PRODUCTS

TETRADIUM RUTICARPUM FRUIT EXTRACT

Tetradium Ruticarpum Fruit Extract has also being shown to possess antitumor activity.
Tetradium Ruticarpum Fruit Extract is frequently used in a combination supplement called Wu Zhu Yu Tang, which consists of Evodia fruit with Jujube Fruit and Panax Ginseng (1:1:1 ratio) and Ginger root (twice the amount of any one other ingredient) which is a decoction used for hypertension or as Zuo jin wanwhich is used for gastrointestinal distress alongside Rhizoma Coptidis at a 1:6 ratio (Evodia:Coptidis).

CAS Number: Not available
EC Number: Not available

SYNONYMS:
Wu Zhu Yu Extract, Evodia Fruit Extract, Evodia Rutaecarpa Extract, Tetradium Fruit Extract, Evodiamine Extract, Rutaecarpine Extract, Evodia Rutaecarpa Juss Extract, Tetradium ruticarpum Extract, Euodia rutaecarpa fruits Extract, Ampacus ruticarpa fruits Extract

Tetradium Ruticarpum Fruits Extract is obtained from the dried and nearly ripe fruits of Tetradium ruticarpum (A. Juss.) T.G. Hartley, which have long been used in treating headache and gastrointestinal disorders in oriental medicine.
Tetradium Ruticarpum is a small deciduous tree, reaching a height of 9 meters.

The plant has glossy, feathery leaves, reaching a length of 40 centimeters.
Leaflets of the blade are both elliptical and ovoid, less often lanceolate.
Flowers have 4-5 white, yellow or pale green petals, collected in large (up to 18 centimeters) inflorescence.

Fruits that open initially are brightly rusty-red, when fully ripened, crack and uncover the shiny, black seeds.
Tetradium ruticarpum (Evodia rutaecarpa) is a plant, which belongs to a genus of 9 species of trees.
It is known as Euodia or Bee bee tree in the west because it was classified to the genus Euodia in the ancient literature.

The volatile oil of Tetradium ruticarpum (Evodia rutaecarpa) fruits contains evodene, evodol, and limonin.
Fruits contain evodiamine, rutaecarpine, evocarpine, Hydroxyevodiamine, wuchuyine, ocimene, evodione, evogin, rutaevin, aspartic acid, tryptophan, threonine, serine, cystine, and so on.

The fruit of Tetradium ruticarpum which is also known as Wu zhu yu (Wu Zhu Yu) or Evodia Fruit, is used in Traditional Chinese Medicine at doses of 3-9 grams (of the berries) thrice a day for the purposes of warmth, intestinal comfort (specifically; to alleviate abdominal pain, acid regurgitation, nausea and diarrhea), dysmenorrheal, and fighting inflammation and infections.

The fruit of Tetradium ruticarpum, known as Evodiae Fructus, is a traditional herbal medicine used to treat gastric and duodenal ulcers, vomiting, and diarrhea.
The traditional usage can be potentially associated with the antibacterial activity of Tetradium Ruticarpum Fruit Extract against Helicobacter pylori.

However, so far, the antibacterial activity of Tetradium Ruticarpum Fruit Extract and antibacterial components against H. pylori has not been investigated despite the traditional folk use.
Tetradium ruticarpum is a tree that comes from China and Korea.

It was previously classified in the genus Euodia as Euodia ruticarpa.
Tetradium Ruticarpum Fruit Extract is usually used, denoted sometimes as fructus.
Tetradium Ruticarpum Fruit Extract has a strong bitter taste, and is used in traditional Chinese medicine (TCM) and is a recognized herb in Kampo.

Both the former genus name and the species name are often misspelled, and the plant usually appears in sources dealing with traditional Chinese medicine as "Evodia(e) rutaecarpa".
Evodia (Tetradium Ruticarpum) is a small deciduous flowering tree or a shrub (3-5 m tall) native to Korea and China.

It belongs to the Rutaceae family.
The white or light yellow flowers have five petals.
They grow in clusters and have a bitter taste.
Their size is about 4-5 mm in diameter.

USES and APPLICATIONS of TETRADIUM RUTICARPUM FRUIT EXTRACT:
Tetradium Ruticarpum Fruits Extract is obtained from the dried and nearly ripe fruits of Tetradium ruticarpum (A. Juss.) T.G. Hartley, which have long been used in treating headache and gastrointestinal disorders in oriental medicine.

Tetradium Ruticarpum Fruit Extract is frequently used in a combination supplement called Wu Zhu Yu Tang, which consists of Evodia fruit with Jujube Fruit and Panax Ginseng (1:1:1 ratio) and Ginger root (twice the amount of any one other ingredient) which is a decoction used for hypertension or as Zuo jin wanwhich is used for gastrointestinal distress alongside Rhizoma Coptidis at a 1:6 ratio (Evodia:Coptidis).

Another decoction exists called Fan zuo jin wan, which is Rhizome Coptidis and Evodia in the inverse ratio.
Tetradium Ruticarpum Fruit Extract has also being shown to possess antitumor activity.

