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SODIUM OMADINE


Sodium omadine is the common name of an organosulfur compound with molecular formula C5H5NOS, chosen as an abbreviation of pyridinethione, and found in the Persian shallot. It exists as a pair of tautomers, the major form being the thione 1-hydroxy-2(1H)-pyridinethione and the minor form being the thiol 2-mercaptopyridine N-oxide; it crystallises in the thione form. It is usually prepared from either 2-bromopyridine, 2-chloropyridine, or 2-chloropyridine N-oxide, and is commercially available as both the neutral compound and its sodium salt. It is used to prepare  Sodium omadine, which is used primarily to treat dandruff and seborrhoeic dermatitis in medicated shampoos, though is also an anti-fouling agent in paints.

CAS NO: 3811-73-2
EC NUMBER: 223-296-5,3


IUPAC NAMES: 
2-Mercaptopyridine N-oxide sodium salt
2-Mercaptopyridine N-Oxide Sodium Salt Anhydrous
2-Pyridinethiol, 1-oxide, sodium salt
2-Pyridinthiol-1-oxid, Na-Salz
bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-(T-4) sodium
Pyridine-2-thiol 1-oxide, sodium salt
pyridine-2-thiol 1-oxide, sodium salt
Pyridine-2-thiol-1-oxide, sodium salt
pyridine-2-thiol-1-oxide, sodium salt
sodium (1-oxo-1lambda5-pyridin-2-yl)sulfanide
Sodium (2-Sodium 2-pyridenethio-1-oxide)
Sodium 1-oxidopyridine-2-thione
sodium 1-oxidopyridine-2-thione
Sodium pyrithione
sodium-1-oxidopyridine-2-thione
Sodium-2-pyridinethiol-1-oxide
sodium;1-oxidopyridine-2-thione
Triadine 10


