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TELMISARTAN

CAS NO.:  144701-48-4
EC / LIST NO.:  620-494-7

Telmisartan is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.
Telmisartan is a reasonable initial treatment for high blood pressure.
Telmisartan is taken by mouth.
Versions are available as the combination telmisartan/hydrochlorothiazide, telmisartan/cilnidipine and telmisartan/amlodipine.
Compared to other drugs in its class, Telmisartan has a relatively high dosing, on average 80 mg/day.

Common side effects include upper respiratory tract infections, diarrhea, and back pain. 
Serious side effects may include kidney problems, low blood pressure, and angioedema.
Use in pregnancy may harm the baby and use when breastfeeding is not recommended.
Telmisartan is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II. 

Telmisartan was patented in 1991 and came into medical use in 1999.
Telmisartan is available as a generic medication.
In 2018, it was the 292nd most commonly prescribed medication in the United States, with more than 1 million prescriptions


Telmisartan is an angiotensin II receptor blocker (sometimes called an ARB) that is used to treat high blood pressure (hypertension). 
Lowering blood pressure may lower your risk of a stroke or heart attack.

Telmisartan is also used to reduce the risk of stroke, heart attack, or death from heart problems in people who are at least 55 years old with risk factors for serious heart disorders.

Telmisartan may also be used for purposes not listed in this medication guide.

Telmisartan oral tablet is a prescription drug that’s available as the brand-name drug Micardis. 
Telmisartan also available as a generic drug. 
Generic drugs usually cost less than the brand-name version. 
In some cases, they may not be available in all strengths or forms as the brand-name drug.

Telmisartan is used to lower high blood pressure. 
Telmisartan may also be used to lower your risk for heart attack, stroke, or death from heart disease. 
Telmisartan given to adults who are 55 years or older and at high risk of major heart disease events who can’t take angiotensin-converting enzyme (ACE) inhibitors.

To treat high blood pressure, telmisartan may be taken in combination with other blood pressure-lowering drugs.

Telmisartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). 
A class of drugs is a group of medications that work in a similar way. 
They’re often used to treat similar conditions.


Telmisartan works by blocking the effect of angiotensin. 
This makes your blood vessels relax more. 
Telmisartan also allows your kidney to get rid of excess water and salt. 
This helps lower your blood pressure.

This is a summary of the European public assessment report (EPAR) for Telmisartan Teva Pharma. 
Telmisartan explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Telmisartan Teva Pharma.

Telmisartan is used to treat high blood pressure (hypertension), sometimes in combination with other blood pressure medications.

Telmisartan is also used to reduce the risk of stroke, heart attack, or death from heart problems in people who are at least 55 years old with risk factors for serious heart disorders.

Telmisartan may also be used for purposes not listed in this medication guide.

Telmisartan (Micardis) is an angiotensin receptor blocker (ARB). 
Telmisartan blocks a chemical in your body that tightens blood vessels, which makes blood vessels more relaxed. 
Having more relaxed blood vessels causes your blood pressure to go down.

Telmisartan is an angiotensin receptor blocker (also called an angiotensin-II receptor antagonist (A2RA)). 
Telmisartan is used to treat high blood pressure (hypertension). 
People with high blood pressure often do not feel unwell but, if left untreated, high blood pressure can harm the heart and damage blood vessels.

Telmisartan works by blocking the effect of a natural chemical made in your bloodstream, called angiotensin II. 
Angiotensin II causes your blood vessels to narrow, so by blocking this effect, telmisartan allows your blood vessels to relax and widen.
As this happens, the pressure within your blood vessels is reduced. 
This also makes it easier for your heart to pump blood around your body.

Telmisartan is also used to help prevent heart attacks and strokes in people who may be at risk of these because of other medical conditions, such as diabetes.

Telmisartan is also available in a combination tablet with another medicine used to reduce high blood pressure, called hydrochlorothiazide. 
Taking combination tablets like this can help reduce the number of tablets you need to take each day.


Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. 
Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure. 
Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.

