PRODUCTS

SODIUM THIOGLYCOLATE

CAS NO: 367-51-1
EC NO: 206-696-4

SYNONYMS:

Sodium thioglycollate; SODIUM THIOGLYCOLATE; sodium thioglycolate; 367-51-1; Sodium mercaptoacetate; Sodium 2-sulfanylacetate; Mercaptoacetic acid sodium salt; Thioglycolate sodium; Sodium thioglycollate; Mollescal SF; Mercaptoacetic acid, sodium salt; sodium 2-mercaptoacetate; Sodium 2-mercatoethanoate; Erhavit D; Thioglycollic acid, sodium salt; Acetic acid, mercapto-, monosodium salt; Thioglycolic acid sodium salt; UNII-D94M78P69V; Thioglycolic acid, sodium salt; CCRIS 4874; USAF EK-5199; Mercaptoacetic acid monosodium salt; EINECS 206-696-4; Sodium thioglycolate, 95%; D94M78P69V; MFCD00043386; sodium sulfanylacetate; Acetic acid, 2-mercapto-, sodium salt (1:1); Mercaptoacetic acid, sodium salt, 98%; EINECS 253-166-3; sodium mercaptoacetate; ACMC-209ioi; C2H3NaO2S; Mercaptoacetic acid sodium; sodium 2-sulfanylethanoate; Mercaptoaceticacidsodiumsalt; EC 206-696-4; Sodium thioglycolate, 98%; Sodium carboxymethanethiolate; Germanium Amino Acid Chelate; SCHEMBL60834; Mercaptoaceticacid, sodium salt; KSC492G8F; Mercaptoacetic acid, sodium salt; DTXSID3026142; CHEBI:86481; CTK3J2382; KS-00000XWW; Acetic acid, mercapto-, sodium salt; ANW-28480; AKOS015897598; CCG-214509; MCULE-5989133747; 36722-22-2; AS-58194; U688; FT-0628212; M0053; A823356; Q-100436; Q3991662; Thioglycolic acid sodium salt; Mercaptoacetic acid sodium salt; Sodium mercaptoacetate; sodium 2,2,3,3-tetrafluoropropionate; Sodium tetraformate; Sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; Sodium tetraphenylboron; Sodium tetraphosphate; Sodium theophylline glycinate; Sodium 2-thiobarbiturate; Sodium thioctate; Sodium thiocyanate; Sodium thiododecylate; Sodium thiomethoxide; Sodium thiophenolate; Sodium thiophosphate; Sodium thiosulfate; Sodium thiosulfate pentahydrate; Sodium Thymol Blue; Sodium titanate; Sodium tolmetin dihydrate; Sodium toluene-4-sulphinate; Sodium toluenesulphonate; Sodium thioglycollate [Wiki]; 206-696-4 [EINECS]; 367-51-1 [RN]; Acetic acid, 2-mercapto-, sodium salt (1:1) [ACD/Index Name]; AI7700000; D94M78P69V; Mercaptoacetic acid sodium salt; Mercaptoacetic acid, sodium salt; MFCD00043386 [MDL number]; Sodium sulfanylacetate [ACD/IUPAC Name]; Sodium Thioglycolate; Thioglycolic acid sodium salt; [367-51-1]; 12773-25-0 [RN]; 28381-98-8 [RN]; Acetic acid, mercapto-, monosodium salt; EINECS 206-696-4; Erhavit D; Germanium Amino Acid Chelate; MERCAPTOACETIC ACID SODIUM SALT; Mercaptoacetic acid monosodium salt; Mercaptoacetic acid,sodium salt; Mercaptoaceticacid,sodium salt; Mercaptoaceticacidsodiumsalt; Mollescal SF; sodium 2-mercaptoacetate; Sodium 2-mercatoethanoate; sodium 2-sulfanylacetate; sodium 2-sulfanylethanoate; sodium and 2-sulfanylacetate; Sodium mercaptoacetate; Sodium mercaptoacetate; Sodium sulphanylacetate; Sodium mercaptoacetate; Sodium sulfanylacetate; Sodium thioacetate; Sodium thioglycolate, 95%; Sodium thioglycolate, 98%; SODIUM THIOGLYCOLATE; SODIUM 2-SULFANYLACETATE; Sodiume thinobycliate; sodiumthioglycolate; Thioglycolate sodium; THIOGLYCOLIC ACID, SODIUM SALT; Thioglycollic acid, sodium salt; UNII:D94M78P69V; UNII-D94M78P69V; mercaptoacetic acid; thioglycolic acid; 68-11-1; 2-Thioglycolic acid; Acetic acid, mercapto-; Sulfanylacetic acid; 2-Mercaptoacetic acid; Thioglycollic acid; Thiovanic acid; 2-sulfanylacetic acid; Mercaptoessigsaeure; Glycolic acid, thio-; thioglycolate; Glycolic acid, 2-thio-; Mercaptoethanoic acid; Acetic acid, 2-mercapto-; USAF CB-35; 2-Mercaptoacetate; mercapto acetic acid; alpha-Mercaptoacetic acid; Thioglycolic acid solution; NSC 1894; .alpha.