PRODUCTS

SODIUM STARCH GLYCOLATE

Sodium Starch Glycolate is used to enhance the texture and stability of creams and lotions, providing a smooth application experience.
Sodium Starch Glycolate is used as a disintegrant, a suspending agent and as a gelling agent.
Sodium Starch Glycolate is widely used as a pharmaceutical grade dissolution excipient for tablets and capsules.

CAS Number: 9063-38-1
Alternate CAS Number: Free acid: 9057-06-1
Molecular Formula：C2H4O3·xNa·x
Molecular formula: C10H19NaO8

SYNONYMS:
Sodium Carboxymethyl Starch, Sodium Carboxymethyl Starch, Starch, Carboxymethyl Ether, Sodium Salt, Sodium carboxymethyl starch, Carboxymethyl Starch Sodium Salt, Covagel, Crayon B 300P, Deprogel, Emsize CMS 100, Emsize CMS 60, Explosol, Explotab, Polvitex Z, Polytex 60, Primojel, Sodium CM-starch, Vivastar P, USP Sodium Starch Glycolate Type Al, starch carboxymethylether, sodium salt, sodium carboxyl methylstarch,SODIUM STARCH GLYCOLATE,SODIUM STARCH GLYCOLLATE,PRIMOJEL(R),CARBOXYMETHYL STARCH SODIUM,CARBOXYMETHYL STARCH SODIUM SALT,CMS-Na ,explotab, Carboxymethyl starch, sodium salt, carboxymethylamylum natricum, Explosol, Explotab, Glycolys, Primojel, starch carboxymethyl ether, sodium salt, Tablo, Vivastar P, Carboxymethyl Starch Sodium Salt, Covagel, Sodium Carboxymethyl Starch, Solvitose CL, USP Sodium Starch Glycolate Type A, Sodium Carboxymethyl Starch, Sodium starch glycolate, SODIUM STARCH GLYCOLATE (II), SODIUM STARCH GLYCOLATE [II], SODIUM STARCH GLYCOLATE (MART.), SODIUM STARCH GLYCOLATE [MART.], Sodium starch glycolate type a, SODIUM STARCH GLYCOLATE TYPE A (USP-RS), SODIUM STARCH GLYCOLATE TYPE A [USP-RS], SODIUM STARCH GLYCOLATE TYPE A POTATO (II), SODIUM STARCH GLYCOLATE TYPE A POTATO [II], SODIUM STARCH GLYCOLATE (TYPE A) (EP MONOGRAPH), SODIUM STARCH GLYCOLATE (TYPE A) [EP MONOGRAPH], Covagel, Explotab, Glycolys, Primojel, Explotab (TN), Sodium starch glycollate, RefChem:887881, H8AV0SQX4D, Carboxymethyl starch sodium salt, DTXSID6051271, Sodium starch glycolate (type a), dium starch glycolate type A potato, SODIUM STARCH GLYCOLATE [JAN], 5856J3G2A2, SODIUM STARCH GLYCOLATE [VANDF], Starch, carboxymethyl ether, sodium salt, SODIUM STARCH GLYCOLLATE [WHO-DD], SODIUM STARCH GLYCOLATE TYPE A POTATO, Starch, carboxymethyl ether, monosodium salt, SODIUM STARCH GLYCOLATE TYPE A, UNSPECIFIED SOURCE, 618-597-7, 9063-38-1, Carboxy methyl starch sodium, SODIUM CARBOXYL METHYLSTARCH, Sodium carboxyl methylstarch, CMS-Na, sodium carboxyl methylstarch, SODIUM STARCH GLYCOLATE, SODIUM STARCH GLYCOLLATE, PRIMOJEL(R), CARBOXYMETHYL STARCH SODIUM, CARBOXYMETHYL STARCH SODIUM SALT, CMS-Na , explotab, Sodium carboxymethyl starch, Carboxymethyl Starch Sodium Salt, Covagel, Crayon B 300P, Deprogel, Emsize CMS 100, Emsize CMS 60, Explosol, Explotab, Polvitex Z, Polytex 60, Primojel, Sodium CM-starch, Vivastar P, USP Sodium Starch Glycolate Type Al, starch carboxymethylether, sodium salt

Sodium starch glycolate is the sodium salt of cross-linked carboxymethyl starch.
Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules.
Sodium Starch Glycolate is manufactured by chemical modification of starch, i.e., carboxymethylation to enhance hydrophilicity and cross-linking to reduce solubility.

