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SODIUM METAPERIODATE

EC / List no.: 232-197-6
CAS no.: 7790-28-5
Mol. formula: HIO4.Na


Sodium metaperiodate is an inorganic salt, composed of a sodium cation and the periodate anion. 
Sodium metaperiodate may also be regarded as the sodium salt of periodic acid. 
Like many periodates, it can exist in two different forms: sodium metaperiodate (formula‍ NaIO4) and sodium orthoperiodate (normally Na2H3IO6, but sometimes the fully reacted salt Na5IO6). 
Both salts are useful oxidising agents.

Preparation
Classically, periodate was most commonly produced in the form of sodium hydrogen periodate (Na3H2IO6). 
This is commercially available, but can also be produced by the oxidation of iodates with chlorine and sodium hydroxide.

Structure
Sodium metaperiodate (NaIO4) forms tetragonal crystals (space group I41/a) consisting of slightly distorted IO−
4 ions with average I–O bond distances of 1.775 Å; the Na+ ions are surrounded by 8 oxygen atoms at distances of 2.54 and 2.60 Å.

Sodium hydrogen periodate (Na2H3IO6) forms orthorhombic crystals (space group Pnnm). 
Iodine and sodium atoms are both surrounded by an octahedral arrangement of 6 oxygen atoms; however the NaO6 octahedron is strongly distorted. 
IO6 and NaO6 groups are linked via common vertices and edges.

Powder diffraction indicates that Na5IO6 crystallises in the monoclinic system (space group C2/m).

Uses:
Further information: Periodate § Reactions
Sodium metaperiodate can be used in solution to open saccharide rings between vicinal diols leaving two aldehyde groups. 
This process is often used in labeling saccharides with fluorescent molecules or other tags such as biotin. 
Because the process requires vicinal diols, periodate oxidation is often used to selectively label the 3′-ends of RNA (ribose has vicinal diols) instead of DNA as deoxyribose does not have vicinal diols.

NaIO4 is used in organic chemistry to cleave diols to produce two aldehydes.


Description    
Sodium metaperiodate is an inorganic salt, composed of a sodium cation and the periodate anion. 
Sodium metaperiodate may also be regarded as the sodium salt of periodic acid.
Like many periodates it can exist in two different forms: sodium metaperiodate, which has the formula NaIO4, and sodium orthoperiodate, normally this means sodium hydrogen periodate (Na2H3IO6) but the fully reacted sodium orthoperiodate salt, Na5IO6, can also be prepared. Both salts are useful oxidising agents.

Chemical Properties    
Sodium metaperiodate Na2H3IO6, is formed by reaction of sodium iodate plus sodium hydroxide plus chlorine (sodium chloride also formed), and the periodate separates as crystals from the medium. 
In solution, it is stated, periodate gradually forms ozone and iodate at the ordinary temperatures.

Chemical Properties    
white powder

Uses:
Sodium metaperiodate is the sodium salt of periodic acid used to oxidize cellulose. 
Sodium metaperiodate oxidation is often used to selectively label RNA, saccharides and other compounds with vicinal diols.
Oxidimetric standard; determination of manganese.
Sodium metaperiodate is used as an oxidizing reagent involved in the oxidation of cellulose. 
Sodium metaperiodate is involved in the cleavage of vicinal diols to prepare two aldehydes. 
This oxidation is commonly used in selectively label RNA, saccharides and other compounds with vicinal diols.

Use and Manufacturing

Source of periodic acid, analytical reagent, oxidizing agent.
Analysis. Powerful oxidizer in acid solution; oxidizing manganese compounds to permanganate: used for this purpose in analytical chemistry..., also used for oxidation of some organic compounds
Periodate-methylamine degradation of ribonucleotides ... enables separation of deoxyribonucleotides in cell extracts by high-performance liquid chromatography.
Tissue processing fixation: PLP fixative: 4% paraformaldehyde, 0.2% perioidate and 1.2% lysine in 0.1 M phosphate buffer


Consumer Uses:
Oxidizing compound for reclaiming screens (screen printing application)


Our sodium metaperiodate has important applications in the life sciences sector and the screen printing industry. 
In the life sciences sector, sodium metaperiodate’s ability to perform the classical “periodate 1, 2 diol cleavage” reaction with fine chemical intermediates that have adjacent hydroxyl groups is critical because the oxidation is specific; forming carbonyl compounds in high yields. 
This reaction is particularly important in forming dialdehyde functions for “working up” into pharmaceutical intermediates or for attaching functionalised polysaccharides to suitable substrates.

