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Sodium pyrithione (SPT) acts as bioactive ligand and forms palladium and platinum complexes, which were tested as potential antitrypanosomal agents.
Sodium pyrithione (SPT) acts on bacterial cells.
Sodium pyrithione (SPT) is an organosulfur compound with broad spectrum antimicrobial, provides excellent inhibition of the growth of bacteria and fungi in a many household and industrial products, such as shampoo, hair care products, laundry products and surface cleaning products, pesticides, textile&leather treatment, etc.
CAS Number: 3811-73-2
Molecular Formula: C5H6NNaOS
Molecular Weight: 151.16
EINECS Number: 223-296-5
Sodium pyrithione, PYRITHIONE SODIUM, Sodium Omadine, 15922-78-8, Omadine sodium, 3811-73-2, Omacide 24, Pyrithione sodium [USAN], AL02725, sodium;1-oxidopyridine-2-thione, 2(1H)-Pyridinethione, 1-hydroxy-, sodium salt, Sodium 2-thioxopyridin-1(2H)-olate, Tomicide s, 1-Hydroxy-2(1H)-pyridinethione, sodium salt, Omadine-sodium, Caswell No. 790A, Pyrithione sodium (USAN), Topcide 280, Sodium 2-sulfidopyridine 1-oxide, NSC-4483, Sodium 2-pyridinethiol-1-oxide, Sodium 1-hydroxypyridine-2-thione, AL-02725, EINECS 240-062-8, EPA Pesticide Chemical Code 088004, SQ 3277, 1-Hydroxy-2(1H)-pyridinethionato sodium, Sodium omadine (TN), Sel de sodium de 1-hydroxy-2 (1H)-pyridinethione [French], Sel de sodium de 1-hydroxy-2 (1H)-pyridinethione, SCHEMBL271923, CHEMBL2105351, DTXSID6034920, XNRNJIIJLOFJEK-UHFFFAOYSA-N, 2-mercaptopyridinen-oxidesodiumsalt, AKOS015891512, FT-0612772, FT-0649466, D05662
Sodium pyrithione (SPT) is a bactericide which can be used as lubricant preservative or used to produce Zinc pyrithione and Copper pyrithione.
Sodium pyrithione (SPT) is mainly used for antisepsis and anti-mildew in the fields of building coating, adhesive, sealant, pesticide, textile, leatherware, metal processing liquid.
Sodium pyrithione (SPT) also can be used to formulate antiseptics, washing chemical and broad-spectrum dermatological antifungal medicine.
Therefore, Sodium pyrithione (SPT) and its like products are widely used in relative fields due to its properties of high efficiency, broad-spectrum and low toxicity.
Sodium pyrithione (SPT) is currently the most effective water-soluble industrial mildew preservative, with high efficiency, broad spectrum, low toxicity and stability.
Sodium pyrithione (SPT) can be used in metal cutting fluid, anti-rust liquid, latex paint, adhesive, leather products, textile.
Products, copper paper, etc. Antibacterial agent has the characteristics of high efficiency, broad spectrum, low toxicity and stable aqueous solution.
The main application areas include: daily chemical products, adhesives, paper, medicine, pesticides, leather products, disinfection products.
Sodium pyrithione (SPT) is the sodium salt form of pyrithione, a fungistatic and antimicrobial derivative of aspergillic acid.
Although the exact mechanism of action remains to be fully elucidated, Sodium pyrithione (SPT) appears to interfere with membrane transport ultimately leading to a loss of metabolic control.
Sodium pyrithione (SPT) zinc is an antibacterial and antifungal agent developed by scientists in the 1930's.
Since then it has been used to treat seborrheic dermatitis of the scalp and other skin conditions such as eczema, athlete's foot, and vitiligo, as well as psoriasis.
Because of its antifungal properties, it is commonly found in dandruff shampoo.
