PRODUCTS

SODIUM SELENITE

CAS Number: 10102-18-8
EC Number: 233-267-9
Chemical formula: Na2O3Se
Molar mass: 172.948 g·mol−1

Sodium selenite is the inorganic compound with the formula Na2SeO3.
This salt is a colourless solid.
The pentahydrate Na2SeO3(H2O)5 is the most common water-soluble selenium compound.

An inorganic form of the trace element selenium with potential antineoplastic activity.
Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen.
This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling.
Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation.

Sodium selenite (Na2SeO3) is a toxic inorganic salt that is highly soluble in water and insoluble in organic solvents.
The crystal structure of the anhydrous salt has been variously reported as tetragonal or monoclinic.

Selenium oxychloride1 (SeOCl2) by heating selenium oxide (SeO2) with sodium chloride.
This finding was reported in a pioneering series of articles on selenium chemistry.

In an improved synthesis prepared Na2SeO3 by evaporating a solution of sodium hydroxide and selenious acid (H2SeO3) at 60–100 °C.
Commercial Na2SeO3 is now made by heating an aqueous solution of SeO2 and NaOH to form Sodium selenites pentahydrate2, which is crystallized and then warmed to 40 °C to liberate the anhydrous salt.

Na2SeO3 and other selenite salts are used to “neutralize” green impurities during the manufacture of colorless glass.
Iron-containing impurities in the natural silicas (e.g., sand) used to make glass absorb red and blue wavelengths of light, giving Sodium selenite a green appearance.
Selenites have no color; but when they are dissolved in the glass mixture, they appear pinkish, counteracting the green hue and making the glass colorless.

Selenious acid

Selenious acid is the acid form of sodium selenite, a form of selenium.

Selenium is an essential trace element and antioxidant.
Sodium selenite is a cofactor metabolic enzyme regulation.
Sodium selenite also plays an important role in maintaining the general health of tissue and muscle and has antioxidant properties.
Selenium is a component of glutathione peroxidase enzyme, which protects cell components from oxidative damage due to peroxides produced during cellular metabolism.

Selenium (Se) has been demonstrated to prevent cancer in numerous animal models when administered selenium at levels exceeding the nutritional requirements.
One study showed efficacy in the prevention of malignancy while utilizing a selenium supplement in humans.
The reports from such studies have heightened the interest in additional human selenium supplementation studies to validate the results in larger populations.

Interestingly, selenium is being studied as a potential therapy in the prevention or management of atherosclerosis.

Selenoprotein Structure and Function:
Sodium selenite is a precursor of Sec biosynthesis, and supplement of cells with Na2SeO3 could significantly increases the Sec level in cells.
In this experiment, the cells were preincubated with Na2SeO3, and then were exposed to Sel-green.

After washing the cells with PBS three times, the fluorescence images were acquired.
When the cells were incubated with sodium selenite for 12 h, the notable fluorescence appears.
A short time treatment (1 h) gives weak but reproducible signal.
These results demonstrate that the probe Sel-green is suitable for imaging endogenous Sec in live cells.

Cardioprotective Roles of Selenium in Diabetes
Ion Homeostasis under Selenium Supplementation
Sodium selenite treatment reversed the prolongation in both action potential duration and twitch duration of the diabetic rats by restoring both fast transient, Ito and sustained, Iss K+ currents51 while treatment of cardiomyocytes from diabetic rats with GSH, like insulin application, have been shown to upregulate Ito density.

Plasma deficiency of Zn2+, a complex antioxidant and a potent inducer of metallothionein (MT), is a risk factor for the development of diabetes with Zn2+ supplementation having beneficial effects and preventing the development of cardiomyopathy in STZ-induced diabetic mice.
Sodium selenite treatment (4 weeks) of the diabetic rats caused a significant normalization of cationic homeostasis.
Thus selenite treatment restored basal [Zn2+]i and [Ca2+]i values and normalized Ca2+ transients of cardiomyocytes isolated from diabetic rats.
Selenite treatment, besides preventing the diabetic-induced increase in [Zn2+]i also restores the decreased metallothionein, MT content.
MT is a potent antioxidant protein and binds seven Zn2+ with sulfur ligands.

