SODIUM PROPYLPARABENE

Synonyms:

35285-69-9;Propylparaben sodium;Sodium Propylparabene ; Sodium 4-(propoxycarbonyl)phenolate;Sodium Propylparabene e Propylparaben sodium salt; Parasept; Caswell No. 714A; Sodium 4-propoxycarbonylphenoxide; UNII-625NNB0G9N,; Natrium propyl 4-hydroxybenzoat; Benzoic acid, 4-hydroxy-, propyl ester, sodium salt; Propyl-4-hydroxybenzoat natriumsalz; EINECS 252-488-1; Propylparaben, sodium salt; Propyl p-hydroxybenzoate, sodium salt; EPA Pesticide Chemical Code 061204; 625NNB0G9N; Sodium Propyl Parahydroxybenzoate; 4-Hydroxybenzoic acid, propyl ester, sodium salt; sodium; Sodıum Propylparaben; Sodium Propylparabene ; Propylparaben De  Sodium; Propylparaben Du Sodium; Sodium Propylparabene ; Sodıum Propylparabene; Sodium Propylparabene e; Propylparabene De  Sodium; Propylparabene Du Sodium; Sodium Propylparabene e; 4-propoxycarbonylphenolate; Propyl 4-hydroxybenzoate sodium salt; Sodium propyl hydroxybenzoate; Propylparaben sodium [USAN]; C10H11NaO3; Propylparaben sodium [USAN:NF]; E217; Propylparaben sodium (NF); 35285-69-9;Propylparaben sodium;Sodium Propylparabene ; Sodium 4-(propoxycarbonyl)phenolate; Propylparaben sodium salt; Parasept; Caswell No. 714A; Sodium 4-propoxycarbonylphenoxide; UNII-625NNB0G9N,; Natrium propyl 4-hydroxybenzoat; Benzoic acid, 4-hydroxy-, propyl ester, sodium salt; Propyl-4-hydroxybenzoat natriumsalz; EINECS 252-488-1; Propylparaben, sodium salt; Propyl p-hydroxybenzoate, sodium salt; EPA Pesticide Chemical Code 061204; 625NNB0G9N; Sodium Propyl Parahydroxybenzoate; 4-Hydroxybenzoic acid, propyl ester, sodium salt; sodium;4-propoxycarbonylphenolate; Propyl 4-hydroxybenzoate sodium salt; Sodium propyl hydroxybenzoate; Propylparaben sodium [USAN]; C10H11NaO3; Propylparaben sodium [USAN:NF]; E217; Propylparaben sodium (NF)

Propylparaben Sodium

What is it?
Propylparaben has been used as an antimicrobial preservative in the food, cosmetic, and pharmaceutical industries for over 50 years. The chemical formula for propylparaben sodium is NaC10H12O3, it is the sodium salt of propylparaben.

Propylparaben is easily absorbed through the gastrointestinal tract and skin, and metabolites are rapidly excreted in the urine. It does not appear to accumulate in the body. It is on the FDA generally regarded as safe list.

Animal toxicity studies suggest propylparaben is relatively nontoxic by both the oral and injectable routes, but may irritate the skin It has not been shown to be carcinogenic, mutagenic or clastogenic.[1][2][3] All parabens have similar structure to estrogen. Studies conducted in the early 2000s located traces of parabens in breast tumors, but evidence has not linked parabens with breast cancer.

The Cosmetic Ingredient Review (CIR) reviewed the safety of methylparaben, propylparaben, and butylparaben in 1984 and concluded they were safe for use in cosmetic products at levels up to 25%. Typically parabens are used at levels ranging from 0.01 to 0.3%.

Name
Propylparaben sodium
Drug Entry
Propylparaben

Propylparaben is used in allergenic testing.