In addition the selective oxidation powers of sodium metaperiodate make it the ideal reagent for the reclamation of silk screens in the printing industry. 
The non-image portions of a design are normally blocked with a cured emulsion of gelatine or polyvinyl alcohol that is chemically resistant. 
Sodium metaperiodate selectively decomposes the cured emulsion so that it can be removed from the delicate and expensive silk screen, which can then be reused.

Application
Oxidative substance in pharmaceutical industry
Cleaning of silk screens for printing

Chemical Properties
Formula : INaO4
Formula Weight: 213.89
Form: Powder
Melting point: 300° dec.
Density: 3.86


Storage & Sensitivity
Hygroscopic. Light Sensitive. Ambient temperatures.
Solubility
Soluble in water, sulfuric acid, nitric acid and acetic acid.

Applications
Source of periodic acid, as an analytical reagent, and as an oxidizing agent Sodium metaperiodate is used as an oxidizing reagent involved in the oxidation of cellulose. 
Sodium metaperiodate is involved in the cleavage of vicinal diols to prepare two aldehydes. 
This oxidation is commonly used in selectively label RNA, saccharides and other compounds with vicinal diols.


Sodium Metaperiodate is generally immediately available in most volumes.
High purity, submicron and nanopowder forms may be considered.

Sodium metaperiodate, or sodium m‐periodate, is a mild oxidant that is routinely used for the conversion of cis‐glycol groups in carbohydrates to reactive aldehdye groups. 
The reactive aldehyde groups are used in chemical conjugation procedures or detection of carbohydrates. 
For proteomic research, sodium m‐periodate is used for the oxidation of the carbohydrate moiety of glycoproteins and offers the advantage of modifying the sugar side chains as opposed to critical amino acids. 

STORAGE CONDITIONS 
Shipped at ambient temperature. 
Upon receipt, store at room temperature. 

PROPERTIES 
•  Synonyms: Sodium m‐periodate, sodium periodate 
•  Linear formula:NaIO4 
•  CAS #. 7790‐28‐5 
•  Molecular weight: 213.89 
•  Form: White crystalline powder 

About Sodium metaperiodate
Helpful information
Sodium metaperiodate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.

Sodium metaperiodate is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Consumer Uses
Sodium metaperiodate is used in the following products: textile treatment products and dyes and washing & cleaning products.
Other release to the environment of Sodium metaperiodate is likely to occur from: indoor use as reactive substance.
Article service life
ECHA has no public registered data on the routes by which Sodium metaperiodate is most likely to be released to the environment. ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

Widespread uses by professional workers
Sodium metaperiodate is used in the following products: washing & cleaning products, coating products, non-metal-surface treatment products and inks and toners.
Sodium metaperiodate is used in the following areas: printing and recorded media reproduction and formulation of mixtures and/or re-packaging.
Other release to the environment of Sodium metaperiodate is likely to occur from: indoor use as reactive substance.
Formulation or re-packing
Sodium metaperiodate is used in the following products: biocides (e.g. disinfectants, pest control products), coating products, non-metal-surface treatment products and inks and toners.
Sodium metaperiodate has an industrial use resulting in manufacture of another substance (use of intermediates).
Release to the environment of Sodium metaperiodate can occur from industrial use: formulation of mixtures.
Uses at industrial sites
Sodium metaperiodate is used in the following products: non-metal-surface treatment products, pharmaceuticals, washing & cleaning products, metal surface treatment products, inks and toners, pH regulators and water treatment products, laboratory chemicals and textile treatment products and dyes.
Sodium metaperiodate has an industrial use resulting in manufacture of another substance (use of intermediates).
Sodium metaperiodate is used in the following areas: printing and recorded media reproduction, scientific research and development and formulation of mixtures and/or re-packaging.
Sodium metaperiodate is used for the manufacture of: chemicals.
Release to the environment of Sodium metaperiodate can occur from industrial use: in processing aids at industrial sites and as processing aid.
Manufacture
Release to the environment of Sodium metaperiodate can occur from industrial use: manufacturing of the substance.