-Mercaptoacetic acid; mercapto-acetic acid; UNII-7857H94KHM; CCRIS 4873; HSDB 2702; EINECS 200-677-4; UN1940; BRN 0506166; AI3-24151; CHEMBL116455; CHEBI:30065; 7857H94KHM; NSC-1894; MFCD00004876; mercaptoacetic acid (thioglycolic acid); DSSTox_CID_6141; Mercaptoacetic acid, 98%; DSSTox_RID_78033; DSSTox_GSID_26141; CAS-68-11-1; mercaptoactic acid; 2-mercaptoaceticacid; Sulfanylacetic acid #; HSCH2COOH; HSCH2CO2H; WLN: SH1VQ; EC 200-677-4; ACMC-1BG92; Thioglycolic acid, >=97%; Thioglycolic acid, >=98%; Thioglycolic acid, >=99%; 4-03-00-00600 (Beilstein Handbook Reference); KSC492E2P; OC(=O)C[S]; AMMONIUM THIOGLY- COLATE; DTXSID8026141; Thioglycolic acid, LR, ~80%; CTK3J2227; CWERGRDVMFNCDR-UHFFFAOYSA-; NSC1894; STR00166; ZINC4658574; Tox21_201717; Tox21_303306; ANW-13583; BDBM50336509; STL264219; AKOS000118940; DB15429; LS-1576; MCULE-8097997001; Thioglycolic acid, for synthesis, 97%; UN 1940; KS-000015P9; NCGC00249103-01; NCGC00257153-01; NCGC00259266-01; NCI60_001579; SC-18319; Thioglycolic acid [UN1940] [Corrosive]; DB-002789; Thioglycolic acid [UN1940] [Corrosive]; FT-0628213; FT-0651867; M0052; NS00003173; 8847-EP2292595A1; 8847-EP2295415A1; 8847-EP2308839A1; 8847-EP2316824A1; C02086; 102887-EP2301938A1; 119037-EP2272817A1; 119037-EP2272843A1; 119037-EP2281817A1; 119037-EP2287155A1; 119037-EP2287160A1; 119037-EP2292597A1; 119037-EP2295414A1; 119037-EP2298756A1; 119037-EP2374786A1; Q414738; Thioglycolic acid solution, ~70 % (w/w) in H2O; F2191-0214; Thioglycolic acid solution, ~80% in H2O, for spectrophotometric det. of palladium, iron, uranium(VI), molybdates and nitrites; AMMONIUM THIOGLYCOLATE; 5421-46-5; Ammonium mercaptoacetate; Acetic acid, mercapto-, monoammonium salt; Thioglycolic acid ammonium salt; Ammonium 2-mercaptoacetate; Thiofaco A-50; Ammonium thioglycollate; USAF MO-2; UNII-6P9E788VZZ; Ammonium thioglycolate solution; HSDB 7167; Thioglycollic acid, ammonium salt; NSC 6954; EINECS 226-540-9; Mercaptoacetic acid, monoammonium salt; AI3-26246; 6P9E788VZZ; ammonium sulfanylacetate; Ammonium thioglycolate, 70 wt.% solution in water; Hair waving agent; ammoniumthioglycolate; ACMC-1AY9V; DSSTox_CID_7599; EC 226-540-9; DSSTox_RID_78524; Acetic acid, 2-mercapto-, ammonium salt (1:1); DSSTox_GSID_27599; SCHEMBL59070; KSC494S7R; C2H3O2S.H4N; Ammonium thioglycollate solution; DTXSID2027599; CTK3J4978; CHEBI:156555; Aceticacid,mercapto-,monoammoniumsalt; Tox21_202751; 6844AF; ANW-41185; AKOS015897608; NCGC00260299-01; LS-12361; SC-18509; CAS-5421-46-5; A2217; FT-0628214; Ammonium thioglycolate solution, ~60% in H2O; Potassium thioglycolate; 34452-51-2; Acetic acid, mercapto-, monopotassium salt; Potassium mercaptoacetate; UNII-XP5WZO5W6H; Potassium 2-mercaptoacetate; XP5WZO5W6H; Acetic acid, 2-mercapto-, potassium salt (1:1); Potassium thioglycolate, 40-44 wt.% solution in water; EINECS 252-038-4; potassium,2-sulfanylacetate; EC 252-038-4; SCHEMBL59723; CTK1C2125; Thioglycollic acid potassium salt; DTXSID30885589; Mercaptoacetic acid, monopotassium salt; FT-0636696; FT-0777828; Q27293945; calcium thioglycolate; Butyl thioglycolate; Butyl mercaptoacetate; 10047-28-6; butyl 2-sulfanylacetate; Butyl 2-mercaptoacetate; Acetic acid, mercapto-, butyl ester; UNII-96L21ZJ8JC; THIOGLYCOLIC ACID N-BUTYL ESTER; Acetic acid, 2-mercapto-, butyl ester; 96L21ZJ8JC; n-Butyl thioglycolate; butyl-2-mercapto acetate; butylthioglycolate; Butyl thioglicolate; EINECS 233-156-5; NSC 65453; Butyl sulfanylacetate #; AI3-63085; ACMC-2097qe; OCTANOIC1-13CACID; Thioglycolic Acid Butyl Ester; SCHEMBL160260; Mercaptoacetic Acid Butyl Ester; DTXSID4064929; CTK0H8428; SKGVGRLWZVRZDC-UHFFFAOYSA-; NSC65453; ZINC4501341; ANW-14292; NSC-65453; SBB061004; AKOS005207055; MCULE-4331308025; FT-0628215; NS00013417; ST50409775; Q27271908; F0001-0048