Tetradium Ruticarpum Fruit Extract is widely used in Asia to treat gastrointestinal disorders and pain.
Stir-frying with licorice aqueous extract is a traditional processing procedure of Tetradium Ruticarpum Fruit Extract formed in a long-term practice and performed before clinical application, and believed to reduce TR’s toxicity.

CHEMICAL CONSTITUENTS OF TETRADIUM RUTICARPUM FRUIT EXTRACT:
*Active Components:
Alkaloids, limonoids, flavonoids, and volatile oils

*Evodiamine:
A major alkaloid known for its anti-inflammatory and anticancer properties

*Rutaecarpine:
Another key alkaloid with anti-inflammatory and vasodilatory effects

*Limonoids:
Offer antioxidant and cytoprotective effects

*Flavonoids:
Contribute to antioxidant properties

*Essential Oils:
Provide the characteristic fragrance and some therapeutic effects

FUNCTIONS AND USES OF TETRADIUM RUTICARPUM FRUIT EXTRACT:
*Traditional Uses:
In traditional Chinese medicine, Wu Zhu Yu is used to alleviate pain, regulate blood circulation, and treat digestive disorders

*Modern Applications:
Tetradium Ruticarpum Fruit Extract is used in supplements for digestive health, pain relief, and as an anti-inflammatory agent

*Pharmacological Effects:
Analgesic, anti-inflammatory, antioxidant, potential anticancer properties, vasodilation, digestive support

FEATURES AND DESCRIPTION OF TETRADIUM RUTICARPUM FRUIT EXTRACT:
*NON GMO!
*Gluten Free!
*Tetradium Ruticarpum Fruit Extract using a cold maceration method of extraction to ensure that the broad spectrum of therapeutic plant compounds - vitamins, minerals, alkaloids, flavonoids and other active constituents of the herbs are fully extracted and maintained.
*Tetradium Ruticarpum Fruit Extract is expertly extracted under strict quality standards and procedures from Evodia Dried fruit.

NOTABLE COMPOUNDS IN TETRADIUM RUTICARPUM FRUIT EXTRACT INCLUDE:
*alkaloids:
rutecarpine, an indole alkaloid that is a COX-2 inhibitor
0-hydroxyrutaecarpine
evodiamine, a possible thermogenic agent and stimulant, named after the former name of the genus
dehydroevodiamine
synephrine, an adrenergic receptor agonist
1-methyl-2-n-nonyl-4(1H)quinolone
evocarpine
dihydroevocarpine

*flavonoids:
isorhamnetin-7-O-rutinoside
diosmetin-7-O-β-d-glucopyranoside

PRODUCTION OF TETRADIUM RUTICARPUM FRUIT EXTRACT:
*Cultivation
Tetradium ruticarpum is grown mainly in China.

*Harvesting
The fruit is picked.
It may be consumed as food.

TRADITIONAL MEDICINE, TETRADIUM RUTICARPUM FRUIT EXTRACT:
*Traditional Chinese medicine
In traditional Chinese medicine the herb is described as a fruit.

*Kampo
Tetradium ruticarpum is called 呉茱萸 (Goshuyu) in Japanese, used in Goshuyu-tou and Unkentou (ja:温経湯).
These are Kampo (漢方) preparations of mixed herbs, the former named after this plant.
The mixture is noted for having a high concentration (132.6 to 706.3 mmol/100 g) of antioxidants, where the other constituents of the mixture rank lower.

*Contraindications
Allergic reactions have occasionally been reported in users of medicinal preparations of the plant.

BIOCHEMICAL ANALYSIS OF TETRADIUM RUTICARPUM FRUIT EXTRACT:
There has been relatively little scientific study of Tetradium ruticarpum except for antioxidant capacity of one of its mixtures.

PHYSICAL and CHEMICAL PROPERTIES of TETRADIUM RUTICARPUM FRUIT EXTRACT:
EC Number: Not available
CAS Number: Not available (natural extracts typically lack standardized CAS and EC numbers unless referring to specific isolated compounds)
Molecular Formula: Not specifically defined (as it is a complex mixture of bioactive compounds)
Appearance: Light brown to brown powder
Odor: Characteristic aromatic odor, pungent
Solubility: Soluble in alcohol and water
pH: Slightly acidic
Melting Point: Not applicable (for extract)
Boiling Point: Not applicable (for extract)
Family: Rutaceae

Genus: Tetradium
Species: T. ruticarpum
Binomial name: Tetradium ruticarpum
Euodia ruticarpa
Evodia ruticarpa
Main Ingredients: Main ingredient: Evodia (Tetradium Ruticarpum) Dry fruit.
Origin of plant material: Indonesia.
Menstruum: Alcohol, vegetable palm glycerin, crystal clear water.
Contains NO: GMO, gluten, artificial colors, heavy metals, preservatives, pesticides, fertilizers.
Strength: Dry plant material / solvents ratio 1:3

FIRST AID MEASURES of TETRADIUM RUTICARPUM FRUIT EXTRACT:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of TETRADIUM RUTICARPUM FRUIT EXTRACT:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of TETRADIUM RUTICARPUM FRUIT EXTRACT:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of TETRADIUM RUTICARPUM FRUIT EXTRACT:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of TETRADIUM RUTICARPUM FRUIT EXTRACT:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of TETRADIUM RUTICARPUM FRUIT EXTRACT:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available