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SymBright 2036 is an exposome-proof skin brightener produced by bio-fermentation of sclareol sourced from Clary sage.
SymBright 2036 acts as a protecting and brightening agent.
SymBright 2036 is a multifunctional molecule from natural origin (Salvia Sclarea) that prevents pigmentation disorders and dark spots resulting from environmental stressors, including UV rays, visible light, pollution and oxidative stress.
CAS Number: 564-20-5
Molecular Formula: C16H26O2
Molecular Weight: 250.38
EINECS Number: 209-269-0
Synonyms: Sclareolide, 564-20-5, (3aR)-(+)-Sclareolide, Norambreinolide, CLAREOLIDE, 12-Norambreinolide, (+)-sclareolide, (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyldecahydronaphtho[2,1-b]furan-2(1H)-one, (3aR,5aS,9aS,9bR)-Decahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan-2(1H)-one, MLS001173371, (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-1,4,5,5a,7,8,9,9b-octahydrobenzo[e][1]benzofuran-2-one, DTXSID8047686, 37W4O0O6E6, SMR000538921, Decahydrotetramethylnaphthofuranone, Norambreinolide, (+)-, UNII-37W4O0O6E6, MFCD00134168, (3aR)-(+)-Sclareolide; (+)-12-Norambreinolide; Decahydrotetramethylnaphthofuranone, Naphtho(2,1-b)furan-2(1H)-one, decahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)-, EINECS 209-269-0, CLARY SAGE LACTONE, SCLAREOLIDE [FHFI], (3a,R)-(+)-Sclareolide, SCHEMBL83395, Sclareolide (Norambreinolide), CHEMBL304461, cid_929262, DTXCID6027686, FEMA NO. 3794, BDBM75178, CHEBI:156168, HMS2860M07, (3aR)-(+)-Sclareolide, 97%, HY-N0129, Tox21_302544, s2355, AKOS015901397, CCG-208493, DS-7369, NCGC00163620-01, NCGC00163620-03, NCGC00256856-01, 3a,4,5,5aalpha,6,7,8,9,9a,9balpha-decahydro-3abeta,6,6,9abeta-tetramethylnaphtho(2,1-b)furan-2(1H)-one, CAS-564-20-5, Naphtho(2,1-b)furan-2(1H)-one, 3a,4,5,5aalpha,6,7,8,9,9a,9balpha-decahydro-3abeta,6,6,9abeta-tetramethyl-, Naphtho(2,1-b)furan-2(1H)-one, decahydro-3a,6,6,9a-tetramethyl-, (3aR-(3aalpha,5abeta,9aalpha,9bbeta))-, (3aR)-(+)-Sclareolide, analytical standard, CS-0007855, S0847, (3aR)-(+)-Sclareolide, natural, 97%, FG, H10516, A869953, SR-01000812893, SR-01000812893-3, BRD-K72925150-001-10-3, BRD-K72925150-001-11-1, (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-1,4,5,5a,7,8,9,9b-octahydrobenzo[e][1]benzouran-2-one, (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-1,4,5,5a,7,8,9,9b-octahydrobenzo[e]benzofuran-2-one, (3AR-(3aalpha,5abeta,9aalpha,9bbeta))decahydro-3a,6,6,9a-tetramethylnaphth(2,1-b)furan-2(1H)-one.
SymBright 2036 is suggested for use in various skin care applications.
SymBright 2036 protects skin luminosity and provides skin brightening effects against exposome induced hyperpigmentation.
This multi-talented natural molecule is proven to prevent pigmentation disorders caused by UVs but also to enhance & protect the skin brightness from other environmental aggressors like visible light, urban pollution & stress.
SymBright 2036 is an exposome-proof skin brightener produced by bio-fermentation of sclareol sourced from Clary sage.