SYNONYMS: 
3811-73-2;Sodium Omadine;Sodium pyrithione;Sodium (2-pyridylthio)-N-oxide;Pyrithione sodium salt;2-Pyridinethiol-1-oxide sodium salt;2-Mercaptopyridine N-oxide sodium salt;PYRITHIONE SODIUM;Omadine sodium;UNII-6L3991491R;2-Mercaptopyridinen-oxide sodiumsalt;2-Mercaptopyridine N-oxide (sodium);MFCD01941547;1-Hydroxy-2-pyridinethione sodium salt;6L3991491R;2-Pyridinethiol, 1-oxide, sodium salt (1:1);2-Mercaptopyridine N-oxide sodium salt anhydrous;2-Pyridinethiol 1-Oxide Sodium Salt;Sodium 2-sulfidopyridine 1-oxide;Sodium-2-pyridinethiol-1-oxide;Sodium omadine (VAN);Sodium pyrithione (VAN);Prestwick_78;NSC 4483;EINECS 223-296-5;Sodium, (2-pyridinylthio)-, N-oxide;2-Pyridinethiol, N-oxide, sodium salt;2-Mercaptopyridine-N-oxide, sodium salt;C5H4NNaOS;(1-Hydroxy-2-pyridinethione), sodium salt;AI3-22596;sodium (1-oxidopyridin-1-ium-2-yl)sulfanide;DSSTox_CID_22390;DSSTox_RID_80011;DSSTox_GSID_42390;SCHEMBL3101261;CHEMBL2364542;DTXSID3042390;AMY3577;2-Mercaptopyridine n-oxide sodium;N-Hydroxypyridinethione Sodium Salt;EBD41219;STR00395;Tox21_300128;AKOS000121187;sodium1-oxidopyridin-1-ium-2-thiolate;2-Mercaptopyridine-1-oxide sodium salt;AC-1079;HY-125785A;Pyridine-2-thiol 1-oxide, sodium salt; NCGC00254107-01; CAS-3811-73-2; CS-0129647;M0632;M2841;Sodium, (2-pyridylthio)-, N-oxide (7CI);2-Mercaptopyridine N-oxide sodium salt, 95%;EC 223-296-5;2-Mercaptopyridine N-oxide sodium salt, >=96%;(1-Hydroxy-2-pyridinethione), sodium salt, tech.;2-Mercaptopyridine N-oxide sodium salt, anhydrous;W-106499;Q27265081;2-Mercaptopyridine N-oxide sodium salt, >=96.0% (NT);Sodium pyridine-2-thiolate N-oxide, 40% aqueous solution;2-Mercaptopyridine N-oxide sodium salt solution, ~40% in H2O, very deep brown;Sodium-2-pyridinethiol-1-oxide; 2-Mercaptopyridine-N-oxide sodium salt;;2-Pyridinethiol-1-oxide sodium salt; N-Hydroxy-2-pyridinethione sodium salt;Omadine sodium; Omadine sodium 40%; pyrithione sodium; 2-Pyridinethiol; 1-Hydroxy-2-pyridinethione sodium salt, 2-Mercaptopyridine-1-oxide sodium salt, 2-Pyridinethiol-1-oxide sodium salt, Pyrithione sodium salt; 2-mercaptopyridine-N-oxide; 1-hydroxypyridine-2-thione; 2-pyridinethiol-1-oxide (CAS No. 1121-31-9); 1-hydroxy-2(1H)-pyridinethione (CAS No. 1121-30-8); NaPT; Sodi; UT900000; SODIUM OMADINE; thione(reagent); Sodium pyrithion; SODIUM PYRITHIONE; PYRITHIONE SODIUM; PYRITHIONE SODIUM SALT; Sodium pyrithione(NaPT); Sodium (2-pyridylthio)-N-oxide (3811-73-2); 15922-78-8: Pyrithione sodium; 1-Hydroxy-2(1H)-pyridinethionato sodium; 1-Hydroxy-2(1H)-pyridinethione, sodium salt; AL02725; Omacide 24; Omadine sodium; SQ 3277; Sel de sodium de 1-hydroxy-2 (1H)-pyridinethione [French]; Sodium 1-hydroxypyridine-2-thione; Sodium 2-pyridinethiol-1-oxide; Sodium Omadine; Sodium pyrithione; 2(1H)-Pyridinethione, 1-hydroxy-, sodium; [ChemIDplus] 3811-73-2: 2-Pyridinethiol, 1-oxide, sodium salt; Sodium (2-pyridylthio)-N-oxide; Sodium pyrithione; (1-Hydroxy-2-pyridinethione), sodium salt; (1-Hydroxy-2-pyridinethione), sodium salt, tech.; 1-Oxo-2-pyridinethiol sodium salt; 2-Mercaptopyridine 1-oxide sodium salt; 2-Mercaptopyridine oxide sodium salt; 2-Mercaptopyridine-N-oxide sodium salt; 2-Pyridinethiol N-oxide sodium salt; 2-Pyridinethiol-1-oxide sodium salt; Omadine sodium; Sodium (2-pyridylthio)-N-oxide; Sodium 2-mercaptopyridine 1-oxide; Sodium 2-pyridinethiol 1-oxide; Sodium 2-pyridinethiol N-oxide; Sodium 2-pyridinethiolate 1-oxide; Sodium omadine (VAN); Sodium, (2-pyridinylthio)-, N-oxide; Thione (reagent); 3811-73-2; Sodium Omadine; Sodium pyrithione; Sodium (2-pyridylthio)-N-oxide; Pyrithione sodium salt; Thione (reagent); 2-Pyridinethiol-1-oxide sodium salt; 2-Mercaptopyridine N-oxide sodium salt; PYRITHIONE SODIUM; Omadine sodium; Sodium omadine (VAN); Sodium pyrithione (VAN); 2-Mercaptopyridine-N-oxide sodium salt; Sodium 2-pyridinethiol N-oxide; Sodium 2-pyridinethiol 1-oxide; Sodium 2-mercaptopyridine 1-oxide; Sodium 2-pyridinethiolate 1-oxide; UNII-6L3991491R; 1-Oxo-2-pyridinethiol sodium salt; NSC 4483; 2-Pyridinethiol N-oxide sodium salt; EINECS 223-296-5; 2-Mercaptopyridine N-oxide (sodium); 2-Mercaptopyridine oxide sodium salt; Sodium, (2-pyridinylthio)-, N-oxide; 1-Hydroxy-2-pyridinethione sodium salt; 2-Mercaptopyridine 1-oxide sodium salt; 2-Pyridinethiol, N-oxide, sodium salt; (1-Hydroxy-2-pyridinethione), sodium salt; AI3-22596; 6L3991491R; 2-Pyridinethiol, 1-oxide, sodium salt (1:1); 2-Mercaptopyridine N-oxide sodium salt anhydrous; 2-Mercaptopyridinen-oxide sodiumsalt; 2-Pyridinethiol 1-Oxide Sodium Salt; Pyridine-2-thiol 1-oxide, sodium salt; Sodium 2-sulfidopyridine 1-oxide; Sodium-2-pyridinethiol-1-oxide; MFCD01941547; Prestwick_78; 2-Mercaptopyridine-N-oxide, sodium salt; C5H4NNaOS; sodium (1-oxidopyridin-1-ium-2-yl)sulfanide; DSSTox_CID_22390; DSSTox_RID_80011; DSSTox_GSID_42390; SCHEMBL3101261; CHEMBL2364542; DTXSID3042390; 2-Mercaptopyridine n-oxide sodium; N-Hydroxypyridinethione Sodium Salt; EBD41219; STR00395; Tox21_300128; Sodium, (2-pyridylthio)-, N-oxide; AKOS000121187; sodium1-oxidopyridin-1-ium-2-thiolate; 2-Mercaptopyridine-1-oxide sodium salt; AC-1079; HY-125785A; NCGC00254107-01