Redox reagents are asymmetrically involved in both directions of Zn2+ transfer from MT to thionein.
Reduced glutathione mediates Zn2+ transfer from enzymes to thionein, whereas glutathione disulfide oxidizes MT with enhanced release and transfer of Zn2+ to apoenzymes.
This pathway seems true for our model study due to increased GSSG and MT and decreased GSH.
Restoring controlled MT content is of importance in connection with the protective function to cells by reducing damage from ROS and inhibiting ROS production.

Process for producing sodium selenite
The present invention relates to a production technology of sodium selenite.

The invention comprises the following steps:
1. a proper amount of selenium dioxide is dissolved in water to form selenious acid solution;

2. sodium hydroxide is added to the selenious acid solution and the pH value is adjusted to 7 to 14;

3. a proper amount of additive and adsorbent is added;

4. filtration, evaporation and crystallization;

5. heating, drying, crushing and screening;

6. finished sodium selenite product.
The sodium selenite production technology of the invention has the advantages of simple production technology, less production equipment investment, as well as simple and convenient operation, and is a highly efficient and energy-saving sodium selenite preparation technology

Background technology
Sodium Selenite is a kind of important chemical product; White crystal, soluble in water, tetragonal crystal.
Main application fields: as the discoloring agent of glass, and fodder additives.
The main production methods of present Sodium Selenite is a sodium carbonate method.

This production technique is with yellow soda ash, joins in the selenous acid solution by a certain amount of, again with this solution evaporation crystallization, thereby obtains the Sodium Selenite crystal.
This production technique is to utilize yellow soda ash and selenous acid reaction to generate the principle of Sodium Selenite.
But this production technique in process of production, can produce this greenhouse gases of great amount of carbon dioxide (environment is impacted), can have certain danger in industrialization is produced; The price of yellow soda ash is higher simultaneously, thereby increases the production cost of Sodium Selenite.

Summary of the invention
Purpose of the present invention mainly is to overcome the deficiency that prior art exists, and a kind of preparation technology of Sodium Selenite is provided.
Preparation technology of the present invention has: production technique is simple, investment of production equipment is little, the characteristics of operation simple and convenient, is a kind of efficient, energy-conservation Sodium Selenite production technique.

For achieving the above object, the present invention has taked following technical scheme:

A kind of preparation technology of Sodium Selenite comprises following technological step:
1. in steel basin, add 1000～3000L water, drop into 500～1500kg tin anhydride, stir, make Sodium selenites dissolving;

2. after tin anhydride dissolves fully, in steel basin, slowly add sodium hydroxide solution (99% mass concentration) 300～1200kg.
Stirring makes Sodium selenites dissolving, adjusts pH value 7～14, synthetic Sodium Selenite;
In the above-mentioned steps, the preferred add-on of sodium hydroxide solution is 300～1000kg.

3. then, take by weighing additive 0.2～2kg, additive is dissolved in the water, join in the steel basin, stirring and dissolving is even; Add sorbent material 0.1～2kg again, stirred 1～5 hour;

4. subsequently sodium selenite solution is filtered, and clear soln is conveyed in the reactor, heating evaporation makes solution form hypersaturated state, and Sodium Selenite is separated out from solution crystallization;

5. the Sodium Selenite crystal that will have crystal water is conveyed in the whizzer, opens the whizzer centrifuge dehydration, and the Sodium Selenite crystal after the centrifuge dehydration is placed in the drying baker, at 80～200 ℃ of following heating, dryings; After Sodium Selenite moisture that water is understood in the baking oven is less than 0.05%, stops heating and cool off;
In the above-mentioned steps, the preferred drying temperature of Sodium Selenite is 80～180 ℃.

6. after the cooling, take out white Sodium Selenite crystal, send in the pulverizer, pulverizing, sub-sieve are made anhydrous sodium sodium selenate product.

Additive described in the technique scheme is mainly the polymeric type material,
Sorbent material described in the technique scheme is mainly and absorbs the class material.
Compared with prior art, the present invention has following beneficial effect:
Preparation technology of the present invention has the advantages that production technique is simple, investment of production equipment is little, operate simple and convenient, is a kind of efficient, energy-conservation sodium selenate preparation technology.