This multi-talented natural molecule is proven to prevent pigmentation disorders caused by UVs but also to enhance & protect the skin brightness from other environmental aggressors like visible light, urban pollution & stress
SymBright 2036 is a patented & optimized complex combining the power of SymBright 2036 with Niacinamide. By targeting UV-induced pigmentation at different stages, it provides optimal skin brigthening effect for any skin types.
SymBright 2036 enhances and protects skin luminosity against UV-induced damage like oxidative stress and pigmentation issues.
SymBright 2036 improves overall skin appearance: both skin tone & skin texture.
It offers proven efficacy on dark spots: day after day, dark spots are less visible, less numerous, less intense & smaller.
SymBright 203636 is a skincare ingredient developed by Symrise, a global supplier of fragrances, flavors, food, nutrition, and cosmetic ingredients.
SymBright 2036 is primarily used for its skin-brightening properties and is included in various cosmetic and personal care formulations.
SymBright 2036, isolated from clary sage by solvent extraction, can be efficiently oxidized by the microorganism Cryptococcus albidus to sclareolide.
SymBright 2036 is a diterpenoid compound mainly used in the perfume industry for its amber like odor.
SymBright 2036 is a natural compound derived from fermented Schisandra fruit.
SymBright 2036, also known as Wu Wei Zi in traditional Chinese medicine, is a fruit known for its adaptogenic properties and antioxidant benefits.
The active compound in SymBright 2036 is Buddlein A, which is known for its potent skin-brightening effects.
SymBright 2036 works by inhibiting the production of melanin, the pigment responsible for skin color.
By reducing melanin synthesis, it helps to lighten dark spots and even out the skin tone, making it effective for hyperpigmentation treatment.
SymBright 2036 protects the skin from oxidative stress caused by UV radiation and environmental pollutants.
This antioxidant activity helps prevent the formation of new dark spots and supports overall skin health.
SymBright 2036 effectively targets and reduces dark spots, freckles, and other forms of hyperpigmentation.
By promoting a more uniform skin tone and reducing pigmentation, SymBright 2036 enhances overall skin luminosity and brightness.
Environmental Stressors: The antioxidant properties help protect the skin from damage caused by free radicals, UV radiation, and environmental pollutants.
Unlike some other brightening agents (such as hydroquinone or high concentrations of AHAs), SymBright 2036 is gentle and suitable for sensitive skin, minimizing the risk of irritation.
SymBright 2036 is used in various skincare formulations, including serums, creams, lotions, and masks, designed to target dark spots, uneven skin tone, and dullness.
SymBright 2036 can be formulated into sunscreens and after-sun products to prevent pigmentation caused by UV exposure and enhance the protective effects of these products.
Due to its brightening and protective effects, it is also found in anti-aging formulations to reduce the appearance of age spots and improve overall skin clarity.
SymBright 2036 is considered safe for daily use in cosmetic formulations.
It has been tested for skin compatibility and does not typically cause irritation or sensitivity.
SymBright 2036 can be used alongside other skincare ingredients, such as niacinamide, hyaluronic acid, peptides, and mild exfoliants, to enhance overall skin-brightening and anti-aging effects.
Melting point: 124-126 °C (lit.)
alpha: 47 º(c=2, chloroform)
Boilingpoint: 321.4±10.0 °C(Predicted)
Density: 1.009±0.06 g/cm3(Predicted)
vapor pressure: 0Pa at 25℃
FEMA: 3794 | SCLAREOLIDE
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly)
form: Solid
color: White to Off-White
Odor: at 10.00 % in isopropyl myristate. dry paper woody ambergris labdanum
Odor Type: woody
optical activity: [α]20/D +47°, c = 2% in chloroform
Water Solubility: 10mg/L at 25℃
JECFA Number: 1165
InChIKey: IMKJGXCIJJXALX-SHUKQUCYSA-N
LogP: 4.5 at 25℃
SymBright 2036 has undergone various clinical studies to demonstrate its efficacy and safety for skin brightening and antioxidant protection.
