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Tetrahydroxypropyl Ethylenediamine (THPE) is a versatile, tetrafunctional amine commonly used as a buffering agent, emulsifier, and stabilizer in various industrial and personal care formulations.
THPE is valued for its pH-regulating and chelating properties, providing stability and enhancing product efficacy across a range of cosmetic, household, and industrial applications.
THPE is particularly effective in controlling pH-sensitive formulations, making it ideal for stabilizing active ingredients and extending product shelf life.
CAS Number: 102-60-3
EC Number: 203-041-4
Molecular Formula: C10H24N2O4
Molecular Weight: 236.31 g/mol
Synonyms: Tetrahydroxypropyl Ethylenediamine, THPE, N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine, Ethylenediamine Tetrakis(2-hydroxypropyl), 3,3'-Ethylenediamine Tetrapropanol, Tetrahydroxypropyl Ethylene Diamine, THPED, Polyhydroxypropyl Ethylenediamine, Hydroxypropyl Quadrol, Quadrol THPE, Tetrafunctional Ethylenediamine, Emulsifier THPE, Polyhydroxy Ethylenediamine, Tetrakis(2-hydroxypropyl)ethylenediamine Buffer, Cosmetic Grade THPE, THPE Buffer, THPE Stabilizer, EDTA Substitute THPE, Polyamine Tetrahydroxypropyl, Tetrahydroxypropyl Buffer, EINECS 203-041-4, 2-Hydroxypropyl Tetramine, Chelating Agent THPE
APPLICATIONS
Tetrahydroxypropyl Ethylenediamine (THPE) is widely used in skincare products like creams and lotions, where it provides pH regulation, stabilizes emulsions, and ensures a smooth, uniform texture.
THPE is applied in sunscreens, where it helps stabilize UV filters and maintains the efficacy of the active ingredients, even in high-temperature environments.
THPE is included in serums and eye creams, where it supports the stability of sensitive ingredients, extending shelf life and enhancing product performance.
THPE is a key component in hair care products, such as shampoos and conditioners, where it acts as a buffering agent and stabilizer, balancing pH and preventing ingredient separation.
THPE is used in body washes and liquid soaps, where it stabilizes emulsions, maintains product texture, and enhances the sensory feel on the skin.
THPE is applied in deodorants and antiperspirants, where it stabilizes formulations and improves the consistency of active ingredients.
THPE is incorporated into household cleaning products as a chelating agent, enhancing cleaning efficacy by binding to metal ions and improving formulation stability.
THPE is essential in industrial cleaning formulations for machinery and surfaces, where it chelates metal ions and stabilizes active ingredients under varied pH conditions.
THPE is effective in disinfectants and sanitizers, acting as a stabilizer that improves the shelf life and antimicrobial efficacy of active compounds.
THPE is used in textile processing, where it controls pH and improves dye penetration, leading to uniform and high-quality finishes on fabrics.
THPE is found in agricultural formulations, where it stabilizes pH-sensitive pesticides and herbicides, improving the performance and longevity of active ingredients.
THPE is utilized in water treatment, where it chelates metal ions, reducing scaling and extending the operational life of equipment and piping.
THPE is commonly used in biochemical research as a buffering agent in enzyme assays and biochemical reactions, maintaining a consistent pH environment.
THPE is included in protein purification processes, where it preserves biomolecules' stability by providing an optimal pH environment.
THPE is an ingredient in electrophoresis buffers, where it enhances resolution and ensures consistent separation results in laboratory applications.
THPE is incorporated into metalworking fluids, where it provides corrosion inhibition, pH stabilization, and extended tool life.
THPE is used in lubricants and greases, where it stabilizes the viscosity and improves the performance under various operating conditions.
THPE is applied in adhesive and sealant formulations, where it stabilizes the consistency and helps improve adhesion strength across different materials.
DESCRIPTION
Tetrahydroxypropyl Ethylenediamine (THPE) is a multi-functional amine known for its chelating, buffering, and stabilizing properties, making it an essential ingredient in personal care, industrial, and research formulations.
THPE is widely used in formulations requiring pH stabilization, ensuring product efficacy, consistency, and extended shelf life.
In personal care, THPE is valued for its mild properties, making it suitable for skin-friendly and sensitive formulations.
THPE has a stable chemical structure that maintains efficacy across a wide range of temperatures and environments, ensuring reliable performance in various applications.
THPE is biodegradable and considered environmentally safe, aligning with sustainability-focused products in industrial and consumer formulations.
THPE’s unique tetrafunctional structure allows it to act as both a chelating and pH-stabilizing agent, providing multiple benefits within complex formulations.
PROPERTIES
Chemical Formula: C10H24N2O4
Molecular Weight: 236.31 g/mol
Common Name: Tetrahydroxypropyl Ethylenediamine (THPE)
Appearance: Clear to pale yellow liquid
Density: Approx. 1.02 g/cm³
Boiling Point: 290°C
Melting Point: Approx. 60°C
Solubility: Highly soluble in water and polar solvents
Flash Point: >150°C
Reactivity: Stable under normal conditions; avoid strong oxidizing agents
Chemical Stability: Stable under recommended storage conditions
Storage Temperature: Store in a cool, dry place away from direct sunlight and moisture
Vapor Pressure: Low
FIRST AID
Inhalation:
If THPE vapors or mists are inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.
Skin Contact:
Wash the affected area with soap and water.
If skin irritation or rash develops, seek medical attention.
Eye Contact:
In case of eye contact, flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.
Ingestion:
If THPE is ingested, do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.
Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.
HANDLING AND STORAGE
Handling:
Personal Protection:
Wear appropriate personal protective equipment (PPE), such as gloves and safety goggles, when handling large quantities of THPE.
Use in a well-ventilated area to avoid inhalation of vapors or mists.
Ventilation:
Ensure adequate ventilation when handling THPE to control airborne concentrations below occupational exposure limits.
Avoidance:
Avoid direct contact with eyes and prolonged skin contact.
Do not eat, drink, or smoke while handling THPE.
Wash hands thoroughly after handling.
Spill and Leak Procedures:
Contain spills to prevent further release and minimize exposure.
Absorb with inert material (e.g., sand, vermiculite) and collect for disposal.
Dispose of in accordance with local regulations.
Storage:
Store THPE in a cool, dry, well-ventilated area away from incompatible materials such as strong oxidizers.
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and moisture.
Handling Cautions:
Avoid inhalation of vapors and direct contact with skin and eyes.
Use explosion-proof equipment in areas where vapors may be present.
