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Sodium salicylate may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons.
Sodium salicylate is used preservative for paste, mucilage, glue and hides.
Sodium salicylate is widely used in pharmaceutical manufacturing as an active pharmaceutical ingredient, intermediate, and formulation component in products requiring salicylate chemistry.
CAS Number: 54-21-7
EC Number: 200-198-0
Molecular Formula: C₇H₅NaO₃
Molecular Weight: 160.10 g/mol
SYNONYMS:
Sodium Salicylate, Sodium 2-Hydroxybenzoate, Sodium o-Hydroxybenzoate, Salicylic Acid Sodium Salt, Salicylate Sodium, Natrium Salicylate, Sodium Salicylas, Sodium Salicylate USP, Sodium Salicylate BP, Sodium 2-hydroxybenzoate, Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin, Enterosalicyl, Kerasalicyl, Alysine, 2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt, Sodium 2-hydroxybenzoate, Sodium salicylate, 54-21-7, Enterosalicyl, Kerasalicyl, Alysine, Benzoic acid, 2-hydroxy-, monosodium salt, Natrum salicylicum, Salicylic acid sodium salt, salicylate sodium, DTXSID5021708, Monosodium 2-hydroxybenzoate, Natrii salicylas, WIQ1H85SYP, Salicylate, sodium, NSC-202167, DTXCID701708, Benzoic acid, 2-hydroxy-, sodium salt (1:1), NSC202167, Sod sal, Pro-Prin, SaliGard 60, RefChem:6246, UNI-SOL, UNI-SOL 60, Aspen Sodium Salicylate 48.6%, AquaPrime Liquid Sodium Salicylate, Aquasource Aqua-Prin Water Soluble Sodium Salicylate, 200-198-0, Sodium 2-hydroxybenzoate, Salsonin, Clin, Enterosalil, Entrosalyl, Glutosalyl, Kerosal, Magsalyl, Nadisal, Salisod, Aroall, Monosodium salicylate, Neo-salicyl, Diuretin, Parbocyl-rev, sodium,2-hydroxybenzoate, Salicylic acid, sodium salt, Sodium o-hydroxybenzoate, salicylic acid sodium, MFCD00002440, o-Hydroxybenzoic acid, sodium salt, Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt, sodiumsalicylate, Natrium salicylat [German], CCRIS 6715, EINECS 200-198-0, UNII-WIQ1H85SYP, NSC 202167, Sodium salicylate [USP:JAN], Sodium salicylate CRS, sodium,2-carboxyphenolate, Sodium salicylate, 99%, Spectrum2_001945, Spectrum3_000900, Spectrum4_000995, Spectrum5_001120, EC 200-198-0, SCHEMBL4603, KBioGR_001429, Sodium Salicylate (Standard), 90218-94-3, SPECTRUM1500533, SPBio_002009, CHEBI:9180, CHEMBL447868, HY-B0167AR, orb1310710, SODIUM SALICYLATE [JAN], SCHEMBL29888959, Sodium salicylate (JP18/USP), HY-B0167A, KBio3_001820, MSK3406, NATRUM SALICYLICUM [HPUS], SODIUM SALICYLATE [VANDF], SODIUM SALICYLATE [MART.], HMS1920P16, HMS2092G17, SALICYLATE SODIUM [WHO-DD], SODIUM SALICYLATE [USP-RS], SODIUM SALICYLATE [WHO-IP], Sodium salicylate, p.a., 99.5%, Tox21_200411, CCG-39474, AKOS003051698, AKOS005766021, CS-2008, CAS-54-21-7, NATRII SALICYLAS [WHO-IP LATIN], SALICYLIC ACID SODIUM SALT [MI], SODIUM SALICYLATE [EP MONOGRAPH], NCGC00094780-01, NCGC00094780-02, NCGC00257965-01, SODIUM SALICYLATE [USP MONOGRAPH], FS157080, SY010161, DB-052516, NS00074304, C07587, D00566, D83111, Sodium salicylate, ReagentPlus(R), >=99.5%, Sodium salicylate, SAJ first grade, >=99.5%, Sodium salicylate, tested according to Ph.Eur., Sodium salicylate, SAJ special grade, >=99.5%, Q414547, Sodium salicylate, Vetec(TM) reagent grade, 99%, Sodium salicylate, meets USP testing specifications, Sodium salicylate, puriss. p.a., >=99.5% (NT), Sodium salicylate, European Pharmacopoeia (EP) Reference Standard, Sodium salicylate, United States Pharmacopeia (USP) Reference Standard, 2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt, Sodium 2-hydroxybenzoate, SALICYLATE,NASAL,2-Hydroxybenzoate,alysine,SALICYLIC ACID SODIUM SALT,2-HYDROXYBENZOIC ACID SODIUM SALT,clin,ardall,aroall,kerosal, Sodium 2-hydroxybenzoate, Monosodium 2-hydroxybenzoate, Salicylic acid sodium salt, o-Hydroxybenzoic acid, sodium salt, 2-Hydroxybenzoic acid monosodium salt, sodium,2-hydroxybenzoate, Enterosalicyl, Enterosalil, Entrosalyl, Glutosalyl, Kerasalicyl, 2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt, Sodium 2-hydroxybenzoate, Natrii salicylas, 2-hydroxybenzenecarboxylate
Sodium salicylate is a sodium salt of salicylic acid.