Description
Sodium Metaperiodate is made of fine white or almost white crystals.

Applications
Recovery and cleaning of screen printing inks and printing.

Powerful oxidant in pharmaceutical processes.


DESCRIPTION
Sodium metaperiodate, which has the formula NaIO4, and sodium orthoperiodate, normally this means sodium hydrogen periodate (Na2H3IO6) but the fully reacted sodium orthoperiodate salt, Na5IO6, can also be prepared.


Sodium periodate can refer to two different chemical compounds which are essentially sodium salts of the two varieties of periodate ion. 
Sodium metaperiodate (often abbreviated as m-periodate) has the formula NaIO4. 
Sodium orthoperiodate (often abbreviated as o-periodate) has the formula Na5IO6. 
Both salts are useful in certain synthetic chemistries for the oxidative power of the periodate ion.

Density is 3,865 kg m-3. 
Sodium metaperiodate is soluble in water. 
When heated, it decomposes to form sodium iodate, NaIO3 and oxygen. This decomposition reaction is catalyzed by the presence of manganese(IV) oxide.

Note that the pronunciation is per-iodate, not period-ate.

Uses:
Sodium periodate is used to oxidize cellulose and create a biocompatible and biodegradable compound that can be used as suture, as a scaffold for tissue engineering, or for drug delivery.

Sodium periodate can be used in solution to open saccharide rings between vicinal diols leaving two aldehyde groups. 
This process is often used in labeling saccharides with fluorescent molecules or other tags such as biotin. 
Because the process requires vicinal diols, periodate oxidation is often used to selectively label RNA (ribose has vicinal diols) instead of DNA deoxyribose does not have vicinal diols.

Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion. 
Sodium metaperiodate may also be regarded as the sodium salt of periodic acid. Like all periodates it can exist in two different forms: sodium metaperiodate, which has the formula NaIO4, and sodium orthoperiodate, normally this means sodium hydrogen periodate (Na2H3IO6) but the fully reacted sodium orthoperiodate salt, Na5IO6, can also be prepared. 
Both salts are useful oxidising agents.

Sodium periodate can be used in solution to open saccharide rings between vicinal diols leaving two aldehyde groups. This process is often used in labeling saccharides with fluorescent molecules or other tags such as biotin. Because the process requires vicinal diols, periodate oxidation is often used to selectively label the 3'-termini of RNA (ribose has vicinal diols) instead of DNA as deoxyribose does not have vicinal diols.

NaIO4 is used in organic chemistry to cleave diols to produce two aldehydes.

Sodium metaperiodate is usually available in various concentration. 
Special packaging information is available on demand. Sodium metaperiodate is stored in original packing and under conditions mentioned on the safety data sheet (SDS).

Description
Information not available

Appearance
Fine crystals whitish. Sodium metaperiodate occurs as fine white crystals.

Solubility
Sodium metaperiodate is soluble in water and acids.

Uses
Sodium metaperiodate is used as a powerful oxidative substance in pharmaceutical industry. Sodium metaperiodate is also used for the cleaning of silk screens for printing.

Classification
Request safety data sheet (SDS) and refer to points 4, 5, 6, 8, 10,13, 14, 15. Technical specifications are provided on request according to the application.

Safety
Request safety data sheet (SDS) and refer to points 4, 5, 6, 7, 8, 10, 13.

Specifications
Technical specifications are provided on request according to the application: sodium metaperiodate is stored in original packing and under conditions mentioned on the safety data sheet (SDS).

Synonyms
Sodium m-periodate.


