SODIUM METHYLPARABEN

CAS number: 5026-62-0
European Community (EC) Number: 225-714-1
Molecular Formula: C8H7O3Na
Molar mass: 174.131 g•mol−1
IUPAC Name: sodium;4-methoxycarbonylphenolate
Other names: Sodium methyl p-hydroxybenzoate; Methylparaben sodium salt; E219

DESCRIPTION:
Sodium methylparaben (sodium methyl para-hydroxybenzoate) is a compound with formula Na(CH3(C6H4COO)O). 
Sodium methylparaben is the sodium salt of methylparaben.

Sodium methylparaben is a food additive with the E number E219 which is used as a preservative.
Sodium Methylparaben (E219, Methylparaben Sodium salt or Sodium Methyl 4-hydroxybenzoate) is a white to off-white odorless powder. 
Sodium Methylparaben is freely soluble in water and sparingly soluble in alcohol while insoluble in fixed oils.

Sodium methylparaben is a sodium salt derived from methylparaben that is produced purely synthetically or occurs naturally in some fruits and vegetables. 
Sodium methylparaben is a fine, odorless, white powder, soluble in water and ethanol, used as an additive in the food industry under the designation E219. 
Sodium methylparaben is used as a preservative in cosmetics - Sodium methylparaben prevents the growth of bacteria and fungi in the product. 
To improve the effects, Sodium methylparaben is often mixed with other parabens and quaternary compounds.

Sodium methylparaben is added to various types of products, including decorative cosmetics and hair dyes. 
In general, parabens are discussed in connection with possible carcinogenic and allergenic effects. However, according to some studies, this situation is only likely at extremely high doses with which the average consumer will not come into contact. 
Sodium methylparaben is often mixed with other parabens in the final product, in which case it may be present in a maximum concentration of 0.4%.
Methylparaben has been used as a preservative used in the food, cosmetic, and pharmaceutical industries for over 50 years. 
The chemical formula for methylparaben sodium is C8H7NaO3. 
Sodium methylparaben may also found naturally in fruits like blueberries where Sodium methylparaben has antimicrobial activity. 
Methylparaben sodium is the sodium salt form of methylparaben.

Methylparaben is completely absorbed through the skin or after ingestion, and it is hydrolyzed to para-hydroxybenzoic acid, and metabolites are rapidly excreted in the urine. 
There is no evidence of accumulation.
Sodium methylparaben is on the FDA generally regarded as safe list.

Acute toxicity studies in animals indicate that methylparaben is practically non-toxic by both oral and injectable routes. 
Sodium methylparaben has not been shown to be teratogenic, carcinogenic, mutagenic or embryotoxic.

Sodium methylparaben does not appear to be irritating when used topically, although some people may show cross-sensitivity in people allergic to local anesthetics that are metabolized to para-aminobenzoic acid. 
Cases of local contact dermatitis have been reported.
All parabens have similar structure to estrogen. 
Studies conducted in the early 2000s located traces of parabens in breast tumors, but evidence has not linked parabens with breast cancer.
The Cosmetic Ingredient Review (CIR) reviewed the safety of methylparaben, propylparaben, and butylparaben in 1984 and concluded they were safe for use in cosmetic products at levels up to 25%. Typically parabens are used at levels ranging from 0.01 to 0.3%.

Sodium Methylparaben is the sodium salt form of Methylparaben, an extremely versatile oleochemical with a wide range of industrial and manufacturing applications. 
Sodium Paraben can be found in blueberries and other fruits. 
Paraben Salts exhibit the same antimicrobial activity as regular parabens, meaning they are capable of preventing the formation of harmful bacteria. 
Other names for Sodium Methylparaben include Benzoic Acid, 4-Hydroxy-, Methyl Ester and Sodium Methyl Hydroxybenzoate.
Along with Sodium Propyl Hydroxybenzoate, another commonly used paraben product, Sodium Methyl Paraben contains a number of beneficial properties. 
Sodium Propyl Paraben and Sodium Methyl Paraben solubility is perhaps their most notable quality. They are characterized by their high solubility in cold water and are extremely effective preservatives in hair styling gels, hair care products and oral care products. 
Sodium Methylparaben is a white crystalline that is either odorless or virtually odorless. 
Sodium Methylparaben is also hygroscopic, which means Sodium Methylparaben has the ability to absorb moisture from the atmosphere.
Sodium Methyl Hydroxybenzoate is regarded as safe to use, which is an extremely important consideration in the manufacturing of personal care products. 
Studies on animals have determined that Sodium Methylparaben is virtually nontoxic when ingested orally and will not irritate the skin during topical applications. 