Products containing Sodium pyrithione (SPT) zinc are available today with and without prescription, and it is the main ingredient in many over-the-counter creams, lotions, soaps, and shampoos.
Sodium pyrithione (SPT) also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera.
Sodium pyrithione (SPT) zinc`s other medical applications include treatments of psoriasis, eczema, ringworm, fungus, athlete's foot, dry skin, atopic dermatitis, tinea, and vitiligo.
Its antifungal effect is thought to derive from its ability to disrupt membrane transport by blocking the proton pump that energizes the transport mechanism.
Sodium pyrithione (SPT) zinc is commonly found as an active ingredient in OTC antidandruff topical treatments such as shampoos.
Sodium pyrithione (SPT) mediates its action by increasing the cellular levels of copper and damaging iron-sulfur clusters of proteins essential for fungal metabolism and growth.
Due to low solubility, Sodium pyrithione (SPT) zinc released from the topical formulations is deposited and retained relatively well onto the target skin surfaces.
Other uses of Sodium pyrithione (SPT) zinc include additives in antifouling outdoor paints and algaecide.
While its use has been approved in the early 1960s by the FDA 4, safety and effectiveness of Sodium pyrithione (SPT) zinc has been reported for decades.
Sodium pyrithione (SPT) is not shown to have any significant estrogenic activity according to the in vivo and in vitro assays.
Sodium pyrithione (SPT) is a bactericide which can be used as lubricant preservative or used to produce Zinc pyrithione and Copper pyrithione.
Sodium pyrithione (SPT) is mainly used for antisepsis and anti-mildew in the fields of building coating, adhesive, sealant, pesticide, textile, leatherware, metal processing liquid.
Sodium pyrithione (SPT) is the sodium salt derivative of pyrithione, a fungistatic and antimicrobial aspergillic acid derivative.
Sodium pyrithione (SPT) is a commonly demanded laboratory chemical used as a wide spectrum biocide, particularly against Gram-positive and Gram-negative bacteria in metal working fluids, rubber & paint, and cosmetics industries. Sodium pyrithione tends to interfere with membrane transporting, causing a lack of metabolic function.
Sodium pyrithione (SPT) is a broad spectrum of antimicrobials derivative of aspergillic acid which inhibits bacterial and fungal growth in domestic and industrial products such as shampoos, hair care, laundry, surface cleaning, pesticides, and fabric & leather treatments.
Sodium pyrithione (SPT) is stable under standard environmental conditions when stored in closed, dark containers.
The presence of Sodium pyrithione (SPT) does not directly affect the alkalinity of working metal fluids.
Sodium pyrithione (SPT) zinc is an antibacterial and antifungal agent developed by scientists in the 1930's.
Since then it has been used to treat seborrheic dermatitis of the scalp and other skin conditions such as eczema, athlete's foot, and vitiligo, as well as psoriasis.
Because of its antifungal properties, Sodium pyrithione (SPT) is commonly found in dandruff shampoo.
Products containing Sodium pyrithione (SPT) zinc are available today with and without prescription, and it is the main ingredient in many over-the-counter creams, lotions, soaps, and shampoos.
Sodium pyrithione (SPT) also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera.
Sodium pyrithione (SPT) zinc`s other medical applications include treatments of psoriasis, eczema, ringworm, fungus, athletes foot, dry skin, atopic dermatitis, tinea, and vitiligo.
Its antifungal effect is thought to derive from its ability to disrupt membrane transport by blocking the proton pump that energizes the transport mechanism.
Sodium pyrithione (SPT) belongs to pyridine derivatives fungicide, appearance is yellow full light dumpling transparent liquid, melting point 250 ℃, slightly characteristic odor.
Soluble in water and ethanol and other organic solvents, solubility (by mass fraction): water 53%, ethanol 19%, polyethylene glycol (PECG400) 12%. Best use pH range 7 to 10, mass fraction of 2% aqueous solution pH 8.0.