Sodium Starch Glycolate is a chemically modified starch that serves primarily as a superdisintegrant in pharmaceutical formulations.
Sodium Starch Glycolate is derived from the carboxymethylation of starch, resulting in a sodium salt of a carboxymethyl ether of starch.
This modification enhances the hydrophilicity of Sodium Starch Glycolate, making it effective in promoting rapid disintegration and dissolution of solid dosage forms such as tablets and capsules.

Sodium Starch Glycolate is characterized by its ability to swell and absorb water quickly, leading to efficient disintegration in gastrointestinal fluids.
Sodium Starch Glycolate is a white to off-white, odorless, tasteless powder used primarily as a disintegrant in pharmaceutical formulations.

Sodium Starch Glycolate is the sodium salt of a carboxymethyl ether of starch.
The molecular weight of Sodium Starch Glycolate is typically 500000-11000000.
Sodium Starch Glycolate absorbs water rapidly.

The reason is by absorbing water quickly so the pill swells and breaks apart into small pieces.
Sodium Starch Glycolate consists of oval or spherical granules, 30-100 μm in diameter with some less-spherical granules ranging from 10-35 μm in diameter.

Sodium Starch Glycolate can be made from several different starchy foods, for example corn, wheat, rice and potatoes.
Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms.
Sodium Starch Glycolate is manufactured by chemical modification of starch, i.e., carboxymethylation to enhance hydrophilicity and cross-linking to reduce solubility.

Sodium starch glycolate is the sodium salt of carboxymethyl ether.
Starch glycolates are of rice, potato, wheat, or corn origin.
Sodium starch glycolate is a white to off-white, tasteless, odorless, relatively free-flowing powder.

Sodium Starch Glycolate is manufactured by chemical modification of starch.
It has been reported in the literature that the source of starch, particle size, amount of sodium chloride (reaction by-product), viscosity, degree of substitution, and cross-linking affect the functionality of sodium starch glycolate.

Sodium Starch Glycolate is known as a disintegrant for tablets and capsules and is also referred to as Carboxymethyl Starch or Carboxymethyl Starch Ether.
Sodium Starch Glycolate is part of the diverse portfolio offered by Arvin Kala.

Sodium starch glycolate is a white or nearly white, free-flowing, and highly hygroscopic powder.
According to PhEur 6.0, microscopic examination reveals that Sodium Starch Glycolate consists of granules that are irregularly shaped, either ovoid or pear-shaped, measuring 30–100 µm, or rounded, measuring 10–35 µm.

Occasionally, Sodium Starch Glycolate granules made up of 2–4 components are observed.
These granules feature an eccentric hilum and clearly visible concentric striations.
When viewed under crossed Nicol prisms, the granules display a distinct black cross intersecting at the hilum, with small crystals visible on their surface.

The granules exhibit significant swelling upon contact with water.
Sodium starch glycolate is white to off-white, tasteless, odorless, relatively free flowing powder.
Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules.

Adding sodium starch glycolate to capsules and tablets to help make them disintegrate and dissolve better, making it easier to absorb.
So the pill swells and breaks apart into small pieces.
Sodium starch glycolate (SSG) is most widely used excipient in the field of pharmaceutical sciences.

Sodium Starch Glycolate, or SSG, is a cross-linked variant of Carboxymethyl starch.
The color of Sodium Starch Glycolate varies from white to off-white tone.
Sodium Starch Glycolate powder is odorless, tasteless, hygroscopic & free-flowing.

Sodium starch glycolate is the sodium salt of carboxymethyl ether.
Starch glycolates are of rice, potato, wheat or corn origin.
Sodium Starch Glycolate is a white to off-white, tasteless, odorless, relatively free flowing powder.

Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules.
Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules.
Being the sodium salt of carboxymethyl ether, Sodium Starch Glycolate is a white to off-white, odourless, tasteless, free-flowing powder.

Sodium Starch Glycolate is practically insoluble in water and also in most organic solvents.
Sodium Starch Glycolate is spherical granules that absorbs water rapidly and swell up.
Sodium Starch Glycolate can be added in capsules and tablets to let them dissolve better and making it easier to absorb.

Sodium Starch Glycolate is well-suited for use in tablets and capsules, matching all the international standards.
Sodium Starch Glycolate absorbs water quickly so the pills swell and can also be used to help form gels.
The increased tablet compression pressure also appears to have no effect on the disintegration time.

In spite of the presence of hydrophobic in excipients such as lubricants, the disintegrates the efficiency of sodium starch glycolate is unimpaired.
Sodium Starch Glycolate has good flowability and remarkable mixing properties.

Preserve well in closed containers, Sodium Starch Glycolate is preferred to keep away from wide variations in temperature and humidity.
This will prevent the caking of Sodium Starch Glycolate.
Having a Shelf-life of up to five years from the date of manufacturing, Sodium Starch Glycolate is FDA approved and ISO certified product.

Sodium starch glycolate is an off-white, odourless, tasteless, free-flowing sodium salt of carboxymethyl ether powder.
Sodium Starch Glycolate is made from corn or potato starch and is used as a pharmaceutical-grade dissolving agent and super disintegrant.
Sodium Starch Glycolate comprises spherical granules that absorb water quickly and swell.

Sodium Starch Glycolate is nearly insoluble in water and most organic solvents.
Mix Sodium Starch Glycolate with a small amount of water.
Blend Sodium Starch Glycolate thoroughly until no lumps remain, then fold it into the batter of the mixture.

USES and APPLICATIONS of SODIUM STARCH GLYCOLATE:
Pharmaceutical Disintegrant: Sodium Starch Glycolate is widely used in oral pharmaceutical formulations as a disintegrant.
Sodium Starch Glycolate helps tablets and capsules disintegrate rapidly in the gastrointestinal tract, ensuring quick release and absorption of the active ingredients.

Food Industry Thickener: In the food industry, Sodium Starch Glycolate acts as a thickener and stabilizer, improving the texture and consistency of products like sauces and dressings.
Personal Care Stabilizer: Sodium Starch Glycolate is used in personal care products to stabilize emulsions, ensuring consistent texture and preventing separation of ingredients.

Binder in Tablets: Sodium Starch Glycolate serves as a binder in tablet formulations, providing structural integrity while allowing for rapid disintegration upon ingestion.
Cosmetic Applications: In cosmetics, Sodium Starch Glycolate is used to enhance the texture and stability of creams and lotions, providing a smooth application experience.

Sodium Starch Glycolate is used as a disintegrant, a suspending agent and as a gelling agent.
Also, because of its spherical shape, Sodium Starch Glycolate can have good flow properties.
Sodium Starch Glycolate is widely used as a pharmaceutical grade dissolution excipient for tablets and capsules.

Sodium Starch Glycolate can also be used to help form gels.
By this way, Sodium Starch Glycolate will swell and accelerate the disintegration of tablets and granules.
Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms.

Sodium Starch Glycolate facilitates the rapid breakdown of tablets and capsules in the gastrointestinal tract, enhancing drug absorption and efficacy.
Sodium Starch Glycolate is also used in the food industry as a thickener and stabilizer.

Sodium Starch Glycolate is a superdisintegrant with an action mechanism based on water absorption, with tridimensional expansion, making the tablets and granules disintegrate quickly.
Sodium Starch Glycolate can be used in the synthesis of capsules for delivery of drugs or medicaments.

Sodium Starch Glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations.
Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms.
Characteristics application of Sodium Starch Glycolate: Superdisintegrant, high-efficiency disintegrant, suspending agent.

Sodium Starch Glycolate is used as a disintegrant, a suspending agent and as a gelling agent.
Sodium Starch Glycolate can also be used to help form gels.
Sodium Starch Glycolate is extensively used as a superdisintegrant in different drug formulations.

