PRODUCTS

SODIUM TOSYLCHLORAMIDE

Sodium tosylchloramide has been developed for the personal care industry in order to answer the need for high purity chemicals with strong chelation properties.
Sodium tosylchloramide uses range from peroxide stabilization to bar soap oxidation prevention.
Sodium tosylchloramide etidronic acid high purity cosmetics grade produced and tested to ensure quality and consistency.

CAS Number: 2809-21-4
EC Number: 220-552-8
Chemical Formula: C2H8O7P2
Molecular weight: 206 g/mol

Synonyms: Acetodiphosphonic acid, Acide etidronique [INN-French], Acido etidronico [INN-Spanish], Acidum etidronicum [INN-Latin], EHDP, Etidronate Disodium, Etidronsaeure, HEDP, Hydroxyethanediphosphonic acid, Oxyethylidenediphosphonic acid, Etidronate, Etidronic acid, 2809-21-4, etidronate, HEDP, 1-Hydroxyethylidene-1,1-diphosphonic acid, EHDP, Etidronsaeure, Acetodiphosphonic acid, Hydroxyethanediphosphonic acid, TURPINAL SL, Oxyethylidenediphosphonic acid, Didronel, Dequest 2015, Dequest Z 010, Acido etidronico, Ferrofos 510, Acide etidronique, 1-Hydroxyethane-1,1-diphosphonate, 1-Hydroxyethane-1,1-diphosphonic acid, Phosphonic acid, (1-hydroxyethylidene)bis-, Diphosphonate (base), (1-Hydroxyethane-1,1-diyl)diphosphonic acid, 1-Hydroxyethanediphosphonic acid, Dequest 2010, Ethane-1-hydroxy-1,1-diphosphonic acid, (Hydroxyethylidene)diphosphonic acid, Ethane-1-hydroxy-1,1-diphosphonate, (1-Hydroxyethylene)diphosphonic acid, Acide etidronique [INN-French], Acido etidronico [INN-Spanish], Acidum etidronicum [INN-Latin], (1-Hydroxyethylidene)diphosphonic acid, 1,1,1-Ethanetriol diphosphonate, 1-Hydroxyethylidene-1,1-bisphosphonate, 1-Hydroxyethane-1,1-bisphosphonic acid, 1-HYDROXY-1,1-DIPHOSPHONOETHANE

Sodium tosylchloramide provides hair damage control in bleaching/ coloring process.
Sodium tosylchloramide acts as chelating agent.

Sodium tosylchloramide etidronic acid high purity cosmetics grade produced and tested to ensure quality and consistency.
Sodium tosylchloramide is ideally suited for personal care and cosmetic applications.

Sodium tosylchloramide belongs to a group of medicines called bisphosphonates.
Sodium tosylchloramide alters the cycle of bone formation and breakdown in the body.

Sodium tosylchloramide is used to treat Paget's disease, and to treat conditions of irregular bone growth due to hip fracture or spinal cord injury.
Sodium tosylchloramide may also be used for purposes not listed in this medication guide.

Incorporate Sodium tosylchloramide at low levels in bar soap and hair care preparations.
Sodium tosylchloramide is an excellent chelating agent for transition metals such as iron, copper, manganese and zinc.
Sodium tosylchloramide is stable in oxygen bleaching conditions.

Sodium tosylchloramide is a personal care products additive.
Sodium tosylchloramide is produced and tested to meet the consistent high quality requirements encountered.

Sodium tosylchloramide type is preferred for formulations based on neutral pH.
Sodium tosylchloramide is miscible with water in all proportions and has a strong complexing capacity with polyvalent cations.

Sodium tosylchloramide is a diphosphonate which affects calcium metabolism.
Sodium tosylchloramide inhibits ectopic calcification and slows down bone resorption and bone turnover.

TURPINAL products are high purity grades of etidronic acid and sodium etidronate which are suitable for use in cosmetics and Personal Care or any applications requiring a very low metal content.
The high purity of these products is guaranteed by thorough quality control procedures (including testing for microbiological contamination).
Moreover, the certificate of analysis accompanying each batch contains detailed information covering chemical purity and trace metal content.

Their chelating properties make them outstanding candidates for the chelation of metal ions, in particular the transition metals (Fe, Cu, Mn, Zn) and the water hardness ions (Ca, Mg).
Thanks to the chelating properties and threshold effect, and added to Sodium tosylchloramide chemical stability in oxidizing environment, TURPINAL can bring substantial benefits in many application fields and more specifically in the cosmetics industry.

