PRODUCTS

SODIUM ISETHIONATE

Sodium Isethionate works as an amphoteric detergent and can also be used as an intermediate in preparing surfactants derived from fatty acid sulfoalkyl esters (acyloxy ethane sulfonate).
Sodium Isethionate increases the formulation's stability, improves the detergency in hard water, and is smooth to the skin.
Sodium Isethionate is used in cleaning/washing agents, disinfectants, cosmetics, surface-active agents, shampoos, and bubble baths.

CAS Number: 1562-00-1
EC Number: 216-343-6
MDL number: MFCD00007534
Molecular Formula: C2H6NaO4S+
Molecular Weight: 149.12 g/mol

SYNONYMS:
ISETHIONIC ACID SODIUM SALT, phonic acid, 2-HydroxyethanesuL, ISETHIONIC ACID SODIUM, 2-hydroxyethyl sulfonate, Sodiumhydroxyethylsulfonate, 2-HYDROXYETHANESULFONIC ACID, SODIUM 2-HYDROXYETHANESULFONATE, HYDROXYETHYLSULFONIC ACID SODIUM SALT, 2-HYDROXYETHANESULFONIC ACID SODIUM SALT, 2-Hydroxyethanesulphonic acid sodium salt , Sodium isethionate , Sodium hydroxyethyl sulphonate, 2-Hydroxyethanesulfonic acid sodium salt, Ethanesulfonic acid, 2-hydroxy-, monosodium salt, Ethanesulfonic acid, 2-hydroxy-, sodium salt, Isethionic acid sodium salt, Sodium 1-hydroxy-2-ethanesulfonate, Sodium 2-hydroxy-1-ethanesulfonate, Sodium 2-hydroxyethanesulfonate, Sodium 2-hydroxyethyl sulfonate, Sodium 2-hydroxyethylsulfonate, Sodium beta-hydroxyethanesulfonate, Sodium hydroxyethylsulfonate, Sodium Isethionate, 1562-00-1, Isethionic acid sodium salt, Sodium 2-hydroxyethanesulfonate, 2-Hydroxyethanesulfonic acid sodium salt, Sodium hydroxyethylsulfonate, Ethanesulfonic acid, 2-hydroxy-, monosodium salt, Sodium beta-hydroxyethanesulfonate, 2-Hydroxyethanesulfonic acid, sodium salt, 3R36J71C17, Ethanesulfonic acid, 2-hydroxy-, sodium salt (1:1), Sodium 2-hydroxyethanesulphonate, Sodium 1-hydroxy-2-ethanesulfonate, Sodium 2-hydroxy-1-ethanesulfonate, Sodium 2-hydroxyethanesulfonate, Sodium 2-hydroxyethylsulfonate, HSDB 5838, NSC-124283, Sodium 1-hydroxy-2-ethanesulfonate, EINECS 216-343-6, MFCD00007534, NSC 124283, sodium,2-hydroxyethanesulfonate, ISETHIONATE, SODIUM SALT, UNII-3R36J71C17, Ethanesulfonic acid, 2-hydroxy-, sodium salt, isethionic acid sodium, 2-hydroxy-ethanesulfonate, DSSTox_CID_7413, EC 216-343-6, sodium hydroxyethyl sulfonate, DSSTox_RID_78445, DSSTox_GSID_27413, Isethionic acid, sodium salt, Istethionic Acid Sodium Salt, SCHEMBL125497, CHEMBL172191, DTXSID7027413, Sodium 2-Hydroxy-Ethanesulfonate, SODIUM ISETHIONATE, Isethionic acid sodium salt, 98%, HY-Y1173, 2-hydroxyethanesulfonic acid, sodium, Tox21_200227, AKOS015912506, NCGC00257781-01, CAS-1562-00-1, SODIUM 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hydroxyethylsulfonate, sodium;2-hydroxyethanesulfonate, Sodium isethionate, 1562-00-1, Isethionic acid sodium salt, Sodium 2-hydroxyethanesulfonate, 2-Hydroxyethanesulfonic acid sodium salt, Sodium hydroxyethylsulfonate, Ethanesulfonic acid, 2-hydroxy-, monosodium salt, Sodium beta-hydroxyethanesulfonate, 2-Hydroxyethanesulfonic acid, sodium salt, DTXSID7027413, Ethanesulfonic acid, 2-hydroxy-, sodium salt (1:1), 3R36J71C17, Sodium 1-hydroxy-2-ethanesulfonate, Sodium 2-hydroxy-1-ethanesulfonate, Sodium 2-hydroxyethanesulfonate, Sodium 2-hydroxyethylsulfonate, Sodium 2-hydroxyethanesulphonate, HSDB 5838, NSC-124283, Sodium 1-hydroxy-2-ethanesulfonate, Sodium 2-hydroxy-1-ethanesulfonate, C2H5NaO4S, EINECS 216-343-6, MFCD00007534, NSC 124283, sodium;2-hydroxyethanesulfonate, UNII-3R36J71C17, Ethanesulfonic acid, 2-hydroxy-, sodium salt, 2-hydroxy-ethanesulfonate, EC 216-343-6, sodium hydroxyethyl sulfonate, Isethionic acid, sodium salt, SCHEMBL125497, CHEMBL172191, DTXCID007413, ISETHIONATE, SODIUM SALT, Sodium 2-Hydroxy-Ethanesulfonate, Sodium isethionate [HSDB], Sodium isethionate [INCI], LADXKQRVAFSPTR-UHFFFAOYSA-M, Isethionic acid sodium salt, 98%, HY-Y1173, 2-hydroxyethanesulfonic acid; sodium, Tox21_200227, AKOS015912506, NCGC00257781-01, CAS-1562-00-1, SODIUM 2-HYDROXYETHANESULFONIC ACID, CS-0017163, FT-0627314, H0241, A809723, J-009283, Q1969744, F1905-7166, 2-Hydroxyethanesulfonic Acid Sodium Salt Isethionic Acid Sodium Salt, sodium 2-hydroxyethanesulfonate, Sodium Isethionate (SI), Sodium isethionate (SHES), 2-Hydroxyethanesulfonic acid sodium salt (SHES), Isethionic acid sodium salt 98%, 2-Hydroxyethanesulfo, 2-hydroxyethyl sulfonate, sodium hydroxyethyl, sodium hydroxyethyl sulfonates, ISETHIONIC ACID SODIUM SALT, HYDROXYETHYLSULFONIC ACID SODIUM SALT, SODIUM 2-HYDROXYETHANESULFONATE, SODIUM ISETHIONATE, 2-HYDROXYETHANESULFONIC ACID, 2-HYDROXYETHANESULFONIC ACID SODIUM SALT, 2-Hydroxyethanesulphonic acid sodium salt, Hydroxyethane, Sodium 2-hydroxyethanesulfonate, Isethionic acid sodium salt, Ethanesulfonic acid, 2-hydroxy-, monosodium salt, Sodium hydroxyethylsulfonate, Sodium beta-hydroxyethanesulfonate, 2-Hydroxyethanesulfonic acid sodium salt, Ethanesulfonate sodium salt, Sodium 2-hydroxyethanesulfonate, Isethionic acid sodium salt, Ethanesulfonic acid, 2-hydroxy-, monosodium salt, Sodium hydroxyethylsulfonate, Sodium beta-hydroxyethanesulfonate, 2-Hydroxyethanesulfonic acid sodium salt, Ethanesulfonate sodium salt

