PRODUCTS

SULPHOSUCCINIC ACID 40 %

Sulphosuccinic acid 40 % is also used as a stabilizer for active pharmaceutical ingredients.
Sulphosuccinic acid 40 % serves as a dispersing agent in textile processing and paint formulations.
Sulphosuccinic acid 40 % is primarily used in producing mild surfactants for personal care products, household cleaners, and industrial applications due to its excellent emulsifying properties.

CAS Number: 5138-18-1
EC Number: 225-898-3
MDL Number: MFCD00075139
Molecular Formula: C₄H₆O₇S
Molecular Weight: 198.15 g/mol

SYNONYMS:
SULFOSUCCINIC ACID, 5138-18-1, 2-Sulfosuccinic acid, Sulphosuccinic acid, Butanedioic acid, sulfo-, Acide sulfosuccinique, Thiosuccinic acid, Succinic acid, sulfo-, Butanedioic acid, 2-sulfo-, X769MZ3BBT, Acide sulfosuccinique [French], DTXSID8042426, EINECS 225-898-3, TEGOKAT S 70, DTXCID6022426, EINECS 249-639-9, Butanedioic acid, sulfo-, monosodium salt, (+-)-SULFOSUCCINIC ACID, SULFOSUCCINIC ACID, (+-)-, 2-Sulfobutanedioic acid, sulfobutanedioic acid, UNII-X769MZ3BBT, 2-Sulfosuccinicacid, 2-sulobutanedioic acid, mono-sulfosuccinic acid, SCHEMBL42084, (+/-)-Sulfobutanedioic acid, CHEMBL3186721, CHEBI:165447, (+/-)-SULFOSUCCINIC ACID, Tox21_301599, SULFOSUCCINIC ACID, (+/-)-, FS74836, NCGC00255996-01, Sulfosuccinic Acid - 70 wt. % in H2O, CAS-5138-18-1, NS00081477, Q2454194, 2-Sulfobutanedioic acid, sodium thiosuccinate, sulfosuccinate, sulfosuccinic acid, thiosuccinic acid, thiosuccinic acid, ammonium salt, thiosuccinic acid, diammonium salt, thiosuccinic acid, disodium salt, thiosuccinic acid, magnesium salt, thiosuccinic acid, monoammonium salt, thiosuccinic acid, monosodium salt, thiosuccinic acid, sodium salt, thiosuccinic acid, trilithium salt, thiosuccinic acid, trisodium salt, (±)-sulfobutanedioate, (±)-sulphobutanedioate, (±)-sulphobutanedioic acid, Thiosuccinic acid, monoammonium salt, Thiosuccinic acid, sodium salt, Thiosuccinic acid, trilithium salt, Sodium thiosuccinate, Sulfosuccinate, Thiosuccinic acid, disodium salt, Thiosuccinic acid, trisodium salt, Thiosuccinic acid, diammonium salt, Thiosuccinic acid, Thiosuccinic acid, ammonium salt, Thiosuccinic acid, magnesium salt, Thiosuccinic acid, monosodium salt, 2-Sulfobutanedioate, 2-Sulphobutanedioate, 2-Sulphobutanedioic acid, Sulfosuccinic acid

Sulphosuccinic acid 40 % is a dicarboxylic acid derivative with a sulfonic acid group (-SO₃H) attached to a succinic acid backbone.
Sulphosuccinic acid 40 %'s bifunctional nature (carboxylic and sulfonic groups) enables versatile applications, particularly in polymer chemistry and membrane technology.

Sulphosuccinic acid 40 % is widely used as a crosslinking agent and proton source in polyvinyl alcohol (PVA)-based membranes for fuel cells, desalination, and pervaporation.
Sulphosuccinic acid 40 % facilitates esterification with hydroxyl groups in polymers, forming durable networks while imparting proton conductivity due to its sulfonic moieties.

Studies highlight Sulphosuccinic acid 40 %'s role in enhancing thermal stability, reducing methanol permeability in fuel cell membranes, and improving desalination efficiency in composite membranes.
Sulphosuccinic acid 40 % is an organic compound with the chemical formula C₄H₆O₇S.

