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Tetrahydroxypropyl Ethylenediamine adjusts the viscosity of products in the cosmetics and personal care industries.
Tetrahydroxypropyl Ethylenediamine is used in the production of adhesives and sealants to improve their performance.
Tetrahydroxypropyl Ethylenediamine maintains stable pH levels in biochemical applications.
CAS Number: 102-60-3
EC Number: 203-041-4
MDL Number: MFCD00004534
INCI Name: Tetrahydroxypropyl Ethylenediamine
Chem/IUPAC Name: 1,1',1'',1'''-Ethylenedinitrilotetrapropan-2-ol
MOLECULAR FORMULA : C14H32N2O4
Molecular Weight: 292.41
SYNONYMS:
102-60-3, Edetol, Quadrol, N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine, Neutrol TE, Entprol, Adeka Quadrol, Quadrol L, 1,1',1'',1'''-(Ethylenedinitrilo)tetra-2-propanol, Edetolum [Latin], 1,1',1'',1'''-(Ethane-1,2-diylbis(azanetriyl))tetrakis(propan-2-ol), Edetolum, Tetrahydroxypropyl ethylenediamine, 2-Propanol, 1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-, Edetol [USAN:INN], NSC 369219, TETRAKIS(2-HYDROXYPROPYL)ETHYLENEDIAMINE, HSDB 5349, EINECS 203-041-4, UNII-Q4R969U9FR, NSC-369219, Edetol (USAN), BRN 1781143, N,N,N',N'-Tetra(2-hydroxypropyl)ethylenediamine, Neutrol TE (TN), CCRIS 8275, 1,1',1'',1'''-Ethylenedinitrilotetrapropan-2-ol, 1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]propan-2-ol, Ethylenediamine-N,N,N',N'-tetra-2-propanol, EDETOL [HSDB], EDETOL [USAN], EDETOL [INN], 2-Propanol, 1',1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-, 2-Propanol, 1,1',1'',1'''-(ethylenedinitrilo)tetra-, 1,1',1'',1'''-(Ethylenedinitrilo)tetrakis(2-propanol), Q4R969U9FR, DTXSID9026689, EC 203-041-4, NNN'N'-Tetrakis(2-Hydroxypropyl)ethylenediamine, Edetolum (Latin), 4-04-00-01685 (Beilstein Handbook Reference), Tetra (2-hydroxypropyl) ethylenediamine, 1,1',1'',1'''-(Ethanediylnitrilo)tetrakis(2-propanol), NCGC00164339-02, DTXCID806689, n,n,n',n'-tetrakis (2-hydroxypropyl) ethylenediamine, N,N,N',N'-Tetrakis(2-Hydroxypropyl)ethylenediamine, 98%, 1,1',1'',1'''-(1,2-ETHANEDIYLDINITRILO)TETRAKIS(2-PROPANOL), CAS-102-60-3, n,n,n,n-tetrakis(2-hydroxypropyl)ethylenediamine, (Ethylenedinitrilo)tetra-2-propanol, N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine;EDTP, 1,1',1'',1'''-(ethane-1,2-diyldinitrilo)tetrapropan-2-ol, Quadrol(R), ENTPROL [MI], SCHEMBL48412, MLS004773924, 1,1',1',1'''-(Ethylenedinitrilo)tetra-2-propanol, N,N,N,N-Tetrakis(2-Hydroxypropyl)- Ethylenediamine, CHEMBL1573178, CHEBI:193592, HMS3264C08, Pharmakon1600-01301023, 2-Propanol, 1,1',1',1'''-(1,2-ethanediyldinitrilo)tetrakis-, HY-B2149, Tox21_112102, Tox21_201973, Tox21_300552, MFCD00004534, NSC369219, NSC760394, tetra(2-hydroxypropyl)ethylenediamine, 