Sodium pyrithione (SPT) is mainly used for anti-mildew and antibacterial products in the fields of daily chemicals (shampoo and hair care products), architectural coatings, adhesives, sealants, pesticides, textiles, leather products, metal working fluids, etc.
At the same time, Sodium pyrithione (SPT) is also an effective fungicide and an excellent common disinfectant for fruit trees, peanuts, wheat, vegetables and other crops.
Sodium pyrithione (SPT) is mainly used for antisepsis and anti-mildew in the fields of building coating, adhesive, sealant, pesticide, textile, leatherware, metal processing liquid.
Unstable to light, oxidizing agents and strong reducing agents.
Non-ionic surfactants will deactivate Sodium pyrithione (SPT) somewhat, and it can chelate with heavy metals.
Sodium pyrithione (SPT) acts as labelling agent during indium-111 labelling of human platelets.
Sodium pyrithione (SPT) is derivative product, zinc pyrithione, is also a commonly used fungicide for daily chemicals.
Sodium pyrithione (SPT) can also be formulated for disinfection agents, detergents and medical broad-spectrum antifungal dermatological products.
Melting point: -25 °C
Boiling point: 109 °C
Density: 1.22
vapor pressure: 0-0Pa at 25℃
refractive index:1.4825
storage temp.. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: H2O: 0.1 M at 20 °C, clear, faintly yellow
form: Solution
color: very deep brown
Water: Solubility: 54.7 g/100 mL
Sensitive: Hygroscopic
λmax: 334nm(H2O)(lit.)
Merck: 14,7994
BRN: 4026050
InChIKey: WNGMMIYXPIAYOB-UHFFFAOYSA-M
LogP: -2.38 at 20℃ and pH7
Sodium pyrithione (SPT) is a weak acid with pKa values of −1.95 and +4.6 (thiol proton), but is a markedly stronger acid than either of its parent compounds (pyridine-N-oxide and pyridine-2-thiol), both of which have pKa > 8.
Sodium pyrithione (SPT) (Na2S2O4) or sodium sulfide with sodium hydroxide will allow the replacement of the bromo substituent with a thiol functional group.
The alternative strategy is to form the mercaptan before introducing the N-oxide moiety.
2-Mercaptopyridine was originally synthesized in 1931 by heating 2-chloropyridine with calcium hydrosulfide, an approach similar to that was first used to prepare Sodium pyrithione (SPT).
The analogous thiourea approach via a uronium salt was reported in 1958 and provides a more convenient route to 2-mercaptopyridine.
Oxidation of the N-oxide can then be undertaken.
The disulfide Sodium pyrithione (SPT), 2,2'-dithiobis(pyridine-N-oxide) Sodium pyrithione is found as a natural product in the Allium stipitatum plant, an Asian species of onion, also known as the Persian shallot.
Sodium pyrithione (SPT) is presence was detected using positive ion mass spectrometry using a DART ion source and the disulfide diSodium pyrithione [de] (2,2'-disulfanediylbis(pyridine)-1,1'-dioxide) has been reported from the same species.
DiSodium pyrithione can be prepared in a laboratory by oxidation of Sodium pyrithione with chlorine in the presence of sodium hydroxide: 2 C5H4NOSH + Cl2 + 2 NaOH → ONC5H4–S–S–C5H4NO + 2 NaCl + 2 H2O
DiSodium pyrithione is used as a fungicide and bactericide, and has been reported to possess novel cytotoxic activity by inducing apoptosis.
Sodium pyrithione (SPT) is only slightly soluble in water (2.5 g L−1) but is soluble in many organic solvents (including benzene, chloroform, dichloromethane, dimethylformamide, dimethylsulfoxide, and ethyl acetate) and slight solubility in others (diethyl ether, ethanol, methyl tert-butyl ether, and tetrahydrofuran).
Sodium pyrithione (SPT) can be used as a source of hydroxyl radical in organic synthesis as it photochemically decomposes to HO• and (pyridin-2-yl)sulfanyl radical.