These products are ideal chelants or additives in the following applications:
In the stabilization of peroxide bonds, in alkaline media specifically,
As a chelant in hair cosmetics containing mercaptan groups, i.e. thioglycolic acid, thiolactic acid,

As a means of limiting hair damage caused by bleaching or colouring,
In the stabilization of bar soaps, where TURPINAL is used as antioxidant and prevents discolouration and rancidity, in particular under the influence of day light,
In the stabilization of fragrances, which would otherwise lose their strength over time during storage of cosmetic formulations.

Uses of Sodium Tosylchloramide:
Use Sodium tosylchloramide as directed by your doctor.
Check the label on the medicine for exact dosing instructions.

Take Sodium tosylchloramide with 6 to 8 ounces (180 to 240 mL) of plain water first thing in the morning, at least 30 minutes before eating, drinking, or taking any other medicine.
Sodium tosylchloramide works best if taken 60 minutes before eating, drinking, or taking any other medicine.

Taking Sodium tosylchloramide with orange juice, coffee, or mineral water may decrease Sodium tosylchloramide effectiveness.
Do not break, crush, suck, or chew the tablet before swallowing.

Do not lie down for at least 30 minutes after taking Sodium tosylchloramide and until after you have had your first meal or snack of the day.
Do not take Sodium tosylchloramide at bedtime or before getting out of bed.

Calcium or iron supplements, vitamins, or antacids containing calcium, magnesium, or aluminum may interfere with the absorption of Sodium tosylchloramide.
These medicines must be taken at least 2 hours after taking Sodium tosylchloramide.

If you miss a dose of Sodium tosylchloramide, skip the missed dose and go back to your regular dosing schedule.
Do not take 2 doses at once.

Recommended Uses of Sodium Tosylchloramide:
Sodium tosylchloramide ideally suited for use in personal care and cosmetic applications.
Sodium tosylchloramide is added to bar soap and hair care preparations at low levels.

Sodium tosylchloramide has a shelf life of at least 1 year in Sodium tosylchloramide original sealed packaging at 5-30 oC.
Sodium tosylchloramide is recommended to add TURPINAL at concentrations between 0.1-2% with reference to the finished product during production.

Usage Areas of Sodium Tosylchloramide:
Sodium tosylchloramide is used in stabilization of peroxide bonds, especially in alkaline environments, as a complexing agent in hair cosmetics containing mercaptan groups (such as thioglycolic acid, thiolactic acid)

Limiting hair damage caused by bleaching and coloring,
Sodium tosylchloramide is used in the stabilization of soap bars, especially under the influence of daylight, where TURPINAL is used as an antioxidant and protects Sodium tosylchloramide from discoloration and molding (sour, smell).

Paget’s Disease:
Sodium tosylchloramide disodium tablets are indicated for the treatment of symptomatic Paget’s disease of bone.

Sodium tosylchloramide disodium therapy usually arrests or significantly impedes the disease process as evidenced by:
Symptomatic relief, including decreased pain and/or increased mobility (experienced by 3 out of 5 patients).

Reductions in serum alkaline phosphatase and urinary hydroxyproline levels (30% or more in 4 out of 5 patients).

Histomorphometry showing reduced numbers of osteoclasts and osteoblasts, and more lamellar bone formation.

Bone scans showing reduced radionuclide uptake at pagetic lesions.

In addition, reductions in pagetically elevated cardiac output and skin temperature have been observed in some patients.
In many patients, the disease process will be suppressed for a period of at least one year following cessation of therapy.
The upper limit of this period has not been determined.

The effects of the Sodium tosylchloramide disodium treatment in patients with asymptomatic Paget’s disease have not been studied.
However, Sodium tosylchloramide disodium treatment of such patients may be warranted if extensive involvement threatens irreversible neurologic damage, major joints, or major weight-bearing bones.

Applications of Sodium Tosylchloramide:
TURPINAL products are high purity grades of etidronic acid and sodium etidronate which are suitable for use in cosmetics or any applications requiring a very low metal content.

Sodium tosylchloramide high purity of TURPINAL is guaranteed by thorough quality control procedures (including testing for microbiological contamination).
Moreover, the certificate of analysis accompanying each batch contains detailed information covering chemical purity and trace metal content.