Sulphosuccinic acid 40 % is a dicarboxylic acid that contains a sulfonic acid group, making it a unique member of the succinic acid family.
Sulphosuccinic acid 40 % is often encountered in its sodium salt form, known as sodium sulfosuccinate, which is widely used as a surfactant and emulsifier.

Sulphosuccinic acid 40 % is characterized by its ability to lower surface tension and enhance the solubility of various substances in water, making it valuable in numerous industrial applications.

USES and APPLICATIONS of SULPHOSUCCINIC ACID 40 %:
Sulphosuccinic acid 40 % has diverse applications across various industries.
Sulphosuccinic acid 40 % is primarily used in producing mild surfactants for personal care products, household cleaners, and industrial applications due to its excellent emulsifying properties.

Sulphosuccinic acid 40 % derivatives are utilized as wetting agents and dispersants in agricultural formulations.
These derivatives enhance the effectiveness of pesticides and herbicides.
Its biocompatibility makes Sulphosuccinic acid 40 % suitable for use in drug formulations.

-Applications of Sulphosuccinic acid 40 % in Drug Delivery:
The ability of this compound to form complexes with hydrophobic drugs enhances their delivery efficiency.
Studies have shown that modifying drug molecules with sulfosuccinate moieties can improve their solubility and bioavailability.

Sulfosuccinate-based surfactants have been synthesized to increase the lipophilicity of therapeutic peptides.
This facilitates their incorporation into lipid-based formulations.

-Electrochemical Applications of Sulphosuccinic acid 40 %:
Proton Exchange Membranes (PEMs)
Sulphosuccinic acid 40 % is utilized as a crosslinker in the development of proton exchange membranes, particularly in fuel cell technologies.

Research indicates that when combined with nanocellulose, Sulphosuccinic acid 40 % enhances mechanical robustness and proton conductivity.
For instance, crosslinked cellulose membranes achieved proton conductivity levels up to 40 mS/cm at elevated temperatures (80 °C), providing a sustainable alternative to traditional perfluorosulfonic acid ionomers used in fuel cells.

-Biomedical Applications of Sulphosuccinic acid 40 %:
*Drug Delivery Systems
Sulphosuccinic acid 40 % has been explored as a component in drug delivery systems due to its biocompatibility and ability to form hydrogels.

These hydrogels can encapsulate therapeutic agents and release them in a controlled manner, enhancing the efficacy of treatments while minimizing side effects.
Studies have shown that Sulphosuccinic acid 40 %-based hydrogels can effectively deliver anti-cancer drugs, improving their bioavailability.

*Wound Healing
In wound care, Sulphosuccinic acid 40 %'s properties can be harnessed to create biocompatible dressings that promote healing.

The incorporation of Sulphosuccinic acid 40 % into polymer matrices has been shown to enhance moisture retention and provide a conducive environment for cellular activities involved in wound healing.

-Cosmetic Applications of Sulphosuccinic acid 40 %:
Surfactants and Emulsifiers
Sulphosuccinic acid 40 % derivatives are widely used in cosmetic formulations as surfactants and emulsifiers.

They help stabilize emulsions and improve the texture of products such as shampoos and lotions.
The ability of Sulphosuccinic acid 40 % to interact with both hydrophilic and lipophilic components makes Sulphosuccinic acid 40 % an effective ingredient for enhancing product performance.

BIOTECHNOLOGICAL APPLICATIONS OF SULPHOSUCCINIC ACID 40 %:
Studies suggest Sulphosuccinic acid 40 % might play a role in chelation, the process of binding metal ions.
This property could be relevant in bioremediation or developing metal-chelating drugs.
Further research is needed to elucidate the specific mechanisms involved.

*Analytical chemistry:
Due to its well-defined structure and predictable behavior, Sulphosuccinic acid 40 % is sometimes used as a standard molecule in analytical techniques like ion chromatography.
In this context, the mechanism of action involves the interaction of the charged groups in the molecule with the stationary phase of the chromatography column.

*Chemical Reactions, including:
Esterification:
The reaction of Sulphosuccinic acid 40 % with alcohols leads to the formation of sulfosuccinate esters, which are commonly used as surfactants.
This process typically involves the reaction of maleic anhydride with fatty alcohols followed by sulfonation of the resulting maleic esters.

*Neutralization:
When reacted with bases, Sulphosuccinic acid 40 % forms salts, such as sodium sulfosuccinate.
This reaction is crucial for Sulphosuccinic acid 40 %'s application in detergents and personal care products.