Sodium salicylate can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure.
Historically, Sodium salicylate has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux.
Sodium salicylate, HOC6H4COONa, is a shiny, white powder with sweetish taste and mild aromatic aroma that is soluble in water,glycerol, and alcohol.
Sodium salicylate is used in medicine and as a preservative.
Sodium salicylate is a salt or ester of salicylic acid.
Sodium salicylate may be prepared by the reaction, in aqueoussolution, by adding equal molar ratio of salicylic acidand sodium bicarbonate; evaporating to dryness yields thewhite salt.
In solution, particularly in the presence of sodiumbicarbonate, Sodium salicylate will darken on standing.
This is the saltof choice for salicylate medication and usually is administeredwith sodium bicarbonate to lessen gastric distress, or itis administered in enteric coated tablets.
However, the useof sodium bicarbonate is ill advised, because it decreases theplasma levels of salicylate and increases the excretion offree salicylate in the urine.
Sodium salicylate, even though not as potent as aspirinfor pain relief, also has less GI irritation and is useful for patientswho are hypersensitive to aspirin.
Sodium salicylate belongs to the class of nonacetylated salicylates.
Sodium salicylate can be prepared from the reaction of salicylic acid and ammonia.
Sodium salicylate exhibits fluorescence at higher concentrations and effectively absorbs β-particles.
Sodium salicylate is the active ingredient in aspirin, commonly used as antipyretic, anti-inflammatory and analgesic drug.
Sodium salicylate is a salt of salicylic acid with anti-inflammatory, analgesic, and antipyretic properties.
Sodium salicylate is used in pharmaceutical formulations to relieve pain and reduce fever, and occasionally as an alternative to aspirin for individuals sensitive to it.
Sodium salicylate also has mild antiseptic and keratolytic effects, making it useful in some topical preparations.
Sodium salicylate is the sodium salt of salicylic acid.
Salicylic acid is found naturally in willow trees, particularly in its bark.
Sodium salicylate is a white, odorless, crystalline powder.
Sodium salicylate is used in medicines as a mild analgesic and antipyretic.
Sodium salicylate was previously made by refluxing methyl salicylate (wintergreen oil) with an excessive amount of sodium hydroxide.
Sodium salicylate is a sodium salt of salicylic acid.
Sodium salicylate can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure.
Historically, Sodium salicylate has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux.
Sodium salicylate is the sodium salt of salicylic acid.
The name of Sodium salicylate gives us information about its structure and its components:
Sodium indicates a sodium ion in the compound.
Sodium ions are positively charged and help increase the solubility of the compound in water.
Salicylate comes from "salicylic acid", indicating that the compound is derived from a type of phenolic acid known for its ability to relieve pain and reduce inflammation.
Sodium salicylate is an organic molecular entity.
Sodium Salicylate is the sodium salt of salicylic acid.
Sodium salicylate is a white, crystalline solid with the chemical formula C7H5NaO3.
Sodium salicylate is highly soluble in water, making it an ideal candidate for various formulations and applications.
Sodium salicylate derives its medicinal properties from its ability to inhibit cyclooxygenase (COX) enzymes, which are crucial in the inflammatory process.
By blocking these enzymes, sodium salicylate effectively reduces pain, fever, and inflammation.
Sodium Salicylate is the sodium salt of salicylic acid, a water-soluble form of this well-known beta-hydroxy acid (BHA).
Sodium salicylate functions as a mild preservative, pH adjuster, masking agent, and gentle exfoliant.
Unlike salicylic acid, its higher solubility in water makes Sodium salicylate easier to incorporate into aqueous systems at low concentrations.
Sodium Salicylate is commonly used in toners, cleansers, shampoos, scalp treatments, anti-dandruff products, acne formulations, and some oral care items.
Sodium salicylate provides clarifying, keratolytic, and antimicrobial benefits while helping control pH and mask odors.
Sodium Salicylate is the sodium salt of salicylic acid, a compound historically derived from willow bark.
As an older generation non-steroidal anti-inflammatory drug (NSAID), Sodium salicylate is primarily known for its ability to alleviate pain, reduce inflammation, and lower fever.
Its mechanism of action is similar to that of aspirin, though Sodium salicylate is generally considered to have a lower potency and different metabolic profile.
Sodium salicylate is soluble in water, 1,4-dioxane, ethanol and glycerol.
Sodium salicylate has been a staple in medicine for its broad therapeutic applications, particularly in managing chronic inflammatory conditions.
Understanding what Sodium Salicylate involves recognizing its chemical structure and its role as a foundational compound in the development of many modern pain relievers and anti-inflammatory agents.
Sodium salicylate is the sodium salt of salicylic acid and is a highly water-soluble aromatic carboxylate widely used in pharmaceutical, cosmetic, laboratory, and industrial applications.
Sodium salicylate is produced by the neutralization of salicylic acid with sodium hydroxide or sodium carbonate, yielding a stable crystalline compound with excellent aqueous solubility.
Sodium salicylate possesses anti-inflammatory, analgesic, and antipyretic properties and historically served as one of the earliest non-steroidal anti-inflammatory agents (NSAIDs).
Although its therapeutic use has largely been replaced by newer salicylates and other NSAIDs, sodium salicylate remains important in pharmaceutical research and specialized medicinal formulations.