Sodium tosylchloramide and TURPINAL 4NL are respectively the acid form and the tetra sodium salt of etidronic acid.
They are colorless to slightly yellow liquids with a neutral odor.
TURPINAL 4NP is the tetrasodium powder form of etidronic acid.

These products can be mixed with water in all ratios and have a strong complexing capacity in relation to polyvalent cations.
The excellent complexing capacity for metals is exploited for the stabilization of H2O2-containing preparations and other preparations with active oxygen.

Sodium tosylchloramide is also suited for application in mercaptan – containing formulations and enhances the color stability of bar soaps.
Sodium tosylchloramide is recommended that TURPINAL be added during production with a concentration of 0.1 – 2% with reference to the finished preparation.

TURPINAL products are ideal chelants or additives in the following applications:
Sodium tosylchloramide the stabilization of peroxide bonds, in alkaline media specifically.
As a chelant in hair cosmetics containing mercaptan groups, i.e. thioglycolic acid, thiolactic acid.

As a means of limiting hair damage caused by bleaching or coloring.
Sodium tosylchloramide the stabilization of bar soaps, where TURPINAL is used as antioxidant and prevents discoloration and rancidity, in particular under the influence of day light.
Sodium tosylchloramide the stabilization of fragrances, which would otherwise lose their strength over time during storage of cosmetic formulations.

Other Applications of Sodium Tosylchloramide:
Cooling water systems / industrial water treatment,
Industrial detergents,
Swimming pools,
Metal surface treatment as a corrosion inhibitor for steel,
Stabilizer in H2O2 solutions,
Sequestering agent in textile auxiliaries,
Cosmetics Oxygenated creams,
Liquid soap,
Bar soaps,
Shampoo,
Hair dyes.

Features of Sodium Tosylchloramide:
Sodium tosylchloramide and 4NL are the acid form and tetra sodium salts of editronic acid, respectively.
Sodium tosylchloramide are colorless to slightly yellow with neutral odor.

TURPINAL 2NZ and 4NP are the disodium and tetra sodium powder forms of editronic acid, respectively.
Miscible with water in all proportions and has a strong complexing capacity with polyvalent cations.

Excellent complexing capacity with metals.
Sodium tosylchloramide is used for the stabilization of peroxide-containing preparations and other preparations to active oxygen.

Sodium tosylchloramide is also suitable for application to formulations containing mercaptan and to increase the color stability of bar soaps.
Sodium tosylchloramide is recommended to add TURPINAL at concentrations of 0.1-2% with reference to the finished product during production.

Sodium tosylchloramide Indication:
Sodium tosylchloramide is used for the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury.

Pharmacology of Sodium Tosylchloramide:
Sodium tosylchloramide is a first generation (non-nitrogenous) bisphosphonate in the same family as clodronate and tiludronate.
Sodium tosylchloramide affects calcium metabolism and inhibits bone resorption and soft tissue calcification.

Sodium tosylchloramide is a high purity etidronic acid solution.
The TURPINAL series has been developed for the personal care industry in order to answer the need for high purity chemicals with strong chelation properties.
The microbiological and trace metal content in Sodium tosylchloramide is carefully monitored in order to provide a high purity product that meets the stricter standards of the personal care product industry.

Of the etidronic acid that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney.
The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface.
Sodium tosylchloramide has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.

Interactions of Sodium Tosylchloramide:
There have been isolated reports of patients experiencing increases in their prothrombin times when etidronate was added to warfarin therapy.
The majority of these reports concerned variable elevations in prothrombin times without clinically significant sequelae.
Although the relevance of these reports and any mechanism of coagulation alterations is unclear, patients on warfarin should have their prothrombin time monitored.

Contraindications of Sodium Tosylchloramide:
Didronel tablets are contraindicated in patients with known hypersensitivity to etidronate disodium or in patients with clinically overt osteomalacia.
Sodium tosylchloramide disodium tablets, USP are indicated for the treatment of symptomatic Paget’s disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury.
Sodium tosylchloramide disodium tablets are not approved for the treatment of osteoporosis.

Heterotopic Ossification of Sodium Tosylchloramide:
Sodium tosylchloramide disodium tablets are indicated in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury.

Sodium tosylchloramide disodium tablets reduce the incidence of clinically important heterotopic bone by about two-thirds.
Among those patients who form heterotopic bone, Sodium tosylchloramide disodium tablets retard the progression of immature lesions and reduces the severity by at least half.
Follow-up data (at least 9 months post-therapy) suggests these benefits persist.