Thioglycolic Acid is an organic compound that contains a thiol group (-SH) and carboxylic acid. It is a colorless liquid. Thioglycolic Acid and some salts and esters of Thioglycolic Acid, such as Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate and Sodium Thioglycolate are used in hair coloring products, permanent wave products, hair straightening products and depilatory products.

Sodium thioglycolate is an organic sodium salt having thioglycolate(1-) as the counterion. It has a role as a reducing agent. It contains a thioglycolate(1-).

It is a white powder with a slight odor. Used in cold-waving of hair and as a dipilatory.

Mercaptoacetic acid sodium salt is used as a reagent that protects tryptophan in amino acid analysis. It is a commonly used reagent for bacteriological research to maintain reducing conditions in media. It also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state.

Sodium Thioglycolate is used when preparing microbiology culture media in a laboratory setting. Sodium Thioglycolate is not intended for use in the diagnosis of disease or other conditions in humans.

Sodium Thioglycolate is used to lower the oxidation-reduction potential of the medium and for the neutralization of mercurial compound preservatives.

Alkaline sodium thioglycolate is used in removal of hair from leather hides. It minimizes wastewater treatment costs as compared to the more toxic and harmful sodium hydrosulfide.

Sodium thioglycolate is a white powder with a melting point greater than 300°C. It appears as hygroscopic crystals with an unpleasant odor characteristic of the sulfhydryl group (mercaptans). Thioglycolic acid can be prepared by the action of sodium sulfhydrate on sodium chloroacetate and by electrolysis of dithioglycollic acid from sodium sulfide and sodium chloroacetate. It is also formed by heating chloroacetic acid with potassium hydrogen sulfide. Thioglycolic acid and its salts and glyceryl esters are not known to occur naturally. Sodium thioglycolate is used in the cosmetic industry as an antioxidant, depilating agent, hair waving/straightening agent, and reducing agent. Its primary cosmetic use is in depilatories. Sodium thioglycolate is also used as an analytical reagent and in bacteriology for the preparation of thioglycolate media.