In addition to pharmaceutical applications, sodium salicylate functions as a corrosion inhibitor, analytical reagent, pH-adjusting component, calibration standard, preservative intermediate, and chemical synthesis reagent.
Because of its excellent water solubility and chemical stability, Sodium salicylate is widely employed in laboratory investigations involving oxidative stress, inflammation, signal transduction, and cellular biology.
Sodium salicylate is a sodium salt of salicylic acid.
Sodium salicylate is a shiny white solid, producing mildly alkaline solutions because it can donate one hydrogen-bond and accept three.
Sodium Salicylate is a sodium salt of salicylic acid.
Sodium Salicylate is a medication widely recognized for its anti-inflammatory, analgesic (pain-relieving), and antipyretic (fever-reducing) properties.
Sodium salicylate belongs to a class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs) and has been utilized in medical practice for many years.
USES and APPLICATIONS of SODIUM SALICYLATE:
Sodium salicylate is used in medicine as an analgesic and antipyretic.
Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis.
Sodium salicylate is also a potential replacement for aspirin for people sensitive to it.
Sodium salicylate may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons.
Sodium salicylate is used preservative for paste, mucilage, glue and hides.
Sodium salicylate is widely used in pharmaceutical manufacturing as an active pharmaceutical ingredient, intermediate, and formulation component in products requiring salicylate chemistry.
Although its direct medicinal use has declined with the introduction of newer non-steroidal anti-inflammatory drugs, Sodium salicylate remains valuable in specialized pharmaceutical preparations and research formulations.
Sodium salicylate is extensively employed in biomedical research as an experimental anti-inflammatory agent for investigating cyclooxygenase-independent pathways, oxidative stress, apoptosis, inflammatory signaling, heat shock protein expression, nuclear factor kappa B (NF-κB) regulation, and cellular defense mechanisms.
In analytical chemistry, sodium salicylate serves as a calibration standard, spectrophotometric reference material, fluorescence reagent, and analytical intermediate because of its well-defined ultraviolet absorption characteristics and high chemical purity.
Sodium salicylate is frequently used in clinical laboratories for assay development, analytical validation, pharmaceutical quality control, chromatographic method development, and biochemical investigations involving salicylate metabolism.
Sodium salicylate functions as a chemical intermediate in the synthesis of pharmaceuticals, dyes, fragrances, preservatives, specialty chemicals, and numerous aromatic organic compounds derived from salicylic acid chemistry.
Sodium salicylate is incorporated into corrosion inhibitor formulations for certain industrial cooling systems and metal treatment applications where organic carboxylate salts provide protective surface interactions.
In educational laboratories, sodium salicylate is widely used to demonstrate acid-base chemistry, aromatic substitution reactions, buffer systems, UV spectroscopy, coordination chemistry, and organic synthesis techniques.
Sodium salicylate is also utilized in veterinary research, agricultural chemistry, biotechnology, microbiology, molecular biology, toxicological studies, environmental analysis, and pharmaceutical formulation development where highly water-soluble salicylate salts are required.
Sodium salicylate is used in medicine as an analgesic and antipyretic.
Sodium salicylate also acts as non - steroidal anti - inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis.
Sodium salicylate is also a potential replacement for aspirin for people sensitive to it.
Sodium salicylate may also be used as a phosphor for the detection of vacuum ultra violet radiation and electrons.
Uses of Sodium salicylate: keratolytic
Uses of Sodium salicylate: In manufacture of aspirin, methyl salicylate, and other salicylates.
Sodium salicylate is used coupling agent for azo dyes.
Sodium salicylate has been used as food preservative.
Sodium salicylate also serves as a useful intermediate in organic synthesis and as a reference material in analytical chemistry due to its well-characterized chemical properties and high purity.
Sodium salicylate may also be used as a phosphor for the detection of vacuum ultraviolet radiation and beta radiation.
Sodium salicylate is used as an analgesic and antipyretic.
Sodium salicylate also acts as a non-steroidal anti-inflammatory drug (NSAID).
Further, Sodium salicylate is used as a phosphor for the detection of vacuum ultraviolet radiation and electrons.
Sodium salicylate serves as a neurofibromatosis kappa B inhibitor and reducer of oxidative stress.
Sodium salicylate finds applications as a drug with the function of being antifebrile and anti-rheumatic.
-Therapeutic Uses of Sodium salicylate:
Sodium salicylate is used for:
Treatment of acne vulgaris
Treatment of psoriases
Treatment of warts
Treatment of scalp dermatoses
Treatment of dermatitis seborreic
-Pharmaceuticals use of Sodium salicylate:
Analgesic & Antipyretic:
Sodium salicylate is used as a non-steroidal anti-inflammatory drug (NSAID) for pain relief and fever reduction.
Antirheumatic Agent:
Sodium salicylate is used in the treatment of rheumatic disorders like arthritis due to its anti-inflammatory properties.
Formulation Intermediate:
Sodium salicylate is used in the formulation of ointments, tablets, and oral solutions for various therapeutic applications.
-Performance Chemicals uses of Sodium salicylate:
Intermediate Compound:
Sodium salicylate acts as a starting material or intermediate in the synthesis of dyes, antiseptics, and other organic compounds.
Precursor to Salicylic Acid Derivatives:
Sodium salicylate is used in the production of more complex salicylate-based chemicals.