1,1',1'',1'''-(Ethane-1,2-diylbis(azanetriyl))-tetrakis(propan-2-ol), AKOS015892820, Tetrakis(2hydroxypropyl)ethylenediamine, Tox21_112102_1, CCG-230630, NSC-760394, SB82446, NCGC00164339-01, NCGC00164339-03, NCGC00164339-04, NCGC00164339-05, NCGC00254289-01, NCGC00259522-01, BS-23689, DA-52809, SMR001600027, CS-0020301, ethane, 1,2-bis(di-2-hydroxypropylamino)-, NS00009765, T0781, D03948, F71260, N,N,N',N'Tetra(2hydroxypropyl)ethylenediamine, 1,1',1',1'''(Ethylenedinitrilo)tetra2propanol, Tetrakis-[N-(2-hydroxy-propyl)]-ethylenediamine, 1,1',1'',1'''(Ethylenedinitrilo)tetra2propanol, A800588, N,N,N',N'Tetrakis(2hydroxypropyl)ethylenediamine, 2Propanol, 1,1',1'',1'''(ethylenedinitrilo)tetra, BRD-A78588743-001-03-4, N,N,N',N'-tetrakis-(2-hydroxypropyl)ethylenediamine, N,N,N,N-Tetrakis(2-hydroxypropyl)ethylenediamine;EDTP, Q26841009, 1,1',1'',1'''(Ethylenedinitrilo)tetrakis(2propanol), 4,7-Diazadecane-2,9-diol, 4,7-bis(2-hydroxypropyl)-, 2Propanol, 1,1',1',1'''(1,2ethanediyldinitrilo)tetrakis, 1,1',1'',1'''-(ethane-1,2-diylbis(azanetriyl))tetrapropan-2-ol, 1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]propan-2-ol, 1-[2-[bis(2-oxidanylpropyl)amino]ethyl-(2-oxidanylpropyl)amino]propan-2-ol, 1,1a(2),1a(2)a(2),1a(2)a(2)a(2)-(Ethylenedinitrilo)tetrakis(2-propanol), 203-041-4, NEUTROL® TE, 1,1',1'',1'''-Ethylenedinitrilotetrapropan-2-ol, Edetol, adeka quadrol, edetol, edetol [USAN:INN], edetolum, entprol, ethylene diamine-N,N,N',N'-tetra-2-propanol, 1,1',1'',1'''-ethylene dinitrilotetrapropan-2-ol, 1,1',1',1'''-(ethylenedinitrilo)tetra-2-propanol, 1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol, 1,1',1'',1'''-(ethylenedinitrilo)tetrakis(2-propanol), 1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]propan-2-ol, neutrol TE, 2-propanol, 1,1',1',1'''-(1,2-ethanediyldinitrilo)tetrakis-, 2-propanol, 1,1',1'',1'''-(ethylenedinitrilo)tetra-, 2-propanol, 1',1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-, quadrol L, N,N,N',N'-tetra(2-hydroxypropyl)ethylenediamine, tetrahydroxypropyl ethylene diamine, tetrakis-(N-(2-hydroxypropyl)) ethylene diamine, tetrakis-N-(2-hydroxypropyl) ethane-1,2-diamine, tetrakis-N-(2-hydroxypropyl) ethylene diamine, N,N,N',N'-tetrakis(2-hydroxypropyl) ethylene diamine, tetrakis(2-hydroxypropyl)ethylenediamine, N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine, Edetol [USAN:INN], 1,1,1,1-(Ethylenedinitrilo)tetra-2-propanol, Entprol, Tetrakis(2-hydroxypropyl)ethylenediamine, 2-Propanol, 1,1,1,1-(1,2-ethanediyldinitrilo)tetrakis-
Tetrahydroxypropyl Ethylenediamine is a substituted amine.
Tetrahydroxypropyl ethylenediamine is a synthetic compound.
Tetrahydroxypropyl Ethylenediamine is formed by reacting ethylenediamine with propylene oxide.
Tetrahydroxypropyl Ethylenediamine is a chelating agent that binds to metal ions or metal compounds, preventing them from adhering to surfaces (e.g. skin, hair or clothing) or causing contamination, for example in the case of trace amounts of iron.