Sodium thioglycolate is soluble in water and slightly soluble in ethanol. It is combustible and discolors on exposure to air or iron.

Sodium thioglycolate is used primarily in the cosmetic industry as an antioxidant, depilating agent, hair waving/straightening agent, and reducing agent. Its primary cosmetic use is in depilatories. Sodium thioglycolate is also used as an analytical reagent and in bacteriology for the preparation of thioglycolate media.

The production and use of sodium thioglycolate is linked to the production and use of thioglycolic acid. Thioglycolic acid can be prepared by the action of sodium sulfhydrate on sodium chloroacetate and by electrolysis of dithioglycollic acid from sodium sulfide and sodium chloroacetate. It is also formed by heating chloroacetic acid with potassium hydrogen sulfide. Thioglycolic acid and its salts and glyceryl esters are not known to occur naturally.

While most of the volume of thioglycolic acid is used for industrial applications, the acid and its salts and glyceryl esters, including sodium thioglycolate, are used in cosmetic hair care products. Thioglycolates reduce the cystine disulfide linkages in the hair cortex, thereby weakening the keratin molecule. The predominant use of thioglycolic acid, ammonium thioglycolate, and glyceryl thioglycolate is in permanent wave and hair straightening products. Thioglycolic acid and ammonium thioglycolate concentrations in these products range from 7% to 19%, while glyceryl thioglycolate concentrations of 20% have been reported. Permanent wave products containing ammonium thioglycolate that are applied to the hair without heat may be expected to remain on the hair and scalp for as long as 10 to 40 minutes; products applied with heat usually contain thioglycolates other than the ammonium salt and are generally processed in 30 minutes but may remain on the head for up to 1 hour. Hair straightening products containing ammonium or ethanolamine thioglycolate or thioglycolic acid are usually applied to the hair for 45 minutes. Thioglycolic acid and its sodium and calcium salts are also used as depilatories. The concentrations of thioglycolic acid and calcium thioglycolate in depilatories are reported to be 2% to 5% and 5% to 7%, respectively. The sodium thioglycolate concentration in depilatories has been reported as 4%. Depilatory products containing thioglycolic acid and/or its salts are commonly applied to the face, legs, and arms, usually for a recommended maximum of 10 minutes, and may come in contact with the scalp and ocular and nasal mucosa.

Sodium thioglycolate is one of the salts of thioglycolic acid commonly used in consumer products to wave, straighten, or remove hair, and it may remain applied to the scalp or skin for up to 1 hour. Sodium thioglycolate is also commonly used as an analytical reagent in the preparation of cell culture media. Workers may be exposed through inhalation of aerosols and dermal contact to sodium thioglycolate, especially when applying hair care products to customers. The general population may be exposed through similar routes as workers during home application of hair care products containing sodium thioglycolate.

Sodium thioglycolate can be:

1. Used as car cleaning agent, material rust remover

2. Used as an inhibitor of copper and magnesia in the flotation of copper-molybdenum ore

3. Used as an analytical reagent or chemical cold solution

Thioglycolic acid protects tryptophan in amino acid analysis,a nd also mediates formation of ATP from ADP. It lowers the oxidation-reduction potential and neutralises mercurial preservatives. An inhibitor of fatty acid oxidation. An agent that prevents the metabolism of fatty acids and stimulates feeding. The sodium salt form is typically used in production of bacteriological culture media.

Thioglycolic acid can cause severe burns and chemical injuries when it enters in contact with the skin, eye, digestive or respiratory tracts. It is corrosive and can even induce a systemic toxicity.
However, thioglycolic acid is still widely used in domestic products such as depilatory creams and by hairdressers for “perms”.

Thioglycolic acid is a colorless liquid with a strong, typical mercaptan disagreeable odor (although olfactory fatigue may occur) which is used in cosmetic formulations including permanent wave solutions and depilatories, in pharmaceutical manufacture, and as a stabilizer for vinyl plastics.

Thioglycolic acid is a contact irritant or corrosive substance of the eyes, skin, and mucous membranes.

It is known to cause severe skin burns and eye damages.

Sodium thioglycolate acts as reducing agent and is suitable for anaerobic and microaerophilic bacterial growth. Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media.

FIRST AID MEASURES:

*General information

Immediately remove any clothing soiled by the product.