Description of drawings
İs preparation technology's schema of the present invention.
Embodiment
Technological principle of the present invention is as follows:
1. tin anhydride is dissolved in the water the formation selenous acid, and chemical equation is:
H 2O+SeO 2＝H 2SeO 3

2. sodium hydroxide joins in the selenous acid solution, and this is an acid-base neutralisation reaction, and sodium hydroxide and Sodium Selenite reaction generate Sodium Selenite:
2NaOH+H 2SeO 3＝Na 2SeO 3+2H 2O

3. adjusting the pH value of reaction soln in 2, is for fear of in the acid-base neutralisation reaction, generates sodium hydroselenite, thereby has influence on the Sodium Selenite quality product.

4. in 2 reaction solns, add the purpose of additive, be for uniform crystal particles when the Sodium Selenite crystallization, increase the solubleness of Sodium Selenite in the aqueous solution.
The purpose of sorbent material is in order to make solution decolouring, and removes the impurity in the solution.
This is because the trace impurity in the solution can make the solution colour developing, adds sorbent material, and the adsorptivity characteristic of utilizing sorbent material to have is removed the impurity element in the solution, thereby reaches the purpose of decolouring.

5. evaporation, centrifugal, oven dry are in order to slough the moisture content in the Sodium Selenite, thereby obtain anhydrous sodium sodium selenate product.
The invention will be further described by specific embodiment below in conjunction with Figure of description.

A kind of preparation technology of Sodium Selenite comprises following technological step:
1. in steel basin, add 1000L water, and drop into the 500kg tin anhydride, the beginning stirring and dissolving;

2. after treating that tin anhydride dissolves fully, in steel basin, slowly add sodium hydroxide (99% mass concentration) 360kg and adjust pH value, synthetic Sodium Selenite.

3. take by weighing additive 0.4kg then, additive is dissolved in the water, join in the steel basin, stir; Add sorbent material 0.5kg again, stirred 1 hour;

5. will have the Sodium Selenite crystal of crystal water, be conveyed in the whizzer, open the whizzer centrifuge dehydration.
Sodium Selenite crystal after the centrifuge dehydration is placed in the baking oven, at 100 ℃ of following heating, dryings; After Sodium Selenite water contained humidity in the baking oven is less than 0.05%, stops heating and cool off;

6. after the cooling, take out white Sodium Selenite crystal and send in the pulverizer.
Pulverize, sub-sieve, make anhydrous sodium sodium selenate product.

A kind of preparation technology of Sodium Selenite comprises following technological step:
1. in steel basin, add 2000L water, and drop into the 1000kg tin anhydride, the beginning stirring and dissolving;

2. after tin anhydride dissolves fully, in steel basin, slowly add sodium hydroxide (99% mass concentration) 720kg and adjust pH value, synthetic Sodium Selenite.

3. then, take by weighing additive 800g, additive is dissolved in the water, join in the steel basin, stir; Add sorbent material 1kg again, stirred 2 hours;

5. the Sodium Selenite crystal that will have crystal water is conveyed in the whizzer, opens the whizzer centrifuge dehydration.
Sodium Selenite crystal after the centrifuge dehydration is placed into inherent 150 ℃ of baking oven, heating, drying; After contained humidity in the Sodium Selenite crystal in the baking oven is less than 0.05%, stop heating, cool off;

6. after the cooling, take out white Sodium Selenite crystal, send in the pulverizer, pulverize sub-sieve, make anhydrous sodium sodium selenate product.

A kind of preparation technology of Sodium Selenite comprises following technological step:
1. add 3000L water in the steel basin, and drop into the 1500kg tin anhydride, the beginning stirring and dissolving.

2. after treating that tin anhydride dissolves fully, in steel basin, slowly add sodium hydroxide (99% mass concentration) 1080kg and adjust pH value, synthetic Sodium Selenite.

3. then, take by weighing additive 1.2kg.
Additive is dissolved in the water, joins in the steel basin, stir; Adding sorbent material 1.5kg again stirred 5 hours.