Tetrahydroxypropyl ethylenediamine is a chelating agent that binds with metal ions or metallic compounds, preventing them from adhering to a surface (such as skin, hair, or clothing) or causing contamination, such as in the case of trace amounts of iron.
Tetrahydroxypropyl Ethylenediamine is a derivative of Ethylenediamine in which all hydrogens connected with nitrogens are replaced with four 2-hydroxypropyl groups.
Tetrahydroxypropyl Ethylenediamine is a clear, viscous, almost odorless liquid, particularly suited as a neutralizing agent for polymers in clear gel formulations.
Tetrahydroxypropyl Ethylenediamine forms clear solutions with solvents like water, ethanol, isopropanol, and propylene glycol.
The gels formulated with Tetrahydroxypropyl Ethylenediamine have excellent alcohol compatibility and a pleasant, non-tacky skin feeling.
It could be proved that Tetrahydroxypropyl Ethylenediamine shows a considerably lower tendency to form nitroamines than other bases containing amines.
Tetrahydroxypropyl Ethylenediamine has been toxicologically tested for cosmetic use.
Within the recommended applications and concentrations of Tetrahydroxypropyl Ethylenediamine, no indications of toxicological risks were found.
Tetrahydroxypropyl Ethylenediamine is present in 0.07% of cosmetics.
Tetrahydroxypropyl ethylenediamine, also known as N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine, is a versatile chemical utilized in various industries.
USES and APPLICATIONS of TETRAHYDROXYPROPYL ETHYLENEDIAMINE:
Catalyst in Urethane Foam Production: Tetrahydroxypropyl Ethylenediamineacilitates the formation of urethane foams used in various applications.
Epoxy Resin Curing Agent: Tetrahydroxypropyl Ethylenediamine enhances the curing process of epoxy resins, improving their mechanical properties.
Complexing Agent: Tetrahydroxypropyl Ethylenediamine binds with metal ions, aiding in various chemical processes.
Plasticizer: Improves the flexibility and workability of polymers.
Surfactant Solubilizer: Tetrahydroxypropyl Ethylenediamine enhances the solubility of surfactants in formulations.
Viscosity Modifier: Tetrahydroxypropyl Ethylenediamine adjusts the viscosity of products in the cosmetics and personal care industries.
Cross-Linking Agent: Tetrahydroxypropyl Ethylenediamine is used in the production of adhesives and sealants to improve their performance.
Biological Buffer: Tetrahydroxypropyl Ethylenediamine maintains stable pH levels in biochemical applications.
Due to its multifunctional properties, Tetrahydroxypropyl ethylenediamine is widely employed across industries such as coatings, adhesives, cleaning products, and personal care items.
Tetrahydroxypropyl Ethylenediamine is used as an ingredient in cosmetics and personal care products.
The cosmetic industry also uses Tetrahydroxypropyl Ethylenediamine in soap-making, stearate creams, and to neutralize sunscreens that contain acid groups.
USAGE AND BENEFITS OF TETRAHYDROXYPROPYL ETHYLENEDIAMINE:
*Epidermal Changes:
Tetrahydroxypropyl ethylenediamine is used to induce changes in superficial epidermal keratinocytes.
Tetrahydroxypropyl Ethylenediamine leads to immediate and long-term clinical improvement in skin appearance and therefore can be considered a new anti-aging cosmetic active ingredient.
*Chelating Agent:
Tetrahydroxypropyl Ethylenediamine acts as a chelating agent by binding to the metallic ions present in the product.
Tetrahydroxypropyl Ethylenediamine stabilizes the product by preventing these metallic ions from reacting with other compounds in the cosmetic product.
*Stability:
Tetrahydroxypropyl Ethylenediamine provides stability to the product and increases its effectiveness.
*Cosmetic Applications:
Tetrahydroxypropyl Ethylenediamine is used in the formulation of creams, lotions, gels, make-up materials, sunscreens and other skin and hair care products.