USE AREAS
Blasting agents, grinding materials, friction agents, general abrasives    
Used to prevent adhesion    
Spray powder used to make an air gap between printed sheets of paper
Related to the maintenance and repair of automobiles, products for cleaning and caring for automobiles (auto shampoo, polish/wax, undercarriage treatment, brake grease) 
Related to the building or construction process for buildings or boats (includes activities such as plumbing and electrical work, bricklaying, etc)
Flooring materials (carpets, wood, vinyl flooring), or related to flooring such as wax or polish for floors    
Wall construction materials, or wall coverings    
The modifier used for chemical, when the chemical is used in a laboratory    
Cooling agents
Includes antifoaming agents, coagulating agents, dispersion agents, emulsifiers, flotation agents, foaming agents, viscosity adjusters, etc    
Includes food packaging, paper plates, cutlery, small appliances such as roasters, etc.; does not include facilities that manufacture food    
Industrial fluids such as hydraulic fluids, lubricating agents, functional fluids, etc    
Generic lubricants, lubricants for engines, brake fluids, oils, etc (does not include personal care lubricants)    
If applied entry is related to the manufacturing process for the product, widely applied, modifiers often included
Furniture, or the manufacturing of furniture
Manufacturing of or related to machinery, for production of cement or food, air/spacecraft machinery, electrical machinery, etc
Rubber products (e.g. tires) and their manufacture
Substances used for preventing, destroying or mitigating pests    
Pesticide for non-agricultural use    
Chemical used to kill or inhibit fungi growth    
Preservatives used in cosmetics, film, wood preserving agents, foods, etc.
Surface treatments for metals, hardening agents, corrosion inhibitors, polishing agents, rust inhibitors, water repellants, etc
For the chemistry of 2-mercaptopyridine-N-oxide, see Aldrichimica Acta.1
sodium Omadine is a preservative that is not commonly used because of some level of toxicity. It is prohibited in Canada, and it is on the eu Annex II list of substances that must not form part of cosmetic product composition.
Sodium omadine is a bactericide for use in cooling fluids and short-term in-can preservation of vinyl acetate latex, paints, and synthetic-fibre lubricants; preservative for cosmetic rinse-off products.

Biocidal Uses
Sodium Omadine is being reviewed for use as a biocide in the EEA and/or Switzerland, for disinfection, product preservation, preservation films, preservation of fibres, leather, rubber, or polymers, preservation for construction materials, preservation for working / cutting fluids.


