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Sulfamethoxazole is a sulfonamide antibiotic widely used in combination with trimethoprim for the treatment of bacterial infections.
Sulfamethoxazole is valued for its broad-spectrum antibacterial activity against gram-positive and gram-negative bacteria.
Sulfamethoxazole is mainly administered orally, often as co-trimoxazole (Sulfamethoxazole + Trimethoprim), for respiratory, urinary, and gastrointestinal infections.
CAS Number: 723-46-6
EC Number: 211-570-4
Molecular Formula: C10H11N3O3S
Molecular Weight: 253.28 g/mol
Synonyms: Sulfamethoxazole, SMX, Sulfamethoxazolum, 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide, Gantanol, Sulfonamide Antibiotic, SMX API, Sulfamethoxazole, Sulfamethoxazol, Sulfamethoxazoleum, Sulfamethoxazolum, Sulfamethoxazole BP, Sulfamethoxazole USP, Sulfamethoxazole EP, Sulfamethoxazole Pharmaceutical Grade, Sulfamethoxazole Pure, Sulfamethoxazole High Purity, Sulfamethoxazole Extra Pure, Sulfamethoxazole Certified, Sulfamethoxazole Assay, Sulfamethoxazole Research Grade, Sulfamethoxazole Laboratory Grade, Sulfamethoxazole Technical Grade, Sulfamethoxazole Industrial Grade, Sulfamethoxazole Bulk Chemical, Sulfamethoxazole Raw Material, Sulfamethoxazole Fine Chemical, Sulfamethoxazole Specialty Chemical, Sulfamethoxazole Laboratory Reagent, Sulfamethoxazole Analytical Reagent, Sulfamethoxazole Certified Reagent, Sulfamethoxazole Analytical Standard, Sulfamethoxazole Laboratory Standard, Sulfamethoxazole Test Reagent, Sulfamethoxazole Compound, Sulfamethoxazole Salt, Sulfamethoxazole Powder, Sulfamethoxazole Granules, Sulfamethoxazole Crystalline, Sulfamethoxazole Solid, Sulfamethoxazole Solution, Sulfamethoxazole Formulation, Sulfamethoxazole Preparation, Sulfamethoxazole Mixture, Sulfamethoxazole Product, Sulfamethoxazole Material, Sulfamethoxazole Functional Additive, Sulfamethoxazole Specialty Additive, Sulfamethoxazole Technical Product, Sulfamethoxazole Pharmaceutical Substance, Sulfamethoxazole Drug Substance, Sulfamethoxazole Active Pharmaceutical Ingredient, Sulfamethoxazole API, Sulfamethoxazole Antibacterial, Sulfamethoxazole Antimicrobial, Sulfamethoxazole Antiinfective, Sulfamethoxazole Sulfonamide, Sulfamethoxazole Sulfa Drug, Sulfamethoxazole Anti-Infective Agent, Sulfamethoxazole Chemotherapeutic Agent, Sulfamethoxazole Therapeutic Agent, Sulfamethoxazole Veterinary Grade, Sulfamethoxazole Veterinary Pharmaceutical, Sulfamethoxazole Medical Grade, Sulfamethoxazole Human Medicine
APPLICATIONS
Sulfamethoxazole is used in urinary tract infection (UTI) treatment.
Sulfamethoxazole targets common pathogens such as E. coli and Proteus mirabilis.
Sulfamethoxazole is effective when combined with trimethoprim.
Sulfamethoxazole is applied in respiratory infections.
Sulfamethoxazole is used to treat bronchitis and pneumonia.
Sulfamethoxazole is active against Haemophilus influenzae and Streptococcus pneumoniae.
Sulfamethoxazole is used in gastrointestinal infections.
Sulfamethoxazole is applied in the treatment of shigellosis and traveler’s diarrhea.
Sulfamethoxazole is effective in combination therapy.
Sulfamethoxazole is used in opportunistic infections.
Sulfamethoxazole is a first-line agent against Pneumocystis jirovecii pneumonia (PCP) in immunocompromised patients.
Sulfamethoxazole is used for prophylaxis in HIV/AIDS patients.
Sulfamethoxazole is applied in ear infections.
Sulfamethoxazole helps manage otitis media in pediatric patients.
Sulfamethoxazole provides broad antimicrobial coverage.
Sulfamethoxazole is employed in skin and soft tissue infections.
Sulfamethoxazole is used against Staphylococcus aureus including MRSA strains.
Sulfamethoxazole is often combined with trimethoprim for synergistic activity.
Sulfamethoxazole is used as an antibiotic in human medicine.
Sulfamethoxazole is prescribed for urinary tract infections.
Sulfamethoxazole is effective against respiratory tract infections.
Sulfamethoxazole is applied in combination therapy.
Sulfamethoxazole is used with trimethoprim as co-trimoxazole.
Sulfamethoxazole enhances the synergistic effect of antimicrobial activity.