Sodium Methylparaben (5026-62-0) is White Powder. 
Sodium Methylparaben is also known as Methylparaben Sodium Salt, Sodium Methyl Parahydroxybenzoate and Methyl 4-Hydroxybenzoate Sodium Salt.
Storage: Keep container tightly closed. 
Keep container in a cool, well-ventilated area. 
Storage of Sodium Methyl Paraben / Sodium Propyl Paraben:
Store medicines at room temperature, away from heat and direct light. 
Do not freeze medicines unless required by package insert. 
Keep medicines away from children and pets.
Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. 
Please consult your pharmacist or doctor for more details on how to safely discard Sodium Methyl Paraben / Sodium Propyl Paraben.
Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.
The invention discloses a preparation method of sodium methylparaben. 
The preparation method of sodium methylparaben comprises the following steps: firstly, adding methyl p-hydroxybenzoate into a reaction vessel, then slowly dropwise adding sodium hydroxide the amount of which is 1.05 times that of methyl p-hydroxybenzoate into the reaction vessel, and reacting for 1 hour at room temperature; and secondly, after reaction is finished, standing for crystallizing, centrifugally filtering, and carrying out vacuum drying, thus obtaining the sodium methylparaben finished product. 
The preparation method of sodium methylparaben has the advantages that a production process is simple and easy, raw materials are easily available, production cost is reduced, no 'waste water, waste gas or industrial residue' is produced, and environmental protection is realized.
Sodium methylparaben is an organic compound having the chemical formula Na(CH3(C6H4COO)O). 
Sodium methylparaben is also named as sodium methyl para-hydroxybenzoate. 
We can categorize Sodium methylparaben as a sodium salt of methylparaben.
Sodium methylparaben is useful as a food additive having the E number E219. 
Sodium methylparaben is added to food items as a preservative agent.

CAS number: 5026-62-0
European Community (EC) Number: 225-714-1
Molecular Formula: C8H7O3Na
Molar mass: 174.131 g•mol−1

USES & APPLICATIONS of SODIUM METHYLPARABEN:
The most common applications of Sodium Methyl Paraben entail the manufacturing of personal care products and preservatives:
Personal Care: The excellent bacteria prevention properties of Sodium Methylparaben enables it to serve as an antimicrobial for personal care items such as hair care and oral care products.
Preservatives: Another common antimicrobial application of Sodium Methyl Paraben is its use as a wide spectrum preservative, which means Sodium Methyl Paraben has the ability to prevent the growth of the “big three:” bacteria, yeast and fungi.
Antimicrobial Preservative: Actively kills and inhibits the growth of unwanted microorganisms which may be harmful.
Preservative: Prevents and inhibits the growth of unwanted microorganisms which may be harmful
Methylparaben is an anti-fungal agent often used in a variety of cosmetics and personal-care products. 
Sodium Methyl Paraben is also used as a food preservative and has the E number E218
Methyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. 
Sodium Methylparaben can be combined with other parabens like propyl 4-hydroxybenzoate or ethyl 4-hydroxybenzoate. 
The sodium salt provides improved solubility in water compared to standard methyl 4-hydroxybenzoate.