*Catalytic Reactions:
Recent studies have explored the use of Sulphosuccinic acid 40 % as a ligand in metal-center catalysts for synthesizing 5-hydroxymethylfurfural from carbohydrates, demonstrating its versatility beyond traditional applications.

*Biological Activity
Sulphosuccinic acid 40 % exhibits a range of biological activities:

*Surfactant Properties:
As a surfactant, Sulphosuccinic acid 40 % can affect cell membranes and influence cellular processes.
Sulphosuccinic acid 40 %'s ability to form micelles makes it useful in drug delivery systems.

*Antimicrobial Activity:
Some studies suggest that Sulphosuccinic acid 40 % derivatives may possess antimicrobial properties, enhancing their utility in pharmaceuticals and personal care products.

*Biocompatibility:
Due to its relatively low toxicity, Sulphosuccinic acid 40 % and its derivatives have been investigated for use in biocompatible materials, such as hydrogels and membranes.

SCIENTIFIC RESEARCH APPLICATIONS OF SULPHOSUCCINIC ACID 40 %:
*Pharmaceutical Research:
Drug Delivery:
Sulphosuccinic acid 40 %'s ability to chelate metal ions makes it a potential candidate for improving the solubility and bioavailability of poorly soluble drugs.
Studies have shown Sulphosuccinic acid 40 %'s effectiveness in enhancing the dissolution rate and oral absorption of hydrophobic drugs.

*Bioconjugation:
Sulphosuccinic acid 40 % can be used as a linker molecule to attach various functional groups to biomolecules like antibodies or peptides.
This allows for targeted drug delivery and the development of novel therapeutic agents.

Material Science:
*Polymer Synthesis and Modification:
Sulphosuccinic acid 40 % acts as a co-monomer or cross-linker in the synthesis of various polymers.
This modification can improve the properties of the materials, such as their biocompatibility, mechanical strength, and water absorption capacity.

*Proton Conducting Membranes:
Sulphosuccinic acid 40 %-based polymers are being investigated for their potential use in proton exchange membrane fuel cells (PEMFCs).
This is due to their good proton conductivity and thermal stability.

Environmental Science:
*Bioremediation:
Sulphosuccinic acid 40 % can be used to chelate heavy metals in contaminated soils and water.
This facilitates their removal and reduces their environmental impact.

*Biosorption:
Sulphosuccinic acid 40 %-modified materials show promise in removing organic pollutants like dyes and pharmaceuticals from wastewater.
This occurs through adsorption processes.

Analytical Chemistry:
*Ion Chromatography:
Sulphosuccinic acid 40 % serves as an eluent in ion chromatography.

This is a separation technique used to analyze various ionic species.
Sulphosuccinic acid 40 %'s specific properties allow for efficient separation and detection of different ions.

*Metal Ion Detection:
Sulphosuccinic acid 40 % can be incorporated into sensors for the selective detection of specific metal ions.
This is due to Sulphosuccinic acid 40 %'s chelating properties.

ALTERNATIVE PARENTS OF SULPHOSUCCINIC ACID 40 %:
*Dicarboxylic acids and derivatives
*Sulfonyls
*Organosulfonic acids
*Alkanesulfonic acids
*Carboxylic acids
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds

SUBSTITUENTS OF SULPHOSUCCINIC ACID 40 %:
*Thia fatty acid
*Dicarboxylic acid or derivatives
*Organic sulfonic acid or derivatives
*Organosulfonic acid or derivatives
*Organosulfonic acid
*Sulfonyl
*Alkanesulfonic acid
*Carboxylic acid derivative
*Carboxylic acid
*Carbonyl group
*Organosulfur compound
*Organooxygen compound
*Organic oxide
*Organic oxygen compound
*Hydrocarbon derivative
*Aliphatic acyclic compound

INTERACTION STUDIES OF SULPHOSUCCINIC ACID 40 %:
Interaction studies involving Sulphosuccinic acid 40 % focus on its behavior in various formulations.
Research has shown that combining Sulphosuccinic acid 40 % with other surfactants can enhance cleaning efficiency.