Sulfamethoxazole is used in the treatment of gastrointestinal infections.
Sulfamethoxazole helps manage traveler’s diarrhea.
Sulfamethoxazole is used in cases of shigellosis and salmonellosis.
Sulfamethoxazole is applied in the treatment of Pneumocystis jirovecii pneumonia.
Sulfamethoxazole is prescribed in HIV/AIDS patients for prophylaxis.
Sulfamethoxazole provides life-saving therapy in immunocompromised individuals.
Sulfamethoxazole is used against ear infections.
Sulfamethoxazole helps treat otitis media in children.
Sulfamethoxazole is effective for persistent or recurrent ear infections.
Sulfamethoxazole is applied in skin and soft tissue infections.
Sulfamethoxazole treats cellulitis and abscesses caused by susceptible bacteria.
Sulfamethoxazole is effective in community-acquired MRSA infections.
Sulfamethoxazole is used for urinary tract prophylaxis.
Sulfamethoxazole prevents recurrent urinary infections.
Sulfamethoxazole is applied in long-term low-dose regimens.
Sulfamethoxazole is employed in veterinary medicine.
Sulfamethoxazole treats bacterial infections in livestock.
Sulfamethoxazole is combined with trimethoprim for animal health use.
Sulfamethoxazole is used for bronchitis treatment.
Sulfamethoxazole provides symptomatic relief by eliminating bacterial causes.
Sulfamethoxazole is effective in acute exacerbations of chronic bronchitis.
Sulfamethoxazole is applied in the treatment of toxoplasmosis.
Sulfamethoxazole provides an alternative when pyrimethamine is not available.
Sulfamethoxazole is considered in combination therapies for parasitic infections.
Sulfamethoxazole is used in wound infection management.
Sulfamethoxazole reduces risk of secondary bacterial complications.
Sulfamethoxazole is prescribed for post-surgical infection prevention.
DESCRIPTION
Sulfamethoxazole is a synthetic sulfonamide antibiotic.
Sulfamethoxazole belongs to the class of bacteriostatic antimicrobial agents.
Sulfamethoxazole inhibits bacterial synthesis of dihydrofolic acid.
Sulfamethoxazole has the molecular formula C10H11N3O3S.
Sulfamethoxazole has a molecular weight of 253.28 g/mol.
Sulfamethoxazole appears as a white to off-white crystalline powder.
Sulfamethoxazole is practically insoluble in water.
Sulfamethoxazole is soluble in alkaline solutions.
Sulfamethoxazole is stable under recommended storage conditions.
Sulfamethoxazole is most effective when combined with trimethoprim.
Sulfamethoxazole enhances the blocking of sequential steps in folate synthesis.
Sulfamethoxazole is widely marketed as co-trimoxazole.
Sulfamethoxazole may cause hypersensitivity reactions.
Sulfamethoxazole should be used cautiously in patients with renal impairment.
Sulfamethoxazole is contraindicated in individuals with sulfa allergies.
Sulfamethoxazole is a white to off-white crystalline powder.
It is odorless and practically tasteless.
It is sparingly soluble in water but soluble in alkaline solutions.
Sulfamethoxazole belongs to the sulfonamide class of synthetic antimicrobials.
It works by inhibiting bacterial folic acid synthesis.
It competitively blocks the enzyme dihydropteroate synthase.
PROPERTIES
Chemical Formula: C10H11N3O3S
Molecular Weight: 253.28 g/mol
Common Name: Sulfamethoxazole
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 165–167°C
Solubility: Sparingly soluble in water; soluble in acetone and alkaline solutions
pKa: ~6.0 (weak acid)
Stability: Stable under normal conditions; sensitive to light and heat
Storage Temperature: Store at 15–30°C in a dry, sealed container
FIRST AID
Inhalation:
Move to fresh air if dust is inhaled.
Seek medical attention if respiratory symptoms persist.
Skin Contact:
Wash thoroughly with soap and water.
Seek medical attention if rash or irritation occurs.
Eye Contact:
Rinse with plenty of water for at least 15 minutes.
Seek medical advice if irritation continues.
Ingestion:
If large amounts are ingested, rinse mouth and seek medical advice immediately.
Monitor for gastrointestinal upset or allergic reaction.
Note to Physicians:
Monitor for hypersensitivity reactions and hematologic abnormalities.
Treat symptomatically; provide supportive therapy as required.
HANDLING AND STORAGE
Handling:
Wear gloves, goggles, and protective clothing when handling bulk material.
Avoid dust generation and inhalation.
Wash hands after handling.
Storage:
Store in tightly sealed containers.
Keep in a cool, dry, well-ventilated place.
Protect from light, heat, and moisture.
Spill and Leak Procedures:
Sweep up spills carefully to avoid dust dispersion.
Dispose of waste according to pharmaceutical regulations.
Clean surfaces with water and detergent.