4. subsequently, sodium selenite solution is filtered, and clear soln is conveyed in the reactor, heating evaporation makes solution form hypersaturated state, and Sodium Selenite is separated out from solution crystallization.

5. the Sodium Selenite crystal that will have crystal water is conveyed in the whizzer, opens the whizzer centrifuge dehydration.
Sodium Selenite crystal after the centrifuge dehydration is placed in the baking oven, at 120 ℃ of following heating, dryings; Contained humidity in Sodium Selenite crystal in the baking oven after 0.05%, stops heating and cools off.

6. after the cooling, take out white Sodium Selenite crystal and send in the pulverizer,, make anhydrous sodium sodium selenate product through pulverizing, sub-sieve.
Among the above embodiment, involved additive is mainly the polymeric type material, and described sorbent material is mainly and absorbs the class material.
The those of ordinary skill that the present technique main points can be in the present technique field is grasped, and can select according to specific circumstances.
The product of the Sodium Selenite that the foregoing description 2 is produced reaches following technical indicator:
Sodium Selenite content: 99.8%
Other foreign matter content: Cu 5, Ag 5, Pb 20, Cd 5, Te 100, As 10,
Fe 10, Ni 5, Hg 0.1

Claims
1. the preparation technology of a Sodium Selenite is characterized in that comprising following technological step:
(1) add 1000～3000L water in steel basin, and drop into 500～1500kg tin anhydride, stirring is dissolved Sodium selenite fully;

(2) after tin anhydride dissolves fully, in steel basin, slowly add sodium hydroxide solution (99% mass concentration) 300～1200kg; Stir, adjust pH value 7～14, synthetic sodium selenite solution;

(3) then, take by weighing additive 0.2～2kg, additive is dissolved in the water, and join in the steel basin, stir; Add sorbent material 0.1～2kg again, stirred 1～5 hour;

(4) subsequently, sodium selenite solution is filtered; And the solution after will filtering is conveyed in the reactor heating evaporation; Make solution form hypersaturated state, Sodium Selenite is separated out from solution crystallization;

(5) will have the Sodium Selenite crystal of crystal water, be conveyed in the whizzer; Open the whizzer centrifuge dehydration, the Sodium Selenite crystal after the centrifuge dehydration is placed in the drying baker, at 80～200 ℃ of following heating, dryings; After Sodium Selenite contained humidity in the baking oven is less than 0.05%, stop heating, cool off;

(6) after the cooling, take out white Sodium Selenite crystal, send in the pulverizer,, make anhydrous sodium sodium selenate product through pulverizing, sub-sieve.

2. the preparation technology of a kind of Sodium Selenite according to claim 1 is characterized in that the add-on of the sodium hydroxide solution described in (2) step (99% mass concentration) is 300～1000kg, and adjusting pH value is 7～14.

3. the preparation technology of a kind of Sodium Selenite according to claim 1 is characterized in that the additive described in (3) step is the polymeric type material.

4. the preparation technology of a kind of Sodium Selenite according to claim 1 is characterized in that the sorbent material described in (3) step is mainly absorption class material.

5. the preparation technology of a kind of Sodium Selenite according to claim 1 is characterized in that 80～180 ℃ of the bake out temperatures of Sodium Selenite in (5) step.

Physical Description of Sodium selenite:
Sodium selenite appears as a white colored crystalline solid.
Soluble in water and more dense than water.
Contact may irritate skin, eyes and mucous membranes.
Toxic by ingestion, inhalation and skin absorption.

Bionecessity of Sodium selenite:
The selenium content of soils and, ultimately, crops is quite variable.
In the USA, areas west of the Mississippi River generally contain higher amounts of selenium, while areas east of the river tend to yield crops deficient in selenium.
Under most practical conditions, 0.2-0.3 mg of added selenium

Synthesis and fundamental reactions of Sodium selenite:
Sodium selenite usually is prepared by the reaction of selenium dioxide with sodium hydroxide:
SeO2 + 2 NaOH → Na2SeO3 + H2O

The hydrate converts to the anhydrous salt upon heating to 40 °C.