IUPAC NAMES:
Sodio meta-Peryodato
SODIUM METAPERIODATE
Sodium Metaperiodate
Sodium Periodate
Sodium periodate
sodium periodate
Sodium periodate
sodium;periodate


SYNONYMS:
sodiuM Metaperiodate in powder
SODIUM METAPERIODATE FOR ANALYSIS EMSURE
Sodium periodate
Periodicacid (HIO4), sodiuM salt (1:1)
Sodium (meta)periodate >=99.0%
Sodium (meta)periodate puriss. p.a., ACS reagent, reag. Ph. Eur., >=99.8%
Sodium periodate 10 wt. %, matrix silica gel support
Sodium periodate ACS reagent, >=99.8%
SODIUM (META)PERIODATE BIOULTRA, >=
SODIUM METAPERIODATE FOR ANALYSIS EMSURE ACS,REAG. PH EUR
Periodate sodium
metaperiodate
periodicacid(hio4),sodiumsalt
Periodicacid,sodiumsalt
sodiummetaperidate
sodiummetaperiodate(sodiumperiodate)
IONAM
Sodium metaperiodate, reagent grade, ACS
Sodium periodate/ 99+%
SODIUM PERIODATE, REAGENTPLUS, 99%
SodiuM Meta-Periodate, GR ACS
SodiuM periodate, for analysis ACS, 99.8+% 100GR
SodiuM periodate, for analysis ACS, 99.8+% 500GR
SodiuM periodate, for analysis ACS, 99.8+% 5GR
SodiuM periodate, for analysis, 99% 100GR
Sodium periodate test solution(ChP)
SODIUM META PERIODATE, BIO-REFINEDSODIUM META PERIODATE, BIO-REFINEDSODIUM META PERIODATE, BIO-REFINEDSODIUM META PERIODATE, BIO-REFINED
SODIUM META PERIODATE, REAGENT (ACS)SODIUM META PERIODATE, REAGENT (ACS)SODIUM META PERIODATE, REAGENT (ACS)SODIUM META PERIODATE, REAGENT (ACS)
Sodium metapriodate
SODIUM PERIODATE META
SODIUM M-PERIODATE
SODIUM METAPERIODATE
SODIUM TETRAOXOIODATE (VII)
SODIUM TETROXOIODATE (VII)
SODIUM TETROXOIODATE(VII) R. G., REAG. A CS, REAG. PH. EUR.
SODIUM M-PERIODATE ACS REAGENT
SODIUM PERIODATE, 99.8+%, A.C.S. REAGENT
SODIUM PERIODATE, 10 WT. % ON SILICA GEL
SODIUM (META)PERIODATE, ACS
SodiumMetaperiodateGr
SodiumMetaperiodateExtraPure
SODIUM META PERIODTAE ( SODIUM PERIODATE )
Sodium(meta)periodate,99%
Sodiummetaperiodate,98%
Sodiummetaperiodate,ACS,99.8-100.3%
Sodium periodate, for analysis, 99%
SODIUM META PERIODATE BIO-REFINED
SODIUM META PERIODATE REAGENT (ACS)
SODIUMPERIODATE,BIOTECHGRADE
SODIUMPERIODATE,GRANULAR,REAGENT,ACS
SODIUM METAPERIODATE extrapure AR
SODIUM METAPERIODATE pure
Hach Sodium Periodate Powder Pillows
Sodium Periodate, Granular, Reagent
Sodium periodate, 99%, for analysis
Sodium periodate, 99.8+%, for analysis ACS
Sodium periodate, for analysis ACS
Sodium periodat, for analysis ACS, 99.8+%
Sodium periodate
Sodium metaperiodate
7790-28-5
Sodium m-periodate
Sodium (meta)periodate
sodium meta-periodate
sodium;periodate
Periodic acid, sodium salt
Sodium meta periodate
UNII-98W4A29X43
MFCD00003534
sodiumperiodate
Periodic acid (HIO4), sodium salt (1:1)
98W4A29X43
Periodic acid (HIO4), sodium salt
HSDB 7298
EINECS 232-197-6
sodium penodate
sodium periodat
sodium-m-periodate
Sodium iodate(VII)
sodium(meta)periodate
sodium-meta-periodate
INaO4
NaIO4
sodium (meta) periodate
ACMC-1C1BE
Na I O4
EC 232-197-6
Sodium periodate, ACS grade
ARONIS24207
Lithium Chelate 0.2%, 40M
CHEBI:75226
DTXSID30894075
BCP04945
AKOS005267138
AKOS015950617
BP-21195
R917
FT-0689066
Q281419


 

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