Definition
Apparently exists in equilibrium with the -SH form. Forms chelates with iron, manganese, zinc, etc.

Sodium Omadine is a bactericide and preservative found in coolants, make-up removers, paints, lubricants, and latex.

Sodium omadine is a broad spectrum antimicrobial compound used as a preservative in certain manufacturing materials and as additive in process fluids which may otherwise be subject to deterioration through bacterial and/or fungal growth.
Sodium omadine may be used as a biocide in aqueous metalworking, cutting, cooling and lubricating fluids latex emulsions used in adhesives, caulks, patching compounds, sealants, pastes and grouts latex emulsions aqueous fiber lubricants and inks laundry rinse additives and detergents carpet cleaners and analytical and diagnostic reagents.

SODIUM OMADINE Fungicide is an amber colored liquid broad spectrum anti-fungal agent.
SODIUM OMADINE is effective against most fungi, yeasts, and molds commonly found in contaminated metalworking fluid systems.
SODIUM OMADINE is one of the few effective water-soluble fungicides available for use by this industry, and an excellent choice as a post treatment additive.
SODIUM OMADINE Fungicide is for use in metalworking, cutting, cooling, and lubricating fluids.

Sodium omadine is currently the most effective water-soluble industrial mildew preservative, with high efficiency, broad spectrum, low toxicity and stability.
Sodium omadine can be used in metal cutting fluids, anti-rust liquids, latex paints, adhesives, leather products, textile Products, copper paper, etc.
Sodium omadine Antibacterial agent has the characteristics of high efficiency, broad spectrum, low toxicity and stable aqueous solution.
The main application areas of Sodium omadine include daily chemical products, adhesives, paper, medicine, pesticides, leather products, disinfection products.


Sodium omadine is an organosulfur compound with broad spectrum antimicrobial, provides excellent inhibition of the growth of bacteria and fungi in a many household and industrial products, such as shampoo, hair care products, laundry products and surface cleaning products, pesticides, textile&leather treatment, etc.


Sodium omadine acts as a biocide (antibacterial, antiviral and anti-fungal).
Sodium omadine belongs to a class of cyclic sulfur organo products containing sulfur atom (S) and often oxygen (O), nitrogen (N), hydrogen (H).


Application

Sodium omadine is currently the most effective water-soluble industrial mildew preservative.

Widely used in the fields of daily chemicals (shampoo and hair care products), latex paint, adhesive, leather products, textile,architectural coatings, adhesives, sealants, pesticides, metalworking fluids,anti-rust liquidetc etc.

Sodium omadine can also formulate products such as disinfectants, astringents and medical broad-spectrum antifungal dermatology drugs.
At the same time, Sodium omadine is an effective fungicide for fruit trees, peanuts, wheat, vegetables and other crops and an excellent disinfectant for silkworm.

Sodium omadine and its similar products are widely used in related fields for their high efficiency, broad spectrum, and low toxicity.


Application:

1) Sodium omadine is widely used in daily chemicals (Shampoo and hair conditioner products) building coating, sealing, sticking, pesticide, textile, leather, metalworking fluid and so on, it is effective antimicrobial to bacterial.

2) Sodium omadine is also used to formulate disinfectant and medical spectrum antifungal skin.

3) Sodium omadine is also used as a biocide and disinfectant for fruit trees, wheat, vegetables, and silkworm.

4) Sodium omadine and the other similar product are widely used in the filed, with high effect, wide spectrum and low toxic advantage.


SODIUM OMADINE is one of the active components in paint, sealants, shampoo, adhesive and aerosol due to its anti-microbial activity.
In biochemistry studies, SODIUM OMADINE is utilized to transport zinc into cells. Further, it is used to form bidentate oxothiolane chelates with transition metals.
SODIUM OMADINE acts as a stabilizer and viscosity building provider in weak basic or neutral medium.