According to X-ray crystallography, both anhydrous Na2SeO3 and Sodium selenites pentahydrate feature pyramidal SeO32−.
The Se-O distances range from 1.67 to 1.72 Å.
Oxidation of this anion gives sodium selenate, Na2SeO4.

Metabolism/Metabolites of Sodium selenite:
Most dietary selenium is in the form of selenomethionine (the major dietary form of selenium) or selenocysteine, both of which are well absorbed.
Other forms of selenium include selenate and selenite, which are not major dietary constituents, but are commonly used in fortified foods and dietary supplements.
Two pools of reserve selenium are present in the body.

The first is as selenomethionine, which is not known to have a physiological function separate from that of methionine.
The second reserve pool is the selenium found in liver glutathione peroxidase.
Ingested selenite, selenate, and selenocysteine are all metabolized directly to selenide, the reduced form of selenium.
Selenomethionine can also be metabolized to selenide.

The addition of sodium selenite (Na2SeO3) to the drinking water of mice for 14 days resulted in the formation of dimethylselenide and also dimethyldiselenide in the breath.
Exhalation seems to be a minor form of selenium elimination.

Metabolic pathways for Selenite in the body were studied for selenite and selenate, with the use of enriched Se.
The concentrations of Se in organs and body fluids and the distributions of their constituents depending on the dose and time after the intravenous administration of Se-selenite and -selenate to rats were determined.
Selenite was taken up by red blood cells within several minutes, reduced to selenide by glutathione, and then transported to the plasma, bound selectively to albumin and transferred to the liver.
Contrary to selenite, intact selenate was either taken up directly by the liver or excreted into the urine.

The Se of selenite origin and that of selenate origin were detected in the forms of the two Se peak materials in the liver, A and B.
The former one was methylated to the latter in vivo and in vitro.
The latter one was identical with the major urinary metabolite and Sodium selenite was identified as Se-methyl-N-acetyl-selenohexosamine (selenosugar).
The chemical species-specific metabolic pathway for Se was explained by the metabolic regulation through selenide as the assumed common intermediate for the inorganic and organic Se sources and as the checkpoint metabolite between utilization for the selenoprotein synthesis and methylation for the excretion of Se.

Biological Half-Life of Sodium selenite:
In humans, whole body retention studies following oral administration of sodium selenite have indicated that selenium elimination is triphasic.
During the initial phase, which lasted about 1 week, elimination of selenium was rapid, with a half-life of approximately 1 day.

In the second phase, which also lasted approximately 1 week, selenium elimination was slower, with a half-life of 8-9 days.
In the third phase, selenium elimination was much slower, with a half-life estimated to be 115-116 days.
The first two elimination phases correspond to the fecal elimination of nonabsorbed selenium and the urinary excretion of absorbed but unutilized selenium

Following a single, oral, 200 ug dose of sodium selenite in six male and female volunteers, the half-time was 200 to 285 hours for terminal plasma elimination and 115 to 285 days for tissues.

The excretion pattern of a single exposure to selenite appears to have at least two phases: a rapid initial phase with as much as 15 to 40 percent of the absorbed dose excreted in the urine the first week.
There is expotential excretion of the remainder of the dose with a half life of 103 days.

Applications of Sodium selenite:
Together with the related barium and zinc selenites, sodium selenite is mainly used in the manufacture of colorless glass.
The pink color imparted by these selenites cancels out the green color imparted by iron impurities.

Because selenium is an essential element, sodium selenite is an ingredient in dietary supplements such as multi-vitamin/mineral products, but supplements that provide only selenium use L-selenomethionine or a selenium-enriched yeast.

The US Food and Drug Administration approved a selenium supplement to animal diets; the most common form is sodium selenite for pet foods.
According to one article, "not much was known about which selenium compounds to approve for use in animal feeds when the decisions were made back in the 1970s.
At the time the regulatory action was taken, only the inorganic selenium salts (sodium selenite and sodium selenate) were available at a cost permitting their use in animal feed.”

Sodium selenite has been proposed as an effective suicide agent.

