PRODUCTS

SODIUM PALMITATE

CAS NO.: 408-35-5
EC/LIST NO: 206-988-1

Sodium palmitate is synthesized by reacting palm oil with sodium hydroxide.
Sodium palmitate is called saponification.
Saponification is a process that produces soap, usually from fats and lye.
Saponification occurs when a fatty acid reacts with an alkali.
Palm oil is the fatty acid and sodium hydroxide is the alkali.
Glycerol and sodium palmate are the end products of this reaction.

Sodium palmitate is a common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
Sodium palmitate is commonly obtained by the saponification of palm oil.

Sodium palmitate belongs to the class of organic compounds known as long-chain fatty acids.
These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms.
Based on a literature review very few articles have been published on sodium hexadecanoate

Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps. Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis, cellular steatosis in various cell lines. Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation. Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression.

Sodium palmitate (C16H31O2Na, CAS Reg. No. 408-35-5) is the sodium salt of palmitic acid (hexadecanoic acid).
Sodium palmitate exists as a white to yellow powder.
Commercially, sodium palmitate is made by mixing and heating flaked sodium hydroxide and palmitic acid.

Sodium palmitate is the sodium salt of palm acid.
Sodium palmitate usually appears as a white paste or granules, and is derived from a mixture of fatty acids from palm (Elaeis guineensis) oil.
We use this ingredient in some of our bar soaps as a surfactant, to gently cleanse skin.

Sodium palmitate can be produced by reacting palm fatty acids with a strong base, typically sodium hydroxide.
Sodium palmitate can be undertaken with almost any fats and alkalis, and is known as saponification - the traditional method for creating soap.
Sodium palmitate can be used in bar soaps and cleansers as a gentler alternative to some harsher surfactants.

Palm oil (PO) is derived from the whole fruit of the plant, whereas palm kernel oil (PKO) is derived from the kernels or seeds.
The two oils are compositionally different, with palm oil having a higher content of the monounsaturated fatty acid oleic acid.

Sodium palmitate acts as a surfactant and emulsifying agent and is a key ingredient in our bar soap.

Sodium palmitate is a skincare and cosmetic ingredient used to saponify oils and fats to create soaps.
Sodium palmitate is derived from palm oil however Sodium palmitate can also be created synthetically, reducing the environmental impact of the ingredient.

Sodium palmitate is used to saponify oils and fats to create soap.
Saponification occurs when fatty acids are reacted with an alkaline ingredient, such as lye.
This allows the oils and fats to foam and bubble without leaving oily residue on the skin.
Palm oil is often used as a fat or oil in this process and when reacted with lye it creates glycerol and sodium palmitate as by products.

Sodium palmitate can be analyzed by this reverse phase (RP) HPLC method with simple conditions.
The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid.
For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid.
Smaller 3 µm particles columns available for fast UPLC applications.
This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation.
Sodium palmitate also suitable for pharmacokinetics.

Sodium palmitate and sodium cocoate are both key ingredients in the soap-making process.
Before scent or other ingredients are added, base soap is nothing more than the sodium or potassium salt of a fatty acid.
Through a chemical process called saponification, Sodium palmitate and sodium cocoate are formed as a result of the reaction between a fatty acid and sodium hydroxide or potassium hydroxide.
The mixture can then be cooled and formed into soaps.

Used as a base ingredient in soap making and cosmetics.
Sodium palmitate is a core ingredient in many types of soap and is made from palm oil.

Sodium palmitate is often combined with sodium cocoate, coconut oil sodium salt and the sodium salt of animal fat, sodium tallow.
Together these three are one the major constituents of modern soap base.
Base soap is the pure soap that has had no additional ingredients like color and scent added to it yet.

As base soap ingredients the hardest formulas use a mix of all three (Sodium palmitate, sodium cocoate, sodium tallow) in various combinations

Sodium palmitate (PA) has been used:
to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay
to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis
as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining

Sodium palmitate is mainly used as a surfactant.
Surfactants help to break down the surface tension between two liquids allowing for a deeper clean.
The breakdown in surface tension allows for dirt and oils to be lifted from the skin and washed away.
This is why sodium palmitate is often found in soaps and some other cleansing products.

Sodium palmitate also helps to emulsify other ingredients.
Emulsifiers help to keep a formulation from splitting.
When you mix oil and water based ingredients they have a tendency to separate and split.
This is because, as the adage says ‘water and oil don’t mix’.
This presents an issue for formulators who want to include the benefits of both water-based ingredients and oil-based ingredients.
This is where emulsifiers like sodium palmitate come in handy.
Emulsifiers help to keep the two types of ingredients mixed together, preventing splitting.
This gives you a stable product that will last.

Used as polymerization catalyst (synthetic rubbers) and emulsifier;
Used in laundry and toilet soaps, detergents, cosmetics, pharmaceuticals, and printing inks

to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay

to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis

as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining

IUPAC NAME :

sodium hexadecanoate

Sodium palmitate

sodium palmitate

sodium;hexadecanoate

SYNONYMS:

206-988-1
3575882
408-35-5
Hexadecanoic acid sodium salt
HEXADECANOIC ACID, SODIUM SALT
Hexadecanoic acid, sodium salt (1:1)
MFCD00002749
Natriumpalmitat
Palmitate de sodium
palmitic acid sodium salt