Sodium isethionate is a multifunctional chemical that has been widely used in medicine, daily chemical, textile and agriculture.
The excellent properties of sodium isethionate make it an indispensable ingredient in many products and make an important contribution to the development of various fields.

With the continuous progress of science and technology, Sodium isethionate is believed that the application field of sodium hydroxyethyl sulfonate will continue to expand, and make greater contributions to the progress and development of society.
Sodium isethionate is valued in formulation science primarily because of its exceptional hydrophilicity and chemical stability, which distinguish it from many other anionic surfactant components.

Unlike sulfate-based materials, sodium isethionate does not contain a sulfate ester bond, making it less susceptible to hydrolysis under a wide range of pH and temperature conditions.
This structural feature contributes to Sodium isethionate's long shelf life and predictable performance in aqueous systems, especially in personal care and detergent applications.

Sodium isethionate's sulfonate group is permanently charged and remains largely at the surface of the skin rather than penetrating deeply into the stratum corneum.
This behavior explains why Sodium isethionate is frequently associated with mild cleansing systems, particularly when compared with traditional alkyl sulfates.

Sodium Isethionate is an organic salt.
Sodium Isethionate makes a dense lather in addition to the lather made by the soap.
Sodium Isethionate is mild on the skin, and non-drying.

USES and APPLICATIONS of SODIUM ISETHIONATE:
As a result, Sodium isethionate is often selected for formulations intended for frequent use or sensitive skin, including facial cleansers and syndet bars.
In surfactant chemistry, sodium isethionate is more commonly used as a functional intermediate rather than a stand-alone surfactant.

Sodium isethionate serves as the hydrophilic head group in acyl isethionates, where fatty acid chains are chemically linked to the isethionate moiety.
These derivatives combine strong cleansing ability with improved dermatological compatibility.