Use and Manufacturing of Sodium selenite:

Sodium selenite is uses of Sodium selenite:
Products for imparting hold, shine, or texture to hair
Make-up or cosmetic products which do not fit into a more refined category

Products intended for pet care which do not fit into a more refined category
Miscellaneous pet treatments (excluding pesticides and shampoos)
Care products specifically for cats which do not fit into a more refined category

Sodium selenite is used as a colorant in glass production; Used in glass manufacturing to remove green color, as an alkaloidal reagent, to test seed germination, as a reagent in bacteriology, for decorating porcelain, and as a dietary supplement.

Methods of Manufacturing of Sodium selenite:
Prepared by evaporating an aqueous solution of sodium hydroxide and selenious acid between 60 and 100 °C; by heating a mixture of sodium chloride and selenium oxide.

General Manufacturing Information of Sodium selenite:
In 1974, US FDA approved use of sodium selenite in feed of swine, turkeys and growing chickens up to 16 wk of age; permissible levels are 0.1 mg/kg in swine and chicken feeds and 0.2 mg/kg in turkey feeds.
Purpose of these additives in feed is to prevent selenium deficiencies, which can result in decr growth rates, disease and death.

First Aid Measures of Sodium selenite:

First Aid of Sodium selenite:
Signs and Symptoms of Sodium Selenite Exposure: Signs and symptoms of acute sodium selenite exposure include the following: garlic odor on breath, drooling, nasal irritation and burning sensation in nostrils, vomiting, hypotension, dizziness, and poor reflexes.
Pulmonary edema, cardiopulmonary arrest, and coma are possible complications.
Contact with sodium selenite often results in skin irritation and burns.

Emergency Life-Support Procedures: Acute exposure to sodium selenite may require decontamination and life support for the victims.
Emergency personnel should wear protective clothing appropriate to the type and degree of contamination.
Air-purifying or supplied-air respiratory equipment should also be worn, as necessary.
Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure of Sodium selenite:
1. Move victims to fresh air.
Emergency personnel should avoid self-exposure to sodium selenite.

2. Evaluate vital signs including pulse and respiratory rate, and note any trauma.
If no pulse is detected, provide CPR.
If not breathing, provide artificial respiration.
If breathing is labored, administer oxygen or other respiratory support.

3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

4. Transport to a health care facility.

Ingestion Exposure of Sodium selenite:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma.
If no pulse is detected, provide CPR.
If not breathing, provide artificial respiration.
If breathing is labored, administer oxygen or other respiratory support.

2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

3. Vomiting may be induced with syrup of Ipecac.
If elapsed time since ingestion of sodium selenite is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age.
Warning: Ingestion of sodium selenite may result in sudden onset of seizures or loss of consciousness.
Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma.
If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz).
Ambulate (walk) the victims and give large quantities of water.
If vomiting has not occurred after 15 minutes, Ipecac may be readministered.
Continue to ambulate and give water to the victims.
If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.

4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.

5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims.
Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.

6. Transport to a health care facility.

Safety of Sodium selenite:
Selenium is toxic in high concentrations.
As sodium selenite, the chronic toxic dose for human beings was described as about 2.4 to 3 milligrams of selenium per day.
In 2000, the U.S. Institute of Medicine set the adult Tolerable upper intake levels (UL) for selenium from all sources - food, drinking water and dietary supplements - at 400 μg/day.
The European Food Safety Authority reviewed the same safety question and set Sodium selenites UL at 300 μg/day.

Storage of Sodium selenite:
Store at +15°C to +25°C.

Identifiers of Sodium selenite:
CAS Number:
10102-18-8
26970-82-1 (pentahydrate)
ChEBI: CHEBI:48843
ChEMBL: ChEMBL112302
ChemSpider: 23308
ECHA InfoCard: 100.030.230
EC Number: 233-267-9
KEGG: D10530
PubChem CID: 24934
RTECS number: VS7350000
UNII:
HIW548RQ3W
0WV4L961ZV (pentahydrate)
UN number: 2630
CompTox Dashboard (EPA): DTXSID0032077
InChI
InChI=1S/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2
Key: BVTBRVFYZUCAKH-UHFFFAOYSA-L check
InChI=1/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2
Key: BVTBRVFYZUCAKH-NUQVWONBAC
SMILES: [Na+].[Na+].[O-][Se]([O-])=O