Sodium pyrithione (SPT) is mainly used for antisepsis and anti-mildew in the fields of building coating, adhesive, sealant, pesticide, textile, leatherware, metal processing liquid.
Sodium pyrithione (SPT) also can be used to formulate antiseptics, washing chemical and broad-spectrum dermatological antifungal medicine.
Sodium pyrithione (SPT) can be oxidized to its N-oxide using a suitable peracid (as per 2-chloropyridine), both approaches being analogous to that reported in Organic Syntheses for the oxidation of pyridine to its N-oxide.
Sodium pyrithione (SPT) is the sodium salt form of pyrithione, a fungistatic and antimicrobial derivative of aspergillic acid.
Although the exact mechanism of action remains to be fully elucidated, Sodium pyrithione (SPT) appears to interfere with membrane transport ultimately leading to a loss of metabolic control.
Metalworking fluids are fertile breeding grounds for microorganisms, particularly bacteria and fungi.
Their unchecked growth causes fluids to deteriorate and degrades the fluid performance; this, in turn, causes damage to the workpiece, cutting tools, and fluid handling systems.
The growth of microorganisms in fluids can also affect workers by causing foul odors, skin irritation, and allergic reactions.
These problems can be reduced or eliminated through the proper use of an antimicrobial agent.
Sodium pyrithione (SPT) Antimicrobial is a proprietary blend based on the antimicrobial activity, Sodium pyrithione (SPT) a fungicidal product with a successful history of use by the metalworking industry.
Sodium pyrithione (SPT) Antimicrobial exhibits increased efficacy against a wide variety of microorganisms found in metalworking fluid systems.
Sodium pyrithione (SPT) is the sodium salt form of pyrithione, a fungistatic and antimicrobial derivative of aspergillic acid.
Although the exact mechanism of action remains to be fully elucidated, Sodium pyrithione (SPT) appears to interfere with membrane transport ultimately leading to a loss of metabolic control.
Sodium pyrithione (SPT) exists as a pair of tautomers, the major form being the thione 1-hydroxy-2(1H)-pyridinethione and the minor form being the thiol 2-mercaptopyridine N-oxide; it crystallizes in the thione form.
Sodium pyrithione (SPT) is usually prepared from either 2-bromopyridine, 2-chloropyridine, or 2-chloropyridine N-oxide, and is commercially available as both the neutral compound and its sodium salt.
Sodium pyrithione (SPT) is used to prepare zinc Sodium pyrithione, which is used primarily to treat dandruff and seborrhoeic dermatitis in medicated shampoos, though is also an anti-fouling agent in paints.
Tautomerisation of the sodium salt of Sodium pyrithione (SPT) (thione form on the left, thiolate form on the right) Sodium pyrithione (SPT) exists as a pair of prototypes, a form of tautomerism whereby the rapid interconversion of constitutional isomers involves the shift of a single proton, in this case between the sulfur and oxygen atoms (shown in the infobox above).
Salts of the conjugate base of Sodium pyrithione (SPT) can also be considered to exhibit tautomerism by notionally associating the sodium ion with whichever heteroatom bears the negative charge of the anion (as opposed to the formal charges associated with the N-oxide); however, considering the anion alone, this could also be described as an example of resonance.
Uses:
Sodium pyrithione (SPT) is widely used in daily chemicals (Shampoo and hair conditioner products) building coating, sealing, sticking, pesticide, textile, leather, metalworking fluid and so on, it is effective antimicrobial to bacterial.
Sodium pyrithione (SPT) is also used to formulate disinfectant and medical spectrum antifungal skin.
Sodium pyrithione (SPT) biocide is also used as a biocide and disinfectant for fruit trees, wheat, vegetables, and silkworm.
Widely used in the filed, with high effect, wide spectrum and low toxic advantage.
Sodium pyrithione (SPT) is currently the most effective water-soluble industrial mildew preservative.
