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bis[tetrakis(hydroxymethyl)phosphonium]sulfatesolution; nci-c55050; Tetrakis (Hydroxymethyl) Phosphonium Sulfate, 75% Aqueous; Bis[tetrakis(hydroxymethyl)phosphonium] sulfate - 70-80% in water; octakis(hydroxymethyl)phosphoniumsulfate; Phosphonium,tetrakis(hydroxymethyl)-,sulfate(2:1)(salt); Pyrosettko; tetrakis(hydroxymethyl)-phosphoniusulfate(2:1); tetrakis(hydroxymethyl)-phosphoniusulfate(2:1)(salt); thps; Bis[tetrakis(hydroxyMethyl)phosphoniuM] sulfate solution,~75% in H2O; Tetrahydroxymethyl phosphonium sulfate; Phosphonium, tetrakis(hydroxymethyl)-, sulfate (2:1); Retardol S; 2[Tetrakis(hydroxymethyl)phosphonium]·sulfuric acid dianion; Ncgc00091951-01; Tetrakis(hydroxymethyl)phosphonium sulfate, 70 - 80 wt.% solution in H2O; Tetrakis(HydroxyMethyl) PhosphoniuM Sulphate (THPS); Bis[tetrakis(hydroxyMethyl)phosphoniuM; Bis[tetrakis(hydroxymethyl)phosphonium] sulfate solution technical, 70-75% in H2O (T); Tetrakis(hydroxymethyl)phosphonium sulfate (75% aqueous solution); bis(tetrakis(hydroxymethyl)phosphonium)sulfate(salt); TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM SULFATE; octakis(hydroxymethyl)diphosphonium sulfate; tetrakis(hydroxymethyl)phosphonium sulphate(2:1); Tetrakis(hydroxymethyl)Phosphonium Sulphate; TetrakisHydroxymethylPhosphoniumSulfate(Thps); Tetrakis(hydroxymethyl)phospho; HISHICOLIN THPS; BIS[TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM] SULFATE; PHOSPHONUIM,TETRAKIS(HYDROXYMETHYL)-,SULPHATE; Tetrakis(hydroxymethyl)phosphoniumsulfat (2:1); TETRAKIS(HYDROXYMETHYL)-PHOSPHONIUSULFATE; Tetrakis(hydroxymethyl)phosphonium Sulfate (ca. 70-80% in Water) THPS (Tech Grade); 75% Tetrakis(hydroxymethyl)phosphonium Sulfate Solution; Tetrakis(hydroxymethyl) phosphonium sulfate (70-80 % in water); Tetrakis(hydroxymethyl)phosphonium sulfate fandachem; Tetrakis Hydroxymethyl phosphonium Sulfate / THPS 75%


CAS No.: 55566-30-8

Molecule Formula: C₈H₂₄O₁₂P₂S

Molecular Weight: 406.28 g/mol

Flash Point: greater than 200 ° F

Melting Point: -31 ° F

Boiling Point: 232 ° F at 760 mm Hg


- THPS is manufactured in a batch process that involves the chemical reaction of phosphine gas with aqueous formaldehyde in the presence of sulfuric acid and water. THPS exists in equilibrium with tris (hydroxymethyl)phosphine and methylene glycol. Under manufacturing and shipping conditions, the equilibrium strongly favors the formation the formation of THPS.

- Hazard Classification & Labelling: Danger! According to the classification provided by companies to ECHA in REACH registrations this substance is toxic if inhaled, is very toxic to aquatic life, is toxic to aquatic life with long lasting effects, is harmful if swallowed, causes serious eye damage, is suspected of damaging fertility or the unborn child and may cause an allergic skin reaction.

- Biocidal Uses: This substance is being reviewed for use as a biocide in the EEA and/or Switzerland, for: product preservation, preservation for liquid systems, controlling slimes.

- Usagein Food Additives and Ingredients: As a preservative in coatings intended for use on paper and paperboard that may contact food, except for use in contact with infant formula and human milk (see Limitations/Specifications).

- Antimicrobial: Type of pesticide used to destroy or inhibit the growth of disease-causing mechanisms, can be impregnated into clothing

- Consumer use: Term applied when the only information the source indicates is 'consumer' or 'consumer product' ; also applied to terms that the source indicates are for consumer use, yet the descriptor term is ambivalent about usage (e.g., cleaning_washing products may be for industrial or consumer use, when the source indicates consumer use, the consumer_use term is also applied) - see appendix for full list of unambiguous consumer related terms plus ambiguous consumer related terms which if indicated are labeled with 'consumer_use'

- Flame_retardant: Fire prevention materials, or additives/coatings to prevent flammability in paints, textiles, plastics, etc.