-Personal Care uses of Sodium salicylate:
Skin Soothing Agent:
Sodium salicylate is used in low concentrations in some topical formulations for skin-soothing and anti-inflammatory effects.
Anti-dandruff & Acne Products:
Sodium salicylate acts similarly to salicylic acid in exfoliating skin and treating scalp or acne-related issues.
-Preservative uses of Sodium salicylate:
Sodium salicylate can be found in cosmetics, personal care products, perfumes, and fragrances, often as a preservative.
Among 16 other salicylate salts in these products, Sodium salicylate has been concluded to be safe.
MEDICAL USES OF SODIUM SALICYLATE:
Pain Relief:
One of the primary uses of sodium salicylate is for pain relief.
Sodium salicylate is often employed in the treatment of various pain conditions, including arthritis, muscle pain, and other inflammatory disorders.
Its effectiveness in alleviating discomfort makes Sodium salicylate a valuable addition to the NSAID family.
Fever Reduction
Sodium salicylate can also be used to reduce fever.
By acting on the hypothalamus, the part of the brain responsible for regulating temperature, Sodium salicylate helps lower elevated body temperatures associated with infections and inflammatory diseases.
Anti-Cancer Potential
Recent research has suggested that sodium salicylate may hold anti-cancer potential.
Studies have indicated that Sodium salicylate could inhibit the growth of cancer cells and induce apoptosis, or programmed cell death, in certain types of tumors.
This emerging area of research highlights sodium salicylate’s potential beyond its traditional uses, paving the way for further investigations into its role in cancer therapy.
Induction of Tinnitus in Research
Sodium salicylate serves as a useful tool in scientific research, particularly in studies related to tinnitus—a condition characterized by ringing or buzzing in the ears.
Researchers have utilized sodium salicylate to induce tinnitus in animal models, allowing for a better understanding of the underlying mechanisms and potential treatments for this challenging condition.
Sodium salicylate is a versatile compound with a wide range of applications in medicine and research.
Sodium salicylate's effectiveness as a non-steroidal anti-inflammatory drug, coupled with its potential anti-cancer properties and utility in tinnitus research, underscores its importance in the pharmaceutical landscape.
MEDICINE USES OF SODIUM SALICYLATE:
Sodium salicylate is used in medicine as an analgesic and antipyretic.
Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis.
Sodium salicylate is a potential replacement for aspirin for people sensitive to it.
Sodium salicylate lends its analgesic effects to the inhibition of cyclooxygenase.
This enzyme converts arachidonic acid to cyclic endoperoxides, which are precursors to prostaglandins, thus preventing the sensitization of pain receptors.
Sodium salicylate, alongside other salicylates, has historically been used to treat rheumatological disorders.
USE & BENEFITS OF SODIUM SALICYLATE:
Denaturant for Ethyl Alcohol:
Sodium salicylate denatures ethyl alcohol in products, making it unsuitable for consumption.
Preservative:
Sodium salicylate inhibits the growth of molds, fungus, or bacteria in the product, increasing its shelf life.
Protection:
Sodium salicylate protects the product from deterioration over time.
Usage in Formulations:
Sodium salicylate is utilized in the formulations of makeup, shampoos, conditioners, and sun and skincare products.
HOW TO USE SODIUM SALICYLATE:
Sodium salicylate is available in various forms, including tablets, powders, and topical preparations.
The choice of administration method depends on the specific condition being treated.
For systemic conditions such as pain and inflammation, oral administration is the most common route.
Tablets and powders are typically ingested with water, and dosages can vary depending on the severity of the condition and the patient's medical history.
The onset of action for sodium salicylate taken orally is relatively quick, generally occurring within 30 minutes to an hour, although this can vary based on individual factors such as metabolism and gastrointestinal absorption.
For topical applications, sodium salicylate is often included in creams and gels designed to be applied directly to the affected area.
This method is particularly useful for localized musculoskeletal pain or inflammation, providing targeted relief with minimal systemic absorption.
Sodium salicylate is essential to follow dosing guidelines and medical advice when using sodium salicylate.
Overuse or misuse can lead to adverse effects and diminished efficacy.
As with all medications, consistency and adherence to prescribed dosages are crucial for achieving optimal therapeutic outcomes.
Sodium salicylate, with the Chemical Abstracts Service (CAS) number 54-21-7, is a fascinating compound that plays a significant role in both pharmaceutical applications and research.
As a sodium salt of salicylic acid, Sodium salicylate is classified as a non-steroidal anti-inflammatory drug (NSAID).
WHAT SODIUM SALICYLATE IS USED FOR AND WHERE?
The first non-steroidal anti-inflammatory drugs (NSAIDs) were salicylates for their anti-inflammatory and analgesic properties.
The best-known applications of salicylates are aspirin (acetylsalicylic acid) and sodium salicylate, both of which are inexpensive and readily available.
***Medicine
Analgesic, antipyretic, non-steroidal anti-inflammatory.
Also used as a substitute for aspirin.
Against keratosis, dandruff and others.
In skin infections caused by fungus.
As a reagent to measure free acid in gastric juices.
as an analytical reagent.
In spot microanalysis to determine uranium dioxide and organic synthesis.
***Cosmetics
Sodium salicylate is a restricted ingredient as V/3 a Relevant Item in the Annexes of the European Cosmetics Regulation 1223/2009.
Maximum concentration in ready for use preparation: Salicylic acid 0,5 % (acid).