CAS Number
35285-69-9
Weight
Average: 202.185
Monoisotopic: 202.06058849
Chemical Formula
C10H11NaO3

Sodium Propylparaben
Sodium Propylparaben
Sodium Propylparaben CAS number: 35285-69-9
 "Controversial / at risk" in all categories.
Origin (s) of Sodium Propylparaben: Synthetic
INCI name of Sodium Propylparaben: Sodium Propylparaben
Chemical name of Sodium Propylparaben: Sodium 4-propoxycarbonylphenoxide
Sodium Propylparaben EINECS / ELINCS No .: 252-488-1
Classification of Sodium Propylparaben: Paraben, Suspected endocrine disruptor, Regulated, Preservative
Restriction in Europe of Sodium Propylparaben: V / 12
The maximum authorized concentration in ready-to-use cosmetic preparations is:
- 0.14% (in acid) for the sum of the individual concentrations

- 0.8% (in acid) for the mixtures of substances mentioned in order numbers 12 and 12a, the sum of the individual concentrations of butylparaben and propylparaben and their salts not exceeding 0.14%

Do not use in leave-in products intended for application to the seat area of ​​children under three years of age.

Wording of conditions of use and warnings:
For leave-in products designed for children under three years of age:
"Do not use on the seat area."
Its functions (INCI)
Preservative: Inhibits the development of microorganisms in cosmetic products.
 Sodium Propylparabene is present in 0.07% of cosmetics.

Property name Property value Reference
Molecular weight 202.18 g / mol calculated by PubChem 2.1 (PubChem release 2019.06.18)
Number of hydrogen bond donors of Sodium Propylparaben: 0 calculated by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Number of hydrogen bond acceptors of Sodium Propylparaben: 3 calculated by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Number of rotary bonds of Sodium Propylparaben: 4 calculated by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Exact mass of Sodium Propylparaben: 202.060588 g / mol calculated by PubChem 2.1 (PubChem release 2019.06.18)
Monoisotopic mass of Sodium Propylparaben: 202.060588 g / mol calculated by PubChem 2.1 (PubChem release 2019.06.18)
Topological polar surface of Sodium Propylparaben: 49.4 Ų calculated by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Number of heavy atoms of Sodium Propylparaben: 14 calculated by PubChem
Formal charge of Sodium Propylparabene: 0 calculated by PubChem
Complexity of Sodium Propylparabene: 165 calculated by Cactvs 3.4.6.11 (PubChem version 2019.06.18)
Number of isotopic atoms of Sodium Propylparaben: 0 calculated by PubChem
Defined number of atomic stereocenters of Sodium Propylparaben: 0 calculated by PubChem
Undefined number of atomic stereocenters of Sodium Propylparabene: 0 calculated by PubChem
Defined number of Sodium Propylparaben bond stereocenters: 0 calculated by PubChem
Number of undefined Sodium Propylparaben binding stereocentre: 0

Cosmetic products Data sheets for toxic molecules to avoid

Unwanted compounds are not uncommon in cosmetics. These sheets list the names of those who seem to us to be the most problematic in the current state of scientific knowledge. For each, you can identify the level of risk depending on whether the user is a pregnant woman or a toddler, a child - likely to be more sensitive to irritant compounds in particular -, a teenager or an adult. Endocrine disruptors are particularly to be banned for certain populations, such as pregnant women, toddlers and adolescents.

 
SUMMARY
1. BHA
2. Butylparaben, propylparaben, sodium butylparaben, Sodium Propylparaben, potassium butylparaben, potassium propylparaben

Claiming to be "paraben-free" seems to have become the prerequisite for selling cosmetics or hygiene products. Even if it means replacing these preservatives with others that are not very clear either, such as methylisothiazolinone. In reality, all the members of this family are not to be put in the same basket: those with short chain, ethylparaben and methylparaben (and the compounds which contain this name, like sodium ethylparaben) were bleached by the French and European experts. Conversely, the most dangerous (isobutyl, isopropyl, benzyl, pentyl, phenylparaben) have been banned since 2014. But butylparaben and propylparaben remain authorized (as well as the ingredients whose compound name appends one of these words to "sodium" or “potassium”) while they are considered endocrine disruptors. A mnemonic to remember it? Those that start with P or B are "Not Good"! However, we still find it, including in references intended for toddlers, such as some wipes, children (some toothpastes), or even in the genital sphere. For children under 3 years old, propyl and butylparaben are prohibited in non-rinsed products intended for use in the seat area (cleansers, wipess, creams) but are found in wipes supposed to be used on the face or hands.

