decrease the cellular uptake of complexes.
This is useful for enhancing the availability and retention time of drugs administered to the eye.
Sodium hyaluronate is immunoneutral, which makes it useful for the attachment of biomaterials for use in tissue engineering and drug delivery systems; it also has important applications in the fields of vascosurgery and vascosupplementation.
IUPAC NAMES
Glycosaminoglycan - Natriumsalz
Hyaluronate Sodium
hyaluronic acid
Hyaluronic Acid sodium salt
Hyaluronic acid sodium salt
Hyaluronic acid, sodium salt
hyaluronic acid, sodium salt
not available
Reaction Mass of Hyaluronic acid and sodium hydroxide
Sodium (2S,3S,4R,5R,6R)-3-[(2S,3R,4R,5S,6R)-3-acetamido-4-[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4,5-dihydroxyoxane-2-carboxylic acid
sodium (2S,3S,4R,5R,6R)-3-[(2S,3R,4R,5S,6R)-3-acetamido-4-[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4,5-dihydroxyoxane-2-carboxylic acid
Sodium (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-acetamido-2-[(2S,3S,4R,5R, 6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2, 5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4, 5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4, 5-trihydroxyoxane-2-carboxylic acid
sodium hyalunorate
SODIUM HYALURONATE
Sodium Hyaluronate
Sodium hyaluronate
sodium hyaluronate
SYNONYMS
cockscomb
Healon
Hyaluronesodium
hyaluronic
Si-4402
Sl-1010
Sph
HYALURONIC ACID SODIUM FROM*STREPTOCOCCU S ZOOEPIDEM
HYALURONIC ACID SODIUM SALT F. STREPTO-C OCCUS EQUI SP.
HYALURONIC ACID SODIUM FROM ROOSTER*COMB
β-Sodium glucuronate-(1,3)-β-N-acetyl-D-glucosamine
Hyaluronic acid-Na-salt from rooster comb
alternating copoly(β-glucuronic acid-[1→3]-β-n-acetylglucosamine-[1→4])
hyaluronic acid sodium salt from human umbilical cord
hyaluronic acid sodium salt from rooster comb
hyaluronic acid sodium salt from streptococcus equi
hyaluronic acid sodium salt from streptococcus zooepidemicus
SODIUMHYALURINATE
SODIUM HYALURONATE(TOPICAL GRADE)
Hyaluronic Acid Sodium Salt from Cockscomb
Chlamyhyaluronic acid sodium salt
Food Grade SodiuM hyaluronate
Injection Grade SodiuM hyaluronate
Medical Grade SodiuM hyaluronate
Hyaluronate
Hyasis 850P
Sodium Hyaluronate(HA)
Hyaluronate Sodium [USAN:JAN]
Hyaluronic Acid Sodium Salt from Microorganism
HYALURONIC ACID - COSMETIC
HYALURONIC ACID - EYE DROP
HYALURONIC ACID - FOOD
HYALURONIC ACID - INJECTION
HYALURONIC ACID EYE DROPS
HYALURONIC ACID GRADE A ( HA-QSS )
HYALURONIC ACID GRADE B ( HA-Q )
HYALURONIC ACID HA-L510 PF
HYALURONIC ACID INJECTABLE
HYALURONIC ACID LMW
HYALURONIC ACID LOW ENDOTOXIN
HYALURONIC ACID LOW MOL (10,000)
SODIUM HYALURONATE 2% SOLUTION
SODIUM HYALURONATE COSMETIC GRADE HMW
SODIUM HYALURONATE COSMETIC GRADE LMW
SODIUM HYALURONATE COSMETIC GRADE MMW
SODIUM HYALURONATE INJECTABLE GRADE LMW
SODIUM HYALURONATE INTRAARTICULAR GRADE HMW
SODIUM HYALURONATE OPHTHALMIC GRADE HMW
SODIUM HYALURONATE OPHTHALMIC GRADE LMW
SODIUM HYALURONATE OPHTHALMIC GRADE MMW
SODIUM HYALURONATE PHARMACEUTICAL GRADE (HMW)
SODIUM HYALURONATE PHARMACEUTICAL GRADE (LMW)
SODIUM HYALURONATE PHARMACEUTICAL GRADE (MMW)
Hyaluronic acid sodium salt from Streptococcus
HYALURONIC ACID SODIUM SALT 2,000,00
HYALURONIC ACID SODIUM SALT 8,000-15
HYALURONIC ACID SODIUM SALT FROM ROO
HYALURONIC ACID SODIUM SALT FROM STR