Excipient, generally considered as an inert component, are of great importance in drug product development.
Interchange between different suppliers can lead to final products with different quality attributes.
Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules.

Sodium Starch Glycolate is used as a disintegrant, a suspending agent and as a gelling agent.
Without a disintegrant, tablets may not dissolve appropriately and may affect the amount of active ingredient absorbed, thereby decreasing effectiveness.

Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules.
Sodium Starch Glycolate is used as a disintegrant, a suspending agent and as a gelling agent.
A disintegrant, a suspending agent and as a gelling agent, Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules.

Sodium Starch Glycolate takes up more than 20 times its own weight of water.
Sodium Starch Glycolate is used as a pharmaceutical-grade dissolution agent and super disintegrant which is produced from corn or potato starch.

Sodium Starch Glycolate improves good flowability and mixing properties.
Sodium Starch Glycolate works as a dissolution enhancer.
Sodium Starch Glycolate works as a food stabiliser and as an anti-ageing agent for bread and in the manufacturing of ice-creams.

Sodium Starch Glycolate works as a disintegrant, a suspending agent, and as a gelling agent.
Sodium Starch Glycolate is recommended that it should be used at a concentration of 6%.

-Applications of Sodium Starch Glycolate in Pharmaceutical Formulation:
Sodium Starch Glycolate is used as a disintegrant in both capsule and tablet formulations.
Commonly, Sodium Starch Glycolate is incorporated into tablets produced through either direct compression or wet granulation methods.
Typically, the concentration used in formulations ranges from 2% to 8%, with an optimal concentration around 4%, although 2% is often adequate.

Disintegration happens through the rapid absorption of water, followed by significant and rapid swelling.
While the effectiveness of many disintegrants can be compromised by the presence of hydrophobic excipients like lubricants, the efficiency of sodium starch glycolate remains unaffected.

Additionally, increasing the tablet compression pressure does not seem to impact the disintegration time.
Sodium starch glycolate has also been explored for its potential use as a suspending agent.

FUNCTIONAL VALUE OF SODIUM STARCH GLYCOLATE IN THE PHARMACEUTICAL INDUSTRY
As a basic excipient, Sodium Starch Glycolate always acts at the best level to boost the disintegration value in the processing of oral solid pharmaceutical products.
Sodium Starch Glycolate is also famous as a dissolution excipient in the pharmaceutical industry, with a standard absorption characteristic to enhance the swelling process, which is highly significant for the sustainable & classic texture of tablets and granules.

CHARACTERISTICS of SODIUM STARCH GLYCOLATE:
Triple unique characteristics of Sodium Starch Glycolate- suspending property, disintegrant & gelling agent play vital roles in tableting industries to ensure the clinical value of tablets.
So, Sodium Starch Glycolate is essential as it provides active ingredients’ absorption in pharmaceutical formulations.

WHAT ARE SODIUM STARCH GLYCOLATE USED FOR?
The following are among the well-known uses of Sodium Starch Glycolate.
Sodium Starch Glycolate works as a dissolution excipient for tablets and capsules.
As a dissolution excipient, Sodium Starch Glycolate helps maintain the effectiveness of active ingredients in tablets and capsules.

These active ingredients are protected from breaking down prematurely while passing through the digestive tract.
After that, the said active ingredients are broken down into areas where absorption occurs, with their maximum effectiveness preserved.
Sodium Starch Glycolate is used as a suspending agent.

Research also shows that Sodium Starch Glycolate may work as a suspending excipient agent.
This means Sodium Starch Glycolate may be useful in protecting active ingredients from caking at the bottom of the drug or dietary supplement form and maintaining their suspension in the formulation.

Sodium Starch Glycolate is believed to work as a suspending agent by filming around active ingredient particles and decreasing inter-particulate attraction.
Sodium Starch Glycolate works as a gelling agent.

Sodium Starch Glycolate may also be used as a gelling agent.
Thus, Sodium Starch Glycolate helps stabilize active ingredients in medications and dietary supplement products.
Sodium Starch Glycolate also works as a thickening agent.