Methyl paraben is an effective inhibitor of molds, yeasts and other microorganisms that commonly grow on food products; Sodium Methylparaben is frequently used as a food preservative. 
Methyl paraben may be found in baked goods, creams and pastes, jams and jellies, syrups, processed vegetables, oils, seasonings, dairy products, and beverages Used for Fungal infection Antimicrobial preservative in the food Anti-fungal agent water-soluble antiseptics

Preservative for the cosmetic industry. 
Sodium Methylparaben is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries and pharmaceuticals. 
Sodium Methylparaben is suitable to preserve both rinse- off and leave- on formulations. 
Sodium is effective against bacteria, molds and yeast. 
The recommended use level to preserve most product types is normally in the range of 0.1 – 0.3 % based on the total weight of the finished product.

Sodium Methylparaben has applications in fruits as an antimicrobial agent; pharmaceutical; cosmetic & personal care; and food & beverages industry as a preservative. 
In cosmetics, Sodium Methylparaben is used in makeup products, hair care products, moisturizer & lotions, shaving products, and toothpastes. 
Sodium Methylparaben also protects pharma products from microorganisms in the pharmaceutical industry. 
Increasing demand for cosmetics products, baked food, creams, jams & jellies, and others in which sodium methylparaben is found also leads to the rise in demand for sodium methylparaben. Attributed to its usage in cosmetics and pharmaceuticals, sodium methylparaben can increase the risk of breast cancer in women and also damage the skin cells and eye cornea. 

Sodium Methylparaben also extend the shelf life of medicines and certain foods (such as salads, fish products or mayonnaise). 
Like all preservatives, Sodium Methylparaben protects against microbial spoilage and thus ensures the safety of the products for the consumer.

Methylparaben also extend the shelf life of medicines and certain foods (such as salads, fish products protect cosmetic products from microbial spoilage and thus make an important contribution to consumer health. 
Sodium Methylparaben is necessary, especially when a cosmetic product contains water. 
Because microorganisms can settle and multiply in water.
Cosmetics often contain not just one preservative, but a mix of several preservatives to act against different bacteria, yeasts or molds at the same time. 
Each of these substances is independently tested to ensure it is safe and tolerable to use in a cosmetic product.
The manufacturers always use the lowest possible concentration in a product, so that optimal durability and carefree use are guaranteed.
Parabens are salts and esters of para-hydroxybenzoic acid. 
Like the related benzoic acid, they have an antimicrobial and fungicidal effect. 
Therefore, some esters in particular have been used as preservatives in cosmetics for more than 80 years.
Para-hydroxybenzoic acid (paraben), methylparaben, ethylparaben, propylparaben, butylparaben and some of their sodium, potassium and calcium salts are permitted in cosmetic products.
In nature, parabens are found in many plants such as cucumbers, carrots, onions, cherries, blueberries and strawberries.

Growth in the application of sodium methylparaben-based products in the food, cosmetics, and pharmaceutical industries are expected to drive the demand for sodium methylparaben over the forecast period. 
Growing applications of sodium methylparaben as an additive in the food & beverage sector, particularly as a preservative in baked goods, jams & jellies, creams, dairy products, syrups, seasonings, oils, processed vegetables, and other beverages, is further expected to fuel the growth of the sodium methylparaben market over the forecast period.

CAS number: 5026-62-0
European Community (EC) Number: 225-714-1
Molecular Formula: C8H7O3Na
Molar mass: 174.131 g•mol−1

Chemical and Physical Properties of Sodium Methylparaben:

Molecular Weight: 174.13    g/mol
Hydrogen Bond Donor Count: 0    
Hydrogen Bond Acceptor Count: 3    
Rotatable Bond Count: 2    
Exact Mass: 174.02928836 g/mol
Monoisotopic Mass: 174.02928836    g/mol
Topological Polar Surface Area:    49.4 Ų    
Heavy Atom Count: 12    
Formal Charge:    0    
Complexity:    141    
Isotope Atom Count:    0    
Defined Atom Stereocenter Count: 0    
Undefined Atom Stereocenter Count: 0    
Defined Bond Stereocenter Count: 0    
Undefined Bond Stereocenter Count: 0    
Covalently-Bonded Unit Count: 2    
Compound Is Canonicalized: Yes    
Physical Description of Sodium Methylparaben:
Sodium Methylparaben is White, hygroscopic powder
pH of Sodium Methylparaben:
9,7-10,3 (0,1 % solution in carbon dioxide free water)
Water Solubility: 11.8 mg/mL    
logP:    1.32    
logP:    1.67    
logS:    -1.2    
pKa (Strongest Acidic):    8.5    
pKa (Strongest Basic):    -6.1    
Physiological Charge:    0    
Hydrogen Acceptor Count:    2    
Hydrogen Donor Count    : 0    
Polar Surface Area: 49.36 Å2    
Rotatable Bond Count:    2    
Refractivity: 50.61 m3•mol-1    
Polarizability: 14.74 Å3    
Number of Rings: 1    
Bioavailability: 1    
Rule of Five: Yes    
Ghose Filter: No    
Veber's Rule: No    
MDDR-like Rule    : No    
Appearance: white to off-white odorless powder
Purity (on dry base): 99.0%–101.5%
Moisture: ≤5.0%
pH value(0.1% solution): 9.5-10.5
Sulfate: ≤300 mg/Kg
Chlorides: ≤350 mg/Kg
Clarity of solution: Clear and transparent
Organic volatile impurities: Meets BP2000/USP 24 standard
Completeness of solution: Meets BP 2000/USP 24 standard
4-Hydroxybenzoic acid: ≤4.0%
Lead: ≤2 mg/Kg

Melting Point of Sodium Methylparaben:
The white precipitate formed by acidifying with hydrochloric acid a 10 % (w/v) aqueous solution of the sodium derivative of methylp-hydroxybenzoate (using litmus paper as indicator) shall, when washed with water and dried at 80 °C for two hours, have a melting range of 125 °C to 128 
CAS number: 5026-62-0
European Community (EC) Number: 225-714-1
Molecular Formula: C8H7O3Na
Molar mass: 174.131 g•mol−1

SAFETY INFORMATION ABOUT SODIUM METHYLPARABEN:
Signal Words: Warning
Hazard statements:
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary statements:
P264: Wash thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: 
IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: 
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. 
Continue rinsing.
P332+P313: 
If skin irritation occurs: Get medical advice/attention.
P337+P313: 
If eye irritation persists: Get medical advice/ attention.
P362: Take off contaminated clothing and wash before reuse.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol: Xi Irritant
Risk Phrases: R36/37/38 Irritating to eyes, respiratory system, and skin

First Aid Measures:

Always seek medical attention after first aid measures are provided.
Inhalation of Sodium Methylparaben:
Remove to fresh air.
If not breathing, give artificial respiration. 
If breathing is difficult, give oxygen. 
Get medical attention.
Ingestion of Sodium Methylparaben: 
Never give anything by mouth to an unconscious person. 
Get medical attention.
Skin Contact: 
Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes.
Remove contaminated clothing and shoes. 
Get medical attention. 
Wash clothing before reuse. 
Thoroughly clean shoes before reuse.
Eye Contact: 
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. 
Get medical attention immediately.

Fire Fighting Measures:

Flammability of the Sodium Methylparaben: 
Non-flammable.
Products of Combustion: Oxides of Carbon and Oxides of Potassium etc.
Explosion: Not an Explosive item.
Fire Extinguishing Media: 
Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. 
Use any means suitable for extinguishing surrounding fire.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. 
At high temperatures under fire conditions, Sodium Methylparaben may produce toxic or irritating fumes. 
Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. 
Uninvolved persons should evacuate to a safe place.