The presence of sodium isethionate in the supply chain is therefore critical for the production of modern sulfate-free cleansing systems.
From a formulation compatibility standpoint, sodium isethionate exhibits excellent tolerance toward electrolytes, water hardness, and a wide variety of co-ingredients.

Sodium isethionate does not readily precipitate in the presence of calcium or magnesium ions, which allows finished products to maintain clarity and performance even in hard water conditions.
Additionally, Sodium isethionate shows good compatibility with amphoteric and nonionic surfactants, making it useful in balanced surfactant blends designed to optimize foam quality and mildness.

In terms of processing behavior, sodium isethionate is thermally stable enough to withstand the elevated temperatures often encountered during soap and detergent manufacturing.
However, Sodium isethionate's hygroscopic nature requires controlled storage conditions to prevent caking and moisture uptake.

In industrial practice, Sodium isethionate is usually handled in closed systems or moisture-resistant packaging to preserve flowability and dosing accuracy.
From a toxicological and regulatory viewpoint, sodium isethionate is generally regarded as a low-risk material when used as intended.

Sodium isethionate does not bioaccumulate due to its high water solubility and ionic character, and it is readily diluted and dispersed in aquatic environments.
While Sodium isethionate can cause irritation in its raw, concentrated form, this is typical of many inorganic and organic salts and does not translate into significant risk in finished formulations when used at appropriate concentrations.

Finally, sodium isethionate plays an important role in the ongoing shift toward sulfate-free and mild cleansing technologies.
Its chemical simplicity, stability, and favorable safety profile make Sodium isethionate a foundational ingredient rather than a marketing-driven additive.

As consumer demand continues to move toward gentler, skin-compatible products, sodium isethionate remains a technically reliable component in modern formulation strategies.
Sodium Isethionate works equally well in soft or hard water.

Sodium Isethionate is also used as an anti-static agent in shampoos.
Sodium Isethionate works as an amphoteric detergent and can also be used as an intermediate in preparing surfactants derived from fatty acid sulfoalkyl esters (acyloxy ethane sulfonate).

Sodium Isethionate increases the formulation's stability, improves the detergency in hard water, and is smooth to the skin.
Sodium Isethionate is used in cleaning/washing agents, disinfectants, cosmetics, surface-active agents, shampoos, and bubble baths.
Sodium Isethionate is an amphoteric detergent used in detergent bar soaps.

Sodium isethionate can interact electrostatic with dyes and fibers to make dyes better adsorbed on fibers and improve the dyeing effect.
Therefore, in the textile industry, Sodium isethionate is often used as an auxiliary agent for dyes, which can improve the uniformity and brightness of dyeing.

In addition, sodium isethionate can also be used as an anti-wrinkle agent and anti-shrink agent for textiles, which can improve the softness and durability of textiles.
Sodium isethionate can provide the sulfur needed by plants to promote plant growth and development.

In agriculture, sodium isethionate is often used as a sulfur fertilizer for plants, which can increase the yield and quality of crops.
Sodium isethionate can also be used as a plant fungicide, which can prevent and treat some plant diseases and improve the resistance of plants.

-Primary Uses of Sodium Isethionate:
Surfactant precursor/intermediate for manufacturing isethionate-type surfactants.
Mild cleansing agent and amphoteric detergent component in personal care products.
Cleansing bars and syndet formulations: contributes foam, mildness, skin feel.
Personal care and cosmetic formulations: in shampoos, soaps, body washes, facial cleansers; compatible with hard water.
Industrial intermediates in producing related sulfonate surfactants.

-Sodium isethionate in daily chemical products:
Sodium isethionate has good cleaning capacity and stability, so it is widely used in daily chemical products.
Sodium isethionate can be used as a surfactant in shampoo, body wash, hand sanitizer and other cleaning products, which is effective in removing oil and dirt while keeping the skin moisturized.
In addition, sodium isethionate can also be used to make toothpaste, dishwashing detergent and other products, so that it has a good foaming and cleaning effect.

WHAT IS THE FUNCTION OF SODIUM ISETHIONATE?
Sodium Isethionate is an organic salt that is an important intermediate in pharmaceuticals, cosmetics and daily chemicals.
Sodium Isethionate another name isethionic acid sodium salt, cas 1562-00-1.
Sodium Isethionate increases the stability of the formula, improves the deterrability of hard water, and is smooth on the skin.

These features are generally applicable to soap and shampoo formulations in the home care, industrial and public facilities, and personal care markets.
The addition of Sodium Isethionate to the final product can produce rich foam, reduce soap residue on the skin, and can also be used as a major anti-static agent in shampoo, so it is well received and recognized by consumers.