Salicylic acid salts: 0,5 % (acid).
***Denaturant.
Sodium salicylate makes cosmetics unpalatable.
Sodium salicylate is sometimes added to cosmetics containing ethyl alcohol to make it unsuitable for ingestion.
The ionic or polar molecules of Sodium salicylate included in formulations that interact with protein groups, modulate the properties of the solution to suit specific needs.
***Preservative.
Any product containing organic, inorganic compounds, water, needs to be preserved from microbial contamination.
Preservatives act against the development of harmful microorganisms and against oxidation of the product.
***Studies
Aspirin is preventive against stroke not only because of its antithrombotic properties but also because of other direct effects.
The aim of this study was to elucidate its direct neuroprotective effects.
The findings of this study show a new mechanism for the neuroprotective effects of aspirin, which occurs at concentrations in the antithrombotic-analgesic range, useful in the management of patients at high risk of ischaemic events.
Tinnitus is thought to be caused by damage to the auditory and non-auditory systems due to exposure to loud noises, ageing or other aetiologies.
Sodium salicylate (NaSal) was used to create an animal model of rats with tinnitus, assessed with prepulsive inhibition behaviour.
The results showed that the acquisition and recovery of spatial memory was impaired by treatment with NaSal.
Sodium salicylate showed inhibitory activity of quorum sensing, a cell density-dependent signalling system that controls the production of many virulence factors and biofilm formation in Pseudomonas aeruginosa and is therefore to be considered as an adjuvant in delayed healing of chronic wounds.
MECHANISM OF ACTION OF SODIUM SALICYLATE:
The primary mechanism through which sodium salicylate exerts its effects is by inhibiting the COX pathways.
COX enzymes play a vital role in the conversion of arachidonic acid to prostaglandins, compounds that mediate inflammation and pain.
By reducing the production of these inflammatory mediators, sodium salicylate provides relief from symptoms associated with various conditions.
In addition to COX inhibition, sodium salicylate also influences the nuclear factor kappa B (NF-κB) signaling pathway.
NF-κB is a transcription factor that, when activated, promotes the expression of pro-inflammatory cytokines.
By modulating this pathway, sodium salicylate further contributes to its anti-inflammatory effects, demonstrating its multifaceted action in pain management.
CHEMICAL PROPERTIES OF SODIUM SALICYLATE:
Sodium salicylate is the sodium salt of salicylic acid and readily dissociates in water into sodium ions and salicylate anions, resulting in excellent aqueous solubility.
Sodium salicylate contains both a phenolic hydroxyl group and a carboxylate group attached to an aromatic benzene ring, providing unique acid-base behavior and coordination ability toward certain metal ions.
Because of its aromatic structure, sodium salicylate exhibits ultraviolet absorption characteristics that make it useful in analytical chemistry and spectroscopic applications.
Sodium salicylate remains chemically stable under normal storage conditions but may gradually decompose when exposed to excessive heat or strong oxidizing agents.
Sodium salicylate reacts with strong mineral acids to regenerate salicylic acid and forms coordination complexes with various transition metals, making it useful in coordination chemistry and analytical procedures.
Sodium salicylate's phenolic functionality enables participation in electrophilic substitution reactions and numerous organic synthesis pathways involving aromatic intermediates.
CHARACTERISTICS OF SODIUM SALICYLATE:
Sodium salicylate exhibits excellent water solubility.
Sodium salicylate possesses high chemical purity suitable for pharmaceutical and laboratory applications.
Sodium salicylate demonstrates excellent stability under normal storage conditions.
Sodium salicylate exhibits weakly alkaline behavior in aqueous solution.
Sodium salicylate possesses characteristic ultraviolet absorption properties.
Sodium salicylate is compatible with numerous aqueous formulations.
Sodium salicylate readily dissociates into sodium and salicylate ions.
Sodium salicylate functions as an effective organic buffering component.
Sodium salicylate exhibits moderate metal-chelating capability.
Sodium salicylate is suitable for analytical, pharmaceutical, and research applications.
Sodium salicylate's aromatic structure provides predictable chemical reactivity.
Sodium salicylate demonstrates excellent batch-to-batch consistency when manufactured to pharmaceutical standards.
BENEFITS OF SODIUM SALICYLATE:
Sodium salicylate dissolves rapidly in water, facilitating the preparation of concentrated aqueous solutions for pharmaceutical and laboratory use.
Sodium salicylate's high chemical stability allows long-term storage without significant degradation when protected from excessive moisture and heat.
Sodium salicylate serves as a valuable intermediate in organic synthesis and pharmaceutical manufacturing.
Sodium salicylate's ultraviolet absorption characteristics support analytical measurements and calibration procedures.
Excellent aqueous compatibility enables formulation in a wide variety of research and industrial applications.
Sodium salicylate provides reproducible performance in biochemical and pharmacological investigations.
Sodium salicylate's ionic nature improves formulation flexibility compared with free salicylic acid.
Sodium salicylate serves as a useful reference standard for salicylate analysis and quality control procedures.
Sodium salicylate's well-documented chemical and pharmacological properties facilitate regulatory acceptance and scientific research.
Sodium salicylate is widely available in pharmaceutical-grade and analytical-grade purity.
SODIUM SALICYLATE MECHANISM OF ACTION:
The mechanism of action of sodium salicylate centers on its ability to inhibit cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2.