Sulphosuccinic acid 40 % can also reduce surface tension more effectively than individual components alone.
Studies indicate that Sulphosuccinic acid 40 % can interact favorably with different polymers.
This leads to improved mechanical properties when used as a crosslinking agent in polymer matrices.

SIMILAR COMPOUNDS OF SULPHOSUCCINIC ACID 40 %:
Sulphosuccinic acid 40 % shares structural similarities with several other compounds.
Its unique combination of dicarboxylic and sulfonic functionalities gives Sulphosuccinic acid 40 % distinct properties.
These properties make Sulphosuccinic acid 40 % particularly effective as a mild surfactant.

It also maintains lower toxicity compared to other surfactants like sodium dodecylbenzenesulfonate.
Sulphosuccinic acid 40 % belongs to the class of organic compounds known as thia fatty acids.
These are fatty acid derivatives obtained by insertion of a sulfur atom at specific positions in the chain.

CHEMICAL STRUCTURE AND PROPERTIES OF SULPHOSUCCINIC ACID 40 %:
Sulphosuccinic acid 40 % is characterized by its sulfonic acid group (-SO₃H) attached to a succinic acid backbone.
This structure imparts unique properties such as increased solubility in water and the ability to act as a surfactant.

The presence of the sulfonic group enhances Sulphosuccinic acid 40 %'s interaction with biological molecules.
This makes Sulphosuccinic acid 40 % a versatile compound in various applications.

*Biological Activity
Surfactant Properties
Sulphosuccinic acid 40 % and its derivatives, such as dioctyl sodium sulfosuccinate (DSS), are widely used as surfactants.
DSS is known for its ability to lower surface tension and enhance the solubility of hydrophobic compounds.

This property is beneficial in drug delivery systems.
Sulphosuccinic acid 40 % can facilitate the absorption of therapeutic agents by improving their solubility in biological fluids.

*Laxative Effects
Dioctyl sodium sulfosuccinate has been used as a stool softener and laxative.
Although anecdotal evidence supports its efficacy, controlled studies have shown mixed results regarding its impact on bowel function.

In one study involving healthy subjects, DSS did not significantly increase stool weight or frequency compared to a placebo.
This suggests that while DSS may have some laxative properties, its effectiveness can vary based on individual circumstances.

*Proton Conductivity
Research has demonstrated that Sulphosuccinic acid 40 % can be utilized in the development of proton-conducting materials.
Sulphosuccinic acid 40 % has been incorporated into polymer matrices to create composite membranes with enhanced proton conductivity.

This is crucial for applications in fuel cells.
These membranes exhibit significant improvements in conductivity due to the presence of sulfonic groups that facilitate proton transport.

SYNTHESIS METHODS OF SULPHOSUCCINIC ACID 40 %:
Several methods are employed to synthesize Sulphosuccinic acid 40 %:

*Reaction with Maleic Anhydride:
The most common method involves reacting maleic anhydride with alcohols under controlled conditions to produce sulfosuccinate esters.
This is followed by sulfonation using sodium sulfite or bisulfite.

*Direct Synthesis from Fumaric Acid:
Another method includes the reaction of fumaric acid with sulfite salts in an aqueous medium, which can yield Sulphosuccinic acid 40 % without introducing metal cations into the product.

*Gas Phase Reactions:
Recent innovations have utilized sulfur dioxide gas under pressure in aqueous solutions containing maleic anhydride or fumaric acid to synthesize Sulphosuccinic acid 40 % directly.

MECHANISM OF ACTION OF SULPHOSUCCINIC ACID 40 %:
Sulphosuccinic acid 40 % exerts its effects primarily through its surfactant properties.
As an anionic surfactant, Sulphosuccinic acid 40 % reduces the surface tension of aqueous solutions, allowing for better mixing and emulsification of hydrophobic substances.

This property is particularly useful in personal care products and pharmaceuticals.
The molecular targets and pathways involved include interactions with lipid membranes and proteins, enhancing the solubility and bioavailability of active ingredients.