Sodium omadine inhibits the growth of fungi, yeast, mold and bacteria.
Sodium omadine is used in formulating anti-microbial property in paint, sealants, shampoo, adhesive and aerosol. Amine N-oxides are active components in body care products such as shampoo, bubble bath, and hand-soap formulations as they are cationic and can act as a mild conditioner in acidic media.
In neutral or weak basic media, they are featured as excellent stabilizer and viscosity building provider.


Sodium Omadine, also known as sodium pyrithione, is an organosulfur compound with the molecular formula C5H4NNaOS.
Sodium Omadine is the sodium salt form of pyrithione, a fungistatic and antimicrobial derivative of aspergillic acid.
Pyrithione sodium appears to interfere with membrane transport, leading to loss of metabolic control.
Sodium Omadine is a broad spectrum antimicrobial, which inhibits the growth of bacteria and fungi in household and industrial products such as shampoos, hair care, laundry, surface cleaning, pesticides, and textile & leather treatment.
Sodium Omadine is used as a broad spectrum biocide especially against fungi and gram positive and gram negative bacteria in metal working fluids, rubber & paint, and cosmetics industries.
At room temperature in the dark, Sodium Omadine is stable in the pH range 4.5 to 9.5.
At 100°C Sodium pyrithione is stable for at least 120 hours, at 150°C 29 % of the substance has decomposed within 48 hours.

Sodium Omadine functions as a wet-state preservative against bacteria and fungus in latex paints.
Sodium Omadine is a highly active, very effective water soluble sodium pyrithione.
Sodium Omadine offers pronounced growth-inhibiting activity against both yeasts and molds.
Sodium Omadine possesses non-irritating and non-sensitizing properties.

Sodium omadine Usage

1. Sodium pyrithione, also known as sodium pyrithione, sodium omepridine, pyrithione, and sodium α-mercaptopyridine-N-oxide, are pyridine derivative fungicides.

2. Appearance is yellow full light transparent liquid, melting point 250 ° C, soluble in water and ethanol and other organic solvents.

3. Unstable to light, oxidant and strong reducing agent. Nonionic surfactants make it slightly inactive, and it can chelate with heavy metals.

4. Main application areas: daily chemical products, adhesives, paper, medicine, pesticides, leather products, disinfection supplies.


In terms of application, the global Sodium Omadine market can be segmented into personal care industry, rubber industry, metal working fluids industry, and paints industry.
The personal care industry segment dominated the market in 2020.
Sodium Omadine is utilized in the personal care industry to manufacture shampoos and hair care products.
Metal working fluids industry was the next major segment.
Sodium Omadine is antimicrobial active, for the use in the metalworking industry.
Sodium Omadine has increased efficacy against various microorganisms found in metalworking fluid systems.
In addition to its anticipated antifungal performance, Sodium Omadine also exhibits antibacterial efficacy.
Sodium Omadine is used as an antimicrobial agent in adhesives and in components of adhesives in paper towels for use in contact with aqueous and fatty foods.


Sodium Omadine can effectively inhibit the growth of bacteria and fungi in a wide variety of household products in areas such laundry care, surface cleaning and aircare. Sodium Omadine is primarily used in personal care products as an antimicrobial agent. Therefore, increase in awareness about personal hygiene and consumer expenditure is expected to drive the global Sodium Omadine market. Sodium Omadine is toxic, and hence personal protective equipment (PPE) and engineering control equipment (chemical resistant gloves) are required in its manufacture. Availability of various substitutes such as zinc pyrithione acts as a restraint of the global Sodium Omadine market.

For Use in Metalworking Fluids
All types of aqueous based coolants are susceptible to contamination from bacteria, yeast, and mold.
Regardless of the type of coolant, bacteria are the most frequently detected microbes in used coolant.
Fungi (yeast and mold), while usually present, are not as easily detected by conventional methods, because the filamentous mycelial forms of mold tend to accumulate in machine crevices, in piping, on sump walls, gear boxes and other solid surfaces.
Routine attempts to completely eliminate bacteria through continual use (and sometimes overuse) of bactericides alone usually result in conditions that encourage the growth of yeast and mold. Heavy fungal contamination can often require both mechanical and chemical treatment.
Dumping, cleaning and recharging fluids are costly procedures.
Moreover, in today’s regulatory climate, disposal of used fluid can be expensive.
Therefore, it is important that the routine treatment of a system includes a fungicide, as well as a bactericide, to ensure longer system life and savings on replacement, cleaning, and disposal costs.
Sodium Omadine fungicide is a highly active, broad-spectrum antimicrobial agent that, when used at recommended concentrations, can help to prevent and minimize problems associated with fungal contamination.