SOURCE of SODIUM STARCH GLYCOLATE:
Sodium Starch Glycolate is available in the starchy substance of potato & corn.
The chemical treatments or modifications with starch properties produce Sodium Starch Glycolate.
The proven chemical treatments with SSG increase the hydrophilicity and reduce the water solubility level.
According to particle sizes, % of sodium chloride, and pH, the manufacturing companies use different grades of Sodium Starch Glycolate to meet the requirements of a faster disintegrant.

METHOD OF MANUFACTURE of SODIUM STARCH GLYCOLATE:
Sodium starch glycolate is a modified derivative of potato starch.
Commercially, Sodium Starch Glycolate is often crosslinked using either sodium trimetaphosphate (Types A and B) or through dehydration (Type C).
Starch undergoes carboxymethylation by reacting with sodium chloroacetate in an alkaline, nonaqueous medium, typically using denatured ethanol or methanol.
This process is followed by neutralization with citric acid, acetic acid, or another acid.
Vivastar P is produced in a methanolic medium, while Explotab is manufactured in an ethanolic medium.

PHYSICAL and CHEMICAL PROPERTIES of SODIUM STARCH GLYCOLATE:
Physical state: Solid
Color: Not available
Odor: Not available
Melting point/freezing point: Not available
Initial boiling point and boiling range: Not available
Flammability (solid, gas): Not available
Upper/lower flammability or explosive limits: Not available
Flash point: Not available
Autoignition temperature: Not available

Decomposition temperature: Not available
pH: Not available
Viscosity:
Kinematic viscosity: Not available
Dynamic viscosity: Not available
Water solubility: Not available
Partition coefficient (n-octanol/water): Not available
Vapor pressure: Not available

Density: Not available
Relative density: Not available
Relative vapor density: Not available
Particle characteristics: Not available
Explosive properties: Not available
Oxidizing properties: Not available
Other safety information: Not available
Appearance (Colour): White

Appearance (Form): Powder
pH (5% aq. suspension): 5.5 - 7.5
Loss on drying: Max. 10%
Identification Test: Passes test
Sodium chloride: Max. 7%
Molecular weight: 515.6862
Purity: Not available
Appearance: Not available
Melting point: Chars at about 200°C

Formulation: Not available
SMILES: Not available
InChi Key: MOSFIJXAXDLOML-UHFFFAOYSA-N
Melting Point: 140°C
Molecular Weight: 266.73 g/mol
Molecular Weight:259.30 g/mol
XLogP3-AA:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4

Rotatable Bond Count:5
Exact Mass:259.06784264 Da
Monoisotopic Mass:259.06784264 Da
Topological Polar Surface Area:71.6 Å²
Heavy Atom Count:17
Formal Charge:0
Complexity:342
Isotope Atom Count:0
Defined Atom Stereocenter Count:0

Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
CAS No:9063-38-1
Molecular formula:C10H19NaO8
Molecular weight:515.6862

Purity:N/A
Appearance:N/A
Melting point:Chars At About 200 ° C
Formulation:N/A
SMILES:N/A
InChi Key:MOSFIJXAXDLOML-UHFFFAOYSA-N
INCI Name-Sodium Starch Glycolate
Molecular Formulae-(C2H4O3)x·(Na)x
Alternative Names-Sodium Carboxymethyl Starch

FIRST AID MEASURES of SODIUM STARCH GLYCOLATE:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of SODIUM STARCH GLYCOLATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Keep in suitable, closed containers for disposal.

FIRE FIGHTING MEASURES of SODIUM STARCH GLYCOLATE:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available

EXPOSURE CONTROLS/PERSONAL PROTECTION of SODIUM STARCH GLYCOLATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection:
Handle with gloves.
Wash and dry hands.
*Body Protection:
Impervious clothing
*Respiratory protection:
Respiratory protection not required.
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of SODIUM STARCH GLYCOLATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.

STABILITY and REACTIVITY of SODIUM STARCH GLYCOLATE:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available