These studies typically involve human volunteers using formulations containing SymBright 2036 over a period of time, with results showing a reduction in melanin content and visible skin brightening.
Laboratory studies on skin cells and tissue cultures have shown that SymBright 2036 can effectively inhibit the enzyme tyrosinase, which is crucial in melanin synthesis.
This inhibition leads to a reduction in melanin production, helping to fade existing dark spots and prevent new ones from forming.
SymBright 2036 is compatible with a wide range of other active ingredients commonly used in skincare.
This combination enhances brightening effects while also improving skin barrier function and reducing redness.
Provides hydration and plumping benefits, which complement the brightening effects of SymBright 2036.
Both are known for their brightening and antioxidant properties, making them a powerful combination for targeting hyperpigmentation and signs of aging.
When used together with SymBright 2036, retinoids can enhance cell turnover and improve skin texture while reducing the risk of irritation that some retinoids might cause.
SymBright 2036 is designed to be stable in various cosmetic formulations.
It maintains its effectiveness over time without significant degradation, even when exposed to light and air, making it an ideal ingredient for a wide range of products.
SymBright 2036 is stable in a range of pH levels commonly used in skincare products, allowing formulators to incorporate it easily into existing product lines without the need for extensive modifications.
Symrise, the developer of SymBright 2036, emphasizes sustainability and responsible sourcing practices.
The active ingredient is derived from natural sources, and the fermentation process used to extract it is designed to minimize environmental impact.
SymBright 2036 is often marketed as a vegan and cruelty-free ingredient, aligning with consumer demand for ethical and sustainable cosmetic products.
SymBright 2036 does not contain animal-derived ingredients, and no animal testing is involved in its development.
In skincare formulations, SymBright 2036 is typically used at concentrations ranging from 0.1% to 1%.
Higher concentrations may offer more potent brightening effects but should be balanced against potential irritation, especially in sensitive skin types.
Products containing SymBright 2036 are usually applied once or twice daily, often after cleansing and before moisturizing.
Users are advised to apply sunscreen during the day to protect against UV damage, which can counteract the brightening effects.
Due to its brightening properties, SymBright 2036 is frequently included in targeted treatments, such as spot correctors or dark spot serums, aimed at addressing specific areas of hyperpigmentation.
SymBright 2036 is also used in serums, creams, and lotions designed for overall skin brightening and evening of skin tone, providing a more uniform complexion.
SymBright 2036 can be effective in products targeting PIH, a common skin concern following acne or other inflammatory conditions.
By reducing melanin synthesis, it helps fade post-acne marks and other discolorations.
Consumers who use products with SymBright 2036 often report visible improvements in skin tone, reduced appearance of dark spots, and an overall brighter complexion.
SymBright 2036 is praised for its effectiveness without causing significant irritation, making it suitable for a wide range of skin types.
Unlike some other brightening agents that can cause irritation or redness, SymBright 2036 is generally well-tolerated, making it a popular choice among individuals with sensitive skin or those new to brightening products.
Research is ongoing to explore new formulations and combinations with SymBright 2036 to enhance its efficacy and expand its use in various cosmetic applications.
This could include integration with new technologies like encapsulation to improve delivery and potency.
Beyond traditional skincare, SymBright 2036 may find use in other areas of personal care, such as body lotions, hand creams, and even hair care products, to offer brightening and antioxidant benefits across different product categories.
Uses
SymBright 2036 is found in Salvia yosgadensis and is a close analog of sclareol, an antifungal diterpene.
SymBright 2036 is used products specifically designed to target and reduce dark spots, age spots, and other forms of hyperpigmentation.
Applied to localized areas of pigmentation to help lighten and even out skin tone.
Incorporated into serums and creams that aim to enhance overall skin brightness and luminosity, providing a more radiant complexion.
SymBright 2036 is used in face masks designed to improve skin clarity and brightness with a single application.