Good to know: some products have drug status, even if they are similar to cosmetics. This is the case with some toothpastes or creams. The propylparaben is then called propyl parahydroxybenzoate (or p-hydroxybenzoate), for Sodium Propylparaben, “sodium” is added.

→ Consult the lists of products that may contain butylparaben, propylparaben, sodium butylparaben, Sodium Propylparaben, potassium butylparaben or potassium propylparaben:
- deodorants and perfumes
- makeup
- solar products
- body care
- dental hygiene products
- products for babies and children
- hair care
- facials

Sodium Propylparaben
Inci name
Sodium Propylparaben
French name
Sodium salt of propylparaben; Sodium Propylparaben
CAS number. Sodium Propylparaben
35285-69-9
EC No. Sodium Propylparaben
252-488-1
Other appellations
Sodium propyl paraben | Sodium Propylparaben
Origins of Sodium Propylparaben
Synthetic
CosIng functions
Conservative

List of parabens used in industry
The compounds of the paraben family used in industry are:

methylparaben or methyl 4-hydroxybenzoate (E218) and its sodium salt (E219);
ethylparaben or ethyl 4-hydroxybenzoate (E214) and its sodium salt (E215);
propylparaben or propyl 4-hydroxybenzoate (E216) and its sodium salt (E217);
isopropylparaben;
butylparaben (en);
isobutylparaben;
benzylparaben.
Natural parabens
Sodium Propylparaben only seems possible to indicate that parabens may exist naturally. However, very few scientific references support these analyzes1. For example, the presence of methyl paraben in vanilla has been demonstrated (Zhang & Mueller, 2012). They are also found in products made by bees (propolis, royal jelly, etc.). They are also naturally present in the human body (precursor of coenzyme Q10) 2.

Sodium Propylparaben (CAS 35285-69-9)
Use of Sodium Propylparaben
Due to their effective antibacterial and antimycotic activity, they are used as preservatives in foods, beverages, cosmetics and pharmaceuticals3. They are found in over 80% of hygiene and toiletry products including shampoos, moisturizers, shaving foams and cleansing gels.

The antimicrobial activity increases with the length of the carbon chain of the esterified alcohol of the paraben; but the most widely used are methylparaben and propylparaben because of their greater solubility and because they have a synergistic effect4.

Specific additives like methyl paraben are added to local anesthetics to increase antibacterial activity. They are added to limit contamination by the entry of different vials [ref. necessary].

Methylparaben is the most widely used preservative in local anesthesia. In its pure state, it is colorless and is not affected by heat or cold. Methylparaben solutions are stable at a pH between 3 and 6, but they are hydrolyzed in an alkaline environment. Propylparaben has similar properties. These preservatives do not replace sterilization techniques but only help to reduce the microbiological load5.

Methylparaben (solid powder) is also used as a plasticizer for certain drugs because of its semiconductor properties [ref. necessary]. Sodium Propylparaben helps control the release of polymer-based drugs and facilitate the thermal process. Plasticizers are important for lowering the glass transition temperature (Tg) and softening polymeric drugs during their extrusion. The Tg of the polymer decreases by increasing the amount of methylparaben, this is due to the increased mobility of molecular chains of the polymer when methylparaben is inserted into the matrix. All this happens under high temperature

Parabens: cream, body milk, deodorants, shower gel, toothpaste ...
Whether it is butylparaben, propylparaben, sodium butylparaben, Sodium propylparaben, potassium butylparaben, potassium propylparaben, these molecules are potentially endocrine disruptors. It is desirable to avoid them in pregnant women, babies and adolescents.
Babies and pregnant women ⇒ significant risk for rinsed and non-rinsed products;
Child ⇒ significant risk for rinsed and non-rinsed products;
Adult ⇒ significant risk for non-rinsed products, medium risk for rinsed products.

Sodium Propylparaben (CAS 35285-69-9)
Sodium Propylparaben
Sodium Propylparaben
Sodium Propylparaben CAS number: 35285-69-9
 "Controversial / at risk" in all cases

Origin (s) of Sodium Propylparaben: Synthetic
INCI name of Sodium Propylparaben: Sodium Propylparaben
Chemical name of Sodium Propylparaben: Sodium 4-propoxycarbonylphenoxide
Sodium Propylparaben EINECS / ELINCS No .: 252-488-1