*Chemical Roles:
Chemically, Tetrahydroxypropyl Ethylenediamine has a variety of roles, including being used as a solvent, cleaning agent, emulsifier, dispersant, corrosion inhibitor, lubricant, antistatic agent, and as an intermediate in organic synthesis.
FUNCTION OF TETRAHYDROXYPROPYL ETHYLENEDIAMINE:
Chelating :
Tetrahydroxypropyl Ethylenediamine reacts and forms complexes with metal ions that could affect the stability and / or appearance of cosmetic products
WHAT DOES TETRAHYDROXYPROPYL ETHYLENEDIAMINE DO IN A FORMULATION?
*Chelating
FUNCTIONS OF TETRAHYDROXYPROPYL ETHYLENEDIAMINE:
*Neutralizing agent
*Opacifier
*Chelating agent
FUNCTIONS OF TETRAHYDROXYPROPYL ETHYLENEDIAMINE IN COSMETIC PRODUCTS:
*CHELATING
Tetrahydroxypropyl Ethylenediamine binds metal ions which could negatively affect the stability and / or appearance of cosmetics
PHYSICAL and CHEMICAL PROPERTIES of TETRAHYDROXYPROPYL ETHYLENEDIAMINE:
CAS No.: 102-60-3
Chemical Name: N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
CB Number: CB6287715
Molecular Formula: C₁₄H₃₂N₂O₄
Molecular Weight: 292.41
MDL Number: MFCD00004534
MOL File: 102-60-3.mol
Melting point: 32°C
Boiling point: 175-181 °C at 0.8 mm Hg (lit.)
Density: 1.03 g/mL at 20 °C (lit.)
Vapor pressure: 1 mm Hg (20 °C)
Refractive index: n₂₀/D 1.4812 (lit.)
Flash point: >230 °F
Storage temp.: Store below +30°C.
Solubility: DMSO: ≥ 83.3 mg/mL (284.87 mM)
pKa: 14.23 ± 0.20 (Predicted)
Form: Clear liquid
Specific Gravity: 1.013
Color: Colorless to Almost colorless
pH: 10.4 (10 g/L, H₂O, 20℃)
Water Solubility: Miscible
Merck: 14,3599
BRN: 1781143
InChIKey: NSOXQYCFHDMMGV-UHFFFAOYSA-N
LogP: -2.08 at 25℃
CAS DataBase Reference: 102-60-3 (CAS DataBase Reference)
Indirect Additives used in Food Contact Substances: N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine
FDA 21 CFR: 177.1680
EWG's Food Scores: 1
FDA UNII: Q4R969U9FR
EPA Substance Registry System: N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine (102-60-3)
Linear Formula: [CH₃CH(OH)CH₂]₂NCH₂CH₂N[CH₂CH(OH)CH₃]₂
CAS Number: 102-60-3
Molecular Weight: 292.41
Beilstein: 1781143
EC Number: 203-041-4
MDL Number: MFCD00004534
UNSPSC Code: 12162002
PubChem Substance ID: 24847480
NACRES: NA.23
IUPAC Name: 1-({2-[bis(2-hydroxypropyl)amino]ethyl}(2-hydroxypropyl)amino)propan-2-ol
Molecular Formula: C₁₄H₃₂N₂O₄
InChI Key: NSOXQYCFHDMMGV-UHFFFAOYNA-N
SMILES: CC(O)CN(CCN(CC(C)O)CC(C)O)CC(C)O
Appearance (Color): Clear colorless
Form: Liquid or viscous liquid
Assay (Non-aqueous acid-base Titration): ≥98.5 to ≤101.5%
Refractive Index: 1.4785-1.4815 @ 20°C
Molecular Formula / Molecular Weight: C₁₄H₃₂N₂O₄ = 292.42
Physical State (20 °C): Liquid
Storage Temperature: Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas: Store under inert gas
Condition to Avoid: Air Sensitive
CAS RN: 102-60-3
Reaxys Registry Number: 1781143
PubChem Substance ID: 87576626
SDBS (AIST Spectral DB): 7391
Merck Index (14): 3599
MDL Number: MFCD00004534
Assay: 95.00 to 100.00,
Food Chemicals Codex Listed: No,
Soluble in: water, 1e+006 mg/L @ 25 °C (est),