Sodium pyrithione (SPT) widely used in the fields of daily chemicals (shampoo and hair care products), latex paint, adhesive, leather products, textile，architectural coatings, adhesives,
sealants, pesticides, metalworking fluids，anti-rust liquidetc etc.
Sodium pyrithione (SPT) can also formulate products such as disinfectants, astringents and medical broad-spectrum antifungal dermatology drugs.
At the same time, Sodium pyrithione (SPT) is an effective fungicide for fruit trees, peanuts, wheat, vegetables and other crops and an excellent disinfectant for silkworm.
Sodium pyrithione (SPT) and its similar products are widely used in related fields for their high efficiency, broad spectrum, and low toxicity.
Sodium pyrithione (SPT) is mainly used for antisepsis and mould proofing in the fields of personal care product (shampoo and hair care products), building coating, adhesive, sealant, pesticide, textile, leatherware, metal processing liquid.
Sodium pyrithione (SPT) also can used to formulate antiseptics, washing chemical and broad-spectrum dermatological antifungal medicine.
Moreover, Sodium pyrithione (SPT) is an effective bactericide for fruit trees, peanuts, wheat and vegetables and antiseptics for silkworm use. T
Sodium pyrithione (SPT) can be used in metal cutting fluid, anti-rust fluid, latex paint, adhesive, leather products, textile products, copper paper and other fields.
Sodium pyrithione (SPT) is used in various anti-fungal drugs and shampoo and skin care products in the pharmaceutical and chemical industry.
Sodium pyrithione (SPT) not only prevents product corruption and mildew, but also relieves itching and dandruff, which is very effective.
Sodium pyrithione (SPT) can be used as an effective fungicide for fruit trees, peanuts, wheat, vegetables and other crops.
Sodium pyrithione (SPT) is also an excellent silkworm disinfectant.
Sodium pyrithione (SPT) can be used to formulate products such as disinfectant, detergent and medical broad-spectrum antifungal dermatology.
Sodium pyrithione (SPT) is currently the most effective water-soluble industrial mildew preservative with high efficiency, broad spectrum, low toxicity and stability, which can be used in metal cutting fluid, antirust fluid, latex paint, adhesive, leather products, textile products, copper board paper and other fields.
Sodium pyrithione (SPT) is also can be used for daily chemical products, paper, medicine, pesticides, leather products, disinfection supplies.
Type of pesticide used to destroy or inhibit the growth of disease-causing mechanisms, can be impregnated into clothing.
Includes food packaging, paper plates, cutlery, small appliances such as roasters, etc.; does not include facilities that manufacture food.
Sodium pyrithione (SPT) is used for preventing, destroying or mitigating pests.
Type of pesticide used to destroy or inhibit the growth of disease-causing mechanisms, can be impregnated into clothing.
Active ingredients in a product (often active ingredients in pesticide, if so also tagged with 'pesticide').
Sodium pyrithione (SPT) is an antibacterial and antifungal agent developed by scientists in the 1930's.
Since then Sodium pyrithione (SPT) has been used to treat seborrheic dermatitis of the scalp and other skin conditions such as eczema, athlete's foot, and vitiligo, as well as psoriasis.
Because of Sodium pyrithione (SPT) is antifungal properties, it is commonly found in dandruff shampoo.
Products containing Sodium pyrithione (SPT) are available today with and without prescription, and it is the main ingredient in many overthe-counter creams, lotions, soaps, and shampoos.
Sodium pyrithione (SPT) also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera.
Sodium pyrithione (SPT) is used as a broad spectrum biocide especially against fungi and gram positive and gram negative bacteria in metalworking fluids (boring and cutting oils, up to 0.5 % in the concentrate) (Olin Corporation 1989f; Tenenbaum and Opdyke 1969), in the rubber industry (Wallhäusser 1984) and paint industry (dispersion paints, 0.05 %–0.2 %) (Clayton and Clayton 1981), and in cosmetics which are rinsed off, such as shampoos and wash lotions for the skin, in concentrations of 0.5 % (Lüpke and Preusser 1978).