These enzymes are key players in the biosynthesis of prostaglandins, lipid compounds that perform a variety of roles, including mediating inflammation, pain, and fever.
By inhibiting COX enzymes, sodium salicylate reduces the production of prostaglandins, thereby alleviating symptoms associated with inflammation and pain.
Interestingly, sodium salicylate does not acetylate the COX enzymes as aspirin does.
Instead, Sodium salicylate competes with arachidonic acid, the natural substrate of COX enzymes, thus preventing the formation of pro-inflammatory prostaglandins.
Additionally, sodium salicylate influences other signaling pathways, including the NF-κB pathway, a crucial mediator of immune and inflammatory responses.
This broader action profile contributes to Sodium salicylate's anti-inflammatory and analgesic effects.
TECHNICAL INFORMATION OF SODIUM SALICYLATE:
Sodium salicylate is the sodium salt of salicylic acid and exhibits significantly greater water solubility than the parent acid, making it particularly useful in aqueous pharmaceutical and laboratory formulations.
Sodium salicylate's aromatic salicylate structure provides both acidic and phenolic functional groups that contribute to its chemical versatility in synthesis, analytical chemistry, and coordination chemistry.
Sodium salicylate has played an important historical role in the development of anti-inflammatory medicines and continues to serve as an important research chemical in studies of inflammation, signal transduction, oxidative stress, and cellular physiology.
Because of its predictable physicochemical behavior, sodium salicylate is widely recognized as a reliable reference compound for analytical chemistry, pharmaceutical development, and biochemical investigations.
MECHANISM OF ACTION OF SODIUM SALICYLATE:
Sodium salicylate inhibits release of prostaglandin E2 when added together with interlukin 1ß
Sodium salicylate also causes a concentration-dependent inhibition of COX-2 activity.
HOW DOES SODIUM SALICYLATE WORK?
The primary mechanism explaining how does sodium salicylate work involves its inhibitory effect on the cyclooxygenase (COX) enzymes.
Specifically, Sodium Salicylate non-selectively inhibits both COX-1 and COX-2 enzymes.
These enzymes are critical in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins, which are lipid mediators involved in inflammation, pain signaling, and fever regulation.
By reducing the production of these inflammatory mediators, Sodium Salicylate effectively diminishes the inflammatory response, alleviates pain, and lowers elevated body temperature.
Sodium salicylate's action helps to reduce swelling and tenderness in affected tissues, providing symptomatic relief for various conditions.
Sodium Salicylate is primarily used for its analgesic, anti-inflammatory, and antipyretic properties.
What odium salicylate is used for often includes the management of mild to moderate pain, such as headaches, muscle aches, and menstrual cramps.
Sodium salicylate is also beneficial in treating inflammatory conditions like rheumatoid arthritis, osteoarthritis, and acute rheumatic fever, where its anti-inflammatory effects help reduce joint pain and swelling.
The benefits of Sodium Salicylate stem from its ability to provide effective relief from symptoms associated with inflammation and pain.
Patients should always refer to comprehensive sodium salicylate drug information provided by healthcare professionals or pharmacists to understand appropriate dosages, contraindications, and potential interactions with other medications.
KEY TAKEAWAYS OF SODIUM SALICYLATE:
Sodium Salicylate is an NSAID used to reduce pain, inflammation, and fever.
Sodium salicylate works by inhibiting cyclooxygenase (COX) enzymes, which are crucial for prostaglandin synthesis.
Sodium salicylate is common uses include managing conditions like arthritis, muscle pain, and headaches.
WHAT IS SODIUM SALICYLATE USED FOR?
Sodium salicylate is a well-known pharmaceutical compound that has garnered considerable attention for its therapeutic properties.
Often overshadowed by its more famous cousin, aspirin (acetylsalicylic acid), sodium salicylate nonetheless plays a significant role in modern medicine.
Sodium salicylate is part of the salicylate family, which has a long history of use in treating pain and inflammation.
Trade names for sodium salicylate include Salison, Salin, and Sodium Acetylsalicylate, among others.
Sodium salicylate functions primarily by targeting cyclooxygenase (COX) enzymes, which are crucial for the synthesis of prostaglandins.
These enzymes are involved in various physiological processes, including inflammation and pain signaling.
Research institutions worldwide are exploring different facets of sodium salicylate, from its molecular mechanisms to its clinical applications.
Sodium salicylate is primarily classified as a non-steroidal anti-inflammatory drug (NSAID).
Sodium salicylate is indicated for a variety of conditions, including mild to moderate pain, fever, and inflammatory disorders such as rheumatoid arthritis and osteoarthritis.
NOTES OF SODIUM SALICYLATE:
Light sensitive.
Store Sodium salicylate in a cool place.
Sodium salicylate is incompatible with strong oxidizing agents, strong acidsmineral acids, metallic salts and iodine.
WHAT IS SODIUM SALICYLATE USED FOR?
Preservative / Antimicrobial:
Sodium salicylate inhibits microbial growth, especially bacteria and fungi.
Sodium salicylate is frequently used in shampoos, scalp tonics, and cleansers to support preservation and reduce dandruff or scalp irritation.
Buffering / pH adjusting:
Sodium salicylate helps stabilize formulation pH in the acidic range (around 4-5.5).
Common in toners, exfoliating products, and cleansers to maintain skin-friendly acidity.
