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Tetrahydrofurfuryl alcohol is a colorless, oily liquid with a slightly sweet odor.
Tetrahydrofurfuryl alcohol has a structure based on the tetrahydrofuran (THF) ring, with an alcohol group (-OH) attached to one of the carbon atoms of the ring.
This compound is known for its relatively low toxicity and versatility in chemical processes.
CAS Number: 97-99-4
Synonyms:,2-(Hydroxymethyl)-tetrahydrofuran,THFA,2-Hydroxy-THF,Tetrahydrofurfuryl alcohol
Introduction to Tetrahydrofurfuryl Alcohol (THFA)
Definition: A clear, colorless, and slightly oily liquid alcohol derived from furfural.
THFA is widely used as a solvent, fuel additive, and in the production of various chemical compounds.
History and Discovery: Exploration of THFA's origins, from its discovery in the early 20th century to its current uses in industry.
Significance in Industry: Why THFA is important in industrial applications, focusing on its versatility as a solvent and intermediate in the production of various chemicals.
Chemical Properties of Tetrahydrofurfuryl Alcohol
Molecular Formula: C5H10O2.
Molecular Structure: Detailed structural analysis of THFA, including functional groups and bond arrangements.
Physical Properties: Properties like boiling point, melting point, density, solubility, and refractive index.
Chemical Stability: Its stability in different environments, susceptibility to oxidation, and how it reacts with other chemicals.
Reactivity: How THFA behaves in various chemical reactions (e.g., polymerization, oxidation).
Synthesis of Tetrahydrofurfuryl Alcohol
Raw Materials and Feedstocks: Discussion of the raw materials like furfural used in the synthesis of THFA.
Methods of Production: Detailed steps for the hydrogenation of furfural to produce THFA, including catalysts, reaction conditions, and yields.
Alternative Synthesis Methods: Exploration of other methods of production, including newer, more sustainable processes.
Challenges in Synthesis: Technical difficulties faced in large-scale production, such as reaction selectivity and efficiency.
Recent Advancements in Synthesis: Innovations in green chemistry and process optimization for more sustainable production methods.
Applications of Tetrahydrofurfuryl Alcohol
Industrial Uses: Detailed examination of its role as a solvent, fuel additive, and in the manufacture of plastics, resins, and coatings.
Pharmaceutical Uses: Its function as an intermediate in pharmaceutical synthesis, particularly in the production of certain antibiotics and other drugs.
Agricultural Applications: Use in agrochemicals, insecticides, and fungicides.
Cosmetic Industry: The role of THFA in the production of fragrances and personal care products.
Other Emerging Applications: Discuss novel applications in areas such as green chemistry, biodegradable materials, and more.
Recent Advancements and Research on Tetrahydrofurfuryl Alcohol
Research in Synthesis: New catalysts and methods improving the efficiency and cost-effectiveness of THFA production.
Applications in Sustainable Technologies: The growing interest in using THFA in biofuels, biodegradable plastics, and other sustainable alternatives.
Green Chemistry Innovations: Exploration of THFA in green chemistry, such as its use in bio-based solvents and polymers.
Future Directions: Potential for THFA in new markets and applications, focusing on emerging research that could change its industrial use.
Conclusion
Summary of Key Points: A concise wrap-up of THFA's importance, its chemical properties, and its widespread industrial use.
Outlook on Future Development: What the future holds for THFA in terms of new technologies, greener production methods, and expanding applications.
Final Thoughts on Sustainability: Emphasizing the importance of sustainable practices in the production and use of THFA to ensure its continued role in various industries.
SAFETY INFORMATION ABOUT TETRAHYDROFURFURYL ALCOHOL
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.
Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials
Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product