Telmisartan is a member of a family of drugs called angiotensin receptor blockers (ARBs), which includes losartan (Cozaar), valsartan (Diovan), irbesartan (Avapro), and candesartan (Atacand). 
Telmisartan formed in the blood by the action of angiotensin converting enzyme (ACE), is a powerful chemical that attaches to angiotensin receptors found in many tissues but primarily on muscle cells of blood vessels. 
Telmisartan attachment to the receptors causes muscle cells to shorten and narrow the blood vessels (vasoconstrict), which leads to an increase in blood pressure (hypertension). 
Telmisartan blocks the angiotensin receptor. 
By blocking the action of angiotensin, telmisartan widens blood vessels (vasodilate) and reduces blood pressure. 
Telmisartan was approved by the FDA in November 2000.
Telmisartan is a member of a family of drugs called angiotensin receptor blockers (ARBs), which includes losartan (Cozaar), valsartan (Diovan), irbesartan (Avapro), and candesartan (Atacand). 
Telmisartan formed in the blood by the action of angiotensin converting enzyme (ACE), is a powerful chemical that attaches to angiotensin receptors found in many tissues but primarily on muscle cells of blood vessels. 
Telmisartan attachment to the receptors causes muscle cells to shorten and narrow the blood vessels (vasoconstrict), which leads to an increase in blood pressure (hypertension). 
Telmisartan blocks the angiotensin receptor. 
By blocking the action of angiotensin, telmisartan widens blood vessels (vasodilate) and reduces blood pressure. 
Telmisartan was approved by the FDA in November 2000.

Telmisartan lowers blood pressure. 
Telmisartan is used for high blood pressure.
The effect comes on gradually over 4 to 8 weeks. 
Then you can measure how much your blood pressure has fallen.
Using it every day reduces the risk of cardiovascular disease.
You may feel dizzy when you stand up for the first few weeks. 
Therefore, take the medicine in the evening for the first few days, when you are sitting on your bed. 
Then you can lie down if you get dizzy.
There are a few important interactions with other agents. 
Ask your pharmacist if it is safe to take telmisartan with your other medicines, including those bought without a prescription.
Do not use if you are pregnant.

Telmisartan belongs to a class of medications known as angiotensin II receptor antagonists. 
These medications reduce blood pressure by blocking the actions of a chemical (angiotensin II) that causes blood vessels to constrict or tighten. 
Telmisartan is used to treat mild-to-moderate high blood pressure.

When blood pressure is allowed to remain high for a long time, the blood vessels of the heart, kidneys, and brain may become damaged. 
This puts a person at increased risk for heart attack and stroke as well as kidney failure and blindness. Keeping blood pressure in the normal range can reduce the risk for these conditions.

Telmisartan is also used to reduce the risk of death caused by a heart attack or stroke, for people who cannot use another type of medication called angiotensin-converting enzyme inhibitor.

This medication may be available under multiple brand names and/or in several different forms.
Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. 
As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. 
If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. 
Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. 
Telmisartan can be harmful for people to take this medication if their doctor has not prescribed it.

Telmisartan is indicated for therapeutic and therapeutic purposes such as Diabetes, High Blood Pressure, Heart attack, Heart training.

Telmisartan, according to the package leaflet (Telmisartan Apotex), is an orally active and selective angiotensin II receptor (type AT1) antagonist. 
Telmisartan displaces angiotensin II with high affinity from its binding site at the AT1 receptor subtype, which is responsible for the known mechanism of action of angiotensin II. 
Telmisartan does not exhibit any partial agonist activity at the AT1 receptor. 
Telmisartan selectively binds the AT1 receptor. 
This connection is long lasting.

Telmisartan has no affinity for other receptors, including the AT2 receptor and other, less understood, AT receptor subtypes. 
The function of these receptors is unknown; the effects of their excessive stimulation by angiotensin II, the concentration of which increases under the influence of telmisartan, are also unknown. Telmisartan lowers the levels of aldosterone.