Keratolytic / Exfoliating:
Sodium salicylate promotes gentle desquamation and removal of dead skin cells.
Ideal for clarifying toners, acne treatments, and scalp care products targeting buildup or flaking.
Masking:
Sodium salicylate neutralizes unpleasant odors from raw materials.
Sodium salicylate is used in functional products like shampoos and deodorants for improved sensory acceptance.
ORIGIN OF SODIUM SALICYLATE:
Sodium Salicylate is produced synthetically by neutralizing salicylic acid with sodium hydroxide or sodium carbonate.
Salicylic acid can be derived from phenol or from natural sources such as willow bark using Kolbe-Schmitt carboxylation.
The resulting white crystalline powder or granules are highly purified to meet cosmetic and pharmaceutical standards.
While salicylic acid has historical roots in willow bark, modern cosmetic-grade Sodium Salicylate is industrially synthesized for consistency and purity.
SYNTHESIS OF SODIUM SALICYLATE:
30 g of sodium hydroxide is dissolved in 300 ml of water, to which 100 g of salicycilic acid is then added with agitation.
The agitation is continued for a while to dissolve the salicylic acid completely and then the solution is evaporated to dryness to obtain 110 g of sodium salicylate.
WHAT DOES SODIUM SALICYLATE DO IN A FORMULATION?
*DENATURANT
*PRESERVATIVE
*ANTIMICROBIAL
*MASKING
*ANTIDANDRUFF
SAFETY PROFILE OF SODIUM SALICYLATE:
Sodium Salicylate is considered safe for cosmetic use at low concentrations, typically 0.1-0.5% as a preservative or pH adjuster, and up to 2% in some exfoliating products.
ALTERNATIVES OF SODIUM SALICYLATE:
*SALICYLIC ACID
*SODIUM BENZOATE
*POTASSIUM SORBATE
SYNTHESIS PROCESS OF SODIUM SALICYLATE:
The synthesis process takes place in several stages:
Sodium salicylate can be synthesized by the reaction of salicylic acid with sodium hydroxide, resulting in the formation of sodium salicylate and water.
Another method of synthesis involves the reaction of sodium phenolate (the sodium salt of phenol) with carbon dioxide, forming sodium salicylate.
This reaction is carried out at high pressure and temperature.
Sodium salicylate can also be synthesized through the metathesis reaction of docusate sodium or sodium NSAID salts with phenothiazine hydrochloride salts.
This reaction causes the formation of liquid co-crystals with varying degrees of ionization.
Sodium salicylate can also be synthesized from the reaction of a metathesis product of 1-methyl-3-(3-trimethoxysilylpropylimidazolium) chloride [MTMSPI][Cl] with sodium salicylate through an ionically exchanged reaction.
This reaction causes the formation of a solid-supported ionic liquid [MTMSPI][Sal].
Sodium salicylate occurs as a fine, white powder or in tiny crystals.
Sodium salicylate is soluble in water, glycerine and sparingly soluble in alcohol, insoluble in ether, chloroform, benzene and other organic solvents.
SYNTHESIS OF SODIUM SALICYLATE:
Sodium salicylate is industrially prepared via the Kolbe-Schmitt process, by reacting sodium phenoxide with carbon dioxide at around 120 °C and 5 atm in a mixed alcohol solvent containing excess phenol.
REACTION OF SODIUM SALICYLATE:
C₆H₅ONa + CO₂ → HOC₆H₄COONa
This reaction proceeds via a nucleophilic addition-elimination mechanism.
Sodium salicylate can also be prepared by neutralizing salicylic acid with a sodium base such as sodium hydroxide or sodium carbonate or by refluxing methyl salicylate with sodium hydroxide.
BENEFITS OF SODIUM SALICYLATE:
Effective relief from mild to moderate pain.
Reduction of inflammation in conditions like arthritis.
Lowering of fever.
