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Sodium Lauroyl Sarcosinate, also known as sarcosyl, is an anionic surfactant derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products.
Sodium Lauroyl Sarcosinate is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.
Since the nitrogen atom is in an amide linkage, the nitrogen is not pH active and is neutrally charged in all aqueous solutions regardless of pH.
CAS: 137-16-6
MF: C15H28NO3.Na
MW: 293.38
EINECS: 205-281-5
Synonyms
n-methyl-n-(1-oxododecyl)glycine sodium salt;N-LAURYL SARCOSINE, SODIUM SALT;N-LAUROYLSARCOSINE NA-SALT;N-LAUROYLSARCOSINE SODIUM SALT;N-LAUROYLSARCOSINE SODIUM SALT HYDRATE;GARDOL;LAUROYLSARCOSINE, SODIUM SALT;N-Methylglycinol
The carboxylate has a pKa of about 3.6 and is therefore negatively charged in solutions of pH greater than about 5.5.
pH-sensitive vesicles can be prepared using this surfactant with another cationic or water-insoluble amphiphiles such as 1-decanol.
Addition of a mixture of equal parts of Sodium Lauroyl Sarcosinate and the non-ionic surfactant sorbitan monolaurate (S20) to a buffered water:ethanol solution led to the formation of micelle-like aggregates, even though neither surfactant formed micelles when present alone.
Such aggregates can help carry other small molecules, such as drugs, through the skin.
Sodium Lauroyl Sarcosinate is an anionic surfactant with an ability to denature proteins.
Due to its microbicidal property, Sodium Lauroyl Sarcosinate is being considered as a potent anti-microbicide in topical formulations, especially against sexually transmitted diseases (STDs).
Sodium Lauroyl Sarcosinate is a powder of a mild biodegradable surfactant produced from amino acid sarcosine.
Sodium Lauroyl Sarcosinate is very mild, can form rich and stable creamy foams, and can help condition and moisturize.
Sodium Lauroyl Sarcosinate is a synthetic or plant-derived surfactant (cleansing agent) that also works as an emulsifier, which is a type of ingredient that keeps unlike substances from separating.
Sodium Lauroyl Sarcosinate is most often used in face and body cleansers and shampoos but is sometimes also used in leave-on products.
In cleansing formulas, Sodium Lauroyl Sarcosinate can contribute to a foaming effect.
This safe, amino acid-based surfactant works well with various glycols, silicones, solvents, and phosphate esters, making it very versatile to formulate with.
Offers excellent chemical stability and is known to be gentle on skin.
Coconut is a common source of sodium lauroyl sarcosinate in cosmetic products.
Sodium Lauroyl Sarcosinate Chemical Properties
Melting point: 46 °C
Density: 1.033 g/mL at 20 °C
Bulk density: 400kg/m3
Vapor pressure: 0.02 hPa (20 °C)
RTECS: MC0598960
Fp: 267℃
Storage temp.: room temp
Solubility: H2O: 1 M at 20 °C, clear, colorless
Form: Powder
Color: White
Specific Gravity: 1.03 (20/4℃)
PH: 7.0-9.0 (25℃, 1M in H2O)
Odor: at 100.00?%. bland
Water Solubility: Soluble in water (293 g/L).
Sensitive: Hygroscopic
λmax λ: 260 nm Amax: 0.2
λ: 280 nm Amax: 0.06
Merck: 14,4368
BRN: 5322974
Stability: Stable. Incompatible with strong oxidizing agents.
LogP: 0.37
CAS DataBase Reference: 137-16-6(CAS DataBase Reference)
EPA Substance Registry System: Sodium Lauroyl Sarcosinate (137-16-6)
Uses
Sodium Lauroyl Sarcosinate, also known as sarkosyl, is a white powder derived from sarcosine, which make it is fate-free and biodegradable.
The surfactant is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.
Sodium Lauroyl Sarcosinate is personal care products as well as in household and industrial applications, and it is used as a co-surfactant in cleanser formulations such as shampoos and body washes.
Sodium Lauroyl Sarcosinate can also be used in oral care applications such as toothpastes and incorporated into syndet and combo bars.
The typical usage levels range from 1-5% on an active basis.
Sodium Lauroyl Sarcosinate is mild, biodegradable anionic surfactants derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products.
Sodium Lauroyl Sarcosinate is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate.
Sodium Lauroyl Sarcosinate is a high foam, eco-friendly surfactant.
Sodium Lauroyl Sarcosinate has good chlorine stability with anti-corrosion properties.
This surfactant has excellent ocular tolerance and gentleness.
Sodium Lauroyl Sarcosinate is often seen in shampoos, bath, cleansing and shaving products as a foaming agent, surfactant, and hair conditioning agent.
Sodium lauroyl sarcosinate has the ability to enhance the appearance and feel of hair by improving body, suppleness and sheen, especially in hair that is chemically damaged.
Sodium Lauroyl Sarcosinate also serves to clean skin and hair by mixing with oil and dirt and enabling them to be rinsed away.
As a modified fatty acid, Sodium Lauroyl Sarcosinate is thought to be more soluble, and have increased crystallinity and acidity compared to its original fatty acid composition.
Detergent, foaming agent, antienzyme for dentifrices: King, US 2689170 (1954 to Colgate-Palmolive).
Sodium Lauroyl Sarcosinate is used for solubilization and separation of membrane proteins and glycoprotein's; reported to inhibit hexokinase.
Sodium Lauroyl Sarcosinate is useful in concentrated salt solutions used in the cell lysis step during RNA purification (helps avoid excessive foaming).
Sodium Lauroyl Sarcosinate has been used to indicate paramagnetic anisotropy sign change in micelle mesophage.
Inhibits bacterial flora of human saliva/gut at 0.25% as well as acting as a fungi static agent in aqueous dispersion (1%).
Biochem/physiol Actions
Sodium Lauroyl Sarcosinate is an anionic surfactant which also has protein denaturant potency.
In addition, Sodium Lauroyl Sarcosinate has been shown as a microbicide for sexually transmitted diseases.