Specifications of Sodium selenite:
Assay (iodometric): ≥ 99 %
pH-value (2 %; water): 4.5 - 7.5
Suitability for microbiology: passes test

Properties of Sodium selenite:
Chemical formula: Na2O3Se
Molar mass: 172.948 g·mol−1
Appearance: colourless solid
Density: 3.1 g/cm3
Melting point: decomposes at 710 °C
Solubility in water: 85 g/100 mL (20 °C)
Solubility: insoluble in ethanol

Molecular Weight: 172.95
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 0
Exact Mass: 173.88080
Monoisotopic Mass: 173.88080
Topological Polar Surface Area: 63.2 Å²
Heavy Atom Count: 6
Formal Charge: 0
Complexity: 18.8
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes

Structure of Sodium selenite:
Crystal structure: tetragonal

Pharmacology of Sodium selenite:
ATC code: A12CE02 (WHO)

Related compounds of Sodium selenite:
Sodium sulfite
Sodium selenate
Sodium selenide

Synonyms of Sodium selenite:
SODIUM SELENITE
Disodium selenite
10102-18-8
Natriumselenit
Selenious acid, disodium salt
Selenious Acid Disodium Salt
disodium;selenite
UNII-HIW548RQ3W
MFCD00003489
Sodium selenite anhydrous
Sodium selenite, anhydrous
HIW548RQ3W
CHEBI:48843
Selenious acid, sodium salt (1:2)
10102-18-8(disodiumsalt)7782-82-3(monosodiumsalt)
Natriumselenit
Selenite sodium
CCRIS 1260
HSDB 768
EINECS 233-267-9
NA2630
Sodium-selenite
H2-O3-Se.1/2Na
Aselend
Selenious acid, sodium salt (2:1)
Sodium Selenite,
Sodium selenite
EC 233-267-9
DSSTox_CID_12077
DSSTox_RID_78904
DSSTox_GSID_32077
CHEMBL112302
DTXSID0032077
Tox21_202977
AKOS015912461
NSC 347466
Sodium selenite
NCGC00260523-01
14013-56-0
CAS-10102-18-8
D10530
SODIUM SELENITE HIGH PURITY GRADE 100G
Q414626
Disodium selenite
Disodium selenium trioxide
Natriumselenit
Selenious acid disodium salt
Selenious acid, disodium salt
Selenious acid, sodium salt (1:2)
Sodium selenite anhydrous
10102-18-8
233-267-9
Dinatriumselenit
Disodium selenite
HIW548RQ3W
MFCD00003489
Sélénite de disodium
Sodium selenite
VS7350000
10102-18-8(disodiumsalt)7782-82-3(monosodiumsalt)
14013-56-0
15498-87-0
26970-82-1
29528-97-0
50647-14-8
7782-82-3
disodium and selenite
disodium selenite pentahydrate
Disodium selenium trioxide
disodium;selenite
EINECS 233-267-9
MFCD00149173
Natriumselenit
Natriumselenit
Selenious acid (H2SeO3), disodium salt
selenious acid disodium salt
SELENIOUS ACID SODIUM SALT (2:1)
Selenious acid, disodium salt
Selenious acid, sodium salt (2:1)
Selenious acid, sodiumsalt (2:1) (9CI)
SODIUM BISELENITE
Sodium hydrogen selenite
Sodium selenite [NA2630]
Sodium selenite anhydrous
Sodium selenite pentahydrate
Sodium selenite, anhydr
Sodium selenite, anhydrous
Sodium selenite,anhydrous
SODIUM SELENITE|DISODIUM SELENITE
SODIUM SELENIUM OXIDE
sodiumselenite
UNII:HIW548RQ3W
UNII-HIW548RQ3W

MeSH of Sodium selenite:
Biselenite, Sodium
Disodium Selenite
Monosodium Selenite
Pentahydrate, Sodium Selenite
Selenite pentahydrate, Sodium
Selenite, Disodium
Selenite, Monosodium
Selenite, Sodium
Selenous Acid Disodium Salt
Selenous Acid, Disodium Salt
Sodium Biselenite
Sodium Selenite
Sodium Selenite pentahydrate