- Food_contact: Includes food packaging, paper plates, cutlery, small appliances such as roasters, etc.; does not include facilities that manufacture food

- Lubricant: Generic lubricants, lubricants for engines, brake fluids, oils, etc (does not include personal care lubricants)

- Manufacturing, apparel General term which includes clothes, shoes, backpacks/purses/luggage, jewelry, pet apparel, etc.; more specific terms (e.g. clothing, footwear, handwear) included as modifiers when known

- Manufacturing, chemical: General term used only when the only information known from the source is 'chemical,' typically related to manufacturing of chemicals, or laboratory chemicals

- Manufacturing, leather: Leather products, and products/chemicals used in the process of tanning and dressing leather

- Manufacturing, leather, apparel, bags: Sub-category of apparel, including backpacks, purses, and luggage

- Manufacturing, paint: Various types of paint for various uses, modifiers included when more information is known

- Manufacturing, paper: Related to the manufcturing of pulp or paper products, or paper products in general

- Manufacturing, textile: Textiles used for clothing or furniture upholstery, processes related to textiles 

- Mining: Related to the mining industry, mining for coal, metals, etc

- Pesticide: Substances used for preventing, destroying or mitigating pests

- Pesticide, active_ingredient: Active ingredients in a product (often active ingredients in pesticide, if so also tagged with 'pesticide')

- Pesticide, antimicrobial : Type of pesticide used to destroy or inhibit the growth of disease-causing mechanisms, can be impregnated into clothing

- Pesticide, antimicrobial, active_ingredient: Active ingredients in a product (often active ingredients in pesticide, if so also tagged with 'pesticide')

- Pesticide, bactericide: Type of pesticide that kills bacteria

- Pesticide, biocide, active_ingredient: Active ingredients in a product (often active ingredients in pesticide, if so also tagged with 'pesticide')

- Pesticide, biocide, non_agricultural: Pesticide for non agricultural use

- Pesticide, growth_inhibitor: Growth inhibitor, unknown usage or application

- Pesticide, preservatives: Includes preservatives used in cosmetics, film, wood preserving agents, foods, etc (note food preservatives are also indicated as food_additive)

- Pesticide, slimicide: Type of pesticide to prevent the growth of slime

- Preservatives: Includes preservatives used in cosmetics, film, wood preserving agents, foods, etc (note food preservatives are also indicated as food_additive)

- Process_regulator: Accelerators, activators, oxidation agents, reducing agents, etc

- Resource_extraction, gas: Related to fracking, natural gas, industrial gases

- Resource_extraction, oil: Crude oil, crude petroleum, refined oil products, fuel oils, drilling oils

- Surface_treatment: Surface treatments for metals, hardening agents, corrosion inhibitors, polishing agents, rust inhibitors, water repellants, etc (surfaces to be applied to often not indicated in source description)

- Water treatment: Includes water softeners, lime removers, and the products used in the process of the collection, purification, and distribution of water

- Both oil base and water base fracturing fluids are being used in the fracturing industry. Water base, which includes alcohol-water mixtures and low strength acids, make up the majority of treating fluids. The common chemicals added to these fluids are polymers for viscosity development, crosslinkers for viscosity enhancement, pH control chemicals, gel breakers for polymer degradation following the treatment, surfactants, clay stabilizers, alcohol, bactericides, fluid loss additives and friction reducer.

- Hydraulic fracturing uses a specially blended liquid which is pumped into a well under extreme pressure causing cracks in rock formations underground. These cracks in the rock then allow oil and natural gas to flow, increasing resource production. ... Chemical Name: Tetrakis hydroxymethyl-phosphonium sulfate; Chemical Purpose: Eliminates bacteria in the water that produces corrosive by-products; Product Function: Biocide.

- Industry Uses: Corrosion inhibitors and anti-scaling agents, Flame retardants, Processing aids, specific to petroleum production

- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992) 

- Disposal Methods: SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

- Storage Conditions: Store AQUCAR THPS 75 Water Treatment Microbiocide in a cool dry area away from direct sunlight and heat to avoid deterioration. Avoid temperatures above 160 °C (320 °F). The active ingredient (THPS) decomposes at elevated temperatures with generation of gas which can cause pressure buildup in closed systems. Exposure to air can decrease the shelf life of the product. Ensure that storage conditions are in conformance with applicable legal, fire, insurance and government requirements. /AQUCAR THPS 75 Water Treatment Microbiocide/

- RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

- FDA Requirements: Slimicides may be safely used in the manufacture of paper and paperboard that contact food, in accordance with the conditions prescribed at 21 CFR 173.300. Chemical: Tetrakis(hydroxymethyl)phosphonium sulfate. Limitation: Maximum use level of 84 mg/kg in the pulp slurry. The additive may also be added to water, which when introduced into the pulp slurry, results in a concentration in the pulp slurry not to exceed 84 mg/kg.

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