In total hip replacement patients, Sodium tosylchloramide disodium tablets do not promote loosening of the prosthesis or impede trochanteric reattachment.
In spinal cord injury patients, Sodium tosylchloramide disodium tablets do not inhibit fracture healing or stabilization of the spine.

Mechanism Of Action:
Bisphosphonates, when attached to bone tissue, are absorbed by osteoclasts, the bone cells that breaks down bone tissue.
Although the mechanism of action of non-nitrogenous bisphosphonates has not been fully elucidated, available data suggest that they bind strongly to hydroxyapatite crystals in the bone matrix, preferentially at the sites of increased bone turnover and inhibit the formation and dissolution of the crystals.

Other actions may include direct inhibition of mature osteoclast function, promotion of osteoclast apoptosis, and interference with osteoblast-mediated osteoclast activation.
Sodium tosylchloramide does not interfere with bone mineralization.
In malignancy-related hypercalcemia, etidronic acid decreases serum calcium by inhibiting tumour-induced bone resorption and reducing calcium flow from the resorbing bone into the blood.

Sodium tosylchloramide also reduces morbidity of osteolytic bone metastases by inhibiting tumour-induced bone resorption.
Sodium tosylchloramide may promote osteoclast apoptosis by competing with adenosine triphosphate (ATP) in the cellular energy metabolism.
The osteoclast initiates apoptosis and dies, leading to an overall decrease in the breakdown of bone.

Drug Interactions of Sodium Tosylchloramide:
Aluminium Formation of non-absorbable complexes
Bismuth Formation of non-absorbable complexes
Calcium Formation of non-absorbable complexes
Iron Formation of non-absorbable complexes
Magnesium oxide Formation of non-absorbable complexes
Magnesium Formation of non-absorbable complexes
Sucralfate Formation of non-absorbable complexes

Food Interactions of Sodium Tosylchloramide:
Take on an empty stomach.
Avoid aluminium, calcium, iron and magnesium.

Identifiers of Sodium Tosylchloramide:
IUPAC Name: (1-hydroxy-1-phosphonoethyl)
CAS Number: 86159-18-4
Chemical Name: Etridonic Acid
Internal Tracking Number: 107607
Substance Type: Chemical Substance
Systematic Name: Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-
CAS Number: 2809-21-4
EPA Registry Name: Etidronic acid
Molecular Weight: 206.03
Molecular Formula: C2H8O7P2

Properties of Sodium Tosylchloramide:
Chemical Formula: C2H8O7P2
Appearance: Clear, slightly yellow liquid
Density: 2.1±0.1 g/cm3
Boiling Point: 578.8±60.0 °C at 760 mmHg
Melting Point: 198~199℃
Molecular Formula: C2H8O7P2
Molecular Weight: 206.028
Flash Point: 303.8±32.9 °C
Exact Mass: 205.974518
PSA: 154.91000
LogP: -3.54
Vapour Pressure: 0.0±3.6 mmHg at 25°C
Index of Refraction: 1.586
Stability: Stable. Incompatible with strong oxidizing agents.

Appearance: clear Colorless To Pale Yellow Aqueous Solution
Specific Gravit: 1.42 - 1.46 G/ml At 25 C
Solubility: soluble In Water
Ph: < 2 (1% Solution)
Iron Content: 5 Ppm Max
Active Matter: 58 - 62%
Phosphoric Acid Content: 2.0% Max
Heavy Metals: as: < 2 Ppm; Cr/cd/mn/cu/co: < 1 Ppm
Chloride: 1.0% Max
Density (25°c): 1.43 - 1.45
Molecular Weight: 206.03

Specifications of Sodium Tosylchloramide:
Molecular weight: 206 g/mol
Freezing point: - 25 oC
Phosphoric acid: < 2%
pH (1% solution), 25 oC: < 2
Arsenic: < 2 ppm
Editronic acid: 60%
Chromium: < 1 ppm
Cobalt: < 1 ppm
Manganese: < 1 ppm
Cadmium: < 1 ppm
Iron: < 2 ppm
Copper: < 1 ppm
Specific gravity, 20/20 oC: 1.45

Other Descriptions of Sodium Tosylchloramide:

Drug Category:
Antihypocalcemic Agents
Antineoplastic Agents
Bisphosphonates
Osteoporosis Prophylactic

Drug Type:
Small Molecule
Approved

Generic Name:
Etidronic acid

Chemical Composition:
Etidronic Acid