Telmisartan - an antihypertensive medicine that prevents the blood vessel walls from spasming. 
Telmisartanbelongs to a group of medicines called angiotensin II receptor antagonists (these medicines are also called sartans or abbreviated as ARB, which is derived from the English name Angiotensin II Receptor Blockers).). 
Telmisartan, like other sartans, works by selectively blocking angiotensin II receptors (specifically the so-called AT1 receptors) found, inter alia, in on the surface of smooth muscle cells in the walls of blood vessels. 
Blocking these receptors prevents them from binding to angiotensin II, which inhibits its effects. 
Angiotensin II is a substance that causes blood vessels to constrict, affects the function of the kidneys and stimulates the release of aldosterone from the adrenal glands. 
The effect of angiotensin II is an increase in blood pressure as well as morphological changes in the cardiovascular system (e.g. thickening of the vascular walls, cardiac hyperplasia). 
The effects of telmisartan, like that of other drugs of this class, are is effective in blocking the biological effects of angiotensin II and as a result leads to vasodilation, a reduction in aldosterone levels and a reduction in blood pressure. 
Telmisartan, like other sartans, is used for treatmenthigh blood pressure. 
Telmisartan lowers blood pressure (systolic and diastolic) without affecting the heart rate. 
Lowering in blood pressure occurs gradually over 3 hours after taking a single dose of telmisartan and is sustained over a 24 hour period. 
Usually it takes 4-8 years for the antihypertensive effect to fully develop. weeks of using the preparation. 
Discontinuation of telmisartan in patients with hypertension does not cause a sudden increase in blood pressure (no rebound effect). 
Blood pressure gradually returns to pre-treatment levels over a period of several days. 
Additionally, telmisartan is used in the prevention of cardiovascular diseases in people at risk. 
People with overt atherosclerotic disease (ischemic heart disease,history of stroke , peripheral arterial disease) and patients with type 2 diabetes with organ damage. 
The incidence of adverse reactions for telmisartan in clinical trials did not differ from the incidence of adverse reactions with placebo.

Telmisartan is used to treat high blood pressure. Lowering blood pressure and keeping it at a normal level will help prevent strokes, heart attacks, and kidney problems. 
This active ingredient works by dilating blood vessels so that blood can flow more easily.

Telmisartan is also used to treat heart failure and to help protect the kidneys from damage caused by diabetes.

Some other side effects of drugs that are not listed on the approved drug label, but your doctor may direct you to take. 
You should only use this medicine to treat certain medical conditions only when prescribed by your doctor.

Read the leaflet provided by your pharmacist carefully before you start using this medicine and each time you use it again. 
If you have any questions, consult your doctor or pharmacist.

Take this medication with or without food as directed by your doctor, usually once a day.

Dosage is based on your medical condition and response to medication.

Take this medication regularly to get the best benefit from it. 
Remember to take your medicine at the same time each day. 
Telmisartan is important to continue taking your medicine even if you feel better. 
Most people with high blood pressure don't usually feel sick. 
For the treatment of high blood pressure, it may take up to 4 weeks to get the full effect from this medicine.

Tell your doctor if your condition does not improve or gets worse (such as if your blood pressure is still high or increased).


Telmisartan Tablets contain NLT 90.0% and NMT 110.0% Change to read:
of the labeled amount of telmisartan (C33H30N4O2).

Telmisartan (Micardis, Pritor), a highly selective angiotensin II (AII) type 1 (AT1) receptor antagonist, is approved for the treatment of hypertension, either as monotherapy or in combination with other antihypertensive agents. 
The long elimination half-life of telmisartan ensures the drug provides effective reductions in blood pressure (BP) across the entire 24-hour dosage interval.
Extensive evidence from well designed clinical trials and the clinical practice setting indicates that telmisartan, either as monotherapy or in combination with other antihypertensive agents, provides long-term antihypertensive efficacy and is well tolerated in a broad spectrum of hypertensive patients, including the elderly and those with coexisting type 2 diabetes mellitus, metabolic syndrome and/or renal impairment. 
Notably, BP control is sustained throughout the 24-hour dosage interval, including during the last 6 hours of this period. 
Independent of its effect on BP, telmisartan displays favourable effects on insulin resistance, lipid levels, left ventricular hypertrophy (LVH) and renal function. 
The consistent antihypertensive efficacy during the entire 24-hour dosage interval and sustained BP-lowering effect in the long term, combined with its favourable tolerability profile, mean that telmisartan is a valuable first-line treatment option for the management of essential hypertension.