Sodium pyrithione (SPT) is widely used preservative for water based metal working fluids and as mold and midewcide in gypsum boards.
Sodium pyrithione (SPT) activity spectrum provides for control of fungal growth.
Sodium pyrithione (SPT) is a highly effective microbiocide even at very low usage levels.
Sodium pyrithione (SPT) can be used to treat dandruff and seborrhoeic dermatitis.
Sodium pyrithione (SPT) also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera.
Sodium pyrithione (SPT) is other medical applications include treatments of psoriasis, eczema, ringworm, fungus, athlete's foot, dry skin, atopic dermatitis, tinea versicolor, and vitiligo.
Due to its low solubility in water (8 ppm at neutral pH), Sodium pyrithione is suitable for use in outdoor paints and other products that provide protection against mildew and algae.
Sodium pyrithione (SPT) is an effective algaecide.
Sodium pyrithione (SPT) is chemically incompatible with paints relying on metal carboxylate curing agents.
When used in latex paints with water containing a high amount of iron, a sequestering agent that will preferentially bind the iron ions is needed.
Sodium pyrithione (SPT) is decomposition by ultraviolet light is slow, providing years of protection even against direct sunlight.
Sodium pyrithione (SPT) is also used as an antibacterial treatment for household sponges, most notably by the 3M Corporation.
A process to apply Sodium pyrithione (SPT) to cotton with washable results was patented in the United States in 1984.
Sodium pyrithione (SPT) is now used to prevent microbe growth in polyester.
Textiles with applied Sodium pyrithione (SPT) protect against odor-causing microorganisms.
Sodium pyrithione (SPT) is a preservative that is not commonly used because of some level of toxicity.
Sodium pyrithione (SPT) is prohibited in Canada, and it is on the eu Annex II list of substances that must not form part of a cosmetic product composition.
Sodium pyrithione (SPT) is a bactericide for use in cooling fluids and short-term in-can preservation of vinyl acetate latex, paints, and synthetic-fiber lubricants; preservative for cosmetic rinse-off products.
Sodium pyrithione (SPT) salt is one of the active components in paint, sealants, shampoo, adhesive and aerosol due to its anti-microbial activity.
In biochemistry studies, Sodium pyrithione (SPT) is utilized to transport zinc into cells.
Further, Sodium pyrithione (SPT) is used to form bidentate oxothiolane chelates with transition metals.
Sodium pyrithione (SPT) acts as a stabilizer and viscosity building provider in weak basic or neutral medium.
Sodium pyrithione (SPT) is currently the most effective water-soluble industrial anti-mold preservative.
Sodium pyrithione (SPT) has the characteristics of high efficiency, broad spectrum, low toxicity, and stability.
Sodium pyrithione (SPT) is mainly used in personal care products (shampoo and hair care products), architectural coatings, adhesives, sealants, pesticides, textiles, leather products, metalworking fluids, and other fields of anti-mildew.
Sodium pyrithione (SPT) can also formulate preservatives, detergent chemicals, and broad-spectrum dermatological antifungal drugs.
In addition, Sodium pyrithione (SPT) is an effective fungicide for fruit trees, peanuts, wheat, and vegetables and a preservative for silkworms.
Sodium pyrithione (SPT) can be formulated as a disinfectant, detergent, and broad-spectrum antifungal dermatological drug for medical use.
Sodium pyrithione (SPT) is derivative, zinc pyrithione, is a common fungicide used in daily chemicals.
Safety Profile:
Poison by intraperitoneal and intravenous routes.
Moderately toxic by ingestion, subcutaneous and parenteral routes.
Sodium pyrithione (SPT) is used in preservation of cosmetics.
When heated to decomposition Sodium pyrithione (SPT) emits very toxic fumes of Na2O, NOx, and SOx.