Added to formulations targeting signs of aging, such as uneven skin tone and dullness, to improve skin radiance and reduce the appearance of age spots.
Included in overnight treatments to enhance skin tone and brightness as part of a nighttime skincare regimen.
Formulated into sunscreens to provide additional brightening effects while protecting the skin from UV damage, which can exacerbate pigmentation issues.
SymBright 2036 is used in products designed to soothe and repair the skin after sun exposure, helping to prevent post-sun pigmentation.
Suitable for sensitive skin types, where it is used in products designed to brighten the skin without causing irritation or redness.
Combined with other soothing ingredients to address redness and uneven skin tone in sensitive skin.
SymBright 2036 is used in formulations targeting post-acne marks and scars to help fade discoloration and even out skin tone.
Added to products aimed at reducing pigmentation resulting from inflammatory skin conditions.
Incorporated into everyday moisturizers to provide continuous brightening benefits while hydrating the skin.
Sometimes included in cleansers or exfoliating products to enhance skin radiance and clarity through gentle exfoliation.
SymBright 2036 utilized in professional spa treatments and facials for immediate and visible brightening effects.
Featured in premium skincare products marketed for their advanced brightening and anti-aging properties.
Added to primers or foundations to provide a luminous base and even skin tone before applying makeup.
Incorporated into highlighters to enhance skin radiance and create a glowing effect.
SymBright 2036 is used in body lotions to improve skin tone and reduce discoloration on larger areas of the body.
Although less common, it may be used in hair care products to address scalp pigmentation issues or enhance overall scalp health.
SymBright 2036 helps to even out skin tone by reducing the appearance of uneven pigmentation.
SymBright 2036 can be particularly useful for individuals with redness or discoloration from conditions like rosacea or post-acne marks.
Added to post-surgical or post-procedure skincare products to help manage pigmentation changes and support skin healing.
SymBright 2036 can be used in products designed to address pigmentation changes resulting from dermatological treatments.
SymBright 2036 is used in conjunction with other skin-brightening agents, such as vitamin C, alpha hydroxy acids (AHAs), or beta hydroxy acids (BHAs), to enhance overall brightening effects and improve skin texture and clarity.
Combined with moisturizing ingredients like hyaluronic acid or glycerin to boost hydration while addressing pigmentation concerns.
SymBright 2036 utilized in customized skincare formulations tailored to individual skin concerns, such as specific types of hyperpigmentation or uneven skin tone.
Included in at-home skincare recipes or DIY formulations for personalized skin brightening treatments.
Found in dermatologist-recommended products for patients dealing with pigmentation disorders or post-inflammatory pigmentation.
SymBright 2036 is used in therapeutic skincare lines that address specific pigmentation issues or other skin health concerns.
Formulated according to international regulations and standards for cosmetic ingredients, ensuring safety and efficacy in various markets.
Often included in products with claims of skin brightening, even skin tone, and radiance enhancement, supported by clinical research and safety data.
Safety Profile:
In some individuals, SymBright 2036 can cause irritation, redness, or sensitivity, particularly if they have sensitive skin or are using products with high concentrations of the ingredient.
SymBright 2036 is advisable to perform a patch test before using products containing SymBright 2036 extensively to ensure there is no adverse reaction.
Although rare, some users might experience allergic reactions or contact dermatitis, which could include symptoms like itching, swelling, or rash.
SymBright 2036 have a history of allergies to cosmetic ingredients, consult with a dermatologist before using products containing SymBright 2036.
SymBright 2036 may interact with other active ingredients, such as retinoids or strong exfoliants, potentially leading to increased sensitivity or irritation.
Ensure compatibility when using SymBright 2036 in conjunction with other active ingredients to prevent adverse effects.
While SymBright 2036 itself does not increase sun sensitivity, products aimed at brightening the skin may make the skin more susceptible to sun damage if proper sun protection is not used.
Always use broad-spectrum sunscreen during the day when using brightening products to protect the skin from UV radiation.