Telmisartan is chemically described as 4'-[(1,4'-dimethyl-2'-propyl [2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid. 
Telmisartan empirical formula is C33H30N4O2, its molecular weight is 514.63,

Telmisartan is a white to slightly yellowish solid. 
Telmisartan is practically insoluble in water and in the pH range of 3 to 9, sparingly soluble in strong acid (except insoluble in hydrochloric acid), and soluble in strong base. 


Read the Patient Information Leaflet if available from your pharmacist before you start taking telmisartan and each time you get a refill. 
If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

The dosage is based on your medical condition and response to treatment.

Use this medication regularly to get the most benefit from it. 
To help you remember, take it at the same time each day. 
Keep taking this medication even if you feel well. 
Most people with high blood pressure do not feel sick. 
For the treatment of high blood pressure, it may take up to 4 weeks before you get the full benefit of this drug.

Telmisartan is used to treat high blood pressure, heart failure, and diabetic kidney disease.
Telmisartan is a reasonable initial treatment for high blood pressure.
Telmisartan is contraindicated during pregnancy. 
Like other drugs affecting the renin–angiotensin system (RAS), telmisartan can cause birth defects, stillbirths, and neonatal deaths. 
Telmisartan is not known whether the drug passes into the breast milk.
Also Telmisartan is contraindicated in bilateral renal artery stenosis in which it can cause kidney failure.

This medication is used to treat high blood pressure (hypertension). 
Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. 
Telmisartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). 
Telmisartan works by relaxing blood vessels so blood can flow more easily.

Telmisartan is used for the treatment of hypertension. 
Telmisartan may be used alone or in combination with other antihypertensive agents.

Telmisartan is used for reducing the risk of heart attack, stroke, or death from cardiovascular causes in patients 55 years of age or older who are at high risk for developing major cardiovascular events and unable to take ACE inhibitors. 
High risk for cardiovascular events can be evidenced by a history of coronary artery disease, peripheral arterial disease, stroke, transient ischemic attack, or high-risk diabetes (insulin-dependent or non-insulin dependent) with evidence of end-organ damage

Telmisartan is used alone or in combination with other drugs to treat high blood pressure . 
Telmisartan is also used to reduce the risk of heart attack , stroke or death in people 55 years of age or older who are at high risk of developing cardiovascular disease.

Telmisartan, as already mentioned, belongs to a class of drugs known as angiotensin II receptor antagonists. 
Telmisartan works by blocking the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly and the heart to pump more efficiently.

High blood pressure is a common condition and, if left untreated, it can damage the brain, heart, blood vessels, kidneys and other parts of the body. 
Damage to these organs can cause heart disease, heart attack, heart failure , stroke, kidney failure , blindness, and other problems.

In addition to taking medications, changing your lifestyle will also help control your blood pressure. 
These changes include eating a diet low in fat and salt, maintaining a healthy weight, exercising for at least 30 minutes most days, quitting smoking and reducing alcohol consumption, preferably stopping alcohol altogether.

IUPAC NAME:

2-(4-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic acid
 
2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]-methyl]phenyl]benzoic acid
 
2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid
  
4'-((1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazol-3'-yl)methyl)biphenyl-2-carboxylic acid
 
4'-((2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-benzimidazole-1-yl)methyl)biphenyl-2-carbonic acid
 
4'-(1,7'-Dimethyl-2'-propyl-1H-[2,5']bibenzoimidazolyl-3'-ylmethyl)-biphenyl-2-carboxylic acid

SYNONYMS:

[1,1'-Biphenyl]-2-carboxylic acid, 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-  
144701-48-4  
4'[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid
4'-[(1,7'-Dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]-2-biphenylcarbonsäure  
4'-[(1,7'-Dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]-2-biphenylcarboxylic acid   
4'-[(1,7'-Dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carbonsäure  
4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid
7144
Acide 4'-[(1,7'-diméthyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)méthyl]-2-biphénylcarboxylique   
acide 4'-[(1,7'-diméthyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)méthyl]biphényl-2-carboxylique 
 

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