SODIUM OMADINE is a proprietary blend based on the antimicrobial active, sodiumpyrithione (CAS # 3811-73-2) a fungicidal product with a successful history of use by the metalworking industry.
SODIUM OMADINE exhibits increased efficacy against a wide variety of microorganisms found in metalworking fluid systems.
In addition to its anticipated antifungal performance, SODIUM OMADINE Antimicrobial also exhibits antibacterial efficacy


Alternatively Sodium Omadine may be added to latex or other types of coating systems routinely applied to the surfaces of walls, ceiling tiles, partitions, etc. at the same dosage as above.

Sodium Omadine is used at treatment rates of 0.02% to 1.0%, based on the weight of the leather stock, to prevent the bacterial or fungal degradation of hides and skins.

Application level is dependent on the type of hide or leather to be protected, the length of protection desired and the presence of other constituents in the processing formula.
The optimum addition should be determined by trial for each individual application.
For soaking raw hides Sodium Omadine should be added to the water to be used for soaking.
For treating hides cured with dry salt, this product should be applied to the hides or should be mixed with the salt before it is applied to the hides.
Sodium Omadine can be used for the protection of wet leather stock such as pickled, chrome, chrome alternative, metal free, and vegetable tanned leathers from mold and mildew during intannery wet processing and for the protection of wet-blue during long storage and transportation times.

Sodium Omadine is the sodium salt form of pyrithione, a fungistatic and antimicrobial derivative of aspergillic acid. Although the exact mechanism of action remains to be fully elucidated, Sodium Omadine appears to interfere with membrane transport ultimately leading to a loss of metabolic control.
Metalworking fluids are fertile breeding grounds for microorganisms, particularly bacteria and fungi. Their unchecked growth causes fluids to deteriorate and degrades the fluid performance; this in turn causes damage to the work piece, cutting tools and fluid handling systems. Growth of microorganisms in fluids can also affect workers by causing foul odors, skin irritation and allergic reactions. These problems can be reduced or eliminated through the proper use of an antimicrobial agent. Sodium omadine Antimicrobial is a proprietary blend based on the antimicrobial active, sodium pyrithione (CAS # 3811-73-2) a fungicidal product with a successful history of use by the metalworking industry. Sodium omadine Antimicrobial exhibits increased efficacy against a wide variety of microorganisms found in metalworking fluid systems. In addition to its anticipated antifungal performance, Sodium omadine Antimicrobial also exhibits antibacterial efficacy.
The improved antimicrobial performance of Sodium omadine Antimicrobial is not a result of combinations with formaldehyde-based condensates, phenols, or isothiazoline-based products. This proprietary product is a blend of sodium pyrithione with a potentiator, and an amine coupler. This versatile antimicrobial blend can eliminate the need for formulating with multiple products. Sodium omadine Antimicrobial provides broad-spectrum antimicrobial control to a variety of metalworking fluid formulations and is suitable for use in both metalworking fluid concentrates and as a post treatment additive.


 Sodium omadine has a long history of use in medicated shampoos to treat dandruff and seborrhoeic dermatitis (dandruff can be considered a mild form of seborrheic dermatitis). It exhibits both antifungal and antimicrobial properties, inhibiting the Malassezia yeasts which promote these scalp conditions. The mechanisms by which this work are the subject of ongoing study. It can be used as an antibacterial agent against Staphylococcus and Streptococcus infections for conditions such as athlete's foot, eczema, psoriasis, and ringworm. It is known to be cytotoxic against Pityrosporum ovale, especially in combination with ketoconazole, which is the preferred formulation for seborrheic dermatitis. Sodium omadine itself inhibits membrane transport processes in fungi.
Paints used in external environments sometimes include  Sodium omadine as a preventive against algae and mildew.