In case of irregular breathing or respiratory arrest provide artificial respiration.

*After inhalation

Supply fresh air. If required, provide artificial respiration. Keep patient warm.

Seek immediate medical advice.

*After skin contact

Immediately wash with water and soap and rinse thoroughly.

Seek immediate medical advice.

*After eye contact Rinse opened eye for several minutes under running water. Then consult a doctor.

After swallowing Seek medical treatment.

Information for doctors:

Most important symptoms and effects, both acute and delayed

Causes skin irritation.

Harmful if swallowed.

Toxic in contact with skin.

Causes serious eye irritation.

May cause an allergic skin reaction.

Indication of any immediate medical attention and special treatment needed No further relevant information available.

FIRE FIGHTING MEASURES:

Extinguishing media

Suitable extinguishing agents Carbon dioxide, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.

Special hazards arising from the substance or mixture

If this product is involved in a fire, the following can be released:

Carbon monoxide and carbon dioxide

Sulfur oxides (SOx)

Sodium oxide

Advice for firefighters

Protective equipment:

Wear self-contained respirator.

Wear fully protective impervious suit.

ACCIDENTAL RELEASE MEASURES:

Personal precautions, protective equipment and emergency procedures

Wear protective equipment. Keep unprotected persons away.

Ensure adequate ventilation

Environmental precautions: Do not allow product to reach sewage system or any water course.

Methods and material for containment and cleaning up: Dispose of contaminated material as waste according to section 13.

Prevention of secondary hazards: No special measures required. Reference to other sections

Protective Action Criteria for Chemicals

PAC-1: Substance is not listed.
PAC-2: Substance is not listed.
PAC-3: Substance is not listed.

HANDLING AND STORAGE:

Handling

Precautions for safe handling

Handle under dry protective gas.

Keep container tightly sealed.

Store in cool, dry place in tightly closed containers.

Ensure good ventilation at the workplace.

Information about protection against explosions and fires: No information known.

Conditions for safe storage, including any incompatibilities

Storage

Requirements to be met by storerooms and receptacles: No special requirements.

Information about storage in one common storage facility:

Store away from air.

Store away from water/moisture.

Store away from oxidizing agents.

Further information about storage conditions:

Store under dry inert gas.

This product is hygroscopic.

This product is air sensitive.

Keep container tightly sealed.

Store in cool, dry conditions in well sealed containers.

Protect from humidity and water.

Specific end use(s) No further relevant information available

PHYSICAL AND CHEMICAL PROPERTIES:

Information on basic physical and chemical properties

General Information

Appearance:

Form: Powder

Odor: Stench

Odor threshold: Not determined.

pH-value (100 g/l) at 20 °C (68 °F): 6

Change in condition

Melting point/Melting range: >300 °C (>572 °F)

Boiling point/Boiling range: Not determined

Sublimation temperature / start: Not determined

Flammability (solid, gaseous) Not determined.

Ignition temperature: Not determined

Decomposition temperature: Not determined

Auto igniting: Not determined.

Danger of explosion: Not determined.

Explosion limits:

Lower: Not determined

Upper: Not determined

Vapor pressure: Not applicable.

Density: Not determined

Relative density Not determined.

Vapor density Not applicable.

Evaporation rate Not applicable.

Solubility in / Miscibility with

Water at 20 °C (68 °F): 1000 g/l

Partition coefficient (n-octanol/water): Not determined.

Viscosity:

dynamic: Not applicable.

kinematic: Not applicable.

TRANSPORT INFORMATION

UN-Number: UN2811

UN proper shipping name

DOT: Toxic solids, organic, n.o.s. (Mercaptoacetic acid sodium salt)

ADR: 2811 Toxic solids, organic, n.o.s. (Mercaptoacetic acid sodium salt)

IMDG, IATA: TOXIC SOLID, ORGANIC, N.O.S. (Mercaptoacetic acid sodium salt)

DOT CLASS: 6.1 Toxic substances

DOT LABEL: 6.1

ADR CLASS: 6.1 (T2) Toxic substances

ADR LABEL: 6.1

IMDG, IATA CLASS: 6.1 Toxic substances

IMDG, IATA LABEL: 6.1

Packing group

DOT, ADR, IMDG, IATA: III