Molecular Formula: C14H32N2O4,
CAS: 102-60-3,
Molecular Formula: C14H32N2O4,
Molecular Weight (g/mol): 292.42,
MDL Number: MFCD00004534,
InChI Key: NSOXQYCFHDMMGV-UHFFFAOYSA-N,
PubChem CID: 7615,
IUPAC Name: 1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]propan-2-ol,
SMILES: CC(CN(CCN(CC(C)O)CC(C)O)CC(C)O)O,
Molecular Weight: 292.41 g/mol,
XLogP3-AA: -0.7,
Hydrogen Bond Donor Count: 4,
Hydrogen Bond Acceptor Count: 6,
Rotatable Bond Count: 11,
Exact Mass: 292.23620751 g/mol,
Monoisotopic Mass: 292.23620751 g/mol,
Topological Polar Surface Area: 87.4 Ų,
Heavy Atom Count: 20,
Formal Charge: 0,
Complexity: 199,
Isotope Atom Count: 0,
Defined Atom Stereocenter Count: 0,
Undefined Atom Stereocenter Count: 4,
Defined Bond Stereocenter Count: 0,
Undefined Bond Stereocenter Count: 0,
Covalently-Bonded Unit Count: 1,
Compound Is Canonicalized: Yes
Melting point: 32°C,
Boiling point: 175-181 °C at 0.8 mm Hg (lit.),
Density: 1.03 g/mL at 20 °C (lit.),
Vapor pressure: 1 mm Hg (20 °C),
Refractive index: n20/D 1.4812 (lit.),
Flash point: >230 °F,
Storage temp.: Store below +30°C,
Solubility: DMSO: ≥ 83.3 mg/mL (284.87 mM),
Form: clear liquid,
pKa: 14.23 ± 0.20 (Predicted),
Color: Colorless to almost colorless,
Specific Gravity: 1.013,
pH: 10.4 (10g/L, H2O, 20°C),
Water Solubility: miscible,
Merck: 14,3599,
BRN: 1781143,
CAS DataBase Reference: 102-60-3 (CAS DataBase Reference),
EPA Substance Registry System: N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine (102-60-3),
Molecular Weight: 292.41500,
Exact Mass: 292.41,
EC Number: 203-041-4,
UNII: Q4R969U9FR,
NSC Number: 760394 | 369219,
DSSTox ID: DTXSID9026689,
Color/Form: Viscous liquid | water-white liquid,
HScode: 29221980,
PSA: 87.40000,
XLogP3: -0.88640,
Appearance: Liquid,
Density: 1.013,
Melting Point: <25 °C,
Boiling Point: 190 °C @ Press: 1.0 Torr,
Flash Point: 100°C,
Refractive Index: 1.4795-1.4815,
Water Solubility: miscible with water;
soluble in methanol, ethanol, toluene, ethylene glycol, perchloroethylene,
Storage Conditions: Keep container closed when not in use.
Store in a tightly closed container.
Store in a cool, dry, well-ventilated area away from,
Vapor Pressure: 1 mm Hg (20 °C)
Molecular Weight:292.41
XLogP3:-0.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:292.23620751
Monoisotopic Mass:292.23620751
Topological Polar Surface Area:87.4
Heavy Atom Count:20
Complexity:199
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
FIRST AID MEASURES of TETRAHYDROXYPROPYL ETHYLENEDIAMINE:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available
ACCIDENTAL RELEASE MEASURES of TETRAHYDROXYPROPYL ETHYLENEDIAMINE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of TETRAHYDROXYPROPYL ETHYLENEDIAMINE:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of TETRAHYDROXYPROPYL ETHYLENEDIAMINE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of TETRAHYDROXYPROPYL ETHYLENEDIAMINE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
hygroscopic
STABILITY and REACTIVITY of TETRAHYDROXYPROPYL ETHYLENEDIAMINE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available