PHYSICAL and CHEMICAL PROPERTIES of SULPHOSUCCINIC ACID 40 %:
Physical state: liquid
Color: colorless
Odor: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available

Decomposition temperature: No data available
pH: ca.1 at 20 °C
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: 1,438 g/cm³ at 25 °C
Relative density: No data available

Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: Not classified as explosive
Oxidizing properties: none
Other safety information: No data available
Chemical Formula: C4H6O7S
Average Molecular Mass: 198.151 g/mol
Monoisotopic Mass: 197.983 g/mol
CAS Registry Number: 5138-18-1

IUPAC Name: 2-sulfobutanedioic acid
Traditional Name: 2-sulfobutanedioic acid
SMILES: OC(=O)CC(C(O)=O)S(O)(=O)=O
InChI Identifier: InChI=1S/C4H6O7S/c5-3(6)1-2(4(7)8)12(9,10)11/h2H,1H2,(H,5,6)(H,7,8)(H,9,10,11)
InChI Key: ULUAUXLGCMPNKK-UHFFFAOYSA-N
Water Solubility: 27.3 g/L
logP: -1.1
logS: -0.86
pKa (Strongest Acidic): -1.7
Physiological Charge: -3

Hydrogen Acceptor Count: 7
Hydrogen Donor Count: 3
Polar Surface Area: 128.97 Å²
Rotatable Bond Count: 4
Refractivity: 33.52 m³·mol⁻¹
Polarizability: 15.06 Å³
Number of Rings: 0
Bioavailability: 1
Rule of Five: Yes

Ghose Filter: No
Veber's Rule: No
MDDR-like Rule: No
CAS No.: 5138-18-1
M. Wt: 198.15 g/mol
InChI Key: ULUAUXLGCMPNKK-UHFFFAOYSA-N
IUPAC Name: 2-sulfobutanedioic acid
InChI: InChI=1S/C4H6O7S/c5-3(6)1-2(4(7)8)12(9,10)11/h2H,1H2,(H,5,6)(H,7,8)(H,9,10,11)
InChI Key: ULUAUXLGCMPNKK-UHFFFAOYSA-N

Canonical SMILES: C(C(C(=O)O)S(=O)(=O)O)C(=O)O
Molecular Formula: C4H6O7S
Related CAS: 52740-64-4 (di-NH4 salt),
13419-59-5 (tri-Na salt), 14933-03-0 (di-Na salt),
20526-58-3 9Na salt),
29454-16-8 (mono-Na salt), 55098-36-7 (Mg salt),
64051-32-7 (mono-NH4 salt),
75499-40-0 (NH4 salt), 94138-92-8 (tri-Li salt)
DSSTOX Substance ID: DTXSID8042426
Molecular Weight: 198.15 g/mol

CAS No.: 5138-18-1
Boiling point: 140 °C (1013 hPa)
Density: 1.46 g/cm3 (20 °C)
pH value: 1 (H₂O, 20 °C) (saturated aqueous solution)
Molecular Weight: 198.15 g/mol
XLogP3-AA: -1.8
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 7
Rotatable Bond Count: 4
Exact Mass: 197.98342370 Da
Monoisotopic Mass: 197.98342370 Da

Topological Polar Surface Area: 137 Å²
Heavy Atom Count: 12
Formal Charge: 0
Complexity: 283
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1

Compound Is Canonicalized: Yes
Linear Formula: HOOCCH2CH(SO3H)COOH
CAS Number: 5138-18-1
Molecular Weight: 198.15
Beilstein: 1727687
MDL number: MFCD00075139
UNSPSC Code: 12162002
PubChem Substance ID: 24860555
NACRES: NA.23

CAS Number: 5138-18-1
Product Name: Sulfosuccinic acid
IUPAC Name: 2-sulfobutanedioic acid
Molecular Formula: C4H6O7S
Molecular Weight: 198.15 g/mol
InChI: InChI=1S/C4H6O7S/c5-3(6)1-2(4(7)8)12(9,10)11/h2H,1H2,(H,5,6)(H,7,8)(H,9,10,11)
InChI Key: ULUAUXLGCMPNKK-UHFFFAOYSA-N
SMILES: C(C(C(=O)O)S(=O)(=O)O)C(=O)O

FIRST AID MEASURES of SULPHOSUCCINIC ACID 40 %:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of SULPHOSUCCINIC ACID 40 %:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of SULPHOSUCCINIC ACID 40 %:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of SULPHOSUCCINIC ACID 40 %:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of SULPHOSUCCINIC ACID 40 %:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of SULPHOSUCCINIC ACID 40 %:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available