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CAS Number: 1338-39-2
Synonyms: Sorbitan monododecanoate, Span™ 20, Sorbitan laurate, E 493, Lauric acid sorbitan ester, Sorbitan lauric acid monoester, Sorbitan monolauric acid ester, Tween 28
Chemical Profile
Sorbitan monolaurate is a detergent and monoester of lauric acid and hexitol anhydrides derived from sorbitol . It has the molecular formula C₁₈H₃₄O₆ and molecular weight of 346.46 g/mol . The IUPAC name is 2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl dodecanoate .
Physical Properties
Density: 1.032
Refractive Index: 1.474
Flash Point: >110°C (230°F)
Melting Point: 18°C
HLB Value: 8
Acid Value: Maximum 7 mg KOH/g
Hydroxyl Value: 330-360 mg KOH/g
Saponification Value: 158-170 mg KOH/g
Water Content: Maximum 2%
Merck Index: 14,8724
Solubility
Soluble in 2-ethoxyethanol, ethanol, and methanol
Not miscible or difficult to mix in water
Function
Sorbitan monolaurate functions as a :
Non-ionic surfactant
Emulsifier (both O/W and W/O)
Anti-foaming agent
Defoamer
Applications
Pharmaceutical Applications:
Used in studies to assess enhanced solubility and oral bioavailability of itraconazole
Used in drug delivery systems
Pharmaceutical excipient
Food Industry:
Food additive (E 493)
Emulsifier in food products
Cosmetic Applications:
Emulsifier in cosmetic formulations
Used in combination with ethoxylated sorbitan esters for O/W emulsions
Research Applications:
Used in studies investigating the oxidation of unsaturated lipids in oil-in-water emulsions
Industrial Applications:
Lubricants
Textile auxiliaries
Inks and coatings
Agrochemicals
Feed and veterinary products
Storage and Handling
Store in a cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents .
Packaging Availability
Available in 200 kg drums, 1000 kg IBCs, and bulk quantities
SAFETY INFORMATION ABOUT SORBITAN MONOLAURATE
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.
Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials
Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product