PHYSICAL and CHEMICAL PROPERTIES of SODIUM SALICYLATE:
Chemical Name: Sodium Salicylate
IUPAC Name: Sodium 2-Hydroxybenzoate
Chemical Type: Organic Sodium Salt
Chemical Family: Salicylates
CAS No.: 54-21-7
EC No.: 200-198-0
Molecular Formula: C₇H₅NaO₃
Molecular Weight: 160.10 g/mol
UN Number: Not classified as a dangerous good for transport
Physical Form: Crystalline Solid
Chemical Classification: Aromatic Carboxylate Salt
Appearance: White crystalline powder or crystals
Color: White
Odor: Odorless or faint characteristic odor
Physical State: Solid
Chemical Formula: C₇H₅NaO₃
Molecular Weight: 160.10 g/mol
Crystal Structure: Crystalline
Purity (Typical): ≥99%
Density: Approximately 1.59 g/cm³
Melting Point: Decomposes upon strong heating (no true melting point)
Decomposition Temperature: Above 200°C
Boiling Point: Not applicable (decomposes)
Water Solubility (20°C): Highly soluble (approximately 600–700 g/L)
Solubility in Ethanol: Slightly soluble
Solubility in Methanol: Soluble
Solubility in Ether: Practically insoluble
pH (5% aqueous solution): Approximately 6.5–8.5
pKa (Salicylic Acid): Approximately 2.97
Vapor Pressure: Negligible
Volatility: Non-volatile
Flash Point: Not applicable
Autoignition Temperature: Not applicable
Flammability: Not highly flammable; combustible under fire conditions
Oxidizing Properties: None
Reducing Properties: None
Hygroscopicity: Slightly hygroscopic
Chemical Stability: Stable under recommended storage conditions
Light Sensitivity: Slightly sensitive to prolonged light exposure
Thermal Stability: Good under normal conditions
Electrical Conductivity: High in aqueous solution due to ionic dissociation
Buffering Capacity: Moderate in aqueous systems
Chemical Formula: C7H5NaO3
Molar Mass: 160.104 g·mol−1
Appearance: White crystals
Melting Point: 200 °C (392 °F; 473 K)
Solubility in Water: 25.08 g/100 g (-1.5 °C)
107.9 g/100 g (15 °C)
124.6 g/100 g (25 °C)
141.8 g/100 g (78.5 °C)
179 g/100 g (114 °C)
Solubility: Soluble in glycerol, 1,4-Dioxane, alcohol
Solubility in Methanol: 26.28 g/100 g (15 °C)
34.73 g/100 g (67.2 °C)
Molecular Weight: 160.10 g/mol
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 1
Exact Mass: 160.01363830 Da
Monoisotopic Mass: 160.01363830 Da
Topological Polar Surface Area: 60.4 Ų
Heavy Atom Count: 11
Formal Charge: 0
Complexity: 138
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Canonicalized: Yes
Physical State: crystalline
Color: white
Odor: odourless
Melting Point/Freezing Point: Melting point/ range: > 300 °C - lit.
Flammability (solid, gas): No data available
Upper/Lower Flammability or Explosive Limits: No data available
Flash Point: 98,3 °C - Pensky-Martens closed cup
Autoignition Temperature: > 250 °C
Decomposition Temperature: No data available
pH: 6,85 at 26,3 °C
Viscosity: Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water Solubility: 575,7 g/l at 25 °C - OECD Test Guideline 105- completely miscible
Partition Coefficient: n-octanol/water
log Pow: -1,259 at 25 °C - Bioaccumulation is not expected.
Vapor Pressure: < 0,1 hPa at 25 °C
Density: 0,32 g/cm3 at 25 °C
Relative Density: No data available
Relative Vapour Density: No data available
Particle Characteristics: No data available
Explosive Properties: No data available
Oxidizing Properties: none
Dissociation Constant: 0 at 25 °C
CAS: 54-21-7
IUPAC Name: sodium 2-hydroxybenzoate
Molecular Formula: C7H5NaO3
InChI Key: ABBQHOQBGMUPJH-UHFFFAOYSA-M
SMILES: [Na+].OC1=CC=CC=C1C([O-])=O
Molecular Weight (g/mol): 160.10
Synonym: salicylate-sodium
Appearance (Color): White or colorless to pale cream
Form: Crystals or powder or crystalline powder
Assay (Non-aqueous acid-base Titration): ≥98.5 to ≤101.5% (UK Sourced Material)
Assay from Supplier's CofA: ≥98.5% (US Sourced Material)
Comment: Material Sourced in UK and US
Identification (FTIR): Conforms (UK Sourced Material)
Melting Point: >300°C (UK Sourced Material)
CBNumber: CB1255762
Molecular Formula: C7H5NaO3
Molecular Weight: 160.1
MDL Number: MFCD00002440
MOL File: 54-21-7.mol
Melting Point: >300 °C (lit.)
Boiling Point: 237°
Bulk Density: 320kg/m3
Density: 0.32 g/cm3 (20℃)
Vapor Pressure: <1 hPa (25 °C)
Refractive Index: 1.435
Flash Point: 98.3°
Storage Temp.: Store at +15°C to +25°C.
Solubility: 1000g/l
Form: Crystals or Crystalline Powder
Color: White
Odor: wh. lustrous cryst. scales or amorphous powd., odorless or faint odor, saline taste
PH: 6.5 (100g/l, H2O, 20℃)
Water Solubility: 1000 g/L (20 ºC)
Sensitive: Light Sensitive
Merck: 14,8332
BRN: 3732792
Stability: Stable.
Incompatible with mineral acids, metallic salts, iodine.
May be light-sensitive.
Major Application: pharmaceutical (small molecule)
Cosmetics Ingredients Functions:
DENATURANT
PRESERVATIVE
InChI: 1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
InChIKey: ABBQHOQBGMUPJH-UHFFFAOYSA-M
SMILES: [Na+].Oc1ccccc1C([O-])=O
LogP: 2.061 (est)
CAS DataBase Reference: 54-21-7(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances: SODIUM SALICYLATE
FDA 21 CFR: 175.105
EWG's Food Scores: 1
FDA UNII: WIQ1H85SYP
NCI Dictionary of Cancer Terms: nasal; sodium salicylate
NCI Drug Dictionary: sodium salicylate
ATC Code: N02BA04
EPA Substance Registry System: Sodium salicylate (54-21-7)
UNSPSC Code: 41116107
NACRES: NA.77
FIRST AID MEASURES of SODIUM SALICYLATE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available
ACCIDENTAL RELEASE MEASURES of SODIUM SALICYLATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of SODIUM SALICYLATE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of SODIUM SALICYLATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of SODIUM SALICYLATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
STABILITY and REACTIVITY of SODIUM SALICYLATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available