Accidental Release Measures:

Personal precautions, protective equipment, and emergency procedures: 
Avoid breathing dust/fumes/gas/mist/vapors/spray. 
Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses)
Restrict unprotected personnel from the area. 
Prevent any contact with hot surfaces. 
Do not approach facing the wind. 
Do not touch the spilled material.
Environmental precautions: 
Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill of Sodium Methylparaben:
Avoid dust formation. 
Avoid breathing dust. 
Ensure adequate ventilation. 
Use appropriate tools to put the spilled solid in a convenient waste disposal container. 
Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill of Sodium Methylparaben: 
Do not inhale dust, vapors, mist, or gas. 
Avoid dust formation. 
Contain spilled material. 
Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). 
Use a shovel to put the material into a convenient waste disposal container. 
Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.
Handling and Storage of Sodium Methylparaben:
Precautions for safe handling:
Apply according to good manufacturing and industrial hygiene practices. 
Ensure proper ventilation. 
In case of insufficient ventilation, wear suitable respiratory equipment. 
Wash thoroughly after handling. 
Do not drink, eat, or smoke while handling. 
Avoid contact with skin, eyes, and clothing. 
Minimize dust generation. 
Avoid breathing dust/fumes/gas/mist/vapors/spray. 
Avoid contact with eyes, skin, and clothing. 
Keep container tightly closed. Avoid ingestion and inhalation. 
Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: 
Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. 
Keep air contact to a minimum.
Store protected from heat, sparks and ignition sources and incompatible materials. 
Avoid contact with skin and eyes. 
Avoid inhalation of dust/mist/vapor. 
Do not store with incompatible materials like strong oxidizing agents, highly alkaline or acidic materials.
Exposure Controls/Personal Protection:
Ventilation System: 
A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. 
For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: 
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: 
Maintain good housekeeping in work area. 
Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. 
Handle in accordance with good industrial hygiene and safety practice. 
Wash hands after handling.
Stability and Reactivity of Sodium Methylparaben:
Stability: 
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: 
Sodium Methylparaben emits oxides of carbon, potassium and fumes when heated to decomposition.
Hazardous Polymerization: 
Will not occur.
Incompatibilities: 
Strong oxidizing agents, highly alkaline or acidic materials.
Conditions to Avoid:
Incompatibles heat, light and moisture.

CAS number: 5026-62-0
European Community (EC) Number: 225-714-1
Molecular Formula: C8H7O3Na
Molar mass: 174.131 g•mol−1

Synonyms:    
MeSH Entry Terms:
4-hydroxybenzoic acid methyl ester

methyl p-hydroxybenzoate

methyl-4-hydroxybenzoate

methylparaben

methylparaben, sodium salt

Nipagin

Depositor-Supplied Synonyms:
5026-62-0

Methylparaben sodium

Sodium 4-(methoxycarbonyl)phenolate

Sodium methylparaben

Methyl 4-hydroxybenzoate, sodium salt

Preserval MS

sodium methyl paraben

Methyl 4-hydroxybenzoate sodium salt

Sodium 4-carbomethoxyphenolate

sodium;4-methoxycarbonylphenolate

UNII-CR6K9C2NHK

CR6K9C2NHK

Sodium methyl p-hydroxybenzoate

Sodium Methyl Parahydroxybenzoate

MFCD00016470

Solparol

Bonomold OMNa

Sodium p-methoxycarbonylphenoxide

EINECS 225-714-1

Methyl p-hydroxybenzoate, sodium salt

Methylparaben, sodium salt

Methyl p-hydroxybenzoate sodium

Paratexin ms

Paridol mna

Sodium methyl 4-hydroxybenzoate

Nipagin m sodium

Methylparaben sodium [USAN:NF]

Methylis parahydroxybenzoas natricum

Solbrol m sodium salt

Methylparaben sodium (NF)

EC 225-714-1

sodium 4carbomethoxyphenolate

SCHEMBL48756

Ns 3500s

CHEMBL2106903

DTXSID1042156

AKOS015961950

4-Hydroxybenzoic acid-methyl ester sodium

AC-15527

AS-14805

M659

FT-0635516

D02458

Sodium, (p-carboxyphenoxy)-, methyl ester (7CI)

Q-201383

Q3963920

UNII-F57SQP06GK component PESXGULMKCKJCC-UHFFFAOYSA-M

BENZOIC ACID, p-HYDROXY-, METHYL ESTER, SODIUM DERIV.

Methyl 4-hydroxybenzoate sodium salt, tested according to Ph.Eur.