Sodium omadine  is an antibacterial and antifungal agent developed by scientists in the 1930's. Since then it has been used to treat seborrheic dermatitis of the scalp and other skin conditions such as eczema, athlete's foot, and vitiligo, as well as psoriasis. Because of its antifungal properties, it is commonly found in dandruff shampoo. Products containing Sodium omadine  are available today with and without prescription, and it is the main ingredient in many over-the-counter creams, lotions, soaps, and shampoos. It also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera. Sodium omadine `s other medical applications include treatments of psoriasis, eczema, ringworm, fungus, athletes foot, dry skin, atopic dermatitis, tinea, and vitiligo. Its antifungal effect is thought to derive from its ability to disrupt membrane transport by blocking the proton pump that energizes the transport mechanism.

Stability: At room temperature in the dark, Sodium omadine is stable in the pH range 4.5 to 9.5. At 100°C it is stable for at least 120 hours, at 150°C 29 % of the substance has decomposed within 48 hours. In the light or in contact with weak oxidizing agents Sodium omadine is converted to the disulfide, 2,2-pyridyl-N-oxide disulfide. With stronger oxidizing agents or in alkaline solution (pH > 9.5) the substance is converted via a number of intermediates to the sulfonic acid; the reaction with reducing agents yields thiopyridine (Olin Corporation 1989f).


Sodium omadine, is a coordination complex consisted of Sodium omadine ligands chelated to  (2+) ions via oxygen and sulfur centers. In the crystalline state, it exists as a centrosymmetric dimer. Due to its dynamic fungistatic and bacteriostatic properties, Sodium omadine  is used to treat dandruff and seborrheic dermatitis. Dandruff is a common scalp disease affecting >40% of the world's adult population, and may be caused by fungi such as Malassezia globosa and M. restricta 3.

Sodium omadine  is commonly found as an active ingredient in OTC antidandruff topical treatments such as shampoos. It mediates its action by increasing the cellular levels of copper, and damaging iron-sulfur clusters of proteins essential for fungal metabolism and growth 1. Due to low solubility, Sodium omadine  released from the topical formulations is deposited and retained relatively well onto the target skin surfaces 2. Other uses of Sodium omadine  include additive in antifouling outdoor paints and algaecide. While its use has been approved in the early 1960's by the FDA 4, safety and effectiveness of Sodium omadine  has been reported for decades.


Uses
Medical
Sodium omadine can be used to treat dandruff and seborrhoeic dermatitis.[medical citation needed] It also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera.[medical citation needed] Its other medical applications include treatments of psoriasis, eczema, ringworm, fungus, athletes foot, dry skin, atopic dermatitis, tinea versicolor, and vitiligo.
In paint
Due to its low solubility in water (8 ppm at neutral pH), Sodium omadine is suitable for use in outdoor paints and other products that provide protection against mildew and algae. It is an effective algaecide. It is chemically incompatible with paints relying on metal carboxylate curing agents. When used in latex paints with water containing high amount of iron, a sequestering agent that will preferentially bind the iron ions is needed. Its decomposition by ultraviolet light is slow, providing years of protection even against direct sunlight.
In sponges
Sodium omadine is also used as an antibacterial treatment for household sponges, most notably by the 3M Corporation.
In clothing
A process to apply Sodium omadine to cotton with washable results was patented in the United States in 1984. Sodium omadine is now used to prevent microbe growth in polyester. Textiles with applied Sodium omadine protect against odor-causing microorganisms. 

Sodium omadine (or pyrithione zinc) is a coordination complex of zinc. It has fungistatic (that is, it inhibits the division of fungal cells) and bacteriostatic (inhibits bacterial cell division) properties and is used in the treatment of seborrhoeic dermatitis.
Structure of the compound
The pyrithione ligands, which are formally monoanions, are chelated to Zn2+ via oxygen and sulfur centers. In the crystalline state, Sodium omadine exists as a centrosymmetric dimer (see figure), where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond.

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