FUNCTIONAL PERFORMANCE of SODIUM ISETHIONATE:
Sodium Isethionate enhances foam stability and mildness compared to traditional sulfates.
Sodium Isethionate provides antistatic properties when used with other surfactants.
Sodium Isethionate acts as a hydrophilic component assisting detergency in aqueous systems.

MECHANISM OF FUNCTION of SODIUM ISETHIONATE:
As a small sulfonate salt, Sodium Isethionate serves as a hydrophilic (water-loving) head group in surfactants.
Sodium Isethionate promotes interaction with water and helps reduce surface tension, facilitating cleaning and emulsification.
Its mild nature makes Sodium Isethionate suitable near sensitive skin areas.

PREPARATION of SODIUM ISETHIONATE:
Sodium Isethionate is synthesized by the condensation reaction of sodium bisulfite and ethylene oxide.

CHEMICAL FAMILY AND CLASSIFICATION of SODIUM ISETHIONATE:
Sodium Isethionate belongs to the sulfonate salts family — specifically the sodium salt of 2-hydroxyethanesulfonic acid.
Sodium Isethionate is a hydrophilic head group used in surfactants (isethionates) and is distinct from long-chain acyl isethionates (e.g., sodium cocoyl isethionate) used widely in personal care.

CHEMICAL PROPERTIES of SODIUM ISETHIONATE:
Sodium Isethionate is a colorless, syrupy, strongly acidic liquid that can form detergents with oleic acid.
Sodium Isethionate is an organic salt and an important intermediate for pharmaceuticals, cosmetics and daily chemicals.

WHAT IS THE FUNCTION OF SODIUM ISETHIONATE?
Sodium Isethionate in the field of medicine:
Sodium Isethionate is a common pharmaceutical raw material with good solubility and stability, so it is widely used in the pharmaceutical industry.

Sodium isethionate is commonly used as a surfactant, emulsifier and thickener and can be used to make oral liquids, injections, ointments and other drugs.
Sodium isethionate can also be used as a substitute for bisphenol A in the manufacture of sterile injection bottles, infusion bags and other medical devices.

WHAT DOES SODIUM 2-HYDROXYETHYL SULFONATE (SODIUM ISETHIONATE) DO IN A FORMULATION?
*Antistatic
*Cleansing
*Hair conditioning
*Skin conditioning

PHYSICAL and CHEMICAL PROPERTIES of SODIUM ISETHIONATE:
Molecular Weight: 148.12
Molecular Weight: 148.12
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 2
Exact Mass: 147.98062409
Monoisotopic Mass: 147.98062409
Topological Polar Surface Area: 85.8 Å²
Heavy Atom Count: 8
Formal Charge: 0
Complexity: 122

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes
Molecular Formula / Molecular Weight: C2H5NaO4S = 148.11
Physical State (20 deg.C): Solid
Store Under Inert Gas: Store under inert gas

Condition to Avoid: Hygroscopic
CAS RN: 1562-00-1
Reaxys Registry Number: 3633992
PubChem Substance ID: 87570669
Melting point: 191-194 °C(lit.)
Density: 1762.7[at 20℃]
storage temp.: Store below +30°C.
solubility: H2O: 0.1 g/mL, clear, colorless
form:Fine Powder
color: White

PH: 7.0-11.0 (20g/l, H2O, 20℃)
Water Solubility: SOLUBLE
BRN: 3633992
Stability: Stable.
Hygroscopic.
LogP: -4.6 at 20℃
Density: 1762.7[at 20℃]
Melting Point: 191-194°C(lit.)
Water Solubility: SOLUBLE
Solubility: H2O: 0.1g/mL, clear, colorless
Appearance: White crystal

Color: White
Appearance (20°C): Appearance: Crystal-Powder
Color: Off-white
Odor: Odorless
pH: Not available
Melting Point: 194°C
Boiling Point/Boiling Range: Not available
Flash Point: Not available
Explosive Properties: Lower explosive limit not available;
upper explosive limit not available

Density: Not available
Solubility:
Water: Soluble
Other Solvents: Not available
CAS: 1562-00-1
EINECS: 216-343-6
InChI: InChI=1/C2H6O4S/c3-1-2-7(4,5)6/h3H,1-2H2,(H,4,5,6)/p-1
Molecular Formula: C2H5NaO4S
Molar Mass: 148.11 g/mol
Melting Point: 191-194°C (literature value)
Water Solubility: Soluble, 0.1 g/mL, clear, colorless
Appearance: White crystal

BRN: 3633992
pH: 7.0-11.0 (20g/L, H2O, 20°C)
Storage Condition: Store below +30°C
Stability: Stable.
Hygroscopic.
Incompatible with strong oxidizing agents and strong acids.
Sensitive: Easily absorbs moisture
MDL: MFCD00007534
Density: 1.625 g/cm3
Exact Mass: 147.980621 g/mol
PSA (Polar Surface Area): 85.81000
Stability: Stable.

Hygroscopic.
Incompatible with strong oxidizing agents and strong acids.
Common Name:Sodium 2-hydroxyethyl sulfonate
Primary Trade/Common Name:Sodium Isethionate
INCI Name:Sodium Isethionate
CAS Number:1562-00-1
EC / EINECS Number:216-343-6
PubChem CID:517063
ChemSpider ID:14540
Molecular Formula:C₂H₅NaO₄S
Molecular Weight:~148.11 g/mol

Appearance:White to colorless crystalline solid or fine powder
Melting Point:Around 191–194 °C
Solubility:Highly soluble in water at 20 °C (≈650 g/L)
pH in Solution:~7–11 in aqueous solution depending on concentration
Density:Bulk density ~800 kg/m³
Partition Coefficient:Log K_ow highly negative (~-5.50), indicating strong water affinity and low lipid solubility
Vapor Pressure:Extremely low (estimated ~1.3 × 10⁻¹² mm Hg at 25 °C)
Thermal Behavior:Decomposes on heating; no defined boiling point under normal conditions
Stability:Stable under normal storage; non-flammable, not oxidizing

Preferred Substance Name: Sodium Isethionate
IUPAC Name: Sodium;2-hydroxyethanesulfonate
CAS Number: 1562-00-1
EC / EINECS Number: 216-343-6
Molecular Formula: C₂H₅NaO₄S
Molecular Weight: 148.11 g/mol
PubChem CID: 517063
Appearance: White fine crystalline powder.
Odor: Odorless or mild.
Physical State: Solid.

Melting Point: 191–194 °C (lit.) — indicates strong ionic crystal lattice.
Density: ~1.62-1.76 g/cm³ at 20 °C.
Bulk Density: ~800 kg/m³.
Solubility: Soluble in water (≈0.1 g/mL), clear colorless solution.
pH of aqueous solution: ~7.0–11.0 (20 g/L, 20 °C) — weakly basic.
Log P (Octanol/Water): –4.6 (high polarity, low lipophilicity).
Stability: Stable under normal conditions; hygroscopic (absorbs moisture).
Incompatibilities: Strong oxidizing agents, strong acids — may affect stability.
Hygroscopicity: Tends to absorb atmospheric moisture; store dry.
Reactivity: Not reactive under normal conditions; typical ionic salt behavior.
Other: Non-flammable solid.

FIRST AID MEASURES of SODIUM ISETHIONATE:
-Skin Contact:
Remove/Take off immediately all contaminated clothing.
Wash gently with plenty of soap and water.
-If skin irritation or rash occurs:
Get medical advice/attention.
-Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if convenient and easy to do.
Continue to wash.
-In case of eye irritation:
Get medical advice/attention.
-Ingestion:
Get medical advice/attention if you feel unwell.

ACCIDENTAL RELEASE MEASURES of SODIUM ISETHIONATE:
-Environmental Measures:
Prevent from entering sewers.
-Methods and materials for control and cleaning:
Be careful not to scatter.

FIRE FIGHTING MEASURES of SODIUM ISETHIONATE:
-Suitable Extinguishing Media:
Dry chemical, foam, water spray, carbon dioxide
-Specific method:
Non-related personnel should be evacuated to a safe place.

EXPOSURE CONTROLS/PERSONAL PROTECTION of SODIUM ISETHIONATE:
-Engineering control:
Install showers and eyewash stations .
-Personal protective equipment:
*Respiratory protection:
Follow local and government regulations.
*Hand protection:
Protective gloves.
*Eye Protection:
Safety goggles.
Wear a mask if the situation requires it.
*Skin and Body Protection:
Protective clothing.
Wear protective boots if situation requires.

HANDLING and STORAGE of SODIUM ISETHIONATE:
-Handling:
*Technical measures:
Handle in a well-ventilated area.
Wear suitable protective equipment.
Wash hands.
-Storage
Storage Conditions:
Keep container tightly closed.
Store in a cool, dark place.
Store under an inert gas atmosphere.
Moisture-proof.
-Packaging materials:
In accordance with the law.

STABILITY and REACTIVITY of SODIUM ISETHIONATE:
-Chemical stability:
Generally stable.
-Possibility of Hazardous Reactions